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| 1 | Biosynthesis of Triacylglycerol Molecules with a Tailored PUFA Profile in Industrial Microalgae显示文摘The composition of polyun saturated fatty acids (PUFAs) in triacylglycerols (TAGs) is key to health ben efits and for oil applications, yet the underlying genetic mechanism remains poorly understood. In this study, by in si Iico, ex vivo, and in vivo profili ng of type-2 diacylglycerol acyltransferases (DGAT2s) in Nannochloropsis oceanica we revealed two novel PUFA-preferring enzymes that discriminate individual PUFA species in TAG assembly, with NoDGAT2J for linoleic acid (LA) and NoDGAT2K for eicosapentaenoic acid (EPA). The LA and EPA composition of TAG molecules is mediated in vivo via the functional partitioning between NoDGAT2J and 2K, both of which are localized in the chloroplast envelope. By modulating transcript abundance of the DGAT2s, an N. oceanica strain bank was created, where proportions of LA and EPA in TAG vary by 18.7-fold (between 0.21% and 3.92% dry weight) and 34.7-fold (between 0.09% and 3.12% dry weight), respective!y. These findings lay the foundation for producing designer TAG molecules with tailored health benefits or for biofuel applications in industrial microalgae and higher-plant crops. | Yi Xin Chen Shen Yiting She Hong Chen Cong Wang Li Wei Kangsup Yoon Danxiang Han Qiang Hu Jian Xu | 2019 | Molecular Plant2019，12，4： | 10 |
| 2 | Snaill is involved in de novo cardiac fibrosis after myocardial infarction in mice显示文摘Epithelialmesenchymal 转变(EMT ) 是在心肌的梗塞(MI ) 以后的心脏的纤维变性的重要机制。然而,它仍然保持不清楚是否 Snail1, EMT 的一个重要管理者,涉及心脏的纤维变性。在这研究,我们在老鼠探索了 Snail1 和心脏的纤维变性 markerperiostinafter MI 的表示模式然后在老鼠在 MI 以后调查了在 Snail1 和 periostin 之间的合作表示。我们的结果证明 Snail1 和 periostin 的 mRNA 和蛋白质层次显著地在梗塞区域被增加。Snail1 表示模式看起来在在 MI 以后的 14 天以内寓言。另外在 MI 以后,所有 Snail1 积极的房间能表示 periostin。这些结果显示 Snail1 主要在梗塞区域被激活并且涉及 de novo 在在老鼠的 MI 以后的心脏的纤维变性。因此,它是在为在 MI 以后的室的改变的药干预的发展的一个潜在的分子的目标。 | Yajie Liu Jianlin Du Jin Zhang Minjie Weng Xiaoqun Li Di Pu Lingzhi Gao Songbai Deng Shuang Xia Qiang She | 2012 | Acta Biochimica et Biophysica Sinica2012，44，11： | 7 |
| 3 | Anp32e, a higher eukaryotic histone chaperone directs preferential recognition for H2A,Z显示文摘H2A.Z 是在所有种类的高度保存的 histone 变体。H2A.Z 的染色质免职被改变复杂 SWR1 和它的哺乳动物的对应物 SRCAP 的酵母染色质明确地催化。然而, H2A.Z 被 non-histone 蛋白质优先地被认出的机制留下逃犯。这里,我们识别了 Anp32e,为 H2A.Z Anp32e 的新奇更高优核质特定的 histone 女伴优先地在 vitro 并且在 vivo 把 dimers 而非 H2A-H2B dimers 与 H2A.Z-H2B 联系并且分裂 non-nucleosomal 总数由 DNA 和 H2A-H2B 形成了。我们与 H2A.Z-H2B 在建筑群决定了 Anp32e 女伴领域(186-232 ) 的水晶结构更暗淡。在这结构,包含 Anp32e 残余 214-224 的区域,在另外的 Anp32 家庭蛋白质不在,明确地与扩大 H2A.Z α 交往; C 螺旋,哪个展览一个意外 conformational 变化。Anp32e 的染色体宽的介绍表明在 Anp32e 和 H2A.Z 房间 overexpressing Anp32e 之间的显著合作占有在 +1 nucleosomes 显示了强壮的全球 H2A.Z 损失,而房间显示的 Anp32e 弄空在 +1 nucleosomes 的中等全球 H2A.Z 增加。这建议 Anp32e 可以帮助解决 non-nucleosomal H2A.Z 总数并且也在 +1 nucleosomes,和后者便于 H2A.Z 的移动可以帮助 RNA 聚合酶 II 通过第一个 nucleosomal 障碍。 | Zhuo Mao Lu Pan Weixiang Wang Jian Sun Shah Shan Qiang Dong Xiaoping Liang Linchang Dai Xiaojun Ding She Chen Zhuqiang Zhang Bing Zhu Zheng Zhou | 2014 | Cell Research2014，24，4： | 6 |
| 4 | Synthesis and antibacterial activity of pleuromutilin derivatives with novel C(14) side chain显示文摘以便与优异抗菌剂活动和克服的 multidrug 抵抗发现新奇抗菌剂代理人,有新奇 C (14 ) 方面链的一系列 pleuromutilin 衍生物被综合并且评估为他们的在里面 vitro 抗菌剂活动。抗菌剂 acticities 的结果显示大多数衍生物对克积极的有机体显示出有势力活动。特别地,复合 10d 展出了大多数有势力禁止的活动与 pleuromutilin 和 linezoid 相比,为进一步的调查的出现同样潜在的分子。 | Li Qiang Fu Chen Yu Ling Xing Sheng Guo Hui Li He Yu She Yang | 2012 | Chinese Chemical Letters2012，23，1： | 5 |
| 5 | Synthesis and antibacterial activity of C-2(S)-substituted pleuromutilin derivatives显示文摘In order to probe the effect of C-2(S)-substituted groups in the antibacterial activity,a series of novel C-2(S)-substituted pleuromutilin analogues of SB-225586 were synthesized and evaluated for their in vitro antibacterial activity.The results of antibacterial activities indicated that C-2(S)-substituted pleuromutilin derivatives retained appreciable antibacterial activity,and the 2-fluorination compounds 6a and 6b are more potent than the corresponding 2-hydroxylation analogues 7a and 7b. | Li Qiang Fu Xing Sheng Guo Xin Liu Hui Li He Yu Ling Wang Yu She Yang | 2010 | Chinese Chemical Letters2010，21，5： | 5 |
| 6 | Diagnostic Performance of Urea Breath Test, Rapid Urea Test, and Histology for Helicobacter pylori Infection in Patients With Partial Gastrectomy: A Meta-analysis显示文摘 | Xue-Ying Tian Hong Zhu Jing Zhao Qiang She Guo-Xin Zhang | 2012 | Journal of Clinical Gastroenterology2012，，4： | 4 |
| 7 | Effect of Chronic Noise Exposure on Expression of N-Methyl-D-Aspartic Acid Receptor 2B and Tau Phosphorylation in Hippocampus of Rats显示文摘Objective To study the effect of chronic noise exposure on expression of N-methyl-D-aspartic acid receptor 2B (NR2B) and tau phosphorylation in hippocampus of rats. Methods Twenty-four male SD rats were divided in control group and chronic noise exposure group. NR2B expression and tau phosphorylation in hippocampus of rats were detected after chronic noise exposure (100 dB SPL white noise, 4 h/d×30d) and their mechanisms underlying neuronal apoptosis in hippocampus of rats with TUNEL staining. Results The NR2B expression decreased significantly after chronic noise exposure which resulted in tau hyperphosphorylation and neural apoptosis in hippocampus of rats. Immunohistochemistry showed that the tau hyperphosphorylation was most prominent in dentate gyrus (DG) and CA1 region of rat hippocampus. Conclusion The abnormality of neurotransmitter system, especially Glu and NR2B containing NMDA receptor, and tau hyperphosphorylation in hippocampus of rats, may play a role in chronic noise-induced neural apoptosis and cognition impairment. | CUI Bo WU Ming Quan ZHU Li Xing SHE Xiao Jun MA Qiang LIU Hong Tao | 2013 | Biomedical and Environmental Sciences2013，26，3： | 3 |
| 8 | Insulin-like growth factor 1 receptor signaling regulates embryonic epicardial cell proliferation through focal adhesion kinase pathway显示文摘 | Yuling Yan Qin Qin Ling Wu Xiaodong Jing Songbai Deng Qiang She | 2018 | Acta Biochimica et Biophysica Sinica2018，50，10： | 3 |
| 9 | Rapid phenotypic evolution with shallow genomic differentiation during early stages of high elevation adaptation in Eurasian Tree Sparrows显示文摘Known as the‘third polar region’,the Qinghai-Tibet Plateau represents one of the harshest highland environments in the world and yet a number of organisms thrive there.Previous studies of birds,animals and humans have focused on well-differentiated populations in later stages of phenotypic divergence.The adaptive processes during the initial phase of highland adaptation remain poorly understood.We studied a human commensal,the Eurasian Tree Sparrow,which has followed human agriculture to the Qinghai-Tibet Plateau.Despite strong phenotypic differentiation at multiple levels,in particular in muscle-related phenotypes,highland and lowland populations show shallow genomic divergence and the colonization event occurred within the past few thousand years.In a one-month acclimation experiment investigating phenotypic plasticity,we exposed adult lowland tree sparrows to a hypoxic environment and did not observe muscle changes.Through population genetic analyses,we identified a signature of polygenic adaptation,whereby shifts in allele frequencies are spread across multiple loci,many of which are associated with muscle-related processes.Our results reveal a case of positive selection in which polygenic adaptation appears to drive rapid phenotypic evolution,shedding light on early stages of adaptive evolution to a novel environment. | Yanhua Qu Chunhai Chen Ying Xiong Huishang She Yong E Zhang Yalin Cheng Shane DuBay Dongming Li Per G P Ericson Yan Hao Hongyuan Wang Hongfeng Zhao Gang Song Hailin Zhang Ting Yang Chi Zhang Liping Liang Tianyu Wu Jinyang Zhao Qiang Gao Weiwei Zhai Fumin Lei | 2020 | National Science Review2020，7，1： | 2 |
| 10 | Deformation features of garnet-bearing granites from Huwan,western Dabie Mountains显示文摘Foliated garnet-bearing granite,usually associated with high pressure and ultrahigh-pressure(UHP) metamophic rocks,is a particular rock-type extensively exposed in the Mesozoic Dabie-Sulu orogenic belt of China.This study focuses on deformation features and SHRIMP zircon dating of foliated garnet granite in a high-pressure metamorphic unit from Huwan,western Dabie Mountains in order to resolve discrepancies in current versions of its petrogenesis and structural evolution.SHRIMP dating reveals a zircon age of 762 ± 15 Ma(MSWD=1.7) for Huwan granites,representing the Middle to Late Neoproterozoic age of intrusion and crystallization.Field and microstructural studies show that the Huwan granite body underwent multiple-stage deformation.The deformation was manifested by an early stage of rootless folding and imposition of relict foliation(S1);an Indosinian main stage marked by imposition of north-dipping penetrative gneissosity(S2) and development of ductile shear zones under NNE-SSW directed compression;and a final Indosinian stage of southward thrusting of the Huwan high-pressure unit.Shallow level extension prevailed after the Late Triassic,giving rise to south-dipping thrust faults and north-dipping normal faults. | YANG KunGuang LIU Qiang XIE JianLei DAN Wei SHE ZhenBing MA ChangQian | 2009 | Science China Earth Sciences2009，52，1： | 2 |
| 11 | Constructing road safety performance indicators u- sing fuzzy delphi method and grey delphi method 显示文摘 | Ma Zhuang lin Shao Chun-fu Ma She qiang | 2011 | Expert Systems with Applications2011，38，3： | 1 |
| 12 | Reeent Advanee in Peer- to-Peer Media Streaming Systems显示文摘 | Gao Wen Huo Long she Fu Qiang | 2006 | China Communication2006，3，5： | 1 |
| 13 | Matter element analysis for optimal timing and preventive mainte- nance of pavements 显示文摘 | Li Qiang She Xiaohong Wang Kelvin C P | 2010 | Transportation Research Re- cord : Journal of the Transportation Research Board2010，2150，： | 1 |
| 14 | Laboratory column study for remediation of MTBE - contaminated groundwater using a biological two - layer permeable barrier显示文摘 | She - Jiang Liu Bin Jiang Guo - Qiang Huang Xin - Gang Li | 2006 | Water Research2006，40，： | 1 |
| 15 | Nanocrystalline silicon films prepared by laser - induced crystallization显示文摘 | Yu Wei Li She - Qiang | 2003 | Chin Phys2003，12，01： | 1 |
| 16 | Laboratory column study for remediation of MTBE-contaminated groundwater using a biological two-layer permeable barrier显示文摘 | Liu She Jiang Jiang Bin Huang Guo Qiang | 2006 | Water Research2006，40，： | 1 |
| 17 | TNFα inhibitor C87 sensitizes EGFRvⅢ transfected glioblastoma cells to gefitinib by a concurrent blockade of TNFα signaling显示文摘Objective: More than half of human glioblastomas show EGFR gene amplification and mutation, but EGFR inhibitors have not been effective in treating EGFR-positive glioblastoma patients.The mechanism behind this type of primary resistance is not well understood.The aim of this study was to investigate gefitinib resistance in glioblastoma, and explore ways to circumvent this significant clinical problem.Methods: MTT method was used to test the cell viability after EGFR-positive glioblastoma cells were treated with indicated drugs;real-time quantitative PCR method was included to detect the TNFα mRNA levels in glioma tissues and cell lines.ELISA was introduced to measure the TNFα protein levels in cell culture supernatant of glioblastoma cells treated with gefitinib.Western blot was used to detect the activity change of intracellular kinases in drug-treated glioblastoma cells.Two mouse xenograft tumor models were carried out to evaluate the in vivo effects of a combination of EGFR and TNFα inhibitors.Results: We found that glioblastoma resistance to gefitinib may be mediated by an adaptive pro-survival TNFα-JNK-Axl signaling axis, and that high TNFα levels in the glioblastoma microenvironment may further intensify primary resistance.A combination of the TNFα-specific small-molecule inhibitor C87 and gefitinib significantly enhanced the sensitivity of glioblastoma cells to gefitinib in vitro and in vivo.Conclusions: Our findings provide a possible explanation for the primary resistance of glioblastoma to EGFR inhibitors and suggest that dual blockade of TNFα and EGFR may be a viable therapeutic strategy for the treatment of patients with chemotherapy-refractory advanced glioblastoma. | Li Ma Chunhua She Qian Shi Qiang Yin Xinxin Ji Yongrong Wang Yulong Fan Xinyao Kong Peng Li Zengfeng Sun Xiaohui Zhang Zhen Zhang Jian Wang Tong Wang Yuanfu Xu Wenliang Li | 2019 | Cancer Biology & Medicine2019，16，3： | 1 |
| 18 | Age-dependent down-regulation of hyperpolarization-activated cyclic nucleotide-gated channel 4 causes deterioration of canine sinoatrial node function显示文摘在 sinoatrial 节点(圣) 的心律调整器房间的活动是正常湾穴节奏的指示物。临床的研究表明了 SAN 的机能障碍日益增多地与老化增加。在这研究,我们在激活 hyperpolarization 的周期的核苷酸门隧道 4 决定了变化(HCN4 ) 在老化和犬的圣机能障碍之间的表示和关系。心脏的 electrophysiological 决心的结果表明内在的心率从 168 牵摥戠桥癡潩慲?慤慴 | Jianlin Du Songbai Deng Di Pu Yajie Liu Jun Xiao Qiang She | 2017 | Acta Biochimica et Biophysica Sinica2017，49，5： | 0 |
| 19 | Heparin-induced thrombocytopenia in renal insufficiency undergoing dialysis and percutaneous coronary intervention after acute myocardial infarction:A case report显示文摘BACKGROUND Heparin-induced thrombocytopenia(HIT)is a rare complication of heparin therapy,and is characterized by arteriovenous thrombosis and bleeding events.The incidence of HIT after percutaneous coronary intervention(PCI)in patients with myocardial infarction complicated with renal failure is rarely reported.CASE SUMMARY We report a 73-year-old man with acute myocardial infarction and renal failure who underwent hemodialysis and PCI,and developed a progressive decline in platelets and subcutaneous hemorrhage of both upper limbs after heparin treatment.In addition to a gradual decrease in platelets,the patient’s 4T's score was 7,and HIT antibody was positive,confirming the diagnosis of HIT.CONCLUSION Patients receiving heparin combined with antiplatelet therapy should be monitored closely,especially for their platelet count.In the case of thrombocytopenia,HIT should be highly suspected.When the diagnosis of HIT is confirmed,timely individualized treatment should be delivered. | Jing Wang Song-Bai Deng Qiang She | 2020 | World Journal of Cardiology2020，12，12： | 0 |
| 20 | Biological characteristics of embryonic epicardial cells in vitro correlate with embryonic day显示文摘epicardial 房间(史诗) 文化系统在调查涉及史诗的发展的特定的机制和发信号的分子起一个重要作用。从这早形成直到成人生活,史诗在在胚胎的宏伟性质与变化相关的胚胎的基因的表示经历动态变化。胚胎的宏伟性质的差别可以影响宏伟文化系统在被使用的实验的相关结果;然而,这些差别没被探索。因此,在这研究,我们在 vitro 在不同的胚胎的天在史诗的生物特征检验了差别。史诗在胚胎的天(E) 上从胚胎的室将生物的活组织移植于培养基中培养被孤立 11.5, E13.5,和 E15.5。在迁居,增长和区别的差别被擦伤试金,导出的细胞周期分析和血小板在不同胚胎的白天的史诗学习生长 factor-bb (PDGF-BB ) 处理。结果证明史诗从 E11.5, E13.5,和 E15.5 是成功地有教养的胚胎的室将生物的活组织移植于培养基中培养。E11.5, E13.5,和从将生物的活组织移植于培养基中培养的 E15.5 宏伟隔离的时间窗户是不同的。E11.5, E13.5,和 E15.5 史诗的迁居能力在胚胎的开发期间减少了。早阶段史诗的光滑的肌肉房间区别潜力比以后的阶段史诗的好。尽管 E11.5 史诗的增长能力是比 E13.5 和 E15.5 史诗的那些显著地弱的, E13.5 和 E15.5 史诗的增长能力没不同。这些结果建议有预定胚胎的开发的史诗相互关联的生物特征,和室的不同胚胎的舞台应该适当地为取决于特定的实验的目的 culturing 史诗被选择。 | Xiaoming Wei Yulin Gao Xiaodong Jing Songbai Deng Jianlin Du Yajie Liu Qiang She | 2017 | Acta Biochimica et Biophysica Sinica2017，49，1： | 0 |
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