|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Prolonged feeding with guanidinoacetate, a methyl group consumer, exacerbates ethanol-induced liver injury显示文摘AIM To investigate the hypothesis that exposure to guanidinoacetate(GAA, a potent methyl-group consumer) either alone or combined with ethanol intake for a prolonged period of time would cause more advanced liver pathology thus identifying methylation defects as the initiator and stimulator for progressive liver damage.METHODS Adult male Wistar rats were fed the control or ethanolLieber De Carli diet in the absence or presence of GAA supplementation. At the end of 6 wk of the feeding regimen, various biochemical and histological analyses were conducted. RESULTS Contrary to our expectations, we observed that GAA treatment alone resulted in a histologically normal liver without evidence of hepatosteatosis despite persistence of some abnormal biochemical parameters. This protection could result from the generation of creatine from the ingested GAA. Ethanol treatment for 6 wk exhibited changes in liver methionine metabolism and persistence of histological and biochemical defects as reported before. Further, when the rats were fed the GAA-supplemented ethanol diet, similar histological and biochemical changes as observed after 2 wk of combined treatment, including inflammation, macroand micro-vesicular steatosis and a marked decrease in the methylation index were noted. In addition, rats on the combined treatment exhibited increased liver toxicity and even early fibrotic changes in a subset of animals in this group. The worsening liver pathology could be related to the profound reduction in the hepatic methylation index, an increased accumulation of GAA and the inability of creatine generated to exert its hepato-protective effects in the setting of ethanol.CONCLUSION To conclude, prolonged exposure to a methyl consumer superimposed on chronic ethanol consumption causes persistent and pronounced liver damage. | Natalia A Osna Dan Feng Murali Ganesan Priya F Maillacheruvu David J Orlicky Samuel W French Dean J Tuma Kusum K Kharbanda | 2016 | World Journal of Gastroenterology2016，22，38： | 2 |
| 2 | Biomarker-guided sequential targeted therapies to overcome therapy resistance in rapidly evolving highly aggressive mammary tumors显示文摘组合指向的治疗在由堵住治疗癌症是更有效的绕过机制或导致的合成致命性。然而,他们的临床的申请被抵抗和毒性妨碍。遇见这重要挑战,我们用 ErbB2-overexpressing/PTEN-low 开发了并且测试各种各样的指向的治疗的指导 biomarker 的顺序的应用程序的一个新奇概念,高度好攻击的乳癌作为我们的模型。惊人地,从遗传上设计的鼠标与 intratumoral 异质从病人和乳房的肿瘤在两 PTEN-low/trastuzumab-resistant 乳癌支撑了 ErbB2 和下游的小径驱动器 trastuzumab 抵抗的激活。尽管 lapatinib 开始禁止了 trastuzumab 抵抗的鼠标肿瘤,肿瘤由激活表明由量的蛋白质数组出现的网络的 PI3K/mTOR 绕过抑制。有趣地,小径也是的 mTOR 的激活在 neoadjuvant 观察了表明 lapatinib 抵抗的对待 lapatinib 的病人。Trastuzumab + lapatinib 抵抗被一个 PI3K/mTOR 双 kinase 禁止者(BEZ235 ) 的顺序的申请有效地没有重要毒性克服。然而,我们的 p-RTK 数组分析证明 BEZ235 治疗在遗传上设计的老鼠肿瘤导致了增加的 ErbB2 表示和 phosphorylation,导致 BEZ235 抵抗并且在 3-D,然而并非 2-D,文化。机械学地,我们作为 BEZ235 抵抗的新奇机制识别了 ErbB2 蛋白质稳定和激活,它被随后的治疗与 lapatinib + BEZ235 联合颠倒。显著地, biomarker 指导的指向的治疗的这个顺序的应用程序在很快发展加倍的抵抗的肿瘤改变忍受极其好攻击的肿瘤的鼠标的寿命。使用的这条根本上新奇的途径有效地在一个顺序的顺序罐头指向了治疗目标和改编在在治疗期间发展抵抗的癌症的发信号的网络。 | Ozgur Sahin Qingfei Wang Samuel W Brady Kenneth Ellis Hai Wang Chia-Chi Chang Qingling Zhang Preety Priya Rui Zhu Stephen T Wong Melissa D Landis William J Muller Francisco J Esteva Jenny Chang Dihua Yu | 2014 | Cell Research2014，24，5： | 2 |
| 3 | Lewis acid metal ion-exchanged MAPO-5 molecular sieves for solvent free synthesis of coumarin derivative显示文摘 | GOPALAKRISHNAN S VISWANATHAN K R PRIYA S V MABEL J H PALANICHAMY M MURUGESAN V | 2008 | Catalysis Communications2008，10，10： | 1 |
| 4 | Piezoelectric and magnetoelectric thick films for fabricating power sources in wireless sensor nodes显示文摘 | PRIYA S RYU J PARK C S el al | 2009 | Sensors2009，9，： | 1 |
| 5 | Evaluation of antimicrobial efficacy of herbal alternatives (Triphala and green tea polyphenols), MTAD, and 5% sodium hypochlorite against Enterococcus faecalis biofilm formed on tooth substrate: an in vitro study显示文摘 | Prabhakar J Senthilkumar M Priya MS | 2010 | J Endod2010，36，1： | 1 |
| 6 | Effect of hydrophobic and hydrophilic properties of solid acid catalysts on the esterification of mateic anhydride with ethanol显示文摘 | Bhagiyalakshmi M Priya S V Mabel J H | 2008 | Catalysis Communications2008，9，10： | 1 |
| 7 | High power piezoelectric characteristics of BiScO3 -PbTiO3-Pb ( Mn1/3 Nb2/3 ) O3 显示文摘 | Ryu J Priya S Sakaki C | 2002 | Jpn J Appl Phys(Part 1: Regul Pap Short Notes Rev Pap)2002，41，10： | 1 |
| 8 | An outbreak of acute conjunctivitis caused by Coxackie virus A 24显示文摘 | Madhavan HN Malathy J Priya K | 2000 | Indian J Ophthalmol2000，48，： | 1 |
| 9 | FPGA imple- mentation of low power image scaling processor using bilinear interpolation显示文摘 | Priya J J Annalakshmi M Ganesan R | 2014 | Programmable Device Circuits and Systems2014，6，5： | 1 |
| 10 | Poly(vinylidene fluoride)/elay nano- composites prepared by melt intercalation: Crystalliza- tion and dynamic mechanical behavior studies 显示文摘 | Priya L Jog J P | 2002 | J Polym Sci Part B: Polym Phys2002，40，： | 1 |
| 11 | Polymorphism in intercalated poly (vinylidene fluoride) /clay nanocomposites显示文摘 | Priya L Jog J P | 2003 | J Appl Polym Sci2003，89，： | 1 |
| 12 | Laboratory methods in the detection of herpes simplex virus (HSV) in keratitis a 9-year study including polymerase chain reaction (PCR) during last 4 years显示文摘 | Madhavan HN Priya K Malathi J | 2003 | Indian J Pathol Microbiol2003，46，1： | 1 |
| 13 | Intercalated poly(vinylidene fluoride)/clay nanocomposites:structure and properties显示文摘 | Priya L Jog J P | 2003 | J Polym Sci2003，41，1： | 1 |
| 14 | Intercalated poly(vinylidene fluor- ide)/clay nanocomposites: Structure and properties 显示文摘 | Priya L Jog J P | 2003 | J Polym Sci Part B: Polym Phys2003，41，： | 1 |
| 15 | An improved DNA isola- tion method and PCR protocol for efficient detection of muhicompo- nents of begomovirus in legumes 显示文摘 | Rouhibakhsh A Priya J Periasamy M | 2008 | Journal of Virological Methods2008，147，1： | 1 |
| 16 | Sinapic acid prevents hypertension and cardiovascular remodeling in pharmacological model of nitric oxide inhibited rats显示文摘 | Silambarasan T Manivannan J Krishna Priya M | 2014 | PLoS One2014，9，11： | 1 |
| 17 | Sinapic acid protects heart against ischemia/reperfusion injury and H9c2 cardiomyoblast cells against oxidative stress显示文摘 | Silambarasan T Manivannan J Priya MK | 2015 | Biochem Biophys Res Commun2015，456，4： | 1 |
| 18 | Multimodal system for harvesting magnetic and mechanical energy显示文摘 | Dong S X Zhai J Y Li J F Viehland D Priya S | 2008 | Applied Physics Letters2008，93，10： | 1 |
| 19 | EHect of the magnetostrictive layer on magnetoeleetric properties in lead zirconate titanate/ter- fenol-Dlaninate composites 显示文摘 | Ryu J Priya S | 2001 | J Ceram Sci2001，84，12： | 1 |
| 20 | Effect of the magne tostrictive layer on magnetoelectric properties in lead zirconate titanate/Terfennol-D laminate composites显示文摘 | Ryu J Priya S Carazo A V Uchino K | | J Am Cera Soc0，84，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员