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| 1 | The role and modulation of autophagy in experimental models of myocardial ischemia-reperfusion injury显示文摘称为 autophagy 品质上的一个生理的序列由移开蛋白质总数和损坏细胞质的成分决定细胞的生存能力,并且显著地作出贡献到心肌的 ischemia-reperfusion (I/R ) 的度损害。这紧安排的分解代谢的细胞的 ‘ housekeeping’过程向房间提供精力的新来源适应紧张的条件。当支持幸存的机制,而是增加的证据建议它能也导致房间的遗赠,这个过程首先被描述。Autophagy 包括心肌的 I/R 损害在多重心脏的条件的致病被含有。然而,争论至于 autophagy 是否充当保护的机制或在心贡献 I/R 损害的有害效果坚持。这争吵可以在试验性的模型和种包括可变性源自几个因素,并且方法论过去常估计 autophagy。这评论在向操作 autophagy 显著地在压力大多数的条件下面增加心脏的 myocytes 的幸存受到 I/R,和成长兴趣的孤立的心脏的房间在 autophagy 的调整和角色上提供更新的知识是 I/R 损害。这的不安 evolutionarily 保存了细胞内部的清洁的 autophagy 机制,由指向的调整通过在其它之中, rapamycin ( mTOR )的哺乳动物的目标禁止者,腺苷 激活monophosphate 的蛋白质 kinase ( AMPK )调节的人,钙降低代理人, resveratrol , longevinex , sirtuin 使活跃之物, proapoptotic 基因 Bnip3 , IP3 和 lysosome 禁止者,可以对 I/R 授与抵抗到心房间导致的房间死亡。因此,在质问心肌层的 autophagy 的治疗学的操作可以有益于梗塞以后的心脏的愈合并且改变。 | Carol Chen-Scarabelli Pratik R. Agrawal Louis Saravolatz Cadigia Abuniat Gabriele Scarabelli Anastasis Stephanou Leena Loomba Jagat Narula Tiziano M. Scarabelli Richard Knight | 2014 | Journal of Geriatric Cardiology2014，11，4： | 37 |
| 2 | Outcomes of severe sepsis and septic shock patients after stratifi cation by initial lactate value显示文摘BACKGROUND: In the setting of severe sepsis and septic shock, mortality increases when lactate levels are ≥ 4 mmol/L. However, the consequences of lower lactate levels in this population are not well understood. The study aimed to determine the in-hospital mortality associated with severe sepsis and septic shock when initial lactate levels are < 4 mmol/L.METHODS: This is a retrospective cohort study of septic patients admitted over a 40-month period. Totally 338 patients were divided into three groups based on initial lactate values. Group 1 had lactate levels < 2 mmol/L; group 2: 2–4 mmol/L; and group 3: ≥ 4 mmol/L. The primary outcome was in-hospital mortality.RESULTS: There were 111 patients in group 1, 96 patients in group 2, and 131 in group 3. The mortality rates were 21.6%, 35.4%, and 51.9% respectively. Univariate analysis revealed the mortality differences to be statistically significant. Multivariate logistic regression demonstrated higher odds of death with higher lactate tier group, however the findings did not reach statistical significance.CONCLUSION: This study found that only assignment to group 3, initial lactic acid level of ≥ 4 mmol/L, was independently associated with increased mortality after correcting for underlying severity of illness and organ dysfunction. However, rising lactate levels in the other two groups were associated with increased severity of illness and were inversely proportional to prognosis. | Kimberly A. Chambers Adam Y. Park Rosa C. Banuelos Bryan F. Darge Bindu H. Akkanti Annamaria Macaluso Manoj Thangam Pratik B. Doshi | 2018 | World Journal of Emergency Medicine2018，9，2： | 26 |
| 3 | 基于ABAQUS的带帽桩复合地基初始地应力平衡方法浅析显示文摘为探究ABAQUS中何种地应力平衡方法在模拟带帽桩复合地基承载性状中的平衡效果更为理想及其适用性。本研究以带帽管桩复合地基模型为例,利用ABAQUS数值建模进行初始地应力平衡效果精准度问题研究,详细阐述了ABAQUS中5种初始地应力平衡方法的应用,并针对自动平衡方法、关键字定义初始地应力法和ODB导入法的平衡效果进行对比分析,得出自动平衡法的平衡效果最佳,为此模型首选地应力平衡方法;关键字定义初始地应力法的平衡效果较理想,但需满足一定的条件方可适用;ODB导入法平衡效果不是很理想,需要反复导入,才可以达到满意结果。该3种方法模拟地应力平衡效果研究为其他类似模型提供了积极的指导作用和参考价值。 | 杨金尤 雷金波 邹永强 李壮状 万梦华 乐腾胜 Pratik Kumar Bhandari | 2017 | 南昌航空大学学报(自然科学版)2017，31，4： | 7 |
| 4 | Forecasting of Software Reliability Using Neighborhood Fuzzy Particle Swarm Optimization Based Novel Neural Network显示文摘This paper proposes an artificial neural network(ANN) based software reliability model trained by novel particle swarm optimization(PSO) algorithm for enhanced forecasting of the reliability of software. The proposed ANN is developed considering the fault generation phenomenon during software testing with the fault complexity of different levels. We demonstrate the proposed model considering three types of faults residing in the software. We propose a neighborhood based fuzzy PSO algorithm for competent learning of the proposed ANN using software failure data. Fitting and prediction performances of the neighborhood fuzzy PSO based proposed neural network model are compared with the standard PSO based proposed neural network model and existing ANN based software reliability models in the literature through three real software failure data sets. We also compare the performance of the proposed PSO algorithm with the standard PSO algorithm through learning of the proposed ANN. Statistical analysis shows that the neighborhood fuzzy PSO based proposed neural network model has comparatively better fitting and predictive ability than the standard PSO based proposed neural network model and other ANN based software reliability models. Faster release of software is achievable by applying the proposed PSO based neural network model during the testing period. | Pratik Roy Ghanshaym Singha Mahapatra Kashi Nath Dey | 2019 | IEEE/CAA Journal of Automatica Sinica2019，6，6： | 7 |
| 5 | Decreased expression of Klotho in cardiac atria biopsy samples from patients at higher risk of atherosclerotic cardiovascular disease显示文摘BackgroundKlotho 蛋白质(α - 并且 β) 是基于膜的传播调整细胞新陈代谢的蛋白质,以及成纤维细胞生长因素(FGF ) 的 lifespan modulating 活动。最近的数据证明了更高的血浆传播 Klotho 层次减少心血管的风险,建议 Klotho 有在心血管的疾病的一个保护的角色。然而,尽管到目前为止它在各种各样的机关被识别了,它是未知的是否,并且高心血管的风险是否能影响 Klotho 的心脏的表示 cardiomyocytes 快车 Klotho 和 FGF , FGF 和另外的 molecules.MethodsWe 与心血管的疾病和 10 匹配年龄的控制使遭到,估计的10年的低风险经历的一名估计的10年的高动脉粥样硬化患者选择了 20 个病人为除冠的动脉以外的原因的心脏的外科绕过。在心肌的活体检视,我们由免疫组织化学评估了 Klotho 和 FGF 是否在 cardiomyocytes 被表示,并且更高心血管的风险是否影响涉及 endoplasmic 蜂窝胃应力的另外的分子的表示,氧化应力,发炎并且 fibrosis.ResultsOnly ,有更高心血管的风险的病人的 cardiomyocytes 显示出 Klotho 的更低的表示,但是 FGF 的更高的表情。而且,更高心血管的风险与增加的表示被联系氧化并且网状的应力,发炎和 fibrosis.ConclusionsThis 学习的 endoplasmic 第一次证明 Klotho 蛋白质在人的 cardiomyocytes 被表示, Klotho 的那心脏的表情在更高心血管的风险病人是下面调整的,当压力相关的分子的表示显著地被增加时。 | Giovanni Corsetti Evasio Pasini Tiziano M Scarabelli Claudia Romano Pratik R Agrawal Carol Chen-Scarabelli Richard Knight Louis Saravolatz Jagat Narula Mario Ferrari-Vivaldi Vincenzo Flati Deodato Assanelli Francesco S Dioguardi | 2016 | Journal of Geriatric Cardiology2016，13，8： | 7 |
| 6 | Dilemmas in end-stage heart failure显示文摘心失败(HF ) ,复杂临床的症候群由于结构或心的机能紊乱,是一个主要全球健康问题,与在 USA 的超过 580 万的流行独自,并且过去 2300 万世界范围。作为在 65 岁以上的病人之中的住院的一个领先的原因, HF 是保健资源的一个主要消费者,创造保健系统上的实质的紧张。这份报纸在结束阶段 HF 照顾讨论 HF,金融影响,和 multifaceted 困境的传染病学。搜索用象结束阶段心失败那样的关键词在药网站(www.pubmed.gov ) 的美国国家图书馆上被进行,辩解的照顾,道德的窘境。尽管有 HF 的差的预后(比那更坏为许多癌症) ,许多 HF 病人, caregivers,和临床医生不知道差的预后。另外, HF 的无法预言的临床的轨道复杂化计划 end-of-life 照顾,例如辩解的照顾和供旅客休息的招待所,导致如此的资源的 underutilization。在结论,在结束阶段 HF 的道德的窘境是众多的,使不仅病人,而且 caregiver 卷入,保健队,和社会。 | Carol Chen-Scarabelli Louis Saravolatz Benjamin Hirsh Pratik Agrawal Tiziano M. Scarabelli | 2015 | Journal of Geriatric Cardiology2015，12，1： | 4 |
| 7 | Rapid Biosynthesis of Silver Nanoparticles Using Cymbopogan Citratus (Lemongrass) and its Antimicrobial Activity显示文摘The present study deals with the rapid green synthesis of silver nanoparticles using fresh leaves of Cymbopogan Citratus(Lemongrass). Silver nanoparticles were formed within 8~10 minutes by microwave irradiation using aqueous solution of Ag NO3(1 m M) with fresh leaves extract of Cymbopogan Citratus. The synthesized silver nanoparticles were characterized by using UV-visible spectrophotometer analysis, nanoparticle tracking analyzer, transmission electron microscope and energy dispersive X-ray spectra. The antibacterial activity of these nanoparticles was studied against multiple drug resistant hospital isolates of E.coli, S.aureus,P.mirabilis and hospital isolates of S. typhi, K.pnuemoniae. Also, the antifungal activity of these nanoparticles was studied against C.albicans(hospital isolate) and A.niger(NCIM 616). The synergistic effect of silver nanoparticles along with antibiotics was also studied against multiple drug resistant hospital isolates and found to be effective. The extracellular synthesis of Silver nanoparticles using leaves of Cymbopogan Citratus appears to be rapid and eco-friendly. | Shalaka A.Masurkar Pratik R.Chaudhari Vrishali B.Shidore Suresh P.Kamble | 2011 | Nano-Micro Letters2011，3，3： | 4 |
| 8 | 减影冠状动脉CT血管成像对轻中度钙化积分患者的诊断价值显示文摘目的:探讨减影冠状动脉CT血管成像(coronary computed tomography angiography,CCTA)在轻中度钙化积分(Agatston score<400分)患者中的临床应用价值。方法:对接受减影CCTA扫描的69例冠状动脉轻中度钙化患者的临床资料进行回顾性分析。采用4分法评估冠状动脉节段图像质量。定量评估每个钙化节段的狭窄程度,将狭窄分为Ⅰ、Ⅱ、Ⅲ、Ⅳ共4个等级。定量测量每个病变节段所需时间。结果:69例患者共113个钙化节段。常规CCTA与减影CCTA评估钙化节段的平均成像质量分别为(3.4±0.6)分、(3.8±0.4)分,差异有统计学意义(P<0.01);常规CCTA与减影CCTA定量测量钙化节段狭窄程度所需平均时间分别为(105±44)s、(72±44)s,差异有统计学意义(P<0.01)。描述这两种成像方法评估狭窄分级一致性的Kappa值为0.77。结论:上述两种成像方法对评估轻中度钙化冠状动脉狭窄程度具有良好的一致性;与常规CCTA相比,减影CCTA可提高成像质量,减少定量评估冠状动脉病变节段狭窄所需时间。 | 张利军 过伟锋 Tripathi Pratik 杨姗 陆怡菡 陈刚 | 2018 | 中国临床医学2018，25，1： | 3 |
| 9 | Effect of Biosynthesized Silver Nanoparticles on Staphylococcus aureus Biofilm Quenching and Prevention of Biofilm Formation显示文摘The development of green experimental processes for the synthesis of nanoparticles is a need in the field of nanotechnology. The synthesis of silver nanoparticles was achieved using Bacillus cereus supernatant and1 m M silver nitrate. 100 m M glucose was found to quicken the rate of reaction of silver nanoparticles synthesis.UV-visible spectrophotometric analysis was carried out to assess the synthesis of silver nanoparticles. The synthesized silver nanoparticles were further characterized by using Nanoparticle Tracking Analyzer(NTA),Transmission Electron Microscope and Energy Dispersive X-ray spectra. These silver nanoparticles showed enhanced quorum quenching activity against Staphylococcus aureus biofilm and prevention of biofilm formation which can be seen under inverted microscope(40 X). The synergistic effect of silver nanoparticles along with antibiotics in biofilm quenching was found to be effective. In the near future, silver nanoparticles could be used in the treatment of infections caused by highly antibiotic resistant biofilm. | Pratik R.Chaudhari Shalaka A.Masurkar Vrishali B.Shidore Suresh P.Kamble | 2012 | Nano-Micro Letters2012，4，1： | 2 |
| 10 | Design of high-strength refractory complex solid-solution alloys显示文摘Nickel-based superalloys and near-equiatomic high-entropy alloys containing molybdenum are known for higher temperature strength and corrosion resistance.Yet,complex solid-solution alloys offer a huge design space to tune for optimal properties at slightly reduced entropy.For refractory Mo-W-Ta-Ti-Zr,we showcase KKR electronic structure methods via the coherent-potential approximation to identify alloys over five-dimensional design space with improved mechanical properties and necessary global(formation enthalpy)and local(short-range order)stability.Deformation is modeled with classical molecular dynamic simulations,validated from our first-principle data.We predict complex solid-solution alloys of improved stability with greatly enhanced modulus of elasticity(3×at 300 K)over near-equiatomic cases,as validated experimentally,and with higher moduli above 500 K over commercial alloys(2.3×at 2000 K).We also show that optimal complex solid-solution alloys are not described well by classical potentials due to critical electronic effects. | Prashant Singh Aayush Sharma A.V.Smirnov Mouhamad S.Diallo Pratik K.Ray Ganesh Balasubramanian Duane D.Johnson | 2018 | npj Computational Materials2018，，1： | 2 |
| 11 | Curcumin-loaded polymeric nanoparticles for neuro-protection in neonatal rats with hypoxic-ischemic encephalopathy显示文摘 | Andrea Joseph Thomas Wood Chih-Chung Chen Kylie Corry Jessica M. Snyder Sandra E. Juul Pratik Parikh Elizabeth Nance | 2018 | Nano Research2018，11，10： | 2 |
| 12 | Cardiac papillary fibroelastoma:The need for a timely diagnosis显示文摘Cardiac papillary fibroelastomas(CPFs) are the second most common primary cardiac tumors and the most common cardiac valvular tumors. Although they are histologically benign and usually asymptomatic, CPFs can lead to serious and life-threatening complications like myocardial infarction, stroke, pulmonary embolus, cardiac arrest etc. CPFs represent a rare entity in clinical medicine and literature regarding their management is limited. We report two cases which illustrate such complications arising from undiagnosed CPFs on the aortic valve. We further stress on the importance of identifying CPFs early so that they can be managed appropriately based on recommendations from the available literature. | Srikanth Yandrapalli Bella Mehta Pratik Mondal Tanush Gupta Pallavi Khattar John Fallon Randy Goldberg Sachin Sule Wilbert S Aronow | 2017 | World Journal of Clinical Cases2017，5，1： | 2 |
| 13 | Preparation of highly substituted carboxymethyl starch using a twin-screw extruder显示文摘 | Pratik N Bhandari Milford A Hanna | 2011 | Starch/Sta'rke2011，63，： | 1 |
| 14 | Association between Endothelial Dysfunction and Acute Brain Dysfunction during Critical Illness显示文摘 | Christopher G. Hughes Alessandro Morandi Timothy D. Girard Bernhard Riedel Jennifer L. Thompson Ayumi K. Shintani Brenda T. Pun E. Wesley Ely Pratik P. Pandharipande | 2013 | Anesthesiology2013，，3： | 1 |
| 15 | Defining the electronic and geometric structure of one-electron oxidized copper-bis-phenoxide complexes显示文摘 | Tim S Pratik V Russell C | 2008 | J Am Chem Soc2008，130，15： | 1 |
| 16 | CYP2A6 genetic variationand dexmedetomidine disposition 显示文摘 | Utkarsh K Pratik P Mordechai M | 2012 | Eur J Clin Pharmacol2012，68，6： | 1 |
| 17 | Probabilistic stream line q-ball tractography using the residual bootstrap 显示文摘 | Jeffrey IB Sung WC Pratik M | 2008 | Neurohnage2008，39，1： | 1 |
| 18 | A methodology for cumulative impact assessment of opencast mining projects with special reference to air quality assessment显示文摘 | Pratik Dutta Sandip Mahatha | 2004 | Impact Assessment and Project Appraisal2004，22，3： | 1 |
| 19 | Development and validation of a RP-HPLC method for the determination of dapoxetine hydro- chloride in pharmaceutical dosage form 显示文摘 | Pratik M Ujjwal S Seth AK | 2011 | Int J Pharrn Sci RevRes2011，6，2： | 1 |
| 20 | Dental Smile Esthetics: The Assessment and Creation of the Ideal Smile显示文摘 | Pratik K. Sharma Pranay Sharma | 2012 | Seminars in Orthodontics2012，，3： | 1 |
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