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| 1 | Nat Genet:单细胞分析解开结直肠癌细胞的神秘面纱显示文摘结合单细胞基因组学和计算机技术,一个研究团队(包括来自杰克逊实验室(JAx)单细胞生物学主任Paul Robson博士在内)鉴定出了11种结直肠癌肿瘤的癌细胞组成及邻近的非癌细胞。这对于更好的肿瘤靶向诊断和治疗很重要。”使用单细胞测序。”JAX科学家、这篇发表在Nature Genetics上的文章共同第一作者Elise Courtois说道。”我们可以根据肿瘤中的细胞组成将结直肠癌进一步分类。因为每种亚型的肿瘤病人生存率存在差别,我们的方法将为肿瘤医生提供更多的关于肿瘤预后和治疗的信息。” | Huipeng Li, Elise T Courtois, Debarka Sengupta, Yuliana Tan Shyam Prabhakar Elise T Courtois, Yuliana Tan Paul Robson Debarka Sengupta Kok Hao Chen, Jolene Jie Lin Goh Paul Jongjoon Choi Say Li Kong, Axel M Hillmer Iain Beehuat Tan Clarinda Chua Iain Beehuat Tan Lim Kiat Hon Wah Siew Tan Mark Wong Lawrence J K Wee Iain Beehuat Tan Paul Robson Paul Robson Paul Robson | 2017 | 现代生物医学进展2017，17，15： | 37 |
| 2 | 间歇性断食对老年前期肥胖大鼠肠道菌群及代谢的影响显示文摘目的研究间歇性断食对老年前期肥胖大鼠代谢和肠道菌群的影响。方法雌性Wistar大鼠经42周高脂高糖饲料饲养造模,根据体质量选取模型鼠进行间歇性断食干预。干预方法为每2周断食72 h,总干预时间18周。干预后进行口服葡萄糖耐量试验、血脂4项检测。收集粪便,通过Illumina高通量测序检测16S r RNA基因V4可变区,运用QIIME及LEf Se分析肠道菌群。结果间歇性断食组体质量相对于模型对照组显著下降(P<0.01);高密度脂蛋白胆固醇和低密度脂蛋白胆固醇均显著下降(P<0.05);空腹血糖显著上升(P<0.01);葡萄糖耐量测试曲线下面积显著高于模型对照组,糖耐量减退(P<0.05);HE染色显示间歇性断食轻度减少肝脏脂肪变性。肠道菌群结果显示,断食组肠道菌群得到显著改善,具体表现为YS2、RF32、Helicobacteraceae(螺杆菌科)增加,Lactobacillus(乳杆菌属)、Roseburia(罗氏菌属)、Erysipelotrichaceae(韦荣球菌科)、Ralstonia(青枯菌属)、Bradyrhizobiaceae(慢生根瘤菌科)和RF39减少。Spearman相关性分析发现Bradyrhizobiaceae与总胆固醇、高密度脂蛋白胆固醇呈正相关;大鼠体质量与RF39呈负相关。结论间歇性断食能改善肠道菌群,降低老年前期肥胖大鼠体质量和血脂水平,但对糖代谢有不良影响。 | 容祖华 梁少聪 路浚齐 何彦 罗月梅 游超 夏耿红 Prabhakar M 李攀 周宏伟 | 2017 | 南方医科大学学报2017，37，4： | 17 |
| 3 | Studies on NPK drip fertigation in field grown tomato ( Lycopersicon esculentum Mill.)显示文摘 | S.S Hebbar B.K Ramachandrappa H.V Nanjappa M Prabhakar | 2003 | European Journal of Agronomy2003，，1： | 2 |
| 4 | Differentiation of sheep pox and goat pox viruses by sequence and PCR-RFLP of P32 gene显示文摘 | Hosamani M Mondal B Prabhakar A | 2004 | Virus Genes2004，29，1： | 1 |
| 5 | Excitotoxicity: bridge tovarious triggers in neurodegenerative disorders 显示文摘 | Mehta A Prabhakar M Kumar P | 2013 | Eur JPharmacol2013，698，13： | 1 |
| 6 | Brucellamycotic aneurysm of ascending aorta complicatingdiscrete subaortic stenosis显示文摘 | Kumar N Prabhakar G Kandeel M | 1993 | Am Heart J1993，125，6： | 1 |
| 7 | Biological activity of phenylpropionic acid isolated from a terrestrial Streptomycetes显示文摘 | Narayana K J Prabhakar P Vijayalakshmi M | 2007 | Polish Journal of Microbiology2007，56，3： | 1 |
| 8 | Rights protection for relational data显示文摘 | SION R ATALLAH M PRABHAKAR S | 2004 | IEEE Transactions on Knowledge And Data Engineering2004，16，6： | 1 |
| 9 | Evaluation of antimicrobial efficacy of herbal alternatives (Triphala and green tea polyphenols), MTAD, and 5% sodium hypochlorite against Enterococcus faecalis biofilm formed on tooth substrate: an in vitro study显示文摘 | Prabhakar J Senthilkumar M Priya MS | 2010 | J Endod2010，36，1： | 1 |
| 10 | A Theoretical Model of Predicting of Material Removal Rates in Rotary Ultrasonic Machining of Ceramics显示文摘 | Prabhakar D Pei Z J Ferreira P M | 1993 | Transactions of the North American Manufacturing Research Institution of SME1993，，21： | 1 |
| 11 | Ferric reducing ability of lipid peroxidation in hemodialysis patients:Intradialytic Changes显示文摘 | Prabhakar E Reddy Suchitra M Manohar Seshadri V Reddy | | 0，，38： | 1 |
| 12 | Effect of temperature on development, survival and reproduction of the mealybug, Phenacoccus solenopsis Tinsley (Hemiptera: Pseudococcidae) on cotton显示文摘 | Prasad Y G Prabhakar M Sreedevi G | 2012 | Crop Protec- tion2012，39，： | 1 |
| 13 | Compatibility studies of chitosan/PVA blend in 2% aqueous acetic acid solution at 30℃显示文摘 | KUMAR H M P N PRABHAKAR M N PRASAD C V | 2010 | Carbohydrate Polymers2010，82，： | 1 |
| 14 | Differentiation of sheep pox and goat pox by sequence analysis and PCRRFLP of P32 gene显示文摘 | Madhusudan H Bimalendu M Prabhakar A T | 2004 | Virus Gen2004，29，1： | 1 |
| 15 | ECG changes in pediatric patients with severe head injury显示文摘 | Bithal PK Prabhakar H | 2003 | J Neurosurg Anesthesiol2003，15，3： | 1 |
| 16 | The alkaloids of Portuguese ergot显示文摘 | LOBO A M PRABHAKAR S BENITO-RODRIGUEZ A M | 1981 | Rev Port Quim1981，23，： | 1 |
| 17 | Bacopa monniera alleviates N (omega)-nitro-L-arginine arginine-induced but not MK-801-induced amnesia:a mouse Morris watermaze study显示文摘 | Saraf M K Prabhakar S Anand A | 2009 | Neuroscience2009，160，1： | 1 |
| 18 | Separation of pollutants from tannery effluents by electro-flotation显示文摘 | Murugananthan M Bhaskar G R Prabhakar S | 2004 | Separation and Purification Technology2004，40，1： | 1 |
| 19 | Microwave assis- ted hydrothermal synthesis of single crystalline ZnO nano- rods for gas sensor application显示文摘 | Prabhakar R Song H M Kim Y S | 2012 | Mater Lett2012，6890，： | 1 |
| 20 | Hyper homocys teinemia as a risk factor for ischemic stroke:an indian scenario显示文摘 | Modi M Prabhakar S Majumdar S | 2005 | Neurol India2005，53，3： | 1 |
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