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| 1 | Association of the level of heteroplasmy of the 15059G>A mutation in the MT-CYB mitochondrial gene with essential hypertension显示文摘AIM: To examine whether the heteroplasmy level for 15059G>A mutation in the mitochondrial genome might be associated with essential hypertension. METHODS: This cross-sectional study involved 196 unrelated participants randomly selected from general population (90 males and 106 females) who underwent a regular medical check-up at the Institute for Ath-erosclerosis Research (Moscow, Russia). One hundred and twenty of them (61%) had essential hypertension, and 76 (39%) were apparently healthy normotensive persons. The level of heteroplasmy for 15059G>A mutation occurring in the coding region of cytochrome b gene (MT-CYB) of mtDNA isolated from the blood leukocytes, was quantified using DNA pyrosequencing method. RESULTS: The 15059G>A heteroplasmy level ranged between 4% and 83%, with a median level of 31%. Between the upper and lower quartiles of 15059G>A heteroplasmy distribution, significant differences were observed for patients' age, systolic blood pressure, and triglyceride levels. 15059G>A heteroplasmy correlated both with age (r = 0.331, P < 0.001) and the presence of hypertension (r = 0.228, P = 0.002). Regression analysis revealed that the age explains 12% variability of 15059G>A heteroplasmy, and hypertension independently explains more 5% variability. The 15059G>A heteroplasmy exceeding 31% was found to be significantly associated with a higher risk of essential hypertension (odds ratio 2.76; P (Fisher) 0.019]. The study participants with high 15059G>A heteroplasmy level were found to have significantly higher age (P < 0.001) and the prevalence of essential hypertension (P = 0.033), as compared to those with low 15059G>A heteroplasmy level. These observations suggested a positive correlation between the level of 15059G>A heteroplasmy and essential hypertension. CONCLUSION: This study provides the evidence of association of mtDNA 15059G>A mutation heteroplasmy with essential hypertension. | Igor A Sobenin Dimitry A Chistiakov Margarita A Sazonova Maria M Ivanova Yuri V Bobryshev Alexander N Orekhov Anton Y Postnov | 2013 | World Journal of Cardiology2013，5，5： | 3 |
| 2 | Reduction of Ring Artifacts in High Resolution Micro-CT Reconstructions显示文摘 | Sijbers J Postnov A | 2004 | Physics in Medicine and Biology2004，49，14： | 1 |
| 3 | PET imaging shows loss of striatal PDE10A in patients with Huntington disease显示文摘 | Abroad R Bourgeois S Postnov A | 2014 | Neurology2014，82，3： | 1 |
| 4 | Decreased ATP-synthe- sis ability of brain mitochondria in spontaneously hypertensive rats显示文摘 | Doroshchuk A Postnov A Manasyeva G | 2004 | Kardiologiya2004，44，3： | 1 |
| 5 | Reduction of ring artifacts in high resolution micro-CT reconstructions显示文摘 | AIJBERS J POSTNOV A | 2004 | Physics in Medicine and Biology2004，49，14： | 1 |
| 6 | Vascular Calcification Is Associated with Cortical Bone Loss in Chronic Renal Failure Rats with and without Ovariectomy: The Calcification Paradox显示文摘 | De Schutter Tineke M Neven Ellen Persy Veerle P Behets Geert J Postnov Andrei A De Clerck Nora M D’haese Patrick C | 2011 | EN2011，，4： | 1 |
| 7 | Reduction of ring artifacts in high resolution micro-CT reconstructions 显示文摘 | SIJBERS J POSTNOV A | 2004 | Phys- ics in Medicine and Biology2004，49，14： | 1 |
| 8 | Reduction of ring artefacts in high resolution micro-CT reconstructions 显示文摘 | Sijbers J Postnov A | 2004 | Phys Med Biol2004，49，14： | 1 |
| 9 | Study of the genetic markers of thrombosis in hypertensive patients of the native population in the Republic of Mordovia显示文摘 | Postnov A Goncharova L N Khasanova Z B | 2009 | Arkh Patol2009，71，4： | 1 |
| 10 | Adequate phosphate binding with lanthanum carbonate attenuates arterial calcification in chronic renal failure rats显示文摘 | Neven E Dams G Postnov A | 2009 | Nephrology Dialysis Transplantation2009，24，6： | 1 |
| 11 | Reduction of ring artefacts in high resolution micro-CT reconstructions显示文摘 | Sijbers J Postnov A | 2004 | Phys Med Biol2004，49，14： | 1 |
| 12 | Interaction of Phenylferrocenyl Carbocation with Ferrocenyl-substituted 1,3-Butadienes显示文摘 | POSTNOV V N KLIMOVA E I PUSHIN A N | 1991 | J Org Chem1991，453，1： | 1 |
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