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| 1 | 慢性肾脏病中的炎症和动脉硬化:慢性肾功能不全队列研究中的发现显示文摘慢性肾脏病(chronic kidney disease,CKD)和动脉硬化程度与心血管病发病率和死亡率增加相关。目前认为炎症在动脉硬化发展中发挥作用,而CKD被认为是一种促炎症反应的状态。CKD患者的动脉僵硬度增加,横断面数据提示CKD中增多的炎症标志物与较高动脉僵硬度值相关。 | Peyster E Chen J Feldman HI Go AS Gupta J Mitra N Pan Q Porter A Rahman M Raj D Reilly M Wing MR Yang W Townsend RR 陈云 叶鹏 | 2017 | 中华高血压杂志2017，25，11： | 12 |
| 2 | Tenascin C upregulates interleukin-6 expression in human cardiac myofibroblasts via toll-like receptor 4显示文摘AIM:To investigate the effect of Tenascin C(TNC)on the expression of pro-inflammatory cytokines and matrixmetalloproteinases in human cardiac myofibroblasts(CMF).METHODS:CMF were isolated and cultured from patients undergoing coronary artery bypass grafting.Cultured cells were treated with either TNC(0.1μmol/L,24 h)or a recombinant protein corresponding to different domains of the TNC protein;fibrinogen-like globe(FBG)and fibronectin typeⅢ-like repeats(TNⅢ5-7)(both 1μmol/L,24 h).The expression of the proinflammatory cytokines;interleukin(IL)-6,IL-1β,TNFαand the matrix metalloproteinases;MMPs(MMP1,2,3,9,10,MT1-MMP)was assessed using real time RT-PCR and western blot analysis.RESULTS:TNC increased both IL-6 and MMP3(P<0.01)mR NA levels in cultured human CMF but had no significant effect on the other markers studied.The increase in IL-6 mR NA expression was mirrored by an increase in protein secretion as assessed by enzymelinked immunosorbant assay(P<0.01).Treating CMF with the recombinant protein FBG increased IL-6mR NA and protein(P<0.01)whereas the recombinant protein TNⅢ5-7 had no effect.Neither FBG nor TNⅢ5-7 had any significant effect on MMP3 expression.The expression of toll-like receptor 4(TLR4)in human CMF was confirmed by real time RT-PCR,western blot and immunohistochemistry.Pre-incubation of cells with TLR4neutralising antisera attenuated the effect of both TNC and FBG on IL-6 mR NA and protein expression.CONCLUSION:TNC up-regulates IL-6 expression in human CMF,an effect mediated through the FBG domain of TNC and via the TLR4 receptor. | Azhar Maqbool Emma J Spary Iain W Manfield Michaela Ruhmann Lorena Zuliani-Alvarez Filomena O Gamboa-Esteves Karen E Porter Mark J Drinkhill Kim S Midwood Neil A Turner | 2016 | World Journal of Cardiology2016，8，5： | 4 |
| 3 | Research Coordination Networks: Evidence of the Relationship Between Funded Interdisciplinary Networking and Scholarly Impact 显示文摘 | Porter A L Garner J Crowl T | 2012 | Bioscience2012，62，3： | 1 |
| 4 | Alternative approaches to the employee-organization rela- tionship:does investment in employees pay off显示文摘 | TSUI A S PEARCE J L PORTER L W TRIPOLI A M | 1997 | The A cademy of Management Journal1997，40，5： | 1 |
| 5 | Innovation forecasting 显示文摘 | Watts R J Porter A L | 1997 | Technological Forecasting and Social Change1997，56，： | 1 |
| 6 | Technology opportunities analysis:integrating technology monitoring, forecasting and assessment with strategic planning显示文摘 | Porter A L Jin X-Y Gilmour J E Cunningham S W Xu H Stanard C WangL | 1994 | SRA Journal (Society of Research Administrators)1994，，2： | 1 |
| 7 | Simvastatin reduces human atrial myofibroblast proliferation independently of cholesterol lowering via inhibition of RhoA显示文摘 | Porter K E Turner N A O'Regan D J | 2004 | Cardiovasc Res2004，61，4： | 1 |
| 8 | Thermal cycling behavior of plasma-sprayed thermal barrier coatings with various MCrAIX bond coats显示文摘 | Haynes J A Ferber M K Porter W D | | 0，，01： | 1 |
| 9 | A method to detect anti-metabolic factors in fermentations 显示文摘 | Porter A V Lake J C Gill T A | 2010 | J lnst Brew2010，116，3： | 1 |
| 10 | Interdisciplinary research: Meaning, metrics and nurture显示文摘 | Porter A L Roessner J D Cohen A S | 2006 | Research Evaluation2006，15，3： | 1 |
| 11 | Directed differentiation of embryonic stem cells into motor neurons显示文摘 | Wichterle H Lieberam I Porter J A | 2002 | Cell2002，110，： | 1 |
| 12 | FGF-2 enhances the mitotic and chondrogenic potentials of human adult bone marrow-derived mesenchymal stem cells显示文摘 | Solchaga L A Penick K Porter J D | 2005 | J Cell Physiol2005，203，2： | 1 |
| 13 | Directed differentiation ofembryonic stem cells into motor neurons 显示文摘 | Wichterle H Lieberam I Porter J A | 2002 | Cell2002，110，： | 1 |
| 14 | Patent Overlay Mapping= Visualizing Technological Distance 显示文摘 | Kay L Newman N Youtie J Porter A L Rafols I | 2014 | Journal of the Association for Information Science and Technology2014，，12： | 1 |
| 15 | comparison of the ability of feline calicivirus(FCV)vaccines to neutralise a panel of current UK FCV isolates显示文摘 | Porter C J Radford A D Gaskell R M | 2007 | J Feline Med Surg2007，10，1： | 1 |
| 16 | Abnormalities of nerve fibers in the circular muscle of patients with slow transit constipation显示文摘 | Porter A J Wattchow DA Hunter A | 1998 | Int J Colorectal Dis1998，13，： | 1 |
| 17 | Formulation design and bioavailability assessment of lipidic self-emulsifying formulations of halofantrine 显示文摘 | Khoo S M Humberstone A J Porter C J H | 1998 | Int J Pharm1998，167，12： | 1 |
| 18 | Approaches to modular model development显示文摘 | Jones J W Keating B A Porter C H | 2001 | Agriculture Systems2001，70，23： | 1 |
| 19 | Thermal cycling behavior of plasma-sprayed thermal barrier coatings with various McrAlX bond coats显示文摘 | HAYNES J A FERBER M K PORTER W D | 2000 | Journal of Thermal Spray Technology2000，9，： | 1 |
| 20 | 1 A hernative App roaches to the Employee-organization Relation-ship: Does Investment in Employees Pay of 显示文摘 | Tsui A S Pearce J L Porter LW et a | 1997 | Academy of Management Journal1997，，5： | 1 |
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