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| 1 | Narrow-band imaging with magnifying endoscopy is accurate for detecting gastric intestinal metaplasia显示文摘AIM:To investigate the predictive value of narrowband imaging with magnifying endoscopy (NBI-ME) for identifying gastric intestinal metaplasia (GIM) in unselected patients. METHODS:We prospectively evaluated consecutive patients undergoing upper endoscopy for various indications, such as epigastric discomfort/pain, anaemia, gastro-oesophageal reflux disease, suspicion of peptic ulcer disease, or chronic liver diseases. Patients underwent NBI-ME, which was performed by three blinded, experienced endoscopists. In addition, five biopsies (2 antrum, 1 angulus, and 2 corpus) were taken and examined by two pathologists unaware of the endoscopic findings to determine the presence or absence of GIM. The correlation between light blue crest (LBC) appearance and histology was measured. Moreover, we quantified the degree of LBC appearance as less than 20% (+), 20%-80% (++) and more than 80% (+++) of an image field, and the semiquantitative evaluation of LBC appearance was correlated with IM percentage from the histological findings. RESULTS:We enrolled 100 (58 F/42 M) patients who were mainly referred for gastro-esophageal reflux disease/dyspepsia (46%), cancer screening/anaemia (34%), chronic liver disease (9%), and suspected celiac disease (6%); the remaining patients were referred for other indications. The prevalence of Helicobacter pylori (H. pylori ) infection detected from the biopsies was 31%, while 67% of the patients used proton pump inhibitors. LBCs were found in the antrum of 33 patients (33%); 20 of the cases were classified as LBC+, 9 as LBC++, and 4 as LBC+++. LBCs were found in the gastric body of 6 patients (6%), with 5 of them also having LBCs in the antrum. The correlation between the appearance of LBCs and histological GIM was good, with a sensitivity of 80% (95%CI:67-92), a specificity of 96% (95%CI:93-99), a positive predictive value of 84% (95%CI:73-96), a negative predictive value of 95% (95%CI:92-98), and an accuracy of 93% (95%CI:90-97). The NBI-ME examination overlooked GIM in 8 cases, but the GIM was less than 5% in 7 of the cases. Moreover, in the 6 false positive cases, the histological examination showed the presence of reactive gastropathy (4 cases) or H. pylori active chronic gastritis (2 cases). The semiquantitative correlation between the rate of LBC appearance and the percentage of GIM was 79% (P < 0.01). CONCLUSION:NBI-ME achieved good sensitivity and specificity in recognising GIM in an unselected population. In routine clinical practice, this technique can reliably target gastric biopsies. | Edoardo Savarino Marina Corbo Pietro Dulbecco Lorenzo Gemignani Elisa Giambruno Luca Mastracci Federica Grillo Vincenzo Savarino | 2013 | World Journal of Gastroenterology2013，19，17： | 23 |
| 2 | Therapeutic potential of curcumin in digestive diseases显示文摘Curcumin is a low-molecular-weight hydrophobic polyphenol that is extracted from turmeric,which possesses a wide range of biological properties including anti-inflammatory,anti-oxidant,anti-proliferative and anti-microbial activities.Despite its diverse targets and substantial safety,clinical applications of this molecule for digestive disorders have been largely limited to case series or small clinical trials.The poor bioavailability of curcumin is likely the major hurdle for its more widespread use in humans.However,complexation of curcumin into phytosomes has recently helped to bypass this problem,as it has been demonstrated that this new lecithin formulation enables increased absorption to a level 29-fold higher than that of traditional curcuminoid products.This allows us to achieve much greater tissue substance delivery using significantly lower doses of curcumin than have been used in past clinical studies.As curcumin has already been shown to provide good therapeutic results in some small studies of both inflammatory and neoplastic bowel disorders,it is reasonable to anticipate an even greater efficacy with the advent of this new technology,which remarkably improves its bioavailability.These features are very promising and may represent a novel and effective therapeutic approach to both functional and organic digestive diseases. | Pietro Dulbecco Vincenzo Savarino | 2013 | World Journal of Gastroenterology2013，19，48： | 5 |
| 3 | Prevention of postoperative recurrence of Crohn’s disease by Adalimumab: a case series显示文摘 | Edoardo Savarino Pietro Dulbecco Giorgia Bodini Lorenzo Assandri Vincenzo Savarino | 2012 | European Journal of Gastroenterology & Hepatology2012，，4： | 1 |
| 4 | Microscopic esophagitis in gastro-esophageal reflux disease: individual lesions, biopsy sampling, and clinical correlations显示文摘 | Luca Mastracci Paola Spaggiari Federica Grillo Patrizia Zentilin Pietro Dulbecco Paola Ceppa Paola Baccini Carlo Mansi Vincenzo Savarino Roberto Fiocca | 2009 | Virchows Archiv2009，，1： | 1 |
| 5 | Positive Glucose Breath Testing is More Prevalent in Patients With IBS-like Symptoms Compared With Controls of Similar Age and Gender Distribution显示文摘 | Andrea Parodi Pietro Dulbecco Edoardo Savarino Edoardo Giovanni Giannini Giorgia Bodini Marina Corbo Luca Isola Stefano De Conca Elisa Marabotto Vincenzo Savarino | 2009 | Journal of Clinical Gastroenterology2009，，10： | 1 |
| 6 | Microscopic esophagitis distinguishes patients with non-erosive reflux disease from those with functional heartburn显示文摘 | Edoardo Savarino Patrizia Zentilin Luca Mastracci Pietro Dulbecco Elisa Marabotto Lorenzo Gemignani Luca Bruzzone Nicola Bortoli Anna Chiara Frigo Roberto Fiocca Vincenzo Savarino | 2013 | Journal of Gastroenterology2013，，4： | 1 |
| 7 | A Predictive Model Identifies Patients Most Likely to Have Inadequate Bowel Preparation for Colonoscopy显示文摘 | Cesare Hassan Lorenzo Fuccio Mario Bruno Nico Pagano Cristiano Spada Silvia Carrara Chiara Giordanino Emanuele Rondonotti Gabriele Curcio Pietro Dulbecco Carlo Fabbri Domenico Della Casa Stefania Maiero Adriana Simone Federico Iacopini Giuseppe Feliciange | 2012 | Clinical Gastroenterology and Hepatology2012，，5： | 1 |
| 8 | Adalimumab in active ulcerative colitis: A “real-life” observational study显示文摘 | Alessandro Armuzzi Livia Biancone Marco Daperno Alessandra Coli Daniela Pugliese Vito Annese Annalisa Aratari Sandro Ardizzone Paola Balestrieri Fabrizio Bossa Maria Cappello Fabiana Castiglione Michele Cicala Silvio Danese Renata D’Incà Pietro Dulbecco G | 2013 | Digestive and Liver Disease2013，，： | 1 |
| 9 | A Predictive Model Identifies Patients Most Likely to Have Inadequate Bowel Preparation for Colonoscopy显示文摘 | Cesare Hassan Lorenzo Fuccio Mario Bruno Nico Pagano Cristiano Spada Silvia Carrara Chiara Giordanino Emanuele Rondonotti Gabriele Curcio Pietro Dulbecco Carlo Fabbri Domenico Della Casa Stefania Maiero Adriana Simone Federico Iacopini Giuseppe Feliciange | 2012 | Clinical Gastroenterology and Hepatology2012，，5： | 1 |
| 10 | Isotope Ratio Mass Spectrometry (IRMS) Versus Laser-Assisted Ratio Analyzer (LARA)显示文摘 | Vincenzo Savarino Fabiana Landi Pietro Dulbecco Chiara Ricci Laura Tessieri Riccardo Biagini Luigi Gatta Mario Miglioli Guido Celle Dino Vaira | 2000 | Digestive Diseases and Sciences2000，，11： | 1 |
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