5篇
您的检索式：作者名="Petra Voland"
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| 1 | H pylori and gastric cancer: Shifting the global burden显示文摘Infection with H pylori leads to a persistent chronic in?ammation of the gastric mucosa, thereby increasing the risk of distal gastric adenocarcinoma. Numerous studies have determined a clear correlation between H pylori infection and the risk of gastric cancer; however, general eradication is not recommended as cancer prophylaxis and time points for treatment remain controversial in different areas of the world. Prevalence rates in Western countries are decreasing, especially in younger people (< 10%); and a decline in distal gastric adenocarcinoma has been observed. Risk groups in Western countries still show considerably higher risk of developing cancer, especially in patients infected with cagA + strains and in persons harboring genetic polymorphism of the IL-1B promoter (-511T/T) and the corresponding IL-1 receptor antagonist (IL-1RN*2). Thus, general eradication of all infected persons in Western countries not recommended and is limited to risk groups in order to achieve a risk reduction. In contrast, infection rates and cancer prevalence are still high in East Asian countries. A prevention strategy to treat infected persons may avoid the development of gastric cancer to a large extent and with enormous clinical importance. However, studies in China and Japan indicate that prevention of gastric cancer is effective only in those patients that do not display severe histological changes such as atrophy and intestinal metaplasia. Thus, prophylactic strategies to prevent gastric cancer in high risk populations such as China should therefore especially aim at individuals now at younger age when the histological alterations caused by the bacterial infection was still reversible. In countries with a low prevalence of gastric cancer, risk groups carrying cagA+ strains and IL-1 genetic polymorphisms should be identi?ed and treated. | Christian Prinz Susanne Schwendy Petra Voland | 2006 | World Journal of Gastroenterology2006，12，34： | 33 |
| 2 | In vitro activity of moxifloxacin and piperacillin/sulbactam against pathogens of acute cholangitis显示文摘AIM: To analyze the in vitro activity of moxifloxacin and piperacillin/sulbactam against pathogens isolated from patients with acute cholangitis. METHODS: In this prospective study a total of 65 patients with acute cholangitis due to biliary stone obstruction (n = 7), benign biliary stricture (n = 16), and malignant biliary stricture (n = 42) were investigated with regard to spectrum of bacterial infection and antibiotic resistance. Pathogens were isolated from bile cultures in all study patients. In 22 febrile patients, blood cultures were also obtained. In vitro activity of moxifloxacin and piperacillin/ sulbactam was determined by agar diffusion. RESULTS: Thirty-one out of 65 patients had positive bile and/or blood cultures. In 31 patients, 63 isolates with 17 different species were identified. The predominant strains were Enterococcus species (26/63), E.coli (13/63) and Klebsiella species (8/63). A comparable in vitro activity of moxifloxacin and piperacillin/sulbactam was observed for E.coli and Klebsiella species. In contrast, Enterococcus species had higher resistances towards moxifloxacin. Overall bacteria showed antibiotic resistances in vitro of 34.9% for piperacillin/sulbactam and 36.5% for moxifloxacin.CONCLUSION: Enterococcus species , E.coli and Klebsiella species were the most common bacteria isolated from bile and/or blood from patients with acute cholangitis. Overall, a mixed infection with several species was observed, and bacteria showed a comparable in vitro activity for piperacillin/sulbactam and moxifloxacin. | Andreas Weber Wolfgang Huber Klaus Kamereck Philipp Winkle Petra Voland Hans Weidenbach Roland M Schmid Christian Prinz | 2008 | World Journal of Gastroenterology2008，14，20： | 18 |
| 3 | Extracellular and Intracellular Pattern Recognition Receptors Cooperate in the Recognition of Helicobacter pylori显示文摘 | Roland Rad Wibke Ballhorn Petra Voland Katharina Eisen?cher J?rg Mages Lena Rad Ruth Ferstl Roland Lang Hermann Wagner Roland M. Schmid Stefan Bauer Christian Prinz Carsten J. Kirschning Anne Krug | 2009 | Gastroenterology2009，，7： | 1 |
| 4 | Inhibition of T-Cell Proliferation by Helicobacter pylori γ-Glutamyl Transpeptidase显示文摘 | Christian Schmees Christian Prinz Tilman Treptau Roland Rad Ludger Hengst Petra Voland Stefan Bauer Lena Brenner Roland M. Schmid Markus Gerhard | 2007 | Gastroenterology2007，，5： | 1 |
| 5 | Inhibition of T-Cell Proliferation by Helicobacter pylori γ-Glutamyl Transpeptidase显示文摘 | Christian Schmees Christian Prinz Tilman Treptau Roland Rad Ludger Hengst Petra Voland Stefan Bauer Lena Brenner Roland M. Schmid Markus Gerhard | 2007 | Gastroenterology2007，，5： | 1 |
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