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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | Assessment of oxidative stress in chronic pancreatitis patients显示文摘AIM: To assess the levels of antioxidant capacity and oxidative damage in blood of chronic pancreatitis (CP) patients in comparison with those in healthy control sub- jects, by using several different analytical techniques. METHODS: Thirty-five CP patients and 35 healthy con- trol subjects were investigated prospectively with re- spect to plasma levels of thiols, ferric reducing ability of plasma (FRAP, i.e. antioxidant capacity), levels of protein carbonyls and thiobarbituric acid reactive substances (TBARS). Additionally, we evaluated the production of reactive oxygen species (ROS) in whole blood. RESULTS: The antioxidative thiols including cysteine, cysteinylglycine and glutathione were significantly lower in CP patients. In addition, the non-enzymatic antioxi- dant capacity was significantly lower in CP patients, which correlated with the amount of oxidative protein (protein carbonyls) and the extent of lipid damage (TBARS), both were significantly higher in CP patients. The ROS production in whole blood after stimulation with phorbol 12-myritate 13-acetaat, demonstrated a strong tendency to produce more ROS in CP patients. CONCLUSION: Oxidative stress may contribute to the pathogenesis of chronic pancreatitis by decreasing anti- oxidant capacity and increasing oxidative damage in CP patients may be a rationale for intervention with antioxi- dant therapy. | Mariette Verlaan Hennie MJ Roelofs Annie van Schaik Geert JA Wanten Jan BMJ Jansen Wilbert HM Peters Joost PH Drenth | 2006 | World Journal of Gastroenterology2006，12，35： | 3 |
| 3 | A Selective Approach to the Resection of Cystic Lesions of the Pancreas显示文摘 | Peter JA Michael D Mithat G | 2006 | Ann Surg2006，244，4： | 1 |
| 4 | Lymphedema in a cohort of breast cancinoma survivors 20 years after diagnosis显示文摘 | Senie RT Peters M | 1998 | Cancer1998，83，12： | 1 |
| 5 | Increasedoocyte degeneration and fol-licular atresia during the estrous cycle in antimullerian hormone null mice显示文摘 | Visser JA Durlinger AL Peters IJ | 2007 | En-docrinology2007，148，5： | 1 |
| 6 | Retinoids as generalized regulators of cellular growth and differentiation 显示文摘 | Peter JA Davies MD Jamas PB | 1988 | Am J Med Sci1988，296，： | 1 |
| 7 | Lymphedema in a cohort of breast carcinoma survivors 20 years after diagnosis 显示文摘 | Perterk JA Senie RT Peters M | 2001 | Cancer2001，92，： | 1 |
| 8 | Ultrasound contrast imaging:current and new potenial methods显示文摘 | Peter JA Bouaka A Kirkhom J | 2000 | Uhroud Med Biol2000，26，： | 1 |
| 9 | GDNF is abundant in the adult rat gut 显示文摘 | Peters RJ Osinski MA Hongo JA | 1998 | JAutonNervSys1998，70，12： | 1 |
| 10 | Curative resection for esophageal adenocarcinoma: analysis of 100 en bloc esophagectomies 显示文摘 | Hagen JA DeMeester SR Peters JH | 2001 | Ann Surg2001，234，4： | 1 |
| 11 | Guide to Receptors and Channels (GRAC)显示文摘 | Alexander SP Mathie A Peters JA | | 0，，： | 1 |
| 12 | Expresion and secretion fo IL-2 receptor in trauma patients 显示文摘 | Teodoreczyk-lngeyarn JA Mefitehie DI Peters WJ | 1990 | Ann Surery1990，212，： | 1 |
| 13 | A model of the dual effect of gadopentetate dimuglumine on dynamic brain MR images显示文摘 | Barbier EL den Boer JA Peters AR | 1999 | J Magn Reson Imaging1999，10，3： | 1 |
| 14 | The interaction of general anaesthetics with recombinant GABAA and glycine receptors expressed in Xenopus laevis oocytes: a comparative study显示文摘 | Pistis M Belelli D Peters JA | 1997 | Br J Pharmacol1997，122，8： | 1 |
| 15 | Conditionally replicating mycobacteriophages: a system for transposon delivery to Mycobacterium tuberculosis显示文摘 | Belleli D Lambert JJ Peters JA | 1997 | Proc Nat Acad Sci USA1997，94，11： | 1 |
| 16 | Curative resection for esophageal adenocardnoma: analysis of 100 en bloc esophageetomies显示文摘 | Hagen JA DeMeester SR Peters JH | 2001 | Annals of Surgery2001，234，4： | 1 |
| 17 | GABA(B)-mediated inhibition of multiple modes of glutamate release in the nucleus of the solitary tract显示文摘 | FAWLEY JA PETERS JH ANDRESEN MC | 2011 | J Neurophysiol2011，106，4： | 1 |
| 18 | Human IgG Fc receptor heterogeneity:molecular aspects and clinical implications 显示文摘 | Jan GJ van de Winkel JGJ Peter JA | 1993 | Immunnol Today1993，14，： | 1 |
| 19 | Lymph edema in a cohort of breast cancinoma survivors 20 years after diagnosis 显示文摘 | Petrek JA Semie RT Peters M | 1998 | Cancer1998，83，12： | 1 |
| 20 | Increased oocyte degeneration and follicular atresia during the estrous cy- cle in anti-mullerian hormone null mice显示文摘 | VISSER JA DURLINGER AL PETERS Ij | 2007 | Endocrinology2007，148，5： | 1 |
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