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| 1 | Bile-acid-induced cell injury and protection显示文摘Several studies have characterized the cellular and molecular mechanisms of hepatocyte injury caused by the retention of hydrophobic bile acids (BAs) in cholestatic diseases. BAs may disrupt cell membranes through their detergent action on lipid components and can promote the generation of reactive oxygen species that, in turn, oxidatively modify lipids, proteins, and nucleic acids, and eventually cause hepatocyte necrosis and apoptosis. Several pathways are involved in triggering hepatocyte apoptosis. Toxic BAs can activate hepatocyte death receptors directly and induce oxidative damage, thereby causing mitochondrial dysfunction, and induce endoplasmic reticulum stress. When these compounds are taken up and accumulate inside biliary cells, they can also cause apoptosis. Regarding extrahepatic tissues, the accumulation of BAs in the systemic circulation may contribute to endothelial injury in the kidney and lungs. In gastrointestinal cells, BAs may behave as cancer promoters through an indirect mechanism involvingoxidative stress and DNA damage, as well as acting as selection agents for apoptosis-resistant cells. The accumulation of BAs may have also deleterious effects on placental and fetal cells. However, other BAs, such as ursodeoxycholic acid, have been shown to modulate BA-induced injury in hepatocytes. The major beneficial effects of treatment with ursodeoxycholic acid are protection against cytotoxicity due to more toxic BAs; the stimulation of hepatobiliary secretion; antioxidant activity, due in part to an enhancement in glutathione levels; and the inhibition of liver cell apoptosis. Other natural BAs or their derivatives, such as cholyl-N- methylglycine or cholylsarcosine, have also aroused pharmacological interest owing to their protective properties. | Maria J Perez Oscar Briz | 2009 | World Journal of Gastroenterology2009，15，14： | 53 |
| 2 | 中阿40m射电望远镜选址与电磁环境监测显示文摘优良站址的选择是射电望远镜完成既定科学目标并实现高效运行的重要保障。影响射电望远镜选址的主要因素包括电磁环境、水文、气象、地质条件、隔离性与可及性等。对于射电天文观测而言,来自宇宙天体的射电信号往往极其微弱,对望远镜系统及设备的灵敏度要求极高。然而,随着人类活动的不断加强,人们日常工作和生活中使用的电子通讯设备越来越多,无线电干扰源呈爆炸式涌现。在射电望远镜选址工作中,进行电磁环境监测,选择一个电磁环境良好的站址,对于射电望远镜实现常规观测运行、获取有效数据资料至关重要。同时,电磁环境监测结果也是射电望远镜接收机系统研制、站址电磁环境及无线电宁静区立法保护的重要依据。中阿天文学者和技术人员历时1年半完成了16个候选站址的初步勘察,并对优选出的3个主要候选站址进行了深入细致的电磁环境监测工作,获得了大量可靠数据。中阿双方依据电磁环境监测结果并结合各主要候选站址的水文、气象、地质及道路等条件,最终将位于Talacasto戈壁的3号候选站址确定为中阿CART射电望远镜的建设站点。 | 赵卫普 李建斌 李金增 孙建民 齐力 罗滔 马晓耘 莫铠玮 李鹏程 夏跃兵 MALLAMACI C C PODESTA R C PACHECO A M ACTIS E CASTRO J I ALVIS R H LOPEZ C E FRANCILE C PODESTA F PEREZ J | 2014 | 天文学进展2014，32，3： | 4 |
| 3 | Study of photodegradation of the pefticide ethiofencarb in aqueous and non - aqueous media, by gas chromatograghy - mass spectrometry 显示文摘 | J Sanze - Asensio M Plaza - Medina M T Martinez - Soria M Perez -Clavijo | 1999 | Journal of Chromatograghy A1999，84，： | 2 |
| 4 | Lipoprotein lipase gene polymorphism in non-insulin-dependent diabetics: preliminary study显示文摘 | PEREZ F LAFAYETTE T SANTOS J L | 1997 | Rev Med Chil1997，125，11： | 2 |
| 5 | Optimization of the production of a honeybee odorant-binding protein by Pichia pastoris 显示文摘 | Briand L Perez V Huet J C | 1999 | Protein Expression Purification1999，15，： | 2 |
| 6 | All-weather model for sky luminance distribution-preliminary configuration and validation 显示文摘 | Perez R Seals R Michalsky J | 1993 | Solar Energy1993，50，3： | 1 |
| 7 | Novel process for low temperature crystallization of a-SiC: H for optoelectronic applications显示文摘 | Hossain M Perez J R S Rivera J M R | 2009 | Journal of Materials Science2009，20，： | 1 |
| 8 | Effects of secondary phases on the damping behavior of metals, alloys and metal matrix composites显示文摘 | Zhang Jin-min Perez Robert J Wong Catherine R | 1994 | Mat Sci Eng R1994，13，8： | 1 |
| 9 | A route to high surface area, porosity and inclusion of large molecules in ceystals显示文摘 | Chae H K Siberlo Perez D Y Kim J | 2004 | Nature2004，427，： | 1 |
| 10 | Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer显示文摘 | Romond EH Perez EA Bryant J | 2006 | N Engl J Med2006，353，16： | 1 |
| 11 | Stereotactic biopsy for brainstem tumors in pediatric patients 显示文摘 | PEREZ GOMEZ J L RODRIGUEZ ALVAREZ C A MARHX BRACHO A | 2010 | Childs Nerv Syst2010，26，1： | 1 |
| 12 | Blood pressure response to physical exertion in adolescents: influence of overweight and obesity显示文摘 | Carletti L Rodrigues AN Perez A J | 2008 | Arq Bras Cardiol2008，91，1： | 1 |
| 13 | Enhanced production of lovastatin in a bubble column by Aspergillus terreus using a two-stage feeding strategy 显示文摘 | Rodriguez Porcel E M Casas Lepez J L Sanchez Perez J A | 2007 | Journal of Chemical Technology and Biotechnology2007，82，： | 1 |
| 14 | Coloring of titanium through laser oxidation: Comparative study with anodizing 显示文摘 | Perez Del P Ferndndez-Pradas J M Serra P | 2004 | Surface and Coatings Technology2004，187，1： | 1 |
| 15 | Data fusion for trackingwith particles显示文摘 | Perez P Vermaak J Blake A | 2004 | the IEEE2004，92，3： | 1 |
| 16 | Inheritance of tomato yellow leaf curl virus resistance derived from Solanum pimpinellifolium UPV16991显示文摘 | Perez de C A Dlez M J Nuez F | 2007 | Plant Dis2007，91，7： | 1 |
| 17 | Computation of the RCS of Complex Bodies Modeled Using NUBBUS Surfaces显示文摘 | Domingo M M Rivas F Perez J | 1995 | IEEE Antennas and Propagation Magazine1995，37，6： | 1 |
| 18 | Identification of aphid (Homoptera:Aphididae) species and clones by random amplification polymorphic DNA显示文摘 | CENIS J L PEREZ P FERERES A | 1993 | Annals of the Entomological Sciety of America1993，86，5： | 1 |
| 19 | Quantitative NMR Spectroscopy for the Prediction of Base Oil Properties显示文摘 | Adhvaryu A Perez J M Duda J L | 2000 | Tribol T2000，43，2： | 1 |
| 20 | Availability of organic and inorganic phosphorus compounds as phosphorus sources for Carex species显示文摘 | Perez Corona M E Van Der Klundert I Verhoeven J T A | 1996 | New Phytologist1996，132，： | 1 |
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