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| 1 | Can baseline ML Flow test results predict leprosy reactions? An investigation in a cohort of patients enrolled in the uniform multidrug therapy clinical trial for leprosy patients in Brazil显示文摘Background:The predictive value of the serology to detection of IgM against the Mycobacterium leprae-derived phenolic glycolipid-I/PGL-I to identify leprosy patients who are at higher risk of developing reactions remains controversial.Whether baseline results of the ML Flow test can predict leprosy reactions was investigated among a cohort of patients enrolled in The Clinical Trial for Uniform Multidrug Therapy for Leprosy Patients in Brazil(U-MDT/CT-BR).Methods:This was a descriptive study focusing on the main clinical manifestations of leprosy patients enrolled in the U-MDT/CT-BR from March 2007 to February 2012 at two Brazilian leprosy reference centers.For research purposes,753 leprosy patients were categorized according to a modified Ridley-Jopling(R&J)classification and according to the development of leprosy reactions(reversal reaction/RR and erythema nodosum leprosum/ENL),and whether they had a positive or negative bacillary index/BI.Results:More than half of the patients(55.5%)reported leprosy reaction:18.3%(138/753)had a RR and 5.4%(41/753)had ENL.Leprosy reactions were more frequent in the first year following diagnosis,as seen in 27%(205/753)of patients,while 19%(142/753)developed reactions during subsequent follow-up.Similar frequencies of leprosy reactions and other clinical manifestations were observed in paucibacillary(PB)and multibacillary(MB)leprosy patients treated with U-MDT and regular MDT(R-MDT)(P=0.43 and P=0.61,respectively).Compared with PB patients,leprosy reactions were significantly more frequent in MB patients with a high BI,and more patients developed RR than ENL.However,RR and neuritis were also reported in patients with a negative BI.At baseline,the highest rate of ML Flow positivity was observed in patients with a positive BI,especially those who developed ENL,followed by patients who had neuritis and RR.Among reaction-free patients,81.9%were ML Flow positive,however,the differences were not statistically significant compared to reactional patients(P=0.45).Conclusions:MB and PB patients treated with R-MDT and U-MDT showed similar frequencies of RR and other clinical manifestations.Positive ML Flow tests were associated with MB leprosy and BI positivity.However,ML Flow test results at baseline showed limited sensitivity and specificity for predicting the development of leprosy reactions. | Emerith Mayra Hungria Regiane Morillas Oliveira Gerson Oliveira Penna Lúcio Cartaxo Aderaldo Maria Araci de Andrade Pontes Rossilene Cruz Heitor de SáGonçalves Maria Lúcia Fernandes Penna Ligia Regina Franco Sansigolo Kerr Mariane Martins de Araújo Stefani Samira Bührer-Sékula | 2016 | Infectious Diseases of Poverty2016，5，1： | 2 |
| 2 | Human benign prostatic hyperplasia stromal cells as inducers and targets of chronic immuno - mediated inflammation 显示文摘 | Penna G Fibbl B Amuchastegni S etal | 2009 | J Immunol2009，182，1： | 1 |
| 3 | Chronic inflammation in thepathogenesis of benign prostatic hyperplasia显示文摘 | Fibbi B Penna G Morelli A | 2009 | Int J Androl2009，32，8： | 1 |
| 4 | Evaluation of alternative breeding programs for dual purpose zebu cattie显示文摘 | LOBO R N B MADALENA F E PENNA V M | 2000 | Rev Bras Zootec2000，29，5： | 1 |
| 5 | Chronic inflammation in the pathogenesis of benign prostatic hyperplasia显示文摘 | Fibbi B Penna G Morel i A | | 0，，： | 1 |
| 6 | The platelet activating factor triggers preconditioning-like eardioprotective effect via mitochondrial K-ATP channels and redox-sensible signaling 显示文摘 | Penna C Mognetti B Tullio F | 2008 | J Physiol Pharmacol2008，59，1： | 1 |
| 7 | MicroRNA -214 contributes to melanoma tumour progression through suppression of TFAP2C显示文摘 | Penna E Orso F Cimino D Tenag|ia E Lembo A Quaglino E Poliseno L Haimovic A Osella-Abate S De Pitta C Pinatel E Stadler M B Provero P Bemengo M G Osman I Taverna D | 2011 | EMBO Journal2011，30，10： | 1 |
| 8 | Colorectal metastasis (liver and lung) 显示文摘 | PENNA C NORDLINGER B | 2002 | Surg Clin North Am2002，82，5： | 1 |
| 9 | Surgery of liver metastases from colorectal cancer :new promises 显示文摘 | PENNA C NORDLINGER B | 2002 | Br Med Bull2002，64，1： | 1 |
| 10 | The vitamin D receptor agnnist elocalcitol inhibits IL - 8 - dependent benign prostatic hyper- plasia stromal cell proliferation and inflammatory response by tm'ge- ring the RhoA/Rho kinase and NF -kappaB pathways显示文摘 | Penna G Fibbi B Amuchastegui S | 2009 | Prostate2009，69，： | 1 |
| 11 | Hyperspectral image compression employing a model of anomalous pixels 显示文摘 | Penna B Tillo T Magli E Olmo G | 2007 | IEEE Geoscience and Remote Sensing Letters2007，4，4： | 1 |
| 12 | Chronic inflammation in the pathogenesis of benign prostatic hyperplasia 显示文摘 | Fibbi B Penna G Morelli A | 2010 | Int J Androl2010，33，3： | 1 |
| 13 | Hyperspectral image compression employing a model of anomalous pixels 显示文摘 | Tillo T Penna B Magli E | 2007 | IEEE Transactions on Geoscience and Remote Sensing Letters2007，4，4： | 1 |
| 14 | Chronic inflammation in the pathogenesis of benign prostatic hyperplasia显示文摘 | Fibbi B Penna G Morelli A | 2010 | Int J Androl2010，33，3： | 1 |
| 15 | Chronic inflammation in the pathogenesis of benign prostatic hyperplasia显示文摘 | Fibbi B Penna G Morel i A | | 0，，03： | 1 |
| 16 | Colorectal metastasis (liver and lung)显示文摘 | Penna C Nordlinger B | 2002 | Surg Clin North Am2002，82，： | 1 |
| 17 | Surgery of liver metastases from colorectal cancer: new promises显示文摘 | Penna C Nordlinger B | 2002 | Br Med Bull2002，64，： | 1 |
| 18 | Vitamin synthesis in plants:Tocopherols and carotenoids显示文摘 | Penna D D Pogson B | 2006 | ARI2006，，1： | 1 |
| 19 | Management of acute anterior shoulder dislocation显示文摘 | Dala-Ali B Penna M McConnell J | | 0，，08： | 1 |
| 20 | Post-ischaemic activation of kinases in the pre-conditioning-like cardioprotective effect of the platelet-activating factor显示文摘 | PENNA C MOGNETTI B TULLIO F | 2009 | Acta Physiol (Oxf)2009，197，3： | 1 |
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