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| 1 | Photoactivated CRY1 and phyB Interact Directly with AUX/IAA Proteins to Inhibit Auxin Signaling in Arabidopsis显示文摘光是在 Arabidopsis 通过蓝色和调停 cryptochrome 的 red/far-red 光光敏电阻器和调停 phytochrome 的小径禁止胚轴房间延伸的关键环境暗示。相反,作为枢轴的内长的植物激素,植物生长素通过 AUX/IAA 蛋白质(AUX/IAAs ) 的植物生长素受体 TIR1/AFBs-mediated 降级支持胚轴延伸。然而,位于发信号的光和植物生长素的对抗相互作用下面的分子的机制仍然保持不清楚。这里,我们报导光禁止由 cryptochrome 的蓝、红的轻依赖者的相互作用通过 AUX/IAAs 的稳定发信号的植物生长素 1 (CRY1 ) 并且有 AUX/IAAs 的 phytochrome B 分别地。有 AUX/IAAs 的 CRY1 的蓝被触发光的相互作用与 AUX/IAAs 禁止 TIR1 的协会,导致这些蛋白质的导致植物生长素的降级的压抑。我们的结果显示光敏电阻器下游地直接作为一样与植物生长素受体分享 AUX/IAAs 表明部件。我们建议由光敏电阻器和植物生长素受体的 AUX/IAA 蛋白质稳定性的那条对抗规定允许植物平衡光和植物生长素信号优化他们的生长。 | Feng Xu Shengbo He Jingyi Zhang Zhilei Mao Wenxiu Wang Ting Li Jie Hua Shasha Du Pengbo Xu Ling Li Hongli Lian Hong-Quan Yang | 2018 | Molecular Plant2018，11，4： | 24 |
| 2 | TGFβ inhibition enhances the generation of hematopoietic progenitors from human ES cell-derived hemogenic endothelial cells using a stepwise strategy显示文摘 | Chengyan Wang Xuming Tang Xiaomeng Sun Zhenchuan Miao Yaxin Lv Yanlei Yang Huidan Zhang Pengbo Zhang Yang Liu LiyingDu Yang Gao Ming Yin Mingxiao Ding Hongkui Deng | 2012 | Cell Research2012，22，1： | 17 |
| 3 | Probing the seeded protocol for high-concentration preparation of silver nanowires显示文摘因为它的潜在的应用,高质量的银 nanowires (Ag NW ) 的大量生产具有重要重要性。卤素离子广泛地为 Ag NW 的合成被使用了;然而由于进异构的成核过程的深卓见的缺乏,通常喂数量的踪迹(例如[Cl -]< 0.25 公里) 被使用,它接着降低先锋的集中([Ag +]) 。这里,我们系统地调查了成核和 Ag NW 的生长行为并且断定异构的成核地点的数字由 AgCl 种子的全部的表面区域被决定,它在降水期间显示了在 Ag + 和 Cl - 的集中之间的一种线性关系。基于这机制,我们成功地与在以前报导的策略作为与那相比为一个水的系统更高为一个 polyol 系统和 5 次高 20 倍的 Ag + 集中生产了高质量的 Ag NW。而且由由控制 AgCl 种子的尺寸定制异构的成核地点,最后的 Ag NW 的直径能是甚至在高 Ag + 集中控制的井。基于机械学的理解,这合成策略能被扩大到另外的 AgX 种子(X = Br -, 我 - 并且 42-) 和基本原则能因此被使用帮助另外的产量很高的金属 NW 的合理合成做好悦耳的尺寸。 | Cheng Wang Baisong Cheng Haichuan Zhang Pengbo Wan Liang Luo Yun Kuang Xiaoming Sun | 2016 | Nano Research2016，9，5： | 8 |
| 4 | QoS-Aware Dynamic Resource Management in Heterogeneous Mobile Cloud Computing Networks显示文摘In mobile cloud computing(MCC) systems,both the mobile access network and the cloud computing network are heterogeneous,implying the diverse configurations of hardware,software,architecture,resource,etc.In such heterogeneous mobile cloud(HMC) networks,both radio and cloud resources could become the system bottleneck,thus designing the schemes that separately and independently manage the resources may severely hinder the system performance.In this paper,we aim to design the network as the integration of the mobile access part and the cloud computing part,utilizing the inherent heterogeneity to meet the diverse quality of service(QoS)requirements of tenants.Furthermore,we propose a novel cross-network radio and cloud resource management scheme for HMC networks,which is QoS-aware,with the objective of maximizing the tenant revenue while satisfying the QoS requirements.The proposed scheme is formulated as a restless bandits problem,whose 'indexability' feature guarantees the low complexity with scalable and distributed characteristics.Extensive simulation results are presented to demonstrate the significant performance improvement of the proposed scheme compared to the existing ones. | SI Pengbo ZHANG Qian F. Richard YU ZHANG Yanhua | 2014 | China Communications2014，11，5： | 7 |
| 5 | Selective transmission and channel estimation in massive MIMO systems显示文摘Massive MIMO systems have got extraordinary spectral efficiency using a large number of base station antennas,but it is in the challenge of pilot contamination using the aligned pilots.To address this issue,a selective transmission is proposed using time-shifted pilots with cell grouping,where the strong interfering users in downlink transmission cells are temporally stopped during the pilots transmission in uplink cells.Based on the spatial characteristics of physical channel models,the strong interfering users are selected to minimize the inter-cell interference and the cell grouping is designed to have less temporally stopped users within a smaller area.Furthermore,a Kalman estimator is proposed to reduce the unexpected effect of residual interferences in channel estimation,which exploits both the spatial-time correlation of channels and the share of the interference information.The numerical results show that our scheme significantly improves the channel estimation accuracy and the data rates. | 杨睿哲 Zong Liang Si Pengbo Ma Dawei Zhang Yanhua | 2016 | High Technology Letters2016，22，1： | 5 |
| 6 | Phytochrome B and AGB1 Coordinately Regulate Photomorphogenesis by Antagonistically Modulating PIF3 Stability in Arabidopsis显示文摘Phytochrome B (phyB), the primary red light photoreceptor, promotes photomorphogenesis in Arabidopsis by interacting with the basic helix-loop-helix transcriptional factor PIF3 and inducing its phosphorylation and degradation. Heterotrimeric G proteins are known to regulate various developmental processes in plants and animals. In Arabidopsis, the G-protein β subunit AGB1 is known to repress photomorphogenesis. However, whether and how phyB and AGB1 coordinately regulate photomorphogenesis are largely unknown. Here we show that phyB physically interacts with AGB1 in a red light-dependent manner and that AGB1 interacts directly with PIF3. Moreover, we demonstrate that the AGB1-PIF3 interaction inhibits the association of PIF3 with phyB, leading to reduced phosphorylation and degradation of PIF3, whereas the phyB-AGB1 interaction represses the association of PIF3 with AGB1, resulting in enhaneed phosphorylation and degradation of PIF3. Our results suggest that phyB and AGB1 antagonistically regulate PIF3 stability by dynamically interacting with each other and PIF3. This dynamic mechanism may allow plants to balanee phyB and G-protein signaling to optimize photomorphogenesis. | Pengbo Xu Hongli Lian Feng Xu Ting Zhang Sheng Wang Wenxiu Wang Shasha Du Jirong Huang Hong-Quan Yang | 2019 | Molecular Plant2019，12，2： | 5 |
| 7 | Prevalence and clinical significance of pathogenic germline BRCA1/2 mutations in Chinese non-small cell lung cancer patients显示文摘Objective: Germline alterations in the breast cancer susceptibility genes type 1 and 2, BRCA1 and BRCA2, predispose individuals to hereditary cancers, including breast, ovarian, prostate, pancreatic, and stomach cancers.Accumulating evidence suggests inherited genetic susceptibility to lung cancer.The present study aimed to survey the prevalence of pathogenic germline BRCA mutations(gBRCAm) and explore the potential association between gBRCAm and disease onset in Chinese advanced non-small cell lung cancer(NSCLC) patients.Methods: A total of 6,220 NSCLC patients were screened using capture-based ultra-deep targeted sequencing to identify patients harboring germline BRCA1/2 mutations.Results: Out of the 6,220 patients screened, 1.03%(64/6,220) of the patients harbored the pathogenic gB RCAm, with BRCA2 mutations being the most predominant mutations(49/64, 76.5%).Patients who developed NSCLC before 50 years of age were more likely to carry gBRCAm(P = 0.036).Among the patients harboring classic lung cancer driver mutations, those with concurrent gBRCAm were significantly younger than those harboring the wild-type gBRCA(P = 0.029).By contrast, the age of patients with or without concurrent gBRCAm was comparable to those of patients without the driver mutations(P = 0.972).In addition, we identified EGFR-mutant patients with concurrent gBRCAm who showed comparable progression-free survival but significantly longer overall survival(P = 0.002) compared to EGFR-mutant patients with wild-type germline BRCA.Conclusions: Overall, our study is the largest survey of the prevalence of pathogenic gBRCAm in advanced Chinese NSCLC patients.Results suggested a lack of association between germline BRCA status and treatment outcome of EGFR-TKI.In addition,results showed a positive correlation between pathogenic gB RCAm and an early onset of NSCLC. | Xingsheng Hu Dongyong Yang Yalun Li Li Li Yan Wang Peng Chen Song Xu Xingxiang Pu Wei Zhu Pengbo Deng Junyi Ye Hanhan Zhang Analyn Lizaso Hao Liu Xinru Mao Hai Huang Qian Chu Chengping Hu | 2019 | Cancer Biology & Medicine2019，16，3： | 4 |
| 8 | Blockchain and MEC-Assisted Reliable Billing Data Transmission over Electric Vehicular Network:An Actor–Critic RL Approach显示文摘Recently,electric vehicles(EVs)have been widely used under the call of green travel and environmental protection,and diverse requirements for charging are also increasing gradually.In order to ensure the authenticity and privacy of charging information interaction,blockchain technology is proposed and applied in charging station billing systems.However,there are some issues in blockchain itself,including lower computing efficiency of the nodes and higher energy consumption in the consensus process.To handle the above issues,in this paper,combining blockchain and mobile edge computing(MEC),we develop a reliable billing data transmission scheme to improve the computing capacity of nodes and reduce the energy consumption of the consensus process.By jointly optimizing the primary and replica nodes offloading decisions,block size and block interval,the transaction throughput of the blockchain system is maximized,as well as the latency and energy consumption of the system are minimized.Moreover,we formulate the joint optimization problem as a Markov decision process(MDP).To tackle the dynamic and continuity of the system state,the reinforcement learning(RL)is introduced to solve the MDP problem.Finally,simulation results demonstrate that the performance improvement of the proposed scheme through comparison with other existing schemes. | Xinyu Ye Meng Li Pengbo Si Ruizhe Yang Enchang Sun Yanhua Zhang | 2021 | China Communications2021，18，8： | 3 |
| 9 | Three-point bending of honeycomb sandwich beams with facesheet perforations显示文摘A novel square honeycomb-cored sandwich beam with perforated bottom facesheet is investigated under threepoint bending,both analytically and numerically.Perforated square holes in the bottom facesheet are characterized by the area ratio of the hole to intact facesheet(perforation ratio).While for large-scale engineering applications like the decks of cargo vehicles and transportation ships,the perforations are needed to facilitate the fabrication process(e.g.,laser welding)as well as service maintenance,it is demonstrated that these perforations,when properly designed,can also enhance the resistance of the sandwich to bending.For illustration,fair comparisons among competing sandwich designs having different perforation ratios but equal mass is achieved by systematically thickening the core webs.Further,the perforated sandwich beam is designed with a relatively thick facesheet to avoid local indention failure so that it mainly fails in two competing modes:(1)bending failure,i.e.,yielding of beam cross-section and buckling of top facesheet caused by bending moment;(2)shear failure,i.e.,yielding and buckling of core webs due to shear forcing.The sensitivity of the failure loads to the ratio of core height to beam span is also discussed for varying perforation ratios.As the perfo-ration ratio is increased,the load of shear failure increases due to thickening core webs,while that of bending failure decreases due to the weakening bottom facesheet.Design of a sandwich beam with optimal perforation ratio is realized when the two failure loads are equal,leading to significantly enhanced failure load(up to 60%increase)relative to that of a non-perforated sandwich beam with equal mass. | Pengbo Su Bin Han Zhongnan Zhao Qiancheng Zhang Tian Jian Lu | 2018 | Acta Mechanica Sinica2018，34，4： | 3 |
| 10 | Unexpected intercalation-dominated potassium storage in WS2 as a I potassium-ion battery anode显示文摘Unexpected intercalation-dominated process is observed duri ng K^+insertion in WS2 in a voltage range of 0.01-3.0 V.This is different fromthe previously reported two-dimensional(2D)transition metal dichalcogenides that undergo a conversion reaction in a low voltage rangewhen used as anodes in potassium-ion batteries.Charge/discharge processes in the K and Na cells are studied in parallel to demonstrate thedifferention storage mechanisms.The Na^+storage proceeds through intercalation and conversion reactions while the K^+storage is governedby an intercalation reaction.Owing to the reversible K^+intercalation in the van der Waals gaps,the WS2 anode exhibits a low decay rate of 0.07%per cycle,delivering a capacity of 103 mAh·g^-1 after 100 cycles at 100 mA·g^-1.It maintains 57%capacity at 800 mA·g^-1 and shows stablecyclability up to 400 cycles at 500 mA·g^-1.Kinetics study proves the facilitation of K^+transport is derived from the intercalation-dominatedmecha nism.Furthermore,the mechanismis verified by the density functional theory(DFT)calculations,showing that the progressive expansion of the interlayer space can account for the observed results. | Vuhan Wu Yang Xu Yueliang Li Pengbo Lyu Jin Wen Chenglin Zhang Min Zhou Yaoguo Fang Huaping Zhao Ute Kaiser Yong Lei | 2019 | Nano Research2019，12，12： | 3 |
| 11 | Molecular Characterisation of the Faecal Microbiota in Patients with Type II Diabetes显示文摘 | Xiaokang Wu Chaofeng Ma Lei Han Muhammad Nawaz Fei Gao Xuyan Zhang Pengbo Yu Chang’an Zhao Lianchuan Li Aiping Zhou Juan Wang John E. Moore B. Cherie Millar Jiru Xu | 2010 | Current Microbiology2010，，1： | 2 |
| 12 | Preliminary Analysis of Gene Expression Profiles in HepG2 Cell Line Induced by Different Genotype Core Proteins of HCV显示文摘在现在的调查,我们构造了表示 HCV 遗传型 1b , 2a ,和 4d 核心蛋白质的 recombinants ,并且建立了在表示不同 HCV 遗传型核心蛋白质的房间表示了各种各样的遗传型核心 proteins.The 基因表达式侧面的人的 hepatocellular 癌( HepG2 )房间线与在由 microarray 分析的控制的那些相比。在数据分析,阀值被设置消除没被 2.5 褶层变化在在 transfected 房间和控制房间之间的比较增加或减少的所有基因。初步的 microarray 分析建议三种遗传型核心蛋白质调整的基因表达式侧面主要涉及运输,信号 transduction,抄写的规定,朊酶活动,等等,和 pathogenesis/oncogenesis 基因表达式是的那一些在 HepG2 房间线同时调整的 up/down- 。数据建议每核心蛋白质有它的基因表达式侧面并且侧面在 HCV 复制和致病被含有,它可以开创一个新奇方法理解生物的 HCV 变体核心蛋白质和他们的病原的机制的函数。 | Jun Dou Pengbo Liu Jing Wang Xinjian Zhang | 2006 | Cellular & Molecular Immunology2006，3，3： | 2 |
| 13 | Phase Boundary Mapping in ZrNiSn Half-Heusler for Enhanced Thermoelectric Performance显示文摘The solubility range of interstitial Ni in the ZrNi1+xSn half-Heusler phase is a controversial issue,but it has an impact on the thermoelectric properties.In this study,two isothermal section phase diagrams of the Zr-Ni-Sn ternary system at 973K and 1173 K were experimentally constructed based on the binary phase diagrams of Zr-Ni,Zr-Sn,and Ni-Sn.The thermodynamic equilibrium phases were obtained after a long time of heating treatment on the raw alloys prepared by levitation melting.Solubilities of x<0:07 at 973 K and x<0:13 at 1173 K were clearly indicated.An intermediate-Heusler phase with a partly filled Ni void was observed,which is believed to be beneficial to the lowered lattice thermal conductivity.The highest ZT value~0:71 at 973 K was obtained for ZrNi_(1.11)Sn_(1.04).The phase boundary mapping provides an important instruction for the further optimization of ZrNiSn-based materials and other systems. | Xiaofang Li Pengbo Yang Yumei Wang Zongwei Zhang Dandan Qin Wenhua Xue Chen Chen Yifang Huang Xiaodong Xie Xinyu Wang Mujin Yang Cuiping Wang Feng Cao Jiehe Sui Xingjun Liu Qian Zhang | 2020 | Research2020，，1： | 2 |
| 14 | Ferroptosis promotes T-cell activation-induced neurodegeneration in multiple sclerosis显示文摘While many drugs are effective at reducing the relapse frequency of multiple sclerosis (MS), there is an unmet need for treatments that slow neurodegeneration resulting from secondary disease progression. The mechanism of neurodegeneration in MS has not yet been established. Here, we discovered a potential pathogenetic role of ferroptosis, an iron-dependent regulated cell death mechanism, in MS. We found that critical ferroptosis proteins (acyl-CoA synthetase long-chain family member 4, ACSL4) were altered in an existing genomic database of MS patients, and biochemical features of ferroptosis, including lipid reactive oxygen species (ROS) accumulation and mitochondrial shrinkage, were observed in the experimental autoimmune encephalitis (EAE) mouse model. Targeting ferroptosis with ferroptosis inhibitors or reducing ACSL4 expression improved the behavioral phenotypes of EAE mice, reduced neuroinflammation, and prevented neuronal death. We found that ferroptosis was an early event in EAE, which may promote T-cell activation through T-cell receptor (TCR) signaling in vitro and in vivo. These data indicate that ferroptosis may be a potential target for treating MS. | Jinyuan Luoqian Wenyong Yang Xulong Ding Qing-zhang Tuo Zheng Xiang Zhaoyue Zheng Yu-jie Guo Li Li Pengbo Guan Scott Ayton Biao Dong Huiyuan Zhang Hongbo Hu Peng Lei | 2022 | Cellular & Molecular Immunology2022，19，8： | 2 |
| 15 | Effect of tetramethylpyrazine on the spatial learning and memory function of rats after focal cerebral ischemia显示文摘BACKGROUND: Tetramethylpyrazine (TMP) presents the effect of anti-platelet aggregation, reduces arterial resistance, increases cerebral blood flow, and improves microcirculation. OBJECTIVE: To observe the effects of TMP on the learning and memory abilities and the number of neurons in cortex and hippocampus after focal cerebral ischemia in rats DESIGN: A randomized controlled trial. SETTING: Department of Human Anatomy and Histological Embryology, School of Medicine, Xi’an Jiaotong University. MATERIALS: Fifty adult male Sprague-Dawley rats, weighing 250-300 g were supplied by the Experimental Animal Center, School of Medicine, Xi’an Jiaotong University. TMP was purchased from Wuxi Seventh Pharmaceutical Co.Ltd (Lot Number: 2004051106, Specification: 2 mL/piece). METHODS: The experiments were carried out in School of Medicine of Xi’an Jiaotong University from June 2004 to May 2005. The 50 rats were randomly divided into five groups according to the random number table method: sham-operated group, cerebral ischemia control group, low-dose TMP group, middle-dose TMP group and high-dose TMP group, 10 rats in each group. Rats in the TMP groups were immediately treated with intraperitoneal injection of TMP of 40, 80 and 120 mg/kg respectively, and those in the sham-operated group and cerebral ischemia control group were injected intraperitoneally by isovolume saline, once a day for 14 days successively. On the 15th day, the spatial learning and memory abilities of the rats were assessed with the Morris water maze test, and then the changes of neuron numbers in cortex and hippocampus were observed by Nissl staining of brain sections. MAIN OUTCOME MEASURES: The results of Morris water maze test and the changes of neuron numbers in cortex and hippocampus by Nissl staining of brain sections were observed. RESULTS: Finally 39 rats were involved in the analysis of results, and the other 11 died of excessive anesthesia or failure in model establishment. ① The rats in the cerebral ischemia control group manifested obvious spatial cognitive deficits in the place navigation trial and spatial probe trial. The mean values of escape latency in the sham-operated group, low, middle and high-dose TMP groups were obviously shorter than that in the cerebral ischemia control group [(23.92±2.21), (41.84±3.74), (39.50±3.80), (31.38±3.72), (61.60±3.61) s, P < 0.05-0.01]. In the spatial probe trial, significant differences in the percentage of time spending in the former platform quadrant and frequency of crossing the former platform site in the sham-operated group, lose, middle and high-dose TMP groups were obviously higher or more than those in the cerebral ischemia control group [(36.27±3.42) %, (35.84±2.54)%, (38.43±3.08)%, (36.51±1.96)%, (22.24±3.46)%; (11±1), (10±1), (8±1), (8±1), (4±1) times, P < 0.01]. ② In the morphological observation, the numbers of neurons in ipsilateral (left) parietal cortex in the sham-operated group, low, middle and high-dose TMP groups were obviously more than that in the cerebral ischemia control group [(98±8), (65±5), (53±6), (57±6), (37±6)/0.625 mm2, P < 0.01], but the number of neurons in left hippocampus had no obvious differences among the groups (P > 0.05). CONCLUSION: TMP can improve obviously the spatial learning and memory function after permanent focal cerebral ischemia in rats, and the neuroprotective role of the drug in cortex may be involved in its mechanism. | Jianjun Zhao Yong Liu Xinlin Chen Jianxin Liu Yingfang Tian Pengbo Zhang Qianyan Kang Fen Qiu | 2006 | Neural Regeneration Research2006，1，2： | 2 |
| 16 | Association between the Pro12Ala polymorphism of PPAR-γ gene and the non-alcoholic fatty liver disease: A meta-analysis显示文摘 | Jun Wang Xufeng Guo Pengbo Wu Jia Song Chuncui Ye Shijie Yu Jixiang Zhang Weiguo Dong | 2013 | Gene2013，，： | 2 |
| 17 | Stable and realistic crack pattern generation using a cracking node method显示文摘 | Juan ZHANG Fuqing DUAN Mingquan ZHOU Dongcan JIANG Xuesong WANG Zhongke WU Youliang HUANG Guoguang DU Shaolong LIU Pengbo ZHOU Xiangang SHANG | 2018 | Frontiers of Computer Science2018，12，4： | 1 |
| 18 | Study on the influence of supply-voltage fluctuation on shunt active power filter 显示文摘 | WU Longhui ZHUO Fang ZHANG Pengbo | 2007 | IEEE Transactions on Power Delivery2007，22，3： | 1 |
| 19 | Erratum to Prevalence and clinical significance of pathogenic germline BRCA1/2 mutations in Chinese non-small cell lung cancer patients显示文摘In the published article1,the affiliation for the first author,Xingshcng Hu,is'Department of Medical Oncology,Cancer Hospital,Chinese Academy of Medical Sciences',we would like to update it to'Department of Medical Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,100021,China'.We apologize for the errors and for any confusion it may have caused. | Xingsheng Hu Dongyong Yang Yalun Li Li Li Yan Wang Peng Chen Song Xu Xingxiang Pu Wei Zhu Pengbo Deng Junyi Ye Hanhan Zhang Analyn Lizaso Hao Liu Xinru Mao Hai Huang Qian Chu Chengping Hu | 2020 | Cancer Biology & Medicine2020，17，2： | 1 |
| 20 | Numerical simulation of the combined effects of plasma heating and neutron heating loads on the ITER first wall显示文摘 | Zhang Pengbo Zhao Jijun Qin Ying | 2011 | Fusion Eng Des2011，86，1： | 1 |
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