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| 1 | Research progress in ZnO single-crystal:growth, scientific understanding, and device applications显示文摘Zinc oxide,a wide band-gap semiconductor,has shown extensive potential applications in high-efficiency semiconductor photoelectronic devices,semiconductor photocatalysis,and diluted magnetic semiconductors.Due to the undisputed lattice integrity,ZnO single crystals are essential for the fabrication of high-quality ZnO-based photoelectronic devices,and also believed to be ideal research subjects for understanding the underlying mechanisms of semiconductor photocatalysis and diluted magnetic semiconductors.This review,which is organized in two main parts,introduces the recent progress in growth,basic characterization,and device development of ZnO single crystals,and some related works in our group.The first part begins from the growth of ZnO single crystal,and summarizes the fundamental and applied investigations based on ZnO single crystals.These works are composed of the fabrication of homoepitaxial ZnO-based photoelectronic devices,the research on the photocatalysis mechanism,and dilute magnetic mechanism.The second part describes the fabrication of highly thermostable n-type ZnO with high mobility and high electron concentration through intentional doping.More importantly,in this part,a conceptual approach for fabricating highly thermostable p-type ZnO materials with high mobility through an integrated three-step treatment is proposed on the basis of the preliminary research. | Feng Huang Zhang Lin Wenwen Lin Jiye Zhang Kai Ding Yonghao Wang Qinghong Zheng Zhibing Zhan Fengbo Yan Dagui Chen Peiwen Lv Xian Wang | 2014 | Chinese Science Bulletin2014，59，12： | 11 |
| 2 | Anti-rutting performance evaluation of modified asphalt binders: A review显示文摘Asphalt pavement inevitably suffers rutting distress induced by repeated loads under high temperatures, which can be effectively alleviated by the modification of asphalt binders.This paper summarized the asphalt modifiers for enhancing the performance of asphalt pavement at high temperatures in terms of the modifier type, additive amount and improving effect. Then, the anti-rutting performance evaluation methods of asphalt binder were introduced with details, including the ring and ball(R&B) test, the dynamic viscosity test, the zero/low shear viscosity(ZSV/LSV) test, the dynamic shear rheometer(DSR) test,the repeated creep and recovery(RCR) test, and the multiple stress creep and recovery(MSCR) test. Furthermore, the sensitivity of the evaluation method to asphalt modifier was analyzed using the normalization method. It was found that the indicators from the MSCR test could clearly reveal the influence of asphalt modifiers on high temperature performance of asphalt binder. But it still had some limitations affecting the accuracy of evaluation results, such as the number of creep-recovery cycles, the stress level and the recovery time. In addition, according to the rutting resistance improvement ratio(RRIR),the styrene-butadiene-styrene(SBS) modifier performed better in improving the rutting resistance of asphalt binder, compared with other modifiers when added within the usual dosage range. | Yan Li Peiwen Hao Chaozhi Zhao Jwnqiang Ling Tao Wu Dewen Li Jingwen Liu Bowei Sun | 2021 | Journal of Traffic and Transportation Engineering(English Edition)2021，8，3： | 4 |
| 3 | Auxin signaling module OsSK41-OsIAA10-OsARF regulates grain yield traits in rice显示文摘Auxin is an important phytohormone in plants, and auxin signaling pathways in rice play key roles in regulating its growth, development, and productivity. To investigate how rice grain yield traits are regulated by auxin signaling pathways and to facilitate their application in rice improvement, we validated the functional relationships among regulatory genes such as OsIAA10, OsSK41, and OsARF21 that are involved in one of the auxin(OsIAA10) signaling pathways. We assessed the phenotypic effects of these genes on several grain yield traits across two environments using knockout and/or overexpression transgenic lines.Based on the results, we constructed a model that showed how grain yield traits were regulated by OsIAA10 and OsTIR1, OsAFB2, and OsSK41 and OsmiR393 in the OsSK41-OsIAA10-OsARF module and by OsARF21 in the transcriptional regulation of downstream auxin response genes in the OsSK41-OsIAA10-OsARF module. The population genomic analyses revealed rich genetic diversity and the presence of major functional alleles at most of these loci in rice populations. The strong differentiation of many major alleles between Xian/indica and Geng/japonica subspecies and/or among modern varieties and landraces suggested that they contributed to improved productivity during evolution and breeding. We identified several important aspects associated with the genetic and molecular bases of rice grain and yield traits that were regulated by auxin signaling pathways.We also suggested rice auxin response factor(OsARF) activators as candidate target genes for improving specific target traits by overexpression and/or editing subspecies-specific alleles and by searching and pyramiding the ‘best' gene allelic combinations at multiple regulatory genes in auxin signaling pathways in rice breeding programs. | Fuying Ma Fan Zhang Yu Zhu Dengyong Lan Peiwen Yan Ying Wang Zejun Hu Xinwei Zhang Jian Hu Fuan Niu Mingyu Liu Shicong He Jinhao Cui Xinyu Yuan Ying Yan Shujun Wu Liming Cao Hongwu Bian Jinshui Yang Zhikang Li Xiaojin Luo | 2023 | Journal of Integrative Plant Biology2023，65，7： | 1 |
| 4 | Recent progress on the mechanics of sharply bent DNA显示文摘Despite extensive studies on the mechanics of DNA under external constrains, such as tension, torsion, and bending, several important aspects have remained poorly understood. One biologically important example is the mechanics of DNA under sharp bending conditions, which has been debated for a decade without thorough comprehension. The debate is about the interesting phenomenon raised from a series of different experiments: sharply bent DNA has a surprisingly high apparent bending flexibility that deviates from the canonical bending elasticity of DNA. This finding has motivated various theoretical models, which mainly incorporate the excitation of mechanical defects inside severely bent DNA molecules. Here, we review the recent progress on the understanding of the mechanics of sharply bent DNA and provide our view on this important question by interrogating the theoretical foundation of these experimental measurements. | PeiWen Cong Jie Yan | 2016 | Science China(Physics,Mechanics & Astronomy)2016，59，8： | 1 |
| 5 | Viral receptor profiles of masked palm civet revealed by single-cell transcriptomics显示文摘Civets are small mammals belonging to the family Viverridae.The masked palm civets(Paguma larvata)served as an intermediate host in the bat-to-human transmission of severe acute respiratory syndrome coronavirus(SARS-Co V)in 2003(Guan et al.,2003).Because of their unique role in the SARS outbreak,civets were suspected as a potential intermediate host of SARS-Co V-2. | Peiwen Ding Haoyu Wang Jiacheng Zhu Fuyu An Jinqian Xu Xiangning Ding Lihua Luo Weiying Wu Qiuyu Qin Yanan Wei Wandong Zhao Zhiyuan Lv Haimeng Li Yixin Zhu Meiling Li Wensheng Zhang Yanan Zhang Zhihua Ou Huan Liu Yan Hua | 2022 | Journal of Genetics and Genomics2022，49，11： | 0 |
| 6 | Post-transcriptional regulation of grain weight and shape by the RBP-A-J-K complex in rice显示文摘RNA-binding proteins(RBPs)are components of the post-transcriptional regulatory system,but their regulatory effects on complex traits remain unknown.Using an integrated strategy involving map-based cloning,functional characterizations,and transcriptomic and population genomic analyses,we revealed that RBP-K(LOC_Os08g23120),RBP-A(LOC_Os11g41890),and RBP-J(LOC_Os10g33230)encode proteins that form an RBP-A-J-K complex that negatively regulates rice yield-related traits.Examinations of the RBP-A-J-K complex indicated RBP-K functions as a relatively non-specific RBP chaperone that enables RBP-A and RBP-J to function normally.Additionally,RBP-J most likely affects GA pathways,resulting in considerable increases in grain and panicle lengths,but decreases in grain width and thickness.In contrast,RBP-A negatively regulates the expression of genes most likely involved in auxin-regulated pathways controlling cell wall elongation and carbohydrate transport,with substantial effects on the rice grain filling process as well as grain length and weight.Evolutionarily,RBP-K is relatively ancient and highly conserved,whereas RBP-J and RBP-A are more diverse.Thus,the RBP-A-J-K complex may represent a typical functional model for many RBPs and protein complexes that function at transcriptional and post-transcriptional levels in plants and animals for increased functional consistency,efficiency,and versatility,as well as increased evolutionary potential.Our results clearly demonstrate the importance of RBP-mediated post-transcriptional regulation for the diversity of complex traits.Furthermore,rice grain yield and quality may be enhanced by introducing various complete or partial loss-of-function mutations to specific RBP genes using clustered regularly interspaced palindromic repeats(CRISPR)/CRISPR-associated protein 9 technology and by exploiting desirable natural tri-genic allelic combinations at the loci encoding the components of the RBP-A-J-K complex through marker-assisted selection. | Ding Ren Hui Liu Xuejun Sun Fan Zhang Ling Jiang Ying Wang Ning Jiang Peiwen Yan Jinhao Cui Jinshui Yang Zhikang Li Pingli Lu Xiaojin Luo | 2024 | Journal of Integrative Plant Biology2024，66，1： | 0 |
| 7 | Radar false alarm plots elimination based on multi-feature extraction and classification显示文摘Caused by the environment clutter,the radar false alarm plots are unavoidable.Suppressing false alarm points has always been a key issue in Radar plots procession.In this paper,a radar false alarm plots elimination method based on multi-feature extraction and classification is proposed to effectively eliminate false alarm plots.Firstly,the density based spatial clustering of applications with noise(DBSCAN)algorithm is used to cluster the radar echo data processed by constant false-alarm rate(CFAR).The multi-features including the scale features,time domain features and transform domain features are extracted.Secondly,a feature evaluation method combining pearson correlation coefficient(PCC)and entropy weight method(EWM)is proposed to evaluate interrelation among features,effective feature combination sets are selected as inputs of the classifier.Finally,False alarm plots classified as clutters are eliminated.The experimental results show that proposed method can eliminate about 90%false alarm plots with less target loss rate. | Cheng Yi Zhao Yan Yin Peiwen | 2024 | The Journal of China Universities of Posts and Telecommunications2024，31，1： | 0 |
| 8 | Mechanical Strength and Structural Basis ofβ2 Integrin to Mediate Neutrophil Accumulation on Liver Sinusoidal Endothelial Cells:A Study Using Atomic Force Microscopy and Molecular Dynamics Simulations显示文摘Neutrophil(PMN)accumulation on liver sinusoidal endothelial cells(LSECs)is crucial to pathogen clearance and tissue damage in the liver sinusoids and controlled by a series of adhesion molecules expressed on the surface of PMNs and LSECs.The role of lymphocyte function-associated antigen-1(LFA-1)and macrophage-1 antigen(Mac-1)in this process is still contentious.Here we compared the dynamic force spectra of the binding ofβ2 integrin to intercellular adhesion molecule-1(ICAM-1)on LSECs using atomic force microscopy(AFM)and performed free and steered molecular dynamics(MD)simulations to analyze their structural bases of LFA-1-or Mac-1-I-domain and ICAM-1-D1 or D3 pair in their force spectra.Our AFM data suggest that the mechanical strength of LFA-1-ICAM-1 bond is significantly stronger than that of Mac-1-ICAM-1 bond,implying a dominate role for LFA-1 to mediate PMN adhesion under shear flow.MD simulations indicated that spontaneous dissociation of Mac-1-I-domain vs.ICAMD3-domain is slower with the stronger interaction energy than that for LFA-1 I-domain vs.ICAM-D1-domain and that the rupture force for Mac-1 is lower than that for LFA-1,which are in qualitative agreement with the above experimental observations.These data indicate that the biomechanical features of LFA-1 and Mac-1 to mediate PMN adhesion on LSECs in vitro are similar with those in other tissues like cerebrovascular endothelium,while Mac-1-mediated PMN recruitment in liver sinusoids may stem from the slow blood flow in vivo.These findings further the understandings of PMN recruitment under shear flow in liver sinusoids. | Ning Li Xiao Zhang Peiwen Li Hao Yang Chunfang Tong Shouqin Lü Yan Zhang Zhiyi Ye Jun Pan Mian Long | 2018 | Computer Modeling in Engineering & Sciences2018，，8： | 0 |
| 9 | Process analytical technologies and self-optimization algorithms in automated pharmaceutical continuous manufacturing显示文摘The pharmaceutical industry is now paying increased attention to continuous manufacturing.While the revolution to continuous and automated manufacturing is deepening in most of the top pharma companies in the world,the advancement of automated pharmaceutical continuous manufacturing in China is relatively slow due to some key challenges including the lack of knowledge on the related technologies and shortage of qualified personnels.In this review,emphasis is given to two of the crucial technologies in automated pharmaceutical continuous manufacturing,i.e.,process analytical technology(PAT)and self-optimizing algorithm.Research work published in recent 5 years employing advanced PAT tools and self-optimization algorithms is introduced,which represents the great progress that has been made in automated pharmaceutical continuous manufacturing. | Peiwen Liu Hui Jin Yan Chen Derong Wang Haohui Yan Mingzhao Wu Fang Zhao Weiping Zhu | 2024 | Chinese Chemical Letters2024，35，3： | 0 |
| 10 | Alternative splicing patterns of doublesex reveal a missing link between Nix and doublesex in the sex determination cascade of Aedes albopictus显示文摘Sexual development in insects is regulated by a complicated hierarchical cascade of sex determination.The primary signals are diverse,whereas the central nexus doublesex(dsx)gene is relatively conserved within the pathway.Aedes(Stegomyia)albopictus is an important vector with an extensive worldwide distribution.We previously reported that Ae.albopictus dsx(Aalbdsx)yields one male-(Aalbdsx^(M))and three female-specific isoforms(Aalbdsx^(F1-3));however,the spatiotemporal expression profiles and mechanisms regulating sex-specific alternative splicing require further investigation.In this study,we demonstrated that the Aalbdsx^(M) messenger RNA(mRNA)represents the default pattern when analyzed in human foreskin fibroblasts and HeLa cells.We combined reverse transcription polymerase chain reaction with RNA immunoprecipitation using specific antibodies against tagged Ae.albopictus male-determining factor AalNix and confirmed that AalNix indirectly regulates dsx pre-mRNA and regulates its alternative splicing.During the early embryo stage(0-2 and 4-8 h),maternal dsx^(F) and default splicing dsx^(M) were detected in both sexes;the expression of dsx^(M) then decreased until sufficient AalNix transcripts accumulated in male embryos at 20-24 h.These findings suggest that one or more potential dsx splicing enhancers can shift dsx^(M) to dsx^(F) in both sexes;however,the presence of Nix influences the function of this unknown splicing enhancer and ultimately leads to the formation of dsx^(M) in males.Finally,our results provide important insight into the regulatory mechanism of dsx alternative splicing in the mosquito. | Binbin Jin Yijie Zhao Yunqiao Dong Peiwen Liu Yan Sun Xiaocong Li Xin Zhang Xiao-Guang Chen Jinbao Gu | 2021 | Insect Science2021，28，6： | 0 |
| 11 | The kinase OsSK41/OsGSK5 negatively regulates amylose content in rice endosperm by affecting the interaction between OsEBP89 and OsBP5显示文摘Amylose content(AC) is the main factor determining the palatability, viscosity, transparency, and digestibility of rice(Oryza sativa)grains. AC in rice grains is mainly controlled by different alleles of the Waxy(Wx) gene. The AP2/EREBP transcription factor OsEBP89 interacts with the MYC-like protein OsBP5 to synergistically regulate the expression of Wx.Here, we determined that the GLYCOGEN SYNTHASE KINASE 5(OsGSK5, also named SHAGGY-like kinase 41 [OsSK41]) inhibits the transcriptional activation activity of OsEBP89 in rice grains during amylose biosynthesis. The loss of OsSK41 function enhanced Wx expression and increased AC in rice grains. By contrast, the loss of function of OsEBP89 reduced Wx expression and decreased AC in rice grains. OsSK41 interacts with OsEBP89 and phosphorylates four of its sites(Thr-28,Thr-30, Ser-238, and Thr-257), which makes OsEBP89 unstable and attenuates its interaction with OsBP5. Wx promoter activity was relatively weak when regulated by the phosphomimicvariantOsEBP89E–OsBP5but relatively strong when regulated by the nonphosphorylatable variant OsEBP89A–OsBP5.Therefore, OsSK41-mediated phosphorylation of OsEBP89 represents an additional layer of complexity in the regulation of amylose biosynthesis during rice grain development. In addition, our findings provide four possible sites for regulating rice grain AC via precise gene editing. | Zejun Hu Fuan Niu Peiwen Yan Kai Wang Lixia Zhang Ying Yan Yu Zhu Shiqing Dong Fuying Ma Dengyong Lan Siwen Liu Xiaoyun Xin Ying Wang Jinshui Yang Liming Cao Shujun Wu Xiaojin Luo | 2023 | Journal of Integrative Plant Biology2023，65，7： | 0 |
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