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| 1 | Genetic determination of irritable bowel syndrome显示文摘急躁的肠症候群(IBS ) 是普通功能的胃肠的混乱。根据罗马 III 标准, IBS 在下列症状的与二联系的以前的 3 瞬间或更多期间每月为至少 3 d 被定义为周期性的腹的疼痛或不快:有澄清,在凳子的频率与一个变化联系的发作或与一个变化联系处于良好的竟技状态的发作或凳子的外观的改进。在 IBS 关于基因贡献正在种证据,然而, IBS 的精确病原学仍然是未知的。基因影响的评估基于成双的研究,家庭聚集和基因流行病学调查。大多数研究比在 dizygotic 为在单合子显著地更大的 IBS 显示出一个词语索引。研究的多数证明了家庭聚集可以代表暴露到基因因素的类似的环境,以及影响。而没有特定的基因与 IBS 联合被识别了,最近的研究在血清素的倡导者区域注意了多型性的重要性再入伍拿 transporter 基因,G蛋白质贝它 3 子单元基因( C825T ),缩胆囊素受体( CCKAR 基因 779T >C ),并且高制片人的肿瘤坏死因素遗传型。进一步的研究是必要的决定基因因素怎么在 IBS 病人影响临床的表明和 therapeutical 反应。 | Cristina Hotoleanu Radu Popp Adrian Pavel Trifa Laurentiu Nedelcu Dan L Dumitrascu | 2008 | World Journal of Gastroenterology2008，14，43： | 4 |
| 2 | Surgical stress and cytoskeletal changes in lens epithelial cells following manual and femtosecond laser-assisted capsulotomy显示文摘AIM:To study the effect of mechanical stress on the cytoskeleton in lens epithelial cells following conventional phacoemulsification surgery(CPS)and femtosecond laserassisted cataract surgery(FLACS).METHODS:The cytoskeleton of the epithelial cells of the anterior lens capsules(ALC)removed by CPS and FLACS was examined by immunohistochemistry.Expression of the intermediate filament,glial fibrillary acidic protein(GFAP),and glutamine synthetase(GS)immunoreactivity were detected.In order to map the actin network of cells,fluorescently labeled phalloidin was used.The samples were examined using confocal laser scanning microscopy.RESULTS:GFAP expression was visible in a larger number of the epithelial cells after CPS compared to FLACS.In CPS sample’s epithelial cells,GFAP immunoreactivity indicated robust morphological change.Regarding the actin filaments,the presence of tubular elements connecting epithelial cells,regular actin pattern and marked cortical network after CPS were found.Following FLACS,the actin cytoskeleton of the epithelial cells remained densely structured,and the tubular elements were undetectable,however,the above-mentioned regular actin pattern and the marked cortical network were visible.CONCLUSION:The conventional removal of the ALC induces more robust changes of the cytoskeleton of the lens epithelial cells. | ANDrea Krisztina Sükosd Krisztina Szabadfi Edina Szabó-Meleg Beáta Gáspár Pavel Stodulka Gyorgy SétálóJr Róbert Gábriel Miklós Nyitrai Zsolt Biró Hajnalka Abrahám | 2020 | International Journal of Ophthalmology(English edition)2020，13，6： | 2 |
| 3 | AT1 receptor blockade regulates the local angiotensin Ⅱ system in cerebral microvessels from spontaneously hypertensive rats 显示文摘 | Zhou J Pavel J Macova M l | 2006 | Stroke2006，37，5： | 1 |
| 4 | Characteristics of thermal cycling in a magnesium alloy composite显示文摘 | Frantisek C Pavel L Jens K | 2002 | Materials Science and Engineering2002，325，： | 1 |
| 5 | Mitochondrial DNA sequence heteroplasmy in the Grand Duke of Russia Georgij Romanov establishes the authenticity of the remains of Tsar Nicholas II显示文摘 | Pavel L I Mark J W Rhonda K R | 1996 | Nat Genet1996，12，： | 1 |
| 6 | Insulin-like growth factor family and combined antisense approach in therapy of lung carcinoma显示文摘 | Pavelic J Pavelic L Karadza J | 2002 | Mol Med2002，8，3： | 1 |
| 7 | Calix arene-porphyrin Conjugates as Versatile Molecular Receptors for Anions 显示文摘 | Miroslav D Pavel L Ivan S | 2003 | Organic Letters2003，5，2： | 1 |
| 8 | Characterization and remediation of soils contaminated with uranium 显示文摘 | Gavrilescu M Pavel L V Cretescu I | 2008 | Journal of Hazardous Materials2008，163，7： | 1 |
| 9 | Detection of Pglycoprotein with four monoclonal antibodies in normal and tumor tissues显示文摘 | Pavelic Z P Reising J Pavelic L | 1993 | Arch Otolaryngol Head Neck Surg1993，119，7： | 1 |
| 10 | Efficacy of noninvasive hemodynamic monitoring to target reduction of blood pressure levels (the control trial) (Abstract)显示文摘 | Ronald D Pavel L Carlos M | 2005 | Am J Hypertens2005，18，： | 1 |
| 11 | Porphyrin/calixarene self-assemblies in aqueous solution 显示文摘 | Pavel K Kamil L Pavel L | 2008 | J Photochem PhotobiolA2008，198，1： | 1 |
| 12 | Characterization and remediation of soils contaminated with uranium显示文摘 | Gavrilescu M Pavel L V Cretescu I | 2009 | Jour- nal of Hazardous Materials2009，163，23： | 1 |
| 13 | Insulin-like growth factor family and combined antisense approach in therapy of lung carcinoma 显示文摘 | Pavelie J Pavelic L Karadza J | 2002 | Mol Med2002，8，3： | 1 |
| 14 | Characterization and remediation of soils contaminated with uranium 显示文摘 | GAVRILESCU M PAVEL L V CRETESCU I | 2009 | J Hazard Mater2009，163，23： | 1 |
| 15 | DET/TDDFT studies of the geometry,electronic structure and spectra of (12S)-1,4,7,10-tetraazadicyclo-pentadecane-3,11-dione and its derivatives显示文摘 | Y B Wang l Pavel Yuan Q Ye Y Fu E Q Luo M D Hu J M Kiefer W | 2005 | J Phys Chem A2005，109，： | 1 |
| 16 | Interfaces in Magnesium-based Composites显示文摘 | Pavel Lukac | 2001 | Surf Interface Anal2001，，31： | 1 |
| 17 | Nonlinear H∞ control: A J-dissipative approach显示文摘 | PAVEL L FAIRMAV F W | 1997 | IEEE Transactions on Automatic Control1997，42，12： | 1 |
| 18 | c-myc, c- erbB-2, and Ki-67 expression in normal breast tissue and in invasive and noninvasive breast carcinoma显示文摘 | Pavelic ZP Pavelic L Lower EE | 1992 | Cancer Res1992，52，9： | 1 |
| 19 | Leaching of metals from fly ashes in the presence of completing agents显示文摘 | Pavel J Michaela W Tomas L | 2002 | Write Manage2002，22，： | 1 |
| 20 | Comparison theorems for linear dynamic equations on time scales 显示文摘 | Erbe L Peterson A Pavel | 2002 | J Math Amal Appl2002，275，1： | 1 |
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