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| 1 | Gut barrier failure biomarkers are associated with poor disease outcome in patients with primary sclerosing cholangitis显示文摘AIM To assess the prevalence of a panel of serologic markers that reflect gut barrier dysfunction in a mixed cohort of pediatric and adult primary sclerosing cholangitis(PSC) patients.METHODS Sera of 67 PSC patients [median age(range): 32(5-79) years, concomitant IBD: 67% and cirrhosis: 20%] were assayed for the presence of antibodies against to F-actin(AAA Ig A/Ig G) and gliadin(AGA Ig A/Ig G)] and for serum level of intestinal fatty acid-binding protein(I-FABP) by ELISA. Markers of lipopolysaccharide(LPS) exposure [LPS binding protein(LBP)] and various antimicrobial antibodies [anti-OMP Plus Ig A and endotoxin core Ig A antibody(Endo CAb)] were also determined. Poor disease outcome was defined as orthotopic liver transplantation and/or liver-related death during the follow-up [median: 99(14-106) mo]. One hundred and fifty-three healthy subjects(HCONT) and 172 ulcerative colitis(UC) patients were the controls. RESULTS A total of 28.4%, 28.0%, 9% and 20.9% of PSC patients were positive for AAA Ig A, AAA Ig G, AGA Ig A and AGA Ig G, respectively. Frequencies of AAA Ig A and AAA Ig G(P < 0.001, for both) and AGA Ig G(P = 0.01, for both) but not AGA Ig A were significantly higher compared to both of the HCONT and the UC groups. In survival analysis, AAA Ig A-positivity was revealed as an independent predictor of poor disease outcome after adjusting either for the presence of cirrhosis [HR = 5.15(1.27-20.86), P = 0.022 or for the Mayo risk score(HR = 4.24(0.99-18.21), P = 0.052]. AAA Ig A-positivity was significantly associated with higher frequency of antimicrobial antibodies(P < 0.001 for Endo Cab Ig A and P = 0.012 for anti-OMP Plus Ig A) and higher level of the enterocyte damage marker(median I-FABP_(AAA Ig A pos vs neg): 365 vs 166 pg/m L, P = 0.011), but not with serum LBP level. CONCLUSION Presence of Ig A type AAA identified PSC patients with progressive disease. Moreover, it is associated with enhanced mucosal immune response to various microbial antigens and enterocyte damage further highlighting the importance of the gut-liver interaction in PSC. | Tamas Tornai Eszter Palyu Zsuzsanna Vitalis Istvan Tornai David Tornai Peter Antal-Szalmas Gary L Norman Zakera Shums Gabor Veres Antal Dezsofi Gabriella Par Alajos Par Peter Orosz Ferenc Szalay Peter Laszlo Lakatos Maria Papp | 2017 | World Journal of Gastroenterology2017，23，29： | 5 |
| 2 | Excellent long-term survival in patients with primary biliary cirrhosis and biochemical response to ursodeoxycholic acid显示文摘 | Parés A Caballeria L Rodés J | | Gastroenterology0，，： | 2 |
| 3 | Progest erond and non-specific immunologic mechanism in pregnancy 显示文摘 | Par G Szereday L | 1997 | Am J Reprod Imm unol1997，38，3： | 1 |
| 4 | Effect of Talc content on the cell- population density of extruded PP foams显示文摘 | C B Par L S Cheung | 1996 | Cellular and Microcellular Materials ASME1996，76，： | 1 |
| 5 | A combined abnormality in heart rate variation and QT corrected interval is a strong predictor of cardiovascular death in type 1 diabetes显示文摘 | Lykke JA Tamow L Parring HH | 2008 | Scand J Clin Lab Invest2008，，： | 1 |
| 6 | A cross cultural assessment of three theories of pro-environmental behavior: A comparison between business students ofChile and the United States显示文摘 | CORDANO M WELCOMER S SCHERER R F PRADENAS L PAR AD A V | 2011 | Environment and Behavior2011，43，5： | 1 |
| 7 | Production of alpha-1,3galactosyltransferase knockout pigs by nudear transfer cloning显示文摘 | LAI L KOLBER-S1MONDS D PAR K W | 2002 | Science2002，295，： | 1 |
| 8 | Vascular complications after liver transplantation: evaluation with Doppler US显示文摘 | Sad?k Tamsel Gulgun Demirpolat Refik Killi Unal Ayd?n Murat K?l?c Murat Zeytunlu Mustafa Par?ldar Ismail Oran Hakan Ucar | 2007 | Abdominal Imaging2007，，3： | 1 |
| 9 | Analysis of new-product diffusion using a four- segment trial-repeat model显示文摘 | Hahn M Par K S Kishnamurthi L Zoltners A | 1994 | Marketing Science1994，13，3： | 1 |
| 10 | Genetics of diabetic nephropathy 显示文摘 | Parring HH Tarnow L Rossing P | 1996 | J Am Soc Nephrol1996，7，： | 1 |
| 11 | Least-Squares Estimation with Unknown Excitations for Damage Identification of Structures显示文摘 | Yang J N Par S W Lin S L | 2007 | Journal of Structural Engineering2007，1，： | 1 |
| 12 | Immunology of HCV infection: the causes of impaired cellular immune response and the effect of anti- viral treatment显示文摘 | Par G Berki T Palinkas L | 2006 | Orv Hetil2006，147，13： | 1 |
| 13 | Excellent long -term survival in patients with primary biliary cirrhosis and biochemi- cal response to ursodeoxycholic acid 显示文摘 | PAR~:S A CABALLERiA L RODI~S J | 2006 | Gastroenterology2006，130，3： | 1 |
| 14 | Immunology of HCV infection:the causes of impaired cellular immune response and the effect of antiviral treatment显示文摘 | Berki T Palinkas L | 2006 | Orv Hetil2006，147，13： | 1 |
| 15 | Homologous type Ⅱ collagen-induced arthritis in rats显示文摘 | Par L Sandra K Rikard H | 1990 | Arthritis and Rheumatism1990，33，5： | 1 |
| 16 | Introduction and nutritional evaluation of buckwheat sprouts as a new vegetable显示文摘 | Kim S L Kim S K Par C H | 2004 | Food Research international2004，，31： | 1 |
| 17 | The role of smoothmuscle cells in vessel wall pathophysiology and recon-struction using bioactive synthetic polymers显示文摘 | Parízek M NovotnáK BacákováL | 2011 | PhysiolRes2011，60，3： | 1 |
| 18 | Effect of deletionpolymorphism of angiotensin converting enzyme gene on progres-sion of diabetic nephropathy during inhibition of angiotensinconverting enzyme: observational follow up study显示文摘 | Parring HH Jacobsen P Tarnow L | 1996 | Br MedJ1996，313，： | 1 |
| 19 | T cell responses to DosR and Rpf proteins in actively and latently infected individuals from Colombia显示文摘 | Ria o F Arroyo L París S | 2012 | Tuberculosis(Edinb)2012，92，2： | 1 |
| 20 | Antifungal terpenoids from Chenopodium ambrosioides显示文摘 | Paré P W Zajicek J Ferracini V L | 1993 | Biochemical Systematics and Ecology1993，21，： | 1 |
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