| 3 | Eviendep~ reduces number and size of duodenal polyps in familial adenomatous polyposis patients with ileal pouchanal anastomosis显示文摘AIM:To evaluate if 3 mo oral supplementation with Eviendep was able to reduce the number of duodenal polyps in familial adenomatous polyposis(FAP)patients with ileal pouch-anal anastomosis(IPAA).METHODS:Eleven FAP patients with IPAA and duodenal polyps were enrolled.They underwent upper gastrointestinal(GI)endoscopy at the baseline and after 3 mo of treatment.Each patient received 5 mg Eviendep twice a day,at breakfast and dinner time,for3 mo.Two endoscopists evaluated in a blinded manner the number and size of duodenal polyps.Upper GI endoscopies with biopsies were performed at the baseline(T0)with the assessment of the Spigelman score.Polyps>10 mm were removed during endoscopy and at the end of the procedure a new Spigelman score was determined(T1).The procedure was repeated 3 mo after the baseline(T2).Four photograms were examined for each patient,at T1 and T2.The examined area was divided into 3 segments:duodenal bulb,second and third portion duodenum.Biopsy specimens were taken from all polyps>10 mm and from all suspicious ones,defined by the presence of a central depression,irregular surface,or irregular vascular pattern.Histology was classified according to the updated Vienna criteria.RESULTS:At baseline the mean number of duodenal detected polyps was 27.7 and mean sizes were 15.8mm;the mean Spigelman score was 7.1.After polypectomy the mean number of duodenal detected polyps was 25.7 and mean sizes were 7.6 mm;the mean Spigelman score was 6.4.After 3 mo of Eviendep bid,all patients showed a reduction of number and size of duodenal polyps.The mean number of duodenal polyps was 8(P=0.021)and mean size was 4.4 mm;the mean Spigelman score was 6.6.Interrater agreement was measured.Lesions>1 cm found a very good degree of concordance(kappa 0.851)and a good concordance was as well encountered for smaller lesions(kappa 0.641).CONCLUSION:Our study demonstrated that shortterm(90 d)supplementation with Eviendep in FAP patients with IPAA and with recurrent adenomas in the duodenal mucosa,resulted effective in reducing polyps number of 32%and size of 51%. | Carlo Calabrese Chiara Praticò Andrea Calafiore Maurizio Coscia Lorenzo Gentilini Gilberto Poggioli Paolo Gionchetti Massimo Campieri Fernando Rizzello | 2013 | World Journal of Gastroenterology2013，19，34： | 2 |
| 4 | Uveitis in autoimmune hepatitis:A case report显示文摘在这份病案报告,我们第一次描述在自体免疫的肝炎(AIH ) 和眼色素层炎之间的一个协会,没有关于另外的可能的病原学的任何疑问,例如 HCV,自从在为 HCV 相关的肝炎的测试能是可得到的以前,所有旧报告与虹膜睫状体炎描述 AIH 的协会。有反常的肝功能测试和球结膜的充血的一个 38 岁的商人进入医院。在承认,与坚持的发烧介绍的病人,关节痛,结膜充血,白细胞增多和增加的 ESR 前的六年,指了尖锐风湿热。系统病的存在,通常与眼色素层炎联系的大多数,没有结果,被调查,病人然后与热门 corticosteroids 被对待。他解决的症状。为反原子的抗体的测试是阳性的,在 1:320 的一个效价,与一个有斑点、核仁的染色的模式。肝超声与肝的增加的回响结构显示出温和肝肿大。经皮的肝活体检视在超声帮助下面被执行。组织学的检查在门,仙子门和小叶片的区域上显示出 necroinflammation,纤维变性门道与仙子门纤维变性和偶尔的 portal-to-portal bridgings,但是未经触动的肝的建筑学。某 hepatocytes 在小叶片的区域显示出含铁血黄素的恰好看得清的小粒。胆小管没有任何重要词法改变。METAVIR 分数是 A2-F3,根据修改 HAI 等级 / 纤维变性阶段。病人被诊断与温和活动和纤维变性有 AIH 并且在 25 mg 泼尼松上被解除,进入临床、生物化学的宽恕,进一步的证实诊断。在分泌物以后,病人继续在 5 mg 的剂量作为一个门诊病人与 corticosteroids 有治疗。在 2002 年 1 月,病人被重新接纳到医院。为反原子的抗体的测试是阳性的,在 1:320 的一个效价,与一个有斑点、核仁的染色的模式。反光滑的肌肉抗体测试也是阳性的(1:160 ) ,当 anti-LKM 抗体是否定的时。眼科学检查在角膜在左眼,和基质损害的前房揭示了煽动性的房间和 proteinaceous 闪光。他在抑制免疫力的治疗(加为二个星期的热门抗菌素治疗的 5 mg 泼尼松) 上被维持然后排出。症状的完全的宽恕在后续上被登记。目前(2005 年 7 月) ,病人在泼尼松(5 mg ) 上并且没有症状。肝功能测试也在正常范围以内。 | Roberto Giulio Romanelli Giorgio La Villa Fabio Almerigogna Francesco Vizzutti Elena Di Pietro Valentina Fedi Paolo Gentilini Giacomo Laffi | 2006 | World Journal of Gastroenterology2006，12，10： | 1 |
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