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| 1 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 2 | Suppression of lipopolysaccharide- induced nuclear factor- kappaB activity by theaflavin-3,3'-digallate from black tea and other polyphenols through down-regulation of IkappaB kinase activity in macrophages 显示文摘 | Pan M H Lin-shiau S Y Ho C T Lin J H Lin J K | 2000 | Biochem Pharm2000，59，： | 1 |
| 3 | Preliminary design for a China ITER test blanket module 显示文摘 | Feng K M Pan C H Zhang G S | 2006 | Fusion Engineering and Design2006，81，814： | 1 |
| 4 | Solid - Phase Grafting of Glycidyl Methacrylate onto Polypropylane显示文摘 | Y K PAN J M RUAN D F ZHAN | 1996 | J Appl Polym Sci1996，65，： | 1 |
| 5 | Random-peptide librar-ies and antigen-fragment libraries for epitope mappingand the development of vaccines and diagnostics显示文摘 | Irving M B Pan O Scott J K | 2001 | Curr Opin Chem Biol2001，5，3： | 1 |
| 6 | Seismic fragility of con- tinuous steel highway bridges in New York State显示文摘 | Pan Y Agrawal A K Ghosn M | 2007 | Jour- nal of Bridge Engineering2007，12，6： | 1 |
| 7 | MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor显示文摘 | Pan B S Chan G K Chenard M | 2010 | Cancer Res2010，70，4： | 1 |
| 8 | Conversion of alpha helices into beta-sheets features in the formation of thescrapie prion proteins显示文摘 | Pan K M Baldwin M Nguyen J | 1993 | P Natl Acad Sci USA1993，90，10： | 1 |
| 9 | A discrete artificial bee colony algorithm for the lot- streaming flow shop scheduling problem显示文摘 | Pan Q K Tasgetiren M F Suganthan P N | 2011 | Inform Sci2011，181，12： | 1 |
| 10 | Nanotubes from methane flames显示文摘 | YUAN L M SAITO K PAN C X | 2001 | Chem Phys Lett2001，340，： | 1 |
| 11 | Type Ⅱ alveolar epithelial cells and interstitial fibroblasts express connective tissue growth factor in IPF 显示文摘 | Pan LH Yamacchi K Uzuki M Nakanishi T Takigawa M Inoue H | 2001 | Eur Respir J2001，17，6： | 1 |
| 12 | The receptor for the cytotoxic ligand TRAIL显示文摘 | Pan G O'Rourke K Chinnaiyan A M | 1997 | Science1997，276，5309： | 1 |
| 13 | Lilt rasonic insert casting of a- luminum alloy显示文摘 | Pan J Yoshida M Sasa K G | 2000 | Seripta Materialia2000，43，2： | 1 |
| 14 | Poly(acrylonitrile) encapsulated graphite as anode materials for lithium ion batteries 显示文摘 | Guo K K Pan Q M Fang S B | 2002 | J Power Sourees2002，111，： | 1 |
| 15 | Dendritic cells-mediated CTLs targeting hepatocellular carcinoma stem cells显示文摘 | Sun J C Pan K Chen M S | 2010 | Cancer Biology & Therapy2010，10，4： | 1 |
| 16 | Seismic Fragility of Continuous Steel Highway Bridges in New York State 显示文摘 | PAN Y AGRAWAL A K GHOSN M | 2007 | Journal of Bridge Engineering2007，12，6： | 1 |
| 17 | The effect of rare earth metals on the microstructure and electrochemical corrosion behavior of lead calcium grid alloys in sulfuric acid solution 显示文摘 | ZHANG W LI A CHEN H LAN B PAN K ZHANG T FANG M LIU S ZHANG W | 2012 | Journal of Power Sources2012，203，： | 1 |
| 18 | A discrete artificial bee colony algorithm for the multi-objective flexible job-shop schedu- ling problem with maintenance activities显示文摘 | LI J Q PAN Q K TASGETIREN M F | 2014 | Applied Mathemati- cal Modelling2014，38，3： | 1 |
| 19 | Theoretical studies on the BN substituted fullerenes C7o 2x(BN)x(x = 1 -3)-isoelectronic equivalents of C70 显示文摘 | CHEN Z F MA K PAN Y M | 1999 | J Mol Struct : THEOCHEM1999，490，13： | 1 |
| 20 | Health-related quality of life and healthcare resource utilization in Taiwanese women with menopausal symptoms: a nation-wide survey显示文摘 | Shyu Y K Pan C H Liu W M | 2012 | Nurs Res2012，20，3： | 1 |
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