|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Identification of homozygous recessive genotype for the deficiency of uridine monophosphate synthase in 35-day bovine embryos显示文摘 | Shanks R D Popp R G Mcoy G C | 1992 | J Reprod Fert1992，94，： | 1 |
| 2 | The extracellular regulated kinases (ERK) 1/2 mediate cannabinoid-induced inhibition of gap junctional communication in endothelial cells显示文摘 | Popp R Ott G | 2002 | Br J Pharmacol2002，136，5： | 1 |
| 3 | I-dentification of homozygous recessive genotype for the deficiency of uridine monophosphate synthase in35-day bovine embryos显示文摘 | SHANKS R D POPP R G MCCOY G C | 1992 | J Reprod Ferttil1992，94，： | 1 |
| 4 | 人乳头瘤病毒16/18型AS04佐剂疫苗预防肿瘤基因型HPV引起的宫颈感染和癌前病变的效应(PATRICIA):一项在年轻女性中进行的双盲、随机研究的最终分析显示文摘背景在年轻成人中进行的Ⅲ期随机、双盲对照PATRICIA试验(PApilloma TRial)的事件驱动期中分析显示,人乳头瘤病毒(HPV)16/18AS04佐剂疫苗具有免疫原性,且总体耐受性良好,对HPV16或HPV18感染及相关的癌前病变具有预防效应。本文作者旨在评估最终事件驱动分析中的疫苗效应。方法将在基线、1个月和6个月接种疫苗的15~25岁女性分类为符合方案的效应队列(ATP-E队列;疫苗组8093例,对照组8069例)、总接种队列(TVC;包括至少接种1剂疫苗的所有女性,而不考虑其基线HPV状态;代表普遍的年轻女性人群,包括性活跃者;疫苗组9319例,对照组9325例)和TVC-naive(无证据表明基线时存在肿瘤基因型HPV感染;代表无性行为女性;疫苗组5822例,对照组5819例)。主要终点是。在基线时血清和DNA均为阴性且在6个月时为相应类型(ATP-E队列)的女性中,评估疫苗对HPV16或HPV18相关性宫颈上皮内瘤变≥2级(CIN2+)的预防效应。该试验在ClinicalTrial.gov上的注册编码为NCT00122681.结果第3剂疫苗接种后平均随访34.9个月(s=6.4)。在主要分析中疫苗对HPV16/18相关性CIN2+的预防效应为92.9%(96.1%CI79.9%~98.3%),在对可能因多种肿瘤基因型HPV引起的病变(ATP-E队列)的分析中,其预防效应为98.1%(96.1%CI88.4%~100%)。不考虑病变HPVDNA时,疫苗对CIN2+的预防效应在TVC中为30.4%(96.1%CI16.4%~42.1%),在TVC-naive中为70.2%(96.1%CI54.7%~80.9%);而对CIN3+的相应效应在TVC中为33.4%(96.1%CI9.1%~51.5%).在TVC-naive中为87.0%(96.1%CI54.9%~97.7%).在预防12种非疫苗肿瘤基因型HPv相关性CIN2+的效应为54.0%(96.1%CI34.0%~68.4%:ATP-E队列)。在TVC中可见对HPV31、33和45相关性CIN2+的个体交叉保护效应。结论HPV16/18 AS04佐剂疫苗表现出对HPV16/18和非疫苗肿瘤基因型HPV相关性CIN2+较强的预防效应,而要获得整体预防效应就需要在更广泛的人群中进行大面积强化免疫计划。基金 葛兰素史克。 | J Paavonen P Naud J Salmeron C M Wheeler S-N Chow D Apter H Kitchener X Castellsague J C Teixeira S R Skinner J Hedrick U Jaisamrarn G Limson S Garland A Szarewski B Romanowski F Y Aoki T F Schwarz W A J Poppe F X Bosch D Jenkins K Hardt T Zahaf D Descamps F Struyf M Lehtinen G Dubin 周彩虹(译) | 2009 | 世界临床医学2009，，12： | 1 |
| 5 | Positron emission tomography findings in obstructive sleep apnea patients with residual sleepiness treated with continuous positive airway pressure 显示文摘 | Antczak J Popp R Hajak G | 2007 | J Physiol Pharmaeol2007，585，1： | 1 |
| 6 | Long-term follow-up of photodynamic therapy with a self-adhesive 5-aminolaevulinic acid patch: 12 months data 显示文摘 | SZEIMIES R M STOCKFLETH E POPP G | 2010 | Br J Dermatol2010，162，2： | 1 |
| 7 | Perceived social support and working models of self and actual others显示文摘 | Samson B R Picrcc G R Shearin E N Sarason I G Waltz J A Poppe L | 1991 | Journal of Personality and Social Psychology1991，60，： | 1 |
| 8 | Perceived social support and working models of self and actual others 显示文摘 | Sarason B R Pierce G R Shearin E N Sarason I G Waltz J A &Poppe L | 1991 | Journal of Personality and Social Psychology1991，60，： | 1 |
| 9 | Dynamic modulation of interendothelial gap junctional communication by 11,12-epoxyeicosatrienoic acid显示文摘 | Popp R Brandes R Ott G | 2002 | Circ Res2002，90，7： | 1 |
| 10 | Protein crystal structure analysis with electron rays显示文摘 | Hoppe W Langer R Knesch G Poppe C | 1968 | Naturwissenschaften1968，55，7： | 1 |
| 11 | Positron emission tomography findings in obstructive sleep apnea patients with residual sleepiness treated with continuous positive airway pressure显示文摘 | Antczak J Popp R Hajak G | 2007 | J Physiol Pharmacol2007，58，5： | 1 |
| 12 | Association of persistent peroxisome proliferation and oxidative injury with hepatocarcinogenicity in female F344 rats fed di - (2 - ethylhexyl) phthalate for 2 years 显示文摘 | Cattley R C Conway J G Popp J A | 1987 | Cancer Letters1987，38，12： | 1 |
| 13 | Dynamic modulation of interendothelial gap junctional communication by 11, 12 -epoxyeicosatrienoic acid显示文摘 | Popp R Brandes RP Ott G at al | 2002 | Circ Res2002，90，7： | 1 |
| 14 | Testing for deficiency of uridine monophosphate synthase among Holstein Friesian cattle of North America and Europe显示文摘 | Robinson J L Popp R G Shanks R D | 1993 | Livestock Production Science1993，36，： | 1 |
| 15 | Thyroid autoimmunity and hypot- hyroidism before and during pregnancy 显示文摘 | Poppe K G linoe r D | 2003 | Hum Reprod Up-date2003，9，1： | 1 |
| 16 | Transcriptome profiling of grapefruit flavedo following exposure to low temperature and conditioning treatments uncovers principal molecular components involved in chilling tolerance and susceptibility显示文摘 | MAUL D P MCCOLLUM T G POPP M GUY C L PORAT R | 2008 | Plant Cell Environment2008，31，6： | 1 |
| 17 | Testing for deficiency of uridine monophosphate synthase among Holstein-Friesian cattle of North America and Europe显示文摘 | Robinson J L Popp R G Shanks R D | 1993 | Livestock Production Science1993，36，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员