|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Pit-and trench-forming osteoclasts:a distinction that matters显示文摘Osteoclasts(OCs)seeded on bone slices either drill round pits or dig long trenches.Whereas pits correspond to intermittent resorption,trenches correspond to continuous and faster resorption and require a distinct assembly of the resorption apparatus.It is unknown whether the distinction between pits and trenches has any biological relevance.Using OCs prepared from different blood donors,we found that female OCs achieved increased resorption mainly through pit formation,whereas male OCs did so through trench formation.Trench formation went along with high collagenolytic activity and high cathepsin K(CatK)expression,thereby allowing deeper demineralization.A specific CatK inhibitor abrogated the generation of trenches,while still allowing the generation of pits.OCs obtained from bone marrow were more prone to generate trenches than those obtained from blood.Scanning electron microscopy of bone surfaces eroded in vivo showed trenches and pits of similar size as those made by OCs in culture.We conclude that the distinction between trench-and pit-forming OCs is relevant to the differences among OCs from different skeletal sites,different individuals,including gender,and results from differences in colIagenolytic power.This indicates a biological relevance and highlights the importance of discriminating between pits and trenches when assessing resorption. | Ditte MH Merrild Dinisha C Pirapaharan Christina M Andreasen Per Kjxrsgaard-Andersen Anas MJ Mùller Ming Ding Jean-Marie Delaissé Kent Sùe | 2015 | Bone Research2015，3，4： | 2 |
| 2 | Study of the N-H…H-B Dihydrogen Bond Including the Crystal Structure of BH3NH3by Neutron Diffraction 显示文摘 | WIM T K THOMAS F K PER E M S | 1999 | J Am Chem Soc1999，121，27： | 1 |
| 3 | AS160,The Akt substrate regulating GLUT4 translocation,has a functional Rab GTPase-activating protein domain显示文摘 | M?inea CP Sano H Kane S Sano E Fukuda M Per?nen J | 2005 | Biochem J2005，391，1： | 1 |
| 4 | Random aggregates in newly produced platelet units are associated with platelet activation and release of the immunomodulatory factors sCD40L and RANTES 显示文摘 | Per S Stephan M Elias E | 2014 | Transfusion2014，54，3： | 1 |
| 5 | Electronic and magnetic properties of neutral and charged quinone and plastoquinone radicals 显示文摘 | Leif A Eriksson Fahmi Himo Per E M S | 1997 | J Phys Chem1997，101，： | 1 |
| 6 | Characterization and three-dimensional structures of two dis?tinct bacterial xyloglucanases from families GH5 and GH12显示文摘 | TRACEY M G FARID M I KATHERINE M JENS M E SHIRLEY R JOHAN P T MADS E B PER L J STEFFEN D KATJA S J TORBEN V B KEITH S W HARRY B GIDEON J D | 2007 | Journal of Biological Chemistry2007，282，19： | 1 |
| 7 | Endophthalmitis after Cataract Surgery : Risk Factors Relating to Technique and Events of the Operation and Patient History 显示文摘 | Per G M Gabor K Hans E S | 1998 | Ophthalmology1998，105，12： | 1 |
| 8 | Characterization of adsorption sites on a quartz powder from ESCA analysis of an adsorbed fatty diamine显示文摘 | MARIE E PER M C STEN Y S | 1999 | Surf Interface Anal1999，27，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员