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| 1 | Antioxidant effect of Lactobacillus fermentum HFY02-fermented soy milk on D-galactose-induced aging mouse model显示文摘This study aimed to investigate the antioxidant effect of soybean milk fermented by a new type of Lactobacillus fermentum(LF-HFY02)by using D-galactose induced aging mice model.Firstly,the optimal fermentation conditions was screened out by detecting the effects of different fermentation temperature and time on the active components and antioxidant activity of soybean milk in viro.And then unfermented soybean milk and the soybean milk fermented by different Lactobacillus was given by gavage to D-galactose-induced aging mouse.The activities of GSH,GSH-Px,SOD,CAT and T-AOC in serum,brain and liver of soybean milk fermented by LF-HFY02 were significantly increased,while the content of MDA and the level of AGEs in hippocampal were significantly decreased compared with D-galactose induced group.Further more,the mRNA expression of GSH and SOD in mouse liver were obviously up-regulated by soybean milk fermented by LF-HFY02.The skin tissue structure of mice in the LF-HFY02 fermented soybean milk group was more complete,the collagen fibers were increased and arranged orderly and liver inflammation has improved compared with the model group.And Western blot analysis showed that LF-HFY02 effectively upregulated EGFR,SOD and GSH protein expression in mouse liver.These findings suggest that LF-HFY02 can effectively prevent D-galactose-induced oxidation and aging in mice,and the effect was even better than that of the Lactobacillus delbruechii subsp.bulgaricus and vitamin C.Thus,LF-HFY02 may be potentially employed as a probiotic strain.In conclusion,soybean milk fermented by LF-HFY02 can increase the content of antioxidant factors and the activity of antioxidant enzymes by regulating gene and protein expression,and finally inhibit the process of tissue cell peroxidation,and improve the oxidative damage of mouse skin and liver.The results could provide a basis for the research and development and industrial production of probiotic-related fermented soybean milk products. | Tiantian Hu Rui Chen Yu Qian Ke Ye Xingyao Long Kun-Young Park Xin Zhao | 2022 | Food Science and Human Wellness2022，11，5： | 6 |
| 2 | Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases显示文摘 | Sung-Jun Park Faiyaz Ahmad Andrew Philp Keith Baar Tishan Williams Haibin Luo Hengming Ke Holger Rehmann Ronald Taussig Alexandra L. Brown Myung K. Kim Michael A. Beaven Alex B. Burgin Vincent Manganiello Jay H. Chung | 2012 | Cell2012，，3： | 2 |
| 3 | A split- face comparison of ablative fractional lasers (CO2 and Er: YAG) in Asian patients; postprocedure erythema, pain and patient's satisfaction 显示文摘 | Jung KE Jung KH Park YM | 2013 | J Cosmet Laser Ther2013，15，2： | 1 |
| 4 | Synergistic induction of apoptosis by sulindac and simvastatin in A549 human lung cancer cells via reactive oxygen species-dependent mitochondrial dysfunction显示文摘 | Hwang KE Park C Kwon SJ | | 0，，01： | 1 |
| 5 | DNMT1 and DNMT3b cooperate to silence genes in human cancer cells显示文摘 | Rhee I Bachman KE Park BH | 2002 | Nature2002，416，6880： | 1 |
| 6 | Postauricular and axillary approach endoscopic neck surgery : a new technique显示文摘 | Lee KE Kim HY Park WS | 2009 | World JSurg2009，33，4： | 1 |
| 7 | Association between choroidal morphology and anti-vascular endothelial growth factor treatment outcome in myopic choroidal neovascularization显示文摘 | Ahn SJ Woo SJ Kim KE Park KH | 2013 | Invest Ophthalmol Vis Sci2013，54，3： | 1 |
| 8 | Clinical in plications of srum retinol-binding prote in 4in asthmatic children 显示文摘 | Park YH Kin KW Lee KE | 2009 | J Korean Med Sci2009，24，6： | 1 |
| 9 | MR staging accuracy for endometrial cancer based on the new FIGO stage显示文摘 | Shin KE Park BK Kim CK | 2011 | Acta Radiol2011，52，7： | 1 |
| 10 | MR staging ac curacy for endometrial carcinoma based on the new FIGO staging 显示文摘 | Shin KE Park BK Kim CK | 2011 | Acta Radiol2011，52，7： | 1 |
| 11 | Duel nature of TGF - beta signaling: tumor suppressor vs tumor promoter显示文摘 | Bachman KE Park BH | 2005 | Curr Opin Oncol2005，17，1： | 1 |
| 12 | MR staging accuracy for en- dometrial cancer based on the new FIGO stage 显示文摘 | Shin KE Park BK Kim CK | 2011 | Acta Radi- ol2011，152，7： | 1 |
| 13 | Activation of MEK/ERK signaling promotes adipogenesis by enhancing peroxisome proliferator- activated receptor gamma ( PPARgamma ) and C/EBPalpha gene expression during the differentiation of 3T3-L1 preadipocytes显示文摘 | Prusty D Park BH Davis KE | 2002 | J Biol Chem2002，277，46： | 1 |
| 14 | A Multi-Level Network Analysis of Web-Citations among the World's Universities显示文摘 | Barnett G A Park H W Jiang Ke | 2014 | Scientometrics2014，99，1： | 1 |
| 15 | Association between BMI and metabolic syndrome and adenomatous colonic polyps in korean men 显示文摘 | Lee GE Park HS Yun KE | 2008 | Obesity2008，16，6： | 1 |
| 16 | Lip reconstruction显示文摘 | McCam KE Park SS | 2005 | Facial Plast Surg Clin North Am2005，13，： | 1 |
| 17 | Postauricular and axillary approach endoscopic neck surgery: a new technique 显示文摘 | Lee KE Kim HY Park WS | 2009 | World J Surg2009，33，4： | 1 |
| 18 | Post auricular and axillaryapproach endoscopic neck surgery:a new technique 显示文摘 | Lee KE Kim HY Park WS | 2009 | World J Surg2009，33，4： | 1 |
| 19 | The distribution of fat in dried dairy particles determines flavor release and flavor stability显示文摘 | PARK C W KE M A | 2014 | Journal of Food Science2014，79，4： | 1 |
| 20 | Activation of MEK/ERK signaling promotes adipogenesis by enhancing peroxisome proliferator-activated receptor gamma(PPARgamma)and C/EBPalpha gene expression during the differentiation of 3T3-L1 preadipocytes显示文摘 | Prusty D Park BH Davis KE | 2002 | J Biol Chem2002，277，46： | 1 |
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