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| 1 | Gα_s Relays Sphingosine-1-Phosphate Receptor 1 Signaling to Stabilize Vascular Endothelial-Cadherin at Endothelial Junctions to Control Mouse Embryonic Vascular Integrity显示文摘Sphingosine-1-phosphate receptor 1(S1PR1),a G protein-coupled receptor(GPCR),controls vascular stability by stabilizing vascular endothelial(VE)-cadherin junctional localization and inhibiting vascular endothelial growth factor receptor 2(VEGFR2) signaling.However,the molecular mechanisms that link S 1PR1 signaling to intracellular effectors remain unknown,In this study,we demonstrate that the heterotrimeric G protein subfamily member Gα_s,encoded by GNAS,acts as a relay mediator of S1PR1 signaling to control vascular integrity by stabilizing VE-cadherin at endothelial junctions.The endothelial cell-specific deletion of Gαs in mice causes early embryonic lethality with massive hemorrhage and a disorganized vasculature.The immunostalning results revealed that Gα_s deletion remarkably reduces the junctional localization of VE-cadherin,whereas the mural cell coverage of the vessels is not impaired.In addition,we found that Gαs depletion blocks the S1PRl-activation induced VE-cadherin stabilization at junctions,supporting that Gα_s acts downstream of S1PR1 signaling,Thus,our results demonstrate that Gα_s is an essential mediator to relay S1PR1 signaling and maintain vascular integrity. | Ximing Shao Ke Liu Yi Fan Zhihao Ding Min Chen Minyan Zhu Lee S.Weinstein Hongchang Li Huashun Li | 2015 | Journal of Genetics and Genomics2015，42，11： | 8 |
| 2 | Two-dimensional layered material/silicon heterojunctions for energy and optoelectronic applications显示文摘作为最重要的半导体材料之一,硅(Si ) 广泛地在当前的精力和 optoelectronic 设备被使用了,例如太阳能电池和光电探测器。然而,复杂制造处理的传统的 Si pn 连接太阳能电池需要,导致 Si 光电的设备的高费用。基于 Si 的光电探测器的宽应用被他们的低敏感也妨碍到紫外、红外线的光。最近,二维(2D ) 分层的材料为未来精力和 optoelectronic 应用程序与巨大的潜力作为一个新材料系统出现了。有 2D 的 Si 的联合分层的材料代表一条创新途径由利用两材料的互补优点构造高效的 optoelectronic 设备。在这评论,我们在 2D 总结最近的进展分层的 material/Si 异质接面和他们的应用在光电并且 optoelectronic 设备。最后, 2D 的眼界和挑战为高效的设备应用的分层的 material/Si 异质接面被介绍。 | Yuming Wang Ke Ding Baoquan Sun Shuit-Tong Lee Jiansheng Jie | 2016 | Nano Research2016，9，1： | 6 |
| 3 | In-situ oxygen profiling and lignin modification in guts of wood-feeding termites显示文摘 | Jing Ke Jian-Zhong Sun Hung D. Nguyen Deepak Singh Karmen C. Lee Haluk Beyenal Shu-Lin Chen | 2010 | Insect Science2010，17，3： | 5 |
| 4 | Practical high-performance lead-free piezoelectrics:structural flexibility beyond utilizing multiphase coexistence显示文摘Due to growing concern for the environment and human health, searching for high-performance lead-free piezoceramics has been a hot topic of scientific and industrial research. Despite the significant progress achieved toward enhancing piezoelectricity, further efforts should be devoted to the synergistic improvement of piezoelectricity and its thermal stability. This study provides new insight into these topics.A new KNN-based lead-free ceramic material is presented, which features a large piezoelectric coefficient(d33) exceeding 500 pC/N and a high Curie temperature(Tc) of ~200℃. The superior piezoelectric response strongly relies on the increased composition-induced structural flexibility due to lattice softening and decreased unit cell distortion. In contrast to piezoelectricity anomalies induced via polymorphic transition, this piezoelectricity enhancement is effective within a broad temperature range rather than a specific small range. In particular, a hierarchical domain architecture composed of nano-sized domains along the submicron domains was detected in this material system, which further contributes to the high piezoelectricity. | Qing Liu Yichi Zhang Jing Gao Zhen Zhou Dong Yang Kai-Yang Lee Andrew Studer Manuel Hinterstein Ke Wang Xiaowen Zhang Longtu Li Jing-Feng Li | 2020 | National Science Review2020，7，2： | 5 |
| 5 | Resistance mechanisms and reprogramming of microorganisms for efficient biorefinery under multiple environmental stresses显示文摘In the fermentation process of biorefinery,industrial strains are normally subjected to adverse environmental stresses,which leads to their slow growth,yield decline,a substantial increase in energy consumption,and other negative consequences,which ultimately seriously hamper the development of biorefinery.How to minimize the impact of stress on microorganisms is of great significance.This review not only reveals the damaging effects of different environmental stresses on microbial strains but also introduces commonly used strategies to improve microbial tolerance,including adaptive evolution,reprogramming of the industrial host based on genetic circuits,global transcription machinery engineering(gTME)and bioprocess integration.Furthermore,by integrating the advantages of these strategies and reducing the cost of system operation,the tolerance of industrial strains,combined with production efficiency and process stability,will be greatly improved,and the development prospects of biorefinery will be more widespread. | Ke Xu Yun Seo Lee Jun Li Chun Li | 2019 | Synthetic and Systems Biotechnology2019，4，2： | 4 |
| 6 | RELATIVE LEVELS OF INDOOR AND OUTDOOR PARTICLE NUMBER CONCENTRATIONS IN A RESIDENTIAL BUILDING IN XI'AN显示文摘The time series of indoor and outdoor particle number concentrations in a naturally ventilated residential building in Xi’an were tested simultaneously for 7 days in summer. The relationships between indoor and outdoor con-centrations were examined and discussed, and linear regression analysis was employed to correlate the indoor and outdoor concentrations. The diurnal cycles of indoor and outdoor particle concentrations of different particle size ranges all showed positive correlations between indoor and outdoor number concentrations. The I/O ratios of number concen-trations varied with the increase of particle size in the range of 0.89 (±0.19) to 0.99 (±0.15). | Yanming Kang Ke Zhong Shun-Cheng Lee | 2006 | China Particuology2006，4，6： | 3 |
| 7 | Critical size limit of biodegradable nanopartides for enhanced lymph node trafficking and paracortex penetration显示文摘Lymph node (LN) targeti ng through interstitial drain age of nan oparticles (NPs) is an attractive strategy to stimulate a pote nt immune respo nse, as LNs are the primary site for lymphocyte priming by antigen presenting cells (APCs) and triggering of an adaptive immune response. NP size has been shown to influence the efficiency of LN-targeting and retention after subcutaneous injection. For clinical translation, biodegradable NPs are preferred as carrier for vaccine delivery. However, the selective 'size gateM for effective LN-drainage, particularly the kinetics of LN trafficking, is less well defined. This is partly due to the challenge in generating size-controlled NPs from biodegradable polymers in the sub-100-nm range. Here, we report the preparation of three sets of poly(lactic-co-glycolic)-b-poly(ethylene-glycol)(PLGA-b-PEG) NPs with number average diameters of 20-, 40-, and 100-nm and narrow size distributions using flash nanoprecipitation. Using NPs labeled with a near-infrared dye, we showed that 20-nm NPs drain rapidly across proximal and distal LNs following subcutaneous inoculation in mice and are retai ned in LNs more effectively than NPs with a nu mber average diameter of 40-nm. The drain age of 100-nm NPs was n egligible. Furthermore, the 20-nm NPs showed the highest degree of penetration around the paracortex region and had enhanced access to dendritic cells in the LNs. Together, these data confirmed that small, size-controlled PLGA-b-PEG NPs at the lower threshold of about 30-nm are most effective for LN trafficking, retention, and APC uptake after s.c. administration. This report could inform the design of LN-targeted NP carrier for the delivery of therapeutic or prophylactic vaccines. | Gregory P. Howard Garima Verma Xiyu Ke Winter M. Thayer Timothy Hamerly Victoria K. Baxter John E. Lee Rhoel R. Dinglasan Hai-Quan Mao | 2019 | Nano Research2019，12，4： | 3 |
| 8 | Interleukin-18 is associated with increased severity of atopic dermatitis in children 显示文摘 | Sohn MH Lee KE Kim KE | 2004 | Allergy Asthma Proc2004，25，3： | 1 |
| 9 | KRAS mutations in traditionserrated adenomas from Korea herald an aggressive phenotype显示文摘 | Kim KE Jin E Lee MS | 2010 | Am J Surg Pathol2010，34，5： | 1 |
| 10 | Comparison of VIDAS Stallertest and Pharmacia CAP assays for detection of specific IgE antibodies in allergic children 显示文摘 | Sohn MH Lee SY Lee KE | 2005 | Ann Clin Lab Sci2005，35，3： | 1 |
| 11 | Endoscopic thyroidectomy via bilateral axillo-breast approach (BABA): review of 512 cases in a single institute显示文摘 | Choi JY Lee KE Chung KW | 2012 | Surg Endosc2012，26，4： | 1 |
| 12 | Endoscopie thyroideetomy via bilateral axillo- breast approach (BABA) :Review of 512 casesin a single institute 显示文摘 | Choi JY Lee KE Chung KW | 2012 | Surg Enclose2012，26，4： | 1 |
| 13 | Metabolic significance of nonalcoholic fatty liver disease in nonobese, nondiabetic adults显示文摘 | Kim HJ Lee KE Kim DJ | 2004 | Areh Intern Med2004，164，19： | 1 |
| 14 | Components of the metabolic syndrome and risk of cardiovascular disease and diabetes in Beaver Dam显示文摘 | Klein BE Klein R Lee KE | 2002 | Diabetes Care2002，25，10： | 1 |
| 15 | Prognostic significance of p53,nm23,PCNA and c-erbB-2 in gastric cancer显示文摘 | Lee KE Lee HJ Kim YH | 2003 | Jpn J Clin Oncol2003，33，： | 1 |
| 16 | Hole injection and efficiency droop improvement in InGaN/GaN light-emitting diodes by band-engineered electron blocking layer显示文摘 | Wang C H Ke C C Lee C Y | 2010 | Appl Phys Lett2010，97，26： | 1 |
| 17 | Postauricular and axillary approach endoscopic neck surgery : a new technique显示文摘 | Lee KE Kim HY Park WS | 2009 | World JSurg2009，33，4： | 1 |
| 18 | Modulation of IL-8 boosted by Mycoplasma pneumoniae lysate in human airway epithelial cells显示文摘 | Lee KE Kim KW Hong JY | 2013 | J Clin Immunol2013，33，6： | 1 |
| 19 | Components of the metabolic syndrome and risk of cardiovascular disease and diabetes in Beaver Dam 显示文摘 | Klein BE Klein R Lee KE | 2002 | Diabetes Care2002，25，： | 1 |
| 20 | Prognostic significance of P53,nm23,PCNA and c-erbB-2 in gastric cancer显示文摘 | Lee KE Lee H J kim YH | 2003 | Jpn J Clin Oncol2003，33，4： | 1 |
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