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1篇 您的检索式:作者名="P.A. SCHUBIGER"
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1Peptides radiolabeled with Re-186/188 and Tc-99m as potential diagnostic and therapeutic agents显示文摘Small peptide-based compounds have attracted an enormous interest as carrier molecules to selectively de- liver radionuclides to target tissues, sparing critical normal organs. When looking for 'matched pairs' of radionuclides, suitable for radiolabeling of peptides for diagnosis and therapy, technetium and rhenium represent an almost ideal constellation. The important role of technetium-99m and Re-186/188 is based on the decay characteristics, suitable for tumor diagnosis and therapy. Tc-99m and Re-188 are readily available by either a 99Mo/99mTc or the 188W/188Re ra- dionuclide generator system. Furthermore, technetium and rhenium are chemically related and share structural as well as reactive similarities, which prompt an attractive 'matched-pair' situation. This article shows an overview of 99mTc- and 186/188Re-radiolabeled peptides that have been tested for their potential use as imaging and therapeutic agents in oncological diseases.E. GARCíA-GARAYOA R. SCHIBLI P.A. SCHUBIGER 2007Nuclear Science and Techniques2007,18,2:5
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