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| 1 | Evaluation of the Xpert MTB/RIF assay for diagnosis of tuberculosis and rifampin resistance in county-level laboratories in Hunan province, China显示文摘 | Hu Peilei Bai Liqiong Liu Fengping Ou Xichao Zhang Zhiying Yi Songlin Chen Zhongnan Gong Daofang Liu Binbin Guo Jingwei Tan Yunhong | 2014 | Chinese Medical Journal2014，，21： | 24 |
| 2 | Association between Vitamin D Insufficiency and the Risk for Gestational Diabetes Mellitus in Pregnant Chinese Women显示文摘Objective To investigate the association between vitamin D deficiency and risk of gestational diabetes mellitus(GDM) in pregnant Chinese women.Methods A nested case-control study was conducted.Clinical and biochemical data were analyzed for 200 subjects with GDM and 200 subjects with normal glucose tolerance(NGT).Results The median(interquartile range) serum 25-hydroxyvitamin D(25OHD) levels were 22.39(17.67,29.38) and 25.86(19.09,34.88) nmol/L in the GDM and NGT groups,respectively.Rates of 25OHD deficiency or insufficiency were significantly higher in the GDM group than in the NGT group.Subjects with 25OHD levels <25 nmol/L had a 1.8-fold higher risk of GDM compared with subjects with higher vitamin D levels.In the GDM group,serum 25OHD was independently associated with HbA1c and insulin resistance after adjusting for confounding factors.In the NGT group,serum 25OHD was independently associated with fasting plasma glucose and systolic blood pressure after adjusting for maternal age and other confounding factors.Conclusion 25OHD insufficiency is very common in Chinese women.Low 25OHD status may be associated with insulin resistance and act as a risk factor for GDM. | WANG Ou NIE Min HU Ying Ying ZHANG Kui LI Wei PING Fan LIU Jun Tao CHEN Li Meng XING Xiao Ping | 2012 | Biomedical and Environmental Sciences2012，25，4： | 21 |
| 3 | Levels and dynamic changes of serum fibroblast growth factor 23 in hypophosphatemic rickets/osteomalacia显示文摘背景 Hypophosphatemic 佝偻病 / 软骨病是骨头的有缺点的矿化作用由于 hypophosphatemia 和低 1,25-dihydroxy 维生素 D 描述的一组疾病。在磷酸盐动态平衡的规定探索成纤维细胞生长因素 23 的角色(FGF-23 ) ,我们与 hypophosphatemic 在健康个人并且在病人测量了这个生长因素的传播集中佝偻病 / 软骨病。有 hypophosphatemic 佝偻病 / 软骨病的十九个病人在 hypophosphatemic 被包括的方法组织(HP, 12 女性和 7 男、吝啬的年龄是 30 年) ,并且 19 个健康匹配年龄的个人担任了控制组。完整的长度 FGF-23 碎片被二地点的连接酶的 immunosorbent assay.Results 平均数 FGF-23 集中测量在 HP 组是显著地更高的((87.4 芤吗?? | XIA Wei-bo JIANG Yan LI Mei XING Xiao-ping WANG Ou HU Ying-ying ZHANG Hua-bing LIU Huai-cheng MENG Xun-wu ZHOU Xue-ying | 2010 | Chinese Medical Journal2010，，9： | 14 |
| 4 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 5 | Oil filling history of the Bashituo Oilfield in the Markit Slope,SW Tarim Basin,China显示文摘The Markit Slope is an important area for the petroleum exploration in the Tarim Basin. Elucidation of the oil filling history of discovered oilfields has great significance for recognizing the accumulation processes of the whole region. Using molecular geochemistry, fluid inclusion techniques and basin modeling, we studied the oil filling process of the Bashituo Oilfield that is located in the west of the Markit Slope. The molecular migration indexes, such as the methyldibenzothiophene ratio (4-/1-MDBT), trimethylnaphthalene ratio (TMNr) and pyrrolic nitrogen compounds content, decrease from west to east, indicating that the charging direction and migration pathways are from west to east. Lithological analysis and homogenization temperatures of saline fluid inclusions accompanied with oil fluid inclusions suggest that two charging periods occurred in the Devonian oil reservoir. Combining the burial history and heating history of well BT4, Basinmod 1D software modeling shows the two oil filling periods are from 290 Ma to 285 Ma and from 10 Ma to 4 Ma, respectively, and later oil filling dominates. This study may be helpful to understand the accumulation process and provide useful references for oil and gas exploration in the Markit Slope. | Cui Jingwei Wang Tieguan Li Meijun Ou Guangxi Geng Feng Hu Jian | 2013 | Petroleum Science2013，10，1： | 11 |
| 6 | Fatigue damage characterization of carbon fiber reinforced polymer bridge cables:Wavelet transform analysis for clustering acoustic emission data显示文摘Carbon fiber reinforced polymer(CFRP)has many remarkable merits.It is lightweight and has great rigidity and high intensity. High-durability cable produced from CFRP as reinforcement material is widely used in bridge construction projects.However, there is a dearth of studies regarding damage types and mechanism under fatigue load of CFRP bridge cables.In this paper,we adopt acoustic emission(AE)technology to monitor fatigue damage and failure of the CFRP bridge cables,specifically by monitoring the bridge cable’s fatigue test process and using wavelet transformation to analyze data.Results show that damage on the CFRP cable is divided into three stages.Based on wavelet singularity theory,in each stage of AE,the burst signal is obtained and its time-frequency distribution is achieved through wavelet analysis.According to the analysis results,failure modes in each phase and type of acoustic emission source are easy to determine.The characteristics of waveform,types of damages, and frequency distribution of CFRP bridge cable in different damage phases are collected.Research shows that the method used to determine the types of fatigue damage on the CFRP cable is feasible according to the range of distribution characteristic parameters for acoustic emission signal and type of waveform. | LI DongSheng HU Qian OU JinPing LI Hui | 2011 | Science China(Technological Sciences)2011，54，2： | 9 |
| 7 | Variation Characteristics of Water Environmental Capacity in Poyang Lake under the Scheduling of Three Gorges Reservoir显示文摘[Objective] The aim was to study the variation characteristics of water environmental capacity in Poyang Lake under the scheduling of Three Gorges Reservoir.[Method] Choosing chemical oxygen demand (COD),total nitrogen (TN) and total phosphorus (TP) as the control indexes of pollutants in Poyang Lake,the variation characteristics of water environmental capacity in Poyang Lake under the scheduling of Three Gorges Reservoir were analyzed based on the water environment mathematical models of organic compounds and nutrients.[Result] After the operation of Three Gorges Project,high water level in Poyang Lake lasted for a long time in flood season when Three Gorges Reservoir increased discharge volume,while water level went down obviously with the accelerating of recession flow when reservoir decreased discharge volume to store water,so Three Gorges Project had obvious effects on the hydrological regime of Poyang Lake.In 2009,when Three Gorges Reservoir stored water,the water environmental capacity of COD,TN and TP in Poyang Lake in October decreased by 14.0%,15.4% and 15.4% compared with those before operation,while they increased by 3.64%,4.88% and 4.88% in August when reservoir discharged water to prevent flood.[Conclusion] The study could provide scientific foundation for the water pollution control and water environment management of lakes. | OU Ming-liang1,2,ZHOU Wen-bin2,3,HU Chun-hua2,3 1.College of Civil and Environment Engineering,East China Institute of Technology,Fuzhou 344000,China 2.Key Laboratory of Environment and Resource Utilization in Poyang Lake,Ministry of Education,Nanchang 330031,China 3.Institute of Environmental and Chemical Engineering,Nanchang University,Nanchang 330031,China | 2011 | Meteorological and Environmental Research2011，2，3： | 8 |
| 8 | Malnutrition and Quality of Life in Chinese Cancer Patients: a Clinical Study of 23,994 Subjects显示文摘Background Malnutrition is common in patients with cancer,and can negatively impact their quality of life(QoL)and even survival.However,there is currently no large data available on the prevalence of malnutrition in Chinese cancer patients.This study evaluated the prevalence of malnutrition and the QoL of Chinese patients with locoregional,recurrent or metastatic cancer.Methods We conducted a nationwide observational,multi-center,hospital-based cross-sectional study within the Chinese Society of Nutritional Oncology(CSNO)Network.All of the patients were diagnosed with one of the following 18 different types of malignant tumors:lung cancer,gastric cancer,liver cancer,colorectal cancer,breast cancer,esophageal cancer,cervical cancer,endometrial cancer,nasopharyngeal carcinoma,malignant lymphoma,leukemia,pancreatic cancer,ovarian cancer,prostate cancer,bladder cancer,brain cancer,biliary tract malignant tumors or gastrointestinal stromal tumors.These patients were enrolled from 72 hospitals located in different regions of China.The patients’nutritional status was evaluated based on the body mass index(BMI),loss of bodyweight,laboratory measurements and patient generated-subjective global assessment(PG-SGA)scores.The cancer patients’physical status and QoL were assessed by the Karnofsky Performance Status(KPS)questionnaire and the European Organization for Research and Treatment of Cancer(EORTC)QLQ-C30 questionnaire,respectively.Results From December 2013 to April 2016,23,994 patients hospitalized for cancer treatment(such as surgery,chemotherapy or radiotherapy)were enrolled in the study.The patients included 12,494(52.9%)males and 11,124(47.1%)females.The mean age was 55.8±13.7 years.The proportions of patients in cancer stagesⅠ,Ⅱ,Ⅲ,Ⅳand uncertain were 11.5%,20.3%,27.5%,30.2%and 10.5%,respectively.Among the 23,994 inpatients,the proportions of patients who were underweight(BMI<18.5 kg/m2),normal(18.5 kg/m2 | Hong Xia Xu Chun Hua Song Zhen Ming Fu Chang Wang Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua Wang Jing Wu Ying He Jia Jun Yang Cong Hua Xie Fu Xiang Zhou Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Min Weng Qing Hua Yao Jiu Wei Cui Wei Li Han Ping Shi the Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group | 2021 | Journal of Nutritional Oncology2021，6，1： | 8 |
| 9 | Allele-defined genome reveals biallelic differentiation during cassava evolution显示文摘Dear Editor,Generation of heterozygous genomes by hybridization between or within species can help maintain plant diversity and serve as a potential source of new species(Baek et al.,2018).Moreover,genomic heterozygosity is associated with genomic coadaptation,developmental stability,and heterosis.Accurate definition of alleles in haplotypes is necessary to precisely characterize allelic variation controlling agriculturally important traits(Shi et al.,2019).Currently,most released genomes have mosaic assembly of haplotypes due to random selection or collapse of alleles during genome assembly(Shi et al.,2019),which masked allelic variation and functional differentiation of divergent alleles in heterozygous species. | Wei Hu Changmian Ji Haitao shi Zhe Liang Zehong Ding Jianqiu Ye Wenjun Ou Gang Zhou Weiwei Tie Yan Yan Jinghao Yang Xiaoying Yang Yunxie Wei Zhiqiang Jin Jianghui Xie Ming Peng Wenquan Wang Anping Guo Biyu Xu Jianchun Guo Songbi Chen Liming Ma Mingcheng Wang Yang Zhou Xiaolong Li Ruoxi Li Siyi Guo Xinhui Xiao Zhongqing Wan Feifei An Jie Zhang Qingyun Leng Yin Li Ray Ming Kaimian Li | 2021 | Molecular Plant2021，14，6： | 8 |
| 10 | Validity of the Chinese Version of the Patient-Generated Subjective Global Assessment (PG-SGA) in Lung Cancer Patients显示文摘The prevalence of malnutrition is high among oncology patients in China. Although the Patient- Generated Subjective Global Assessment (PG-SGA) is widely recognized as an important nutritional assessment tool, it has not been validated for Chinese cancer patients. The purpose of this study was to conduct an analysis of nutrition screening and assessment data to validate the Chinese version of the PG-SGA in Chinese patients with lung cancer. This was an observational, cross-sectional study of 2,000 consecutive adult patients with lung cancer treated at several tertiary hospitals in China. Anthropometric and patient descriptive data were collected. The PG-SGA generated a score for the nutritional risk and a global rating for the nutritional status. The internal consistency, external consistency, and construct validity were evaluated, and a known-groups comparison and principal component analyses were conducted to evaluate the reliability and validity of the PG-SGA. The known-groups comparison demonstrated the ability of the PG-SGA to differentiate lung cancer patients of different nutritional and body mass index (BMI) groups. A confirmatory factor analysis supported the original four-factor structure of the PG-SGA. In terms of the internal and external consistency, the PG-SGA demonstrated intra-class correlation coefficients (ICC) up to 0.987. Alternative form validity was also demonstrated between Box 4 of the PG-SGA and the Karnofsky Performance Status score, with excellent external consistency (r = 0.972, P < 0.001). The construct validity was supported, and selected questionnaire dimensions were evident in the principal component analysis. Significant Spearman correlations (P < 0.001) were demonstrated. The Chinese version of the PG-SGA demonstrated significant reliability and sufficient exploratory properties to support its validity. It seems to be a valid tool that can be used to access the nutritional status of Chinese lung cancer patients. The validity of the PG-SGA in Chinese cancer patients warrants further investigation in other cancer types. | Zhen Ming Fu Hong Xia Xu Chun Hua Song Wei Li Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua Wang Jing Wu Ying He Jia Jun Yang Cong Hua Xie Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Chang Wang Han Ping Shi The Investigation on Nutrition Status and Clinical Outcome of Common Cancers (INSCOC) Group | 2016 | Journal of Nutritional Oncology2016，1，1： | 7 |
| 11 | Gearbox Deterioration Detection under Steady State,Variable Load, and Variable Speed Conditions显示文摘Multiple dominant gear meshing frequencies are present in the vibration signals collected from gearboxes and the conventional spiky features that represent initial gear fault conditions are usually difficult to detect. In order to solve this problem, we propose a new gearbox deterioration detection technique based on autoregressive modeling and hypothesis testing in this paper. A stationary autoregressive model was built by using a normal vibration signal from each shaft. The established autoregressive model was then applied to process fault signals from each shaft of a two-stage gearbox. What this paper investigated is a combined technique which unites a time-varying autoregressive model and a two sample Kolmogorov-Smirnov goodness-of-fit test, to detect the deterioration of gearing system with simultaneously variable shaft speed and variable load. The time-varying autoregressive model residuals representing both healthy and faulty gear conditions were compared with the original healthy time-synchronous average signals. Compared with the traditional kurtosis statistic, this technique for gearbox deterioration detection has shown significant advantages in highlighting the presence of incipient gear fault in all different speed shafts involved in the meshing motion under variable conditions. | SHAO Yimin CHRIS K Mechefske OU Jiafu HU Yumei | 2009 | Chinese Journal of Mechanical Engineering2009，22，2： | 6 |
| 12 | Validity of the Chinese Version of the Patient-Generated Subjective Global Assessment (PG-SGA) in Gastric Cancer Patients显示文摘Purpose Malnutrition is severe among gastric cancer patients in China. While the Patient-Generated Subjective Global Assessment (PG-SGA) is a widely used nutritional assessment tool, the validation for Chinese patients with gastric cancer has not been performed yet. The aim of this research is to validate the Chinese version of the PGSGA in Chinese gastric cancer patients by conducting analyses of nutrition screening and assessment data. Methods Two thousand consecutive adult patients with gastric cancer were included in this observational, cross-sectional study in several tertiary hospitals in China. A survey was made among those patients, which included several questionnaires and some anthropometric parameters. We calculated the parameters to validate the use of PG-SGA categorizing the nutritional status of gastric cancer patients. Then we performed statistical analysis to evaluate the internal consistency, external consistency, and construct validity. Results This study verified the ability of the PG-SGA to differentiate gastric cancer patients into different nutritional groups. The confirmatory factor analysis verified the original four-factor structure of the PG-SGA. The internal and external consistency was measured by a concordance analysis which showed an intraclass correlation coefficients (ICC) of 0.987. The correlations of the Box 4 score with the Karnofsky performance status score demonstrated alternative form validity with good external consistency (Pearson, r = 0.643, P < 0.001). All three anthropometric dimensions of the PG-SGA were supported by principal component analysis. Spearman correlations (P < 0.001) were significant in the majority of tests. Conclusion The Chinese version of the PG-SGA is a valid tool to access the patients’ nutritional status for Chinese gastric patients. | Zhen Ming Fu Hong Xia Xu Chun Hua Song Wei Li Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua Wang Jing Wu Ying He Jia Jun Yang Cong Hua Xie Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Chang Wang Han Ping Shi The Investigation on Nutrition Status and Clinical Outcome of Common Cancers (INSCOC) Group | 2018 | Journal of Nutritional Oncology2018，3，4： | 5 |
| 13 | Synthesis,insecticidal and acaricidal activities of novel 2-arylpyrroles显示文摘To search for novel 2-arylpyrroles with unique biological activities,a series of novel 2-arylpyrrole derivatives were designed and synthesized,and their structures were characterized by 1 H and 13 C NMR spectroscopy,MS spectrometry,and elemental analysis.Their insecticidal activities against Lepidopteran pests (e.g.Mythimna separata) and acaricidal activities against mites (e.g.Tetranychus urticae) were evaluated.The results of bioassays indicate that some of these title compounds exhibited excellent insecticidal and acaricidal activities.For example,4-bromo-1-((chloromethoxy)methyl)-2-(4-chloro phenyl)-5-(trifluoromethyl)pyrrole-3-carbonitrile (6a),4-bromo-2-(4-chlorophenyl)-1-((2-fluoroethoxy)-methyl)-5-(trifluoromethyl)pyrrole-3-carbonitrile (6d) showed insecticidal activity against Mythimna separata and 4-bromo-2-(4-chlorophenyl)1-((isopropoxymethoxy)methyl)-5-(trifluoro methyl)pyrrole-3-carbonitrile (7d) showed acaricidal activity against Tetranychus urticae.They were more effective than Chlorfenapyr,which has been the only commercialized member of a new class of chemicals of 2-arylpyrroles. | LIU AiPing TANG Ming YU ShuYing LIU XingPing WANG XiaoGuang PEI Hui WU DaoXin HU Li OU XiaoMing HUANG MingZhi | 2013 | Science China Chemistry2013，56，1： | 5 |
| 14 | Liver X receptor agonist T0901317 reduces atherosclerotic lesions in apoE^(-/-) mice by up-regulating NPC1 expression显示文摘In this study, we studied the effect of liver X receptor (LXR) agonist T0901317 on Niemann-Pick C1 protein (NPC1) expression in apoE-/- mice. Male apoE-/- mice were randomized into 4 groups, baseline group (n=10), control group (n=14), treatment group (n=14) and prevention group (n=14). All of the mice were fed with a high-fat/high-cholesterol (HFHC) diet containing 15% fat and 0.25% cholesterol. The baseline group treated with vehicle was sacrificed after 8 weeks of the diet. The control group and the prevention group were treated with either vehicle or T0901317 daily by oral gavage for 14 weeks. The treatment group was treated with vehicle for 8 weeks, and then was treated with the agonist T0901317 for additional 6 weeks. Gene and protein expression was analyzed by real-time quantitative PCR, immunohistochemistry and Western blotting, respectively. Plasma lipid concentrations were measured by commercially enzymatic methods. We used RNA interference technology to silence NPC1 gene expression in THP-1 macrophage-derived foam cells and then detected the effect of LXR agonist T0901317 on cholesterol efflux. Plasma triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C) and apoA-I concentrations were markedly increased in T0901317-treated groups. T0901317 treatment reduced the aortic atherosclerotic lesion area by 64.2% in the prevention group and 58.3% in the treatment group. LXR agonist treatment increased NPC1 mRNA expression and protein levels in the small intestine, liver and aorta of apoE-/- mice. Compared with the normal cells, cholesterol efflux of siRNA THP-1 macrophage-derived foam cells was significantly decreased, whereas cholesterol efflux of LXR agonist T0901317-treated THP-1 macrophage-derived foam cells was significantly increased. Our results suggest that LXR agonist T0901317 inhibits atherosclerosis development in apoE-/- mice, which is related to up-regulating NPC1 expression. | OU Xiang1,2, DAI XiaoYan1, LONG ZhiFeng3, TANG YaLing1, CAO DongLi1, HAO XinRui1, HU YanWei1, LI XiaoXu1 & TANG ChaoKe1 1 Institute of Cardiovascular Research, Key Laboratory for Atherosclerology of Hunan Province, University of South China, Heng- yang 421001, China 2 Department of Physiology, Medical College of Shaoguan University, Shaoguan 512026, China 3 Department of Histology and Embryology, University of South China, Hengyang 421001, China | 2008 | Science China(Life Sciences)2008，51，5： | 5 |
| 15 | Research into comprehensive gas extraction technology of single coal seams with low permeability in the Jiaozuo coal mining area显示文摘For a low permeability single coal seam prone to gas outbursts,pre-drainage of gas is difficult and inefficient,seriously restricting the safety and efficiency of production.Radical measures of increasing gas extraction efficiency are pressure relief and infrared antirefiection.We have analyzed the effect of mining conditions and the regularity of mine pressure distribution in front of the working face of a major coal mine of the Jiaozuo Industrial(Group) Co.as our test area,studied the width of the depressurization zone in slice mining and analyzed gas efficiency and fast drainage in the advanced stress relaxation zone.On that basis,we further investigated and practiced the exploitation technology of shallow drilling,fan drilling and grid shape drilling at the working face.Practice and our results show that the stress relaxation zone is the ideal region for quick and efflcient extraction of gas.By means of an integrated extraction technology,the amount of gas emitted into the zone was greatly reduced,while the risk of dangerous outbursts of coal and gas was lowered markedly.This exploration provides a new way to control for gas in working faces of coal mines with low permeability and risk of gas outbursts of single coal seams in the Jiaozuo mining area. | Fu Jiangwei Fu Xuehai Hu Xiao Chen Li Ou Jianchun | 2011 | Mining Science and Technology2011，21，4： | 5 |
| 16 | A new method for early detection of myocardial ischemia:cardiodynamicsgram(CDG)显示文摘Early detection of myocardial ischemia via electrocardiographic methods is important and challenging. In the study, based on the standard 12-lead electrocardiography(ECG), a new method called cardiodynamicsgram(CDG) is proposed for early detection of myocardial ischemia. Using a recently proposed deterministic learning algorithm, the cardiodynamics information is extracted from the ST-T segments of standard 12-lead ECG. The CDG is generated by plotting the three-dimensional cardiodynamics information. By analyzing CDG morphology, it is found that significant correlations exist between CDG and ischemia. By evaluating ischemia patients and healthy controls from the Physikalisch-Technische Bundesanstalt(PTB) database and the General Hospital of Guangzhou Military Command, the CDG method achieves a mean sensitivity of 90.3% and a mean specificity of 87.8%, which are higher than those of both the standard 12-lead ECG and the exercise ECG. As it is noninvasive, convenient, and inexpensive, it is hopeful that CDG may become a cost-effective screening method for early detection of ischemic heart diseases. | Cong WANG Xunde DONG Shanxing OU Wei WANG Junmin HU Feifei YANG | 2016 | Science China(Information Sciences)2016，59，1： | 5 |
| 17 | Fistulectomy as a surgical option for pulmonary arteriovenous nalformation显示文摘背景外科的切除术为肺的动静脉的畸形性仍然是选择的治疗,但是移开某正常的肺实质。这研究试图从 2003 年 7 月作为肺 resection.Methods 的一种选择评估 fistulectomy 的节省肺的过程的效果和安全到 2008 年 7 月,有肺的动静脉的畸形性的 6 个选择病人经历了 fistulectomies。在他们之中, 1 个病人经历了紧急情况操作, 2 经历了双边的手术。一耐心的收到的手术后的 embolotherapy.Results 没有医院死亡或手术后的病态发生了。PaO_2 在操作以后显著地增加了。所有病人在后续期间没有症状和组织缺氧到 5 years.Conclusions Fistulectomy 的 9 个月了是为有肺的动静脉的畸形性的病人的一个安全、有效的过程并且可以是肺切除术的一种选择。 | ZHANG Shao-yan ZHANG Zhi-tai OU Song-lei HU Yan-sheng SONG Fei-qiang LI Xin MA Xu-chen MA Xin-xin LIANG Lin LI Dong GUO Lin SUN Zhen | 2009 | Chinese Medical Journal2009，，19： | 4 |
| 18 | Research on the Anticorrosion Coating Under the Paved Layer for Highway Steel Box Bridge Deck显示文摘The corrosion of the anticorrosion coating and the defects of the asphalt concrete paved layer have been investigated on long-span steel box bridge decks. The anticorrosion coating lies in the middle of two entirely different materials: a highway steel box bridge deck and a paved layer, which is used as anticorrosion and waterproof coating for the steel bridge deck. For our study, electrochemical corrosion and pull strength experiments have been selected for the investigation of the corrosion properties of inorganic zinc rich coating, epoxy zinc rich coating and arc sprayed zinc coating. The adhesive strength between the coatings and the panel, and the effect of the coating corrosion on the shear properties of the paved layers including cast asphalt, thermal asphalt mortar, epoxy asphalt and modified asphalt concrete have been investigated. The results show that the adhesive strength between the coatings and the bridge panel is controlled by the method of pre-processing rust removal. Coating by sandblasting has stronger adhesive strength than coating by shot peening. The results also reveal that shear strength of the paved layer is affected by the corrosion product of zinc coating. The arc sprayed zinc coating has stronger shear strength than zinc rich coalings. | SHEN Cheng-jin MING Tu-zhang HU Guang-wei OU Xue-mei GEN Ou | 2006 | Journal of China University of Mining and Technology2006，16，4： | 4 |
| 19 | Metasurface-enabled on-chip multiplexed diffractive neural networks in the visible显示文摘Replacing electrons with photons is a compelling route toward high-speed,massively parallel,and low-power artificial intelligence computing.Recently,diffractive networks composed of phase surfaces were trained to perform machine learning tasks through linear optical transformations.However,the existing architectures often comprise bulky components and,most critically,they cannot mimic the human brain for multitasking.Here,we demonstrate a multi-skilled diffractive neural network based on a metasurface device,which can perform on-chip multi-channel sensing and multitasking in the visible.The polarization multiplexing scheme of the subwavelength nanostructures is applied to construct a multi-channel classifier framework for simultaneous recognition of digital and fashionable items.The areal density of the artificial neurons can reach up to 6.25×10^(6)mm^(-2) multiplied by the number of channels.The metasurface is integrated with the mature complementary metal-oxide semiconductor imaging sensor,providing a chip-scale architecture to process information directly at physical layers for energy-efficient and ultra-fast image processing in machine vision,autonomous driving,and precision medicine. | Xuhao Luo Yueqiang Hu Xiangnian Ou Xin Li Jiajie Lai Na Liu Xinbin Cheng Anlian Pan Huigao Duan | 2022 | Light(Science & Applications)2022，11，7： | 4 |
| 20 | Treatment of hypocalcemia caused by hypoparathyroidism or pseudohypoparathyroidism with domestic-made calcitrioh a prospective and self-controlled clinical trial显示文摘背景甲状旁腺的荷尔蒙缺乏或抵抗可以与相关症状和符号引起血钙过少。与维生素 D 或它的代谢物相结合的钙的终生的治疗为这些病人总是是必要的。这里,我们报导在血钙过少的治疗调查国内做 calcitriol 的功效和安全的未来、开标签的试用与证实的 hypoparathyroidism 或 pseudohypoparathyroidism 由 hypoparathyroidism 或 pseudohypoparathyroidism.Methods 引起了 24 个病人(36.5 ? 湯汣獵潩獮吗?? | WANG Ou XING Xiao-ping MENG Xun-wu XIA Wei-bo LI Mei JIANG Yan HU Ying-ying LIU Huai-cheng | 2009 | Chinese Medical Journal2009，，3： | 4 |
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