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| 1 | Helicobacter pylori associated chronic gastritis,clinical syndromes,precancerous lesions,and pathogenesis of gastric cancer development显示文摘Helicobacter pylori(H.pylori)infection is well known to be associated with the development of precancerous lesions such as chronic atrophic gastritis(AG),or gastric intestinal metaplasia(GIM),and cancer.Various molecular alterations are identified not only in gastric cancer(GC)but also in precancerous lesions.H.pylori treatment seems to improve AG and GIM,but still remains controversial.In contrast,many studies,including meta-analysis,show that H.pylori eradication reduces GC.Molecular markers detected by genetic and epigenetic alterations related to carcinogenesis reverse following H.pylori eradication.This indicates that these changes may be an important factor in the identification of high risk patients for cancer development.Patients who underwent endoscopic treatment of GC are at high risk for development of metachronous GC.A randomized controlled trial from Japan concluded that prophylactic eradication of H.pylori after endoscopic resection should be used to prevent the development of metachronous GC,but recent retrospective studies did not show the tendency.Patients with precancerous lesions(molecular alterations)that do not reverse after H.pylori treatment,represent the'point of no return'and may be at high risk for the development of GC.Therefore,earlier H.pylori eradication should be considered for preventing GC development prior to the appearance of precancerous lesions. | Jiro Watari Nancy Chen Peter S Amenta Hirokazu Fukui Tadayuki Oshima Toshihiko Tomita Hiroto Miwa Kheng-Jim Lim Kiron M Das | 2014 | World Journal of Gastroenterology2014，20，18： | 60 |
| 2 | Usefulness of virtual histology intravascular ultrasound to predict distal embolization for ST- segment elevation myocardial infarction 显示文摘 | Kawaguchi R Oshima S Jingu M | 2007 | J Am Coll Cardiol2007，50，17： | 1 |
| 3 | Angiopoietin-2 enhances retinal vessel sensitivity to vascular growth显示文摘 | Oshima Y Deering T Oshima S | 2004 | J Cell Physiol2004，199，3： | 1 |
| 4 | Rapid diagnosis of red sea bream iridovirus infection using the polymerase chain reaction显示文摘 | OSHIMA S HATA J I HIRASAWA N | 1998 | Dis Aquat Organ1998，，： | 1 |
| 5 | Chemoprevention of intestinal polyposis in the Apcdelta716 mouse by rofecoxib, a specific cyclooxygenase-2 inhibitor显示文摘 | Oshima M Murai N Karqman S | 2001 | Cancer Res2001，61，4： | 1 |
| 6 | Survey of surgical indications and results of primary pars plana vitrectomy for rhegmatogenous retinal detachments显示文摘 | Oshima Y Emi K Motokura M Yamanishi S | | 0，，02： | 1 |
| 7 | KL-6 as a novel marker for activities of interstitial pneumonia in connective tissue diseases显示文摘 | Fukaya S Oshima H Kato K | 2000 | Rheumatology International2000，19，6： | 1 |
| 8 | Development of an oral drug delivery systemtargeting immune-regulating cells in experimentalinflammatory bowel disease: a new therapeutic strategy显示文摘 | Nakase H Okazaki K Tabata Y Uose S Ohana M Uchida K Matsushima Y Kawanami C Oshima C IkadaY Chiba T | 2000 | Journal of Pharmacology and ExperimentalTherapeutics2000，292，1： | 1 |
| 9 | Peptidoglycan recognition protein(PGRP)-LE and PGRP-LC act synergistically in Drosophila immunity显示文摘 | Takehana A Yano T Mita S Kotani A Oshima Y Kurata S | | 0，，23： | 1 |
| 10 | Biosynthesis of a- poly- l- lysine by washed mycelium of Streptomyces albulus No346 显示文摘 | Shima S Oshima S Sakai H | 1983 | Nippon Nogeikagaku Kaishi1983，57，： | 1 |
| 11 | In vivo T-cell depletion withalemtuzumab in allogeneic hematopoietic stem celltransplantation: Combined results of two studies on aplasticanemia and HLA-mismatched haploidentical transplantation显示文摘 | Kanda Y Oshima K’Kako S | 2013 | AmJ Hematol2013，88，4： | 1 |
| 12 | Diversity andfunctional importance of phytoplasma membrane proteins显示文摘 | KAKIZAWA S OSHIMA K NAMBA S | 2006 | Trends in Microbiology2006，14，6： | 1 |
| 13 | Suppression of intestinal polyposis in apcd716 knockout mice by inhibition of cyclooxygenase 2 ( COX-2 ) 显示文摘 | OSHIMA M DINCHUK J E KARGMAN S L | 1996 | Cell1996，87，： | 1 |
| 14 | Cardiac angiotensin Ⅱ type 2 receptor activates the kinin/NO system and inhibits fibrosis显示文摘 | Ozono R Oshima T | 2003 | Hypertension2003，41，1： | 1 |
| 15 | Cardiac angiotensin II type 2 receptor activates the kinin/NO system and inhibits fibrosis显示文摘 | Kurisu S Ozono R Oshima T | 2003 | Hypertension2003，41，： | 1 |
| 16 | Angiogenesis-related factors are molecular targets for diagnosis and treatment of patients with esophageal carcinoma 显示文摘 | Oshima Y Yajima S Yamazaki K | 2010 | Ann Thorac Cardiovasc Surg2010，16，6： | 1 |
| 17 | Displacement behavior of CH4 adsorbed on coals by injecting pure CO2, N2, and CO2-N2 mixture显示文摘 | Shimada S Li H Oshima Y | 2005 | Environmental Geology2005，49，1： | 1 |
| 18 | Determination of total and dissolved amount of iron in water samples using catalytic spectrophotometric flow injection analysis显示文摘 | LUNVONGSA S OSHIMA M MOTOMIZU S | 2006 | Talanta2006，68，2： | 1 |
| 19 | Clinical outcome in patients with small intestinal non-Hodgkin lymphoma 显示文摘 | Kako S Oshima K Sato M | 2009 | Leuk Lympho- ma2009，50，10： | 1 |
| 20 | Cardiac angiotensin Ⅱ type 2 receptor activates the kinin/NO system and inhibits fibrosis 显示文摘 | Kurisu S Ozono R Oshima T | 2003 | Hypertension2003，41，1： | 1 |
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