|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Cognitive disorder and dementia in type 2 diabetes mellitus显示文摘Insulin,a key pleiotropic hormone,regulates metabolism through several signaling pathways in target tissues including skeletal muscle,liver,and brain.In the brain,insulin modulates learning and memory,and impaired insulin signaling is associated with metabolic dysregulation and neurodegenerative diseases.At the receptor level,in aging and Alzheimer’s disease(AD)models,the amount of insulin receptors and their functions are decreased.Clinical and animal model studies suggest that memory improvements are due to changes in insulin levels.Furthermore,diabetes mellitus(DM)and insulin resistance are associated with age-related cognitive decline,increased levels ofβ-amyloid peptide,phosphorylation of tau protein;oxidative stress,pro-inflammatory cytokine production and dyslipidemia. Recent evidence shows that deleting brain insulin receptors leads to mildobesity and insulin resistance without influencing brain size and apoptosis development.Conversely, deleting insulin-like growth factor 1 receptor (IGF-1R) affects brain size anddevelopment, and contributes to behavior changes. Insulin is synthesized locally in the brain andis released from the neurons. Here, we reviewed proposed pathophysiological hypotheses toexplain increased risk of dementia in the presence of DM. Regardless of the exact sequence ofevents leading to neurodegeneration, there is strong evidence that mitochondrial dysfunctionplays a key role in AD and DM. A triple transgenic mouse model of AD showed mitochondrialdysfunction, oxidative stress, and loss of synaptic integrity. These alterations are comparable tothose induced in wild-type mice treated with sucrose, which is consistent with the proposal thatmitochondrial alterations are associated with DM and contribute to AD development. Alterationsin insulin/IGF-1 signaling in DM could lead to mitochondrial dysfunction and low antioxidantcapacity of the cell. Thus, insulin/IGF-1 signaling is important for increased neural processing andsystemic metabolism, and could be a specific target for therapeutic strategies to decreasealterations associated with age-related cognitive decline. | Genaro G Ortiz Miguel Huerta Héctor A González-Usigli Erandis D Torres-Sánchez Daniela LC Delgado-Lara Fermín P Pacheco-Moisés Mario A Mireles-Ramírez Blanca MG Torres-Mendoza Roxana I Moreno-Cih Irma E Velázquez-Brizuela | 2022 | World Journal of Diabetes2022，13，4： | 2 |
| 2 | Prevalence andimpact of primary dysmenorrhea among Mexican high school students显示文摘 | Ortiz MI Rangel-Flores E Carrillo-Alarcón LC | 2009 | Int J Gynaecol Obstet2009，107，3： | 1 |
| 3 | Melatonin restores the mitochondrial production of A TP in septic mice显示文摘 | Lopez LC Escames G Ortiz F | 2006 | Neuro Endocrinol Lett2006，27，5： | 1 |
| 4 | Parenteral administration of different amounts of branch-chain amino acids in septic patients 显示文摘 | Carcia DL Ortiz LC Planas M | 1997 | Crit Care Med1997，25，： | 1 |
| 5 | The results of transplantation of intercalary allograft after resection of tumors: a long term follow up study显示文摘 | ORTIZ CRUZ E GEBHARDT MC JENNINGS LC | 1997 | J Bone Joint Surg (Am)1997，79，： | 1 |
| 6 | Randomized,controlled trial comparing the effects of anesthesia withpropofol, isoflurane, desflurane and sevoflurane on pain afterlaparoscopic cholecystectomy显示文摘 | ORTIZ J CHANG LC TOLPIN DA | 2014 | Braz J Anesthesil2014，64，3： | 1 |
| 7 | Attenuation of cardiac mitochondrial dysfunction by melatonin in septic mice 显示文摘 | Escames G Lopez LC Ortiz F | 2007 | FEBS J2007，274，8： | 1 |
| 8 | Melatonin restores the mitochondrial production of ATP in septic mice 显示文摘 | Lopez LC Escames G Ortiz F | 2006 | Neuro Endocrinol Lett2006，27，5： | 1 |
| 9 | Thioredoxin, oxidative stress, cancer and aging显示文摘 | Flores LC Ortiz M Dube S | 2012 | Longer Healthspan2012，1，： | 1 |
| 10 | Randomized, controlled trial comparing the effects of anesthesia with propofol, isoflurane, desflurane and sevoflurane on pain after laparoscopic cholecystectomy显示文摘 | Ortiz J Chang LC Tolpin DA | 2014 | Brazilian journal of anesthesiology2014，64，3： | 1 |
| 11 | Clinical and metabolic effects of two lipid emulsions on the parenteral nutrition of septic patients显示文摘 | Gamacho MJ Ortiz LC Jimenez JFJ | 2002 | Nutrition2002，18，2： | 1 |
| 12 | Nutritional support in severe sepsis显示文摘 | Ortiz LC Ortiz MC Jimenez FJ | 2003 | Clin Pulm Med2003，10，： | 1 |
| 13 | The Emerging Use of Ket- amine for Anesthesia and Sedation in Traumatic Brain Injuries 显示文摘 | Chang LC Raty SR Ortiz J | 2013 | CNS Neurosei Ther2013，19，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员