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| 1 | Influence of different second generation antipsychotics on the QTc interval: A pragmatic study显示文摘AIM To investigate whether differential influence on the QTc interval exists among four second generation antipsychotics(SGAs) in psychosis.METHODS Data were drawn from a pragmatic, randomized headto-head trial of the SGAs risperidone, olanzapine, quetiapine, and ziprasidone in acute admissions patients with psychosis, and with follow-up visits at discharge or maximally 6-9 wk, 3, 6, 12 and 24 mo. Electrocardiograms were recorded on all visits. To mimic clinical shared decision-making, the patients were randomized not to a single drug, but to a sequenceof the SGAs under investigation. The first drug in the sequence defined the randomization group, but the patient and/or clinician could choose an SGA later in the sequence if prior negative experiences with the first one(s) in the sequence had occurred. The study focuses on the time of, and actual use of the SGAs under investigation, that is until treatment discontinuation or change, in order to capture the direct medication effects on the QTc interval. Secondary intention-to-treat(ITT) analyses were also performed. RESULTS A total of 173 patients, with even distribution among the treatment groups, underwent ECG assessments. About 70% were males and 43% had never used antipsychotic drugs before the study. The mean antipsychotic doses in milligrams per day with standard deviations(SD) were 3.4(1.2) for risperidone, 13.9(4.6) for olanzapine, 325.9(185.8) for quetiapine, and 97.2(42.8) for ziprasidone treated groups. The time until discontinuation of the antipsychotic drug used did not differ in a statistically significant way among the groups(Log-Rank test: P = 0.171). The maximum QTc interval recorded during follow-up was 462 ms. Based on linear mixed effects analyses, the QTc interval change per day with standard error was-0.0030(0.0280) for risperidone;-0.0099(0.0108) for olanzapine;-0.0027(0.0170) for quetiapine, and-0.0081(0.0229) for ziprasidone. There were no statistically significant differences among the groups in this regard. LME analyses based on ITT groups(the randomization groups), revealed almost identical slopes with-0.0063(0.0160) for risperidone,-0.0130(0.0126) for olanzapine,-0.0034(0.0168) for quetiapine, and-0.0045(0.0225) for ziprasidone. CONCLUSION None of the SGAs under investigation led to statistically significant QTc prolongation. No statistically significant differences among the SGAs were found. | Roy E Olsen Rune A Kroken Sigmund Bj?rhovde Kristina Aanesen Hugo A J?rgensen Else-Marie L?berg Erik Johnsen | 2016 | World Journal of Psychiatry2016，6，4： | 2 |
| 2 | Effects of temperature on the diversity and community structure of known methanogenic groups and other archaeal in high Arctic peat显示文摘 | HΦJ L OLSEN R A TORSVIK V L | 2008 | The ISME Journal2008，2，1： | 1 |
| 3 | Thermoelas- tic properties of ScBz, TiBz, YB4 and HOB4: Ex- perimental and theoretical studies 显示文摘 | Waskowska A Gerward L Olsen J S | 2011 | Aeta Mater2011，59，： | 1 |
| 4 | Human donor liver and serum concentrations of perfluorooctanesulfonate and other perfluorochemicals显示文摘 | OLSEN G W HANSEN K J STEVENSON L A | 2003 | Environ Sci Technol2003，37，： | 1 |
| 5 | Epidemiology of surgically managed pelvic organ prolapse and urinary incontinence显示文摘 | Olsen A L Smith V J Bergstrom J O | 1997 | Obstet Gynecol1997，89，4： | 1 |
| 6 | Conjugated linoleic acid (CLA) inhibits expression of the Spot 14(THRSP) and fatty acid synthase genes and impairs the growth of human breast cancer and liposarcoma cells显示文摘 | DONNELLY C OLSEN A M LEWIS L D | 2008 | Nutrition Cancer2008，61，1： | 1 |
| 7 | Sexual dimorphic expression pattern of asplice variant of zebrafish vasa during gonadal development显示文摘 | KRVEL A V OLSEN L C | 2004 | Develop-mental Biology2004，271，1： | 1 |
| 8 | A 7-deaza-adenosine analog is a potent and selective inhibitor of hepatitis C virus replication with excellent pharmacokinetic properties显示文摘 | Olsen D B Eldrup AB Bartholomew L Bhat B Bosserman M R Ceccacci A Colwell L F Fay J F Flores O A Getty K L Grobler J A LaFemina R L Markel E J Migliaccio G Prhavc M Stahlhut M W Tomassini J E MacCoss M Hazuda D J Carroll S S | | 0，，10： | 1 |
| 9 | Bent-function sequences显示文摘 | OLSEN J D SCHOLTZ R A WELCH L R | 1982 | IEEE Trans Inform Theory1982，28，11： | 1 |
| 10 | Human donor liver and serum concentrations of perfluorooctanesulfonate and other perfluorochemicals显示文摘 | OLSEN G W HANSEN K J STEVENSON L A | 2003 | Environmental Science and Technology2003，37，5： | 1 |
| 11 | NAC transcription factors, Structurally distinct, functionally diverse 显示文摘 | Olsen A N Ernst H A Leggio L | 2005 | Trends Plant Sci2005，10，2： | 1 |
| 12 | Healing and sealing of a simulated fault gouge under hydrothermal conditions: Implications for fault healing显示文摘 | OLSEN M P SCHOLZ C H L E GER A | 1998 | Journal of Geophysical Research (Solid Earth)1998，103，4： | 1 |
| 13 | A Vasa-like Gene in Zebrafish Identifies Putative Primordial Germ Cells显示文摘 | Olsen L C Aasland R Fjose A | 1997 | Mech Dev1997，66，： | 1 |
| 14 | Bent function sequence显示文摘 | Olsen J D Scholtz R A L R Welch | 1982 | IEEE Transactions on Information Theory1982，28，6： | 1 |
| 15 | Purification and characterization of two trypsin-like enzymes from the digestive tract of anchovy Engraulis encrasicholus 显示文摘 | Martinez A Olsen R L Serra J L | 1988 | Comparative Biochemistry and Physiology Part B1988，91，： | 1 |
| 16 | Effect of treatment with exogenous interferon, polyinosinic acid-polyctyidylic acid or polyi- nnsinic acid-polycytidylic acid-poly-L-lysine complex on encepha- lomyocarditis virus infections in mice显示文摘 | Olsen G A Kern E R Glasgow L A | 1976 | Antimicrob Agents Che- mother1976，10，4： | 1 |
| 17 | Protects animals against aerosol infection with mycobacterium tuberculosis显示文摘 | Doherty T M Olsen A W vanPinxteren L | 2002 | Infect Immun2002，70，6： | 1 |
| 18 | Purification and characterization of two trypsin-like enzymes from the digestive tract of anchovy Engraulis encrasicholus显示文摘 | Martinez A Olsen R L Serra J L | 1988 | Comparative Biochemistry and Physiology1988，91，： | 1 |
| 19 | Purification and characterization of two trypsin-like enzymes from the digestive tract of anchovy Engraulis encrasicholus显示文摘 | Martinez A Olsen R L Serra J L | 1988 | Comp Biochem Physiol1988，91，： | 1 |
| 20 | A new model of the shrinkage characteristic applied to some Norwegian soils显示文摘 | OLSEN P A HAUGEN L E | 1998 | Geoderma1998，83，： | 1 |
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