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| 1 | 镉对生命活动的毒作用机制显示文摘镉是一种众所周知的环境毒物,对人体健康有重大危害。镉与众多疾病相关,例如癌症、神经退化性疾病和代谢综合征等。虽然疾病种类各异,但是都与镉的化学性质和毒作用机制有关。镉易与含硫氮功能基结合,从而取代金属酶内的必需元素锌。镉的促炎症效应伴随促炎因子[肿瘤坏死因子(TNF-α)、白介素(IL)-1、IL-6]的大量产生和抗炎因子(IL-1拮抗剂、IL-4、IL-6、IL-10、IL-13)的明显减少,并且镉的促炎症活性与其通过各种途径所诱导的氧化应激紧密相关。镉还能取代各种蛋白质内的铁铜原子,从而增加自由氧化还原反应的活性金属库,激活芬顿(Fenton)反应;反之,镉对电子传递链的抑制损害了对氧气的利用,增加了活性氧的产生。最后,镉对抗氧化酶的抑制加剧自由基对核酸等生物大分子的损伤,引起遗传毒性并改变基因调控。因此,干扰镉的毒作用机制是预防镉暴露不良健康效应的有效措施。 | Alexey A.TINKOV Olga P.AJSUVAKOVA Jan AASETH Yordanka G.GLUHCHEVA Juliana M.IVANOVA Geir BJФRKLUND Margarita G.SKALNAYA Oksana A.SKALNAYA 黄百粲 林雪 Anatoly V.SKALNY | 2018 | 环境与职业医学2018，35，5： | 11 |
| 2 | Resveratrol engages selective apoptotic signals in gastric adenocarcinoma cells显示文摘AIM: To investigate the intracellular apoptotic signals engaged by resveratrol in three gastric adenocarcinoma cancer cell lines, two of which (AGS and SNU-1) express p53 and one (KATO-Ⅲ) with deleted p53. METHODS: Nuclear fragmentation was used to quanti- tate apoptotic cells; caspase activity was determined by photometric detection of cleaved substrates; formation of oxidized cytochrome C was used to measure cytochrome C activity, and Western blot analysis was used to determine protein expression. RESULTS: Gastric cancer cells, irrespective of their p53 status, responded to resveratrol with fragmentation of DNA and cleavage of nuclear lamins A and B and PARP. Resveratrol, however, has no effect on mitochondria-associated apoptotic proteins Bcl-2, Bcl- xl, Bax, Bid or Smac/Diablo, and did not promote sub- cellular redistribution of cytochrome C, indicating that resveratrol-induced apoptosis of gastric carcinoma cells does not require breakdown of mitochondrial membrane integrity. Resveratrol up-regulated p53 protein in SNU-1 and AGS cells but there was a difference in response of intracellular apoptotic signals between these cell lines. SNU-1 cells responded to resveratrol treatment with down-regulation of survivin, whereas in AGS and KATO- Ⅲ cells resveratrol stimulated caspase 3 and cytochrome C oxidase activities. CONCLUSION: These findings indicate that even within a specific cancer the intracellular apoptotic signals engaged by resveratrol are cell type dependent and suggest that such differences may be related to differentiation or lack of differentiation of these cells. | William L Riles Jason Erickson Sanjay Nayyar Mary Jo Atten Bashar M Attar Oksana Holian | 2006 | World Journal of Gastroenterology2006，12，35： | 8 |
| 3 | Serum concentration of sFas and sFasL in healthy HBsAg carriers,chronic viral hepatitis B and C patients显示文摘AIM: To estimate the amount of apoptosis among healthy HBsAg carriers, patients with chronic HBV infection treated with lamivudine and patients with chronic HCV infedJon treated with interferon alpha and ribavirin. Activity of apoptosis was evaluated by serum sFas/sFasL concentration measurement.Moreover dependence between apoptosis and HBV-DNA or HCV-RNA levels was studied.METHODS: Eighty-six persons were included into study: 34 healthy HBsAg carriers, 33 patients with chronic HBV infection and 19 patients with chronic HCV infection. Serum levels of sFas/sFasL were measured by ELISA assay. HBV-DNA and HCV-RNA were measured by RT-PCR assay. Levels of sFas/sFasL were determined before and 2 and 12 wk after therapy in patients with chronic hepatitis B and C infection.HBV-DNA or HCV-RNA was detected before treatment and 6 mo after treatment.RFSULTS: Twenty-four (71%) healthy HBsAg carriers showed HBV-DNA over 10^5/mL, which was comparable to the patients with chronic hepatitis B. Independently from HBV-DNA levels,the concentration of sFas among healthy HBsAg carriers was comparable to healthy persons. Among patients with chronic hepatitis B and C, the concentration of sFas was significantly higher in comparison to healthy HBsAg carriers and healthy persons. In chronic hepatitis B patients the concentration of sFas was decreased during lamivudine treatment. Among chronic hepatitis C patients the concentration of sFas was increased during IFN alpha and ribavirin treatment, sFasL was not detected in control group. Furthermore sFasL oo:urred more frequently in chronic hepatitis C patients in comparison to chronic hepatitis B patients.CONCLUSION: There are no correlations between apoptosis and HBV-DNA levels. However ther is an association between apoptosis and activity of inflammation in patients with chronic HBV infection. Apoptosis can be increased in patients with chronic hepatitis C by effective treatment which may be a result of apoptosis stimulation by IFN-α. | Tadeusz Wojciech Lapinski Oksana Kowalczuk Danuta Prokopowicz Lech Chyczewski | 2004 | World Journal of Gastroenterology2004，10，24： | 7 |
| 4 | 不同热变形工艺大塑性变形加工超细晶1570C铝合金的组织、强度和超塑性显示文摘将Al-5Mg-0.18Mn-0.2Sc-0.08Zr-0.01Fe-0.01Si(质量分数,%)合金铸锭进行多向等温锻造(应变12)或等径角挤压(应变10,325℃),再进行热轧(325℃)和冷轧(20℃),对比研究合金变形后的组织和力学行为。结果表明,对(亚)晶粒尺寸dUFG=2μm的超细晶组织合金进行多向等温锻造后,其室温延展性提高,超塑性伸长率可达2800%。通过热轧进一步细化晶粒,后续再通过冷轧形成高位错密度的严重变形组织,合金的屈服/极限抗拉强度从多向等温锻造后的235/360 MPa分别提高到热轧和冷轧后的315/460 MPa和400/515 MPa。同时,热轧使超塑性伸长率提高到4000%,而冷轧后的伸长率仍然足够高(高达1500%)。与多向等温锻造相比,经等径角挤压后合金的晶粒细化程度更高(dUFG=1μm),强度和超塑性性能均得到提高。然而,热轧后此效果有所减弱,加工后的板材具有同等的性能。与多向等温锻造后再冷轧的合金相比,经等径角挤压后再冷轧的合金强度更高,超塑性性能略好。 | Oleg SITDIKOV Elena AVTOKRATOVA Oksana LATYPOVA Michael MARKUSHEV | 2021 | Transactions of Nonferrous Metals Society of China2021，31，4： | 4 |
| 5 | Azithromycin in a triple therapy for H.pylori eradication in active duodenal ulcer显示文摘AIM:To assess and compare the efficacy and safety of two triple regimes:A)metronidazole,amoxicillin and omeprazole,which is still widely used in Russia,andB)azithromycin amoxicillin and omeprazole in healing active duodenal ulcer and H.pylori eradication.METHODS:100 patients with active duodenal ulcer were includid in the open,multicentre,randomized study with comparative groups.Patients were randomly assigned to one of the following one-week triple regimes:A)metronidazole500mg bid,amoxicillin1gbid and omeprazole 20mg bid(OAM,n=50)andB)azithromycin1g od for the first3days(total dose3g).amoxicillin 1g bid and first 3days(total dose3g).amoxicillin 1g bid and omeprazole20mg bid(OAA,n=50).Omeprazole 20mg od was given after the eradication course as a monotherapy for three weeks ,The control endoscopy was performed8 weeks after the entry,H.pyloriinfection was determined in the entry of the study and four weeks after the cessation of treatment by means of histology and CLO-test.RESULTS:97 patients completed the study according to the protocol(1patient of the OAM group did not come to the control endoscopy.2patients of the OAA group stopped the treatment because of mild allergic urticaria).Duodenal ulcers were healed in48patients of the OAM group(96%;CI90.5-100%)and in 46patients of the OAAgroup(92%;CI89.5-94.5%)(p=ns).H.pylori infection was eradicated in 15out of 50patients with OAM(30%;CI17-43%)and in36out of 50patients treated with OAA(72%,CI59-85%)(P<0.001)-IПanalysis.CONCLUSION:The triple therapy with omeprazole,amoxicillin and metronidazole failed to eradicateH.pylori in the majorty of patients,which is an essential argument to withdraw this regimen out of the national recommendations,Macrolide with amoxicillin are preferable to achieve higher eradication rates.Azitromycin(1g od for the first3days)can be considered as a successful component of the triple PPI-based regimen. | Vladimir T.Ivashkin Tatiana L.Lapina Oksana Yu.Bondarenko Olga A. Sklanskaya Petr Va.Grigoriev Yuri V.Vasiliev Emilia P.Yakovenko Pavel V.Gulyaev Valeri I.Fedchenko | 2002 | World Journal of Gastroenterology2002，8，5： | 4 |
| 6 | Design method for an acoustic cloak in flows by topology optimization显示文摘In this paper,a design method for an acoustic cloak in the presence of background mean flows is proposed by using topology optimization,which enables the associated fabrication of the cloaking design.The density-based topology optimization method is used to allocate the designated materials,thus providing the structure of the cloak.The optimization problem is efficiently solved with the gradient-based globally convergent method of moving asymptotes,which utilizes the derivative information from the finite element simulation studies of the linearized acoustic potential equation.This paper introduces the whole design method first then numerically demonstrates the corresponding performance,which shall constitute the main contribution of the present work. | Zhengyu Ma Oksana Stalnov Xun Huang | 2019 | Acta Mechanica Sinica2019，35，5： | 3 |
| 7 | Efficiency and safety of lamivudine therapy in patients with chronic HBV infection, dialysis or after kidney transplantation显示文摘AIM: To analyze the effectiveness and safety of lamivudine treatment in patients with chronic HBV infection undergoing hemodialysis or after kidney transplantation, and to study the frequency of tyrosine - methionine - aspartate - aspartate (YMDD) mutation occurrence after lamivudine treatment.METHODS: We analyzed 91 patients with chronic hepatitis B, among whom, 16 patients underwent hemodialysis, 7patients had kidney transplantation and 68 patients had normal function of kidney. The hemodialysis patients were treated by lamivudine 300 mg/wk. Patients after kidney transplantation and patients with normal function of kidney were treated with lamivudine 100 mg/d. Therapy lasted for 12 mo. HBV-DNA, HBsAg, HBeAg and anti-HBe, and antiHCV antibodies were assessed in sera of patients. The analysis was performed before and 6 mo after the end of lamivudine treatment. Before, during and after the lamivudine therapy,the number of erythrocytes, leukocytes, platelets and hemoglobin concentration, ALT and AST activity, as well as bilirubin, urea and creatinine concentrations were analyzed in sera from patients.RESULTS: After the 12-mo lamivudine treatment, elimination of HBV - DNA was observed in 56% patients undergoing hemodialysis and in 53% patients with normal kidney function. Only 1 from 7 (14%) kidney-transplanted patients eliminated HBV-DNA. Furthermore, HBeAg elimination was observed in 36% hemodialysis patients, in 51% patients with normal function of kidneys and in 43% kidneytransplanted patients. Among the patients undergoing dialysis, no YMDD mutation was found after 12 mo of therapy, while it was detected in 9 patients (13%) with normal function of kidney and in 2 kidney-transplanted patients (29%, P<0.006). We did not observe significant side effects of lamivudine treatment in studied patients.CONCLUSION: Effectiveness of lamivudine therapy in dialysis patients is comparable with that in patients withnormal function of kidney. Lamivudine treatment is well tolerated and safe in patients with renal insufficiency undergoing hemodialysis and kidney-transplantation.However, in the latter group, high incidence of YMDD mutation after lamivudine treatment was observed. | Tadeusz Wojciech Lapinski Robert Flisiak Jerzy Jaroszewicz Ma3gorzata Michalewicz Oksana Kowalczuk | 2005 | World Journal of Gastroenterology2005，11，3： | 3 |
| 8 | Expression of auxin synthesis gene tms1 under control of tuber-specific promoter enhances potato tuberization in vitro显示文摘Phytohormones, auxins in particular, play an important role in plant development and productivity.Earlier data showed positive impact of exogenous auxin on potato(Solanum tuberosum L.) tuberization. The aim of this study was to generate potato plants with increased auxin level predominantly in tubers. To this end, a p Bin B33-tms1 vector was constructed harboring the Agrobacterium auxin biosynthesis gene tms1 fused to tuber-speci fi c promoter of the class I patatin gene(B33-promoter) of potato. Among numerous independently generated B33:tms1 lines, those without visible differences from control were selected for detailed studies. In the majority of transgenic lines, tms1 gene transcription was detected, mostly in tubers rather than in shoots. Indoleacetic acid(IAA) content in tubers and the auxin tuber-to-shoot ratio were increased in tms1-expressing transformants. The organ-speci fi c increase in auxin synthesis in B33:tms1-transformants accelerated and intensi fi ed the process of tuber formation, reduced the dose of carbohydrate supply required for in vitro tuberRization, and decreased the photoperiodic dependence of tuber initiation. Overall, a positive correlation was observed between tms1 expression, IAA content in tubers,and stimulation of tuber formation. The revealed properties of B33:tms1 transformants imply an important role for auxin in potato tuberization and offer prospects to magnify potato productivity by a moderate organ-specific enhancement of auxin content. | Oksana O.Kolachevskaya Valeriya V.Alekseeva Lidiya I.Sergeeva Elena B.Rukavtsova Irina A.Getman Dick Vreugdenhil Yaroslav I.Buryanov Georgy A.Romanov | 2015 | Journal of Integrative Plant Biology2015，57，9： | 3 |
| 9 | Stretch-induced human myometrial cytokines enhance immune cell recruitment via endothelial activation显示文摘自发的术语劳动在包括 cytokine 生产和白血球渗入的 myometrium 与放大煽动性的事件被联系;然而,调整如此的事件的潜在的机制充分没被理解。我们由成长胎儿假设了子宫的墙的那机械段由子宫的 myocytes 通过各种各样的 cytokines 的版本便于外部白血球溢出进术语 myometrium。人的 myometrial 房间(hTERT-HM ) 受到静态的机械段;调节段的媒介被收集并且分析了使用 48-plex Luminex 试金和 ELISA。人的子宫的 microvascular endothelial 房间(UtMVEC-Myo ) 的房间粘附分子表示上的调节段的媒介的效果被量的聚合酶链反应(qPCR ) 和流动 cytometry 检测;测试 leukocyte-endothelial 相互作用的功能的试金:到 endothelial 房间和象 THP-1 monocytic 房间的移植一样的标记 calcein 的主要人的 neutrophils 的 transendothelial 移植的白血球的粘附被萤光计估计。在 vitro 学习的水流证明机械段(i)直接由 hTERT-HM 细胞导致多重 cytokines 和 chemokines 的分泌物( IL-6 , CXCL8 , CXCL1 ,移植禁止的因素( MIF ), VEGF , G-CSF , IL-12p70 , bFGF 和导出血小板的生长因素子单元 B ( PDGF-bb ), P< ; 0.05 );导致段的 cytokines (ii ) 提高白血球粘附到包围的内皮细胞层子宫的微脉管系统由(iii ) 导致 endothelial 房间粘附分子的表示并且(iv ) 指导外部白血球的 transendothelial 迁居。(vi )抵销 Chemokine 抗体和用途广泛的 chemokine 禁止者堵住白血球移植。我们的数据从子宫的血容器为白血球招募提供机械规定的一个证明给 myometrium,为白血球建议通常认为的机制在劳动和产后的复杂物期间渗透到子宫。 | Yu-Hui Lee | 2015 | Cellular & Molecular Immunology2015，12，2： | 2 |
| 10 | 几种变性淀粉水晶饺子皮特性的比较研究显示文摘采用马铃薯醋酸酯淀粉、马铃薯羟丙基淀粉、辛烯基琥珀酸淀粉钠和醋酸酯木薯淀粉等4种变性淀粉,按5%、10%、15%的比例分别添加到水晶饺子皮原料粉(小麦淀粉∶玉米淀粉=3∶1)中,进而对新混合粉制成的水晶饺子皮及速冻水晶饺子进行物理指标的测定和分析,结果表明:与空白组相比,含有马铃薯醋酸酯淀粉的混合粉制成的水晶饺子皮,其蒸煮损失降低、透明度升高、生饺子皮亮度增加、熟饺子皮的硬度和咀嚼性升高,其制成的水晶饺子冻裂率显著降低,冻裂率最低为0%。在这4种变性淀粉中,添加量为15%的马铃薯醋酸酯淀粉能够综合提升水晶饺子皮的品质,最适合应用于水晶饺子皮中。 | 王静文 罗杨合 Melnyk Oksana | 2021 | 中国粮油学报2021，36，8： | 2 |
| 11 | BRAF and KRAS Mutations in Hyperplastic Polyps and Serrated Adenomas of the Colorectum: Relationship to Histology and CpG Island Methylation Status显示文摘 | Shi Yang Francis A Farraye Charline Mack Oksana Posnik Michael J O’Brien | 2004 | The American Journal of Surgical Pathology2004，，11： | 2 |
| 12 | Etiology and classification of acute pancreatitis in children admitted to ICU using the Pediatric Sequential Organ Failure Assessment (pSOFA) score显示文摘Background:Pediatric acute pancreatitis(AP)is rare but increasing.Severe AP is associated with higher morbidity and mortality.However,there are no universally accepted prognostic criteria for AP.Methods:This retrospective study included children with AP admitted to an intensive care unit(ICU)of our tertiary pediatric center between January 2009 and December 2018.The severity of organ dysfunction in AP was assessed according to the modified Atlanta criteria using the Pediatric Sequential Organ Failure Assessment(p SOFA)and Computed Tomography Severity Index(CTSI).Results:Seventy acute episodes of AP were evaluated in 55 children with primary pancreatitis.In addition,secondary AP was diagnosed in 15 patients originally admitted to ICU for different indications.Mild AP[no organ dysfunction,normal computed tomography(CT)finding]was the most prevalent(64/85 episodes in 49 children),followed by moderate AP(15 children;p SOFA 2-9 points,CTSI 3-4 points on admission).Severe AP(p SOFA 4-17 points,CTSI 6-10 points)was diagnosed in 6 children with traumatic or secondary AP.The most frequent etiologies of primary AP episodes were idiopathic(39%)and biliary(31%).Children with idiopathic AP had frequent relapses and comorbidities.Hereditary AP was typically mild,but presented with high pancreatic enzyme levels and recurrence rates.Admission at ICU and an interval without enteral nutrition(EN)were relatively short in drug-induced AP and relatively long in secondary and traumatic AP.Endoscopic retrograde cholangiopancreatography(ERCP)was performed in 13 patients with biliary AP and in 4 patients with traumatic AP.No AP-related death was observed.Conclusion:p SOFA score accurately reflects the severity and prognosis of AP in children. | Vratislav Smolka Marie Rohanova Miroslav Seda Eva Karaskova Oksana Tkachyk Martin Zapalka Jana Volejnikova | 2023 | Hepatobiliary & Pancreatic Diseases International2023，22，3： | 2 |
| 13 | Long-term follow-up of children and adolescents with primary sclerosing cholangitis and autoimmune sclerosing cholangitis显示文摘BACKGROUND: Sclerosing cholangitis(SC) is a chronic cholestatic hepatobiliary disease with uncertain long-term prognosis in pediatric patients. This study aimed to evaluate longterm results in children with SC according to the types of SC.METHODS: We retrospectively followed up 25 children with SC over a period of 4-17 years(median 12). The diagnosis of SC was based on biochemical, histological and cholangiographic findings. Patients fulfilling diagnostic criteria for probable or definite autoimmune hepatitis at the time of diagnosis were defined as having autoimmune sclerosing cholangitis(ASC); other patients were included in a group of primary sclerosing cholangitis(PSC). The incidence of the following complications was studied: obstructive cholangitis, portal hypertension, advanced liver disease and death associated with the primary disease.RESULTS: Fourteen(56%) patients had PSC and 11(44%) had ASC. Patients with ASC were significantly younger at the time of diagnosis(12.3 vs 15.4 years, P=0.032) and had higher Ig G levels(22.7 vs 17.2 g/L, P=0.003). The mentioned complications occurred in 4(16%) patients with SC, exclusively in the PSC group: one patient died from colorectal cancer, one patient underwent liver transplantation and two patients, in whom severe bile duct stenosis was present at diagnosis, were endoscopically treated for acute cholangitis. Furthermore, twoother children with ASC and 2 children with PSC had elevated aminotransferase levels. The 10-year overall survival was 95.8% in all patients, 100% in patients without complicated liver disease, and 75.0% in patients with complications.CONCLUSION: In children, ASC is a frequent type of SC, whose prognosis may be better than that in patients with PSC. | Vratislav Smolka Eva Karaskova Oksana Tkachyk Kvetoslava Aiglova Jiri Ehrmann Kamila Michalkova Michal Konecny Jana Volejnikova | 2016 | Hepatobiliary & Pancreatic Diseases International2016，15，4： | 2 |
| 14 | Distinct Types of Tumor-Initiating Cells Form Human Colon Cancer Tumors and Metastases显示文摘 | Sebastian M. Dieter Claudia R. Ball Christopher M. Hoffmann Ali Nowrouzi Friederike Herbst Oksana Zavidij Ulrich Abel Anne Arens Wilko Weichert Karsten Brand Moritz Koch Jürgen Weitz Manfred Schmidt Christof von Kalle Hanno Glimm | 2011 | Cell Stem Cell2011，，4： | 2 |
| 15 | Euxinia as a dominant process during OAEla(Early Aptian)on the Eastern Russian Platform and during OAElb(Early Albian)in the Middle Caspian显示文摘A detailed study of the mineral composition and microstructure of the black shales associated with OAEla(Eastern Russian Platform),OAElb(Middle Caspian),and the host rocks has been carried out using X-ray diffraction,scanning electron microscopic,and microprobe analyses.The results provide important constraints for depositional environments in the sedimentary basins.Black shales with pyrite framboids imply euxinic(sulfidic)conditions with increased organic matter preservation.Disintegrating framboids suggest partial or complete dissolution of the organic matter inside the framboids due to increasing water oxygenation.OAEla on the Eastern Russian Platform is heterogeneous as it includes thin interbeds of concretionary coccolith limestones within the interval of bituminous shales,and correlates with the Lower Aptian Rhagodiscus angustus nannofossil zone.The coccolith limestones indicate short intermittent episodes of interrupted stagnation,rapid oxygenation,and restoration of normal marine conditions.The presence of montmorillonite,albite,microcline,and diopside in the bituminous siltstones and in the host siltstones of OAEla on the Eastern Russian Platform,as well as a high content of titanium in the black siltstones correlated with OAElb in the Middle Caspian allow proposing significant input of pyroclastic material into the extant sea. | Svetlana O. ZORINA Oksana V. PAVLOVA Bulat M. GALIULL1N Vladimir P. MOROZOV Alexey A. ESKIN | 2017 | Science China Earth Sciences2017，60，1： | 2 |
| 16 | The hypoglycemic potential of phenolics from functional foods and their mechanisms显示文摘Long-term postprandial hyperglycemia is a primary risk factor for developing chronic metabolic diseases such as obesity,type 2 diabetes,and cardiovascular disease.Chronic hyperglycemia induces the glycation of proteins,oxidative stress,inflammation and increases plasma insulin and lipid concentrations.Insulin resistance is the primary cause of postprandial excursions of blood glucose and lipids.Hyperglycemia can be treated by lowering dietary carbohydrates intake,digestion,and absorption.Various functional foods improve glucose metabolism by increasing insulin sensitivity and inhibitingα-glucosidase in the small intestine.Natural phytochemicals,especially active phenolics are good antioxidants and show anti-inflammatory action and regulate blood glucose.This review aimed to report on hypoglycemic properties of active phenolics from functional foods and their proposed anti-diabetic mechanisms.Nevertheless,further clinical trials are required to confirm the bioavailability,safety,and efficacy of phenolics,especially the dosage and duration of treatment,to avoid adverse effects and give better dietary recommendations. | Oksana Golovinskaia Chin-Kun Wang | 2023 | Food Science and Human Wellness2023，12，4： | 2 |
| 17 | Sustainable consumption progress: should we be proud or alarmed?显示文摘 | Oksana Mont Andrius Plepys | 2007 | Journal of Cleaner Production2007，，4： | 2 |
| 18 | Structural Aspects of Multistep Phosphorelay- Mediated Signaling in Plants显示文摘multistep phosphorelay (MSP ) 是在集成大量神经质、环境的输入并且控制众多的发展改编的植物的一条中央发信号小径。为位于调停 MSP 的信号识别和 transduction 下面的分子的机制的彻底的理解,小径的单个成员的详细结构的描述是批评的。在我们描述并且讨论的这评论,最近已知的水晶和原子磁性的回声在在更高的植物发信号的 MSP 行动的蛋白质组织,特别地集中于在 Arabidopsis thaliana 发信号的细胞激动素和乙烯。我们通过 phosphorelay 包括 ligand 特性,经由它的 autophosphorylation 的受体的激活,和下游的信号 transduction 的决心讨论可得到的结构的信息的功能的方面的范围。我们把植物结构与他们的细菌的对应物作比较并且证明尽管全面类似高,在结构的细节的差别经常、机能上地重要。最后,我们在 MSP 在分子的识别机制上讨论新兴的知识,并且关于在能在所有更高的植物担任这条小径的一个一般模型的 Arabidopsis MSP 表明特性的结构的决定因素提及最近的调查结果。 | Blanka Pekarova Agnieszka Szmitkowska Radka Dopitova Oksana Degtjarik Lukas Zidek Jan Hejatko | 2016 | Molecular Plant2016，9，1： | 2 |
| 19 | 银纳米颗粒的绿色合成:藻类生命周期对银纳米颗粒合成和长期稳定性的影响(英文)显示文摘用分别培养了1、2、3和4周的凯氏拟小球藻的四种不同的提取物,生物合成球形银纳米颗粒(AgNPs)。研究藻类生命周期对AgNPs合成的影响和不同的储存条件对AgNPs长期稳定性的影响。结果发现,藻类的年龄会影响AgNPs的合成率和溶液中的数量,但不影响AgNPs的长期稳定性。UV–vis和TEM的结果显示,AgNPs的长期稳定性受储存温度的影响,低温更有利于其长期稳定性。储存在黑暗环境和5°C左右时,AgNPs表现出最佳的长期稳定性,而与藻类年龄无关,存储6个月以后,这些AgNPs仍然保持着球形,尺寸细小(5~20nm),且无团聚。 | Oksana VELGOSOVA Anna MRAZIKOVA Elena CIZMAROVA Jaroslav MALEK | 2018 | Transactions of Nonferrous Metals Society of China2018，28，5： | 1 |
| 20 | Acute onset of autoimmune hepatitis in children and adolescents显示文摘Background: Autoimmune hepatitis (AIH) is a rare progressive liver disease, which manifests as acute hepatitis in 40%-50% of pediatric cases. This refers predominantly to spontaneous exacerbations of previ- ously unrecognized subclinical AIH with laboratory and histological signs of chronic hepatitis, or to acute exacerbations of known chronic disease. Only a few of these patients ful ll criteria for acute liver failure (ALF). Methods: Forty children diagnosed with AIH in our center between 2000 and 2018 were included in this study. All of them ful lled revised diagnostic criteria of the International Autoimmune Hepatitis Group (IAIHG) for probable or con rmed AIH, and other etiologies of liver diseases were excluded. Patients were divided into two groups: acute AIH (A-AIH) or chronic AIH (C-AIH). Results: Acute onset of AIH occurred in 19/40 children (48%). Six of them ful lled the criteria of ALF with coagulopathy and encephalopathy. Five of 6 children with ALF suffered from exacerbation of previ- ously undiagnosed chronic AIH, among which 4 children were histologically con rmed as micronodular cirrhosis. The remaining one patient had fulminant AIH with centrilobular necrosis, but no histological signs of previous chronic liver damage. We observed signi cantly lower levels of albumin, higher levels of aminotransferases, bilirubin, INR, IgG, higher IAIHG score and more severe histological ndings in A- AIH than in C-AIH. No differences in patient age and presence of autoantibodies were observed between A-AIH and C-AIH. All children, including those with ALF and cirrhosis, were treated with corticosteroids, and are alive and achieved AIH remission. Liver transplant was not indicated in any patient. Conclusion: Rapid and accurate diagnosis of A-AIH may be di cult. However, timely start of immunosup-pressive therapy improves prognosis and decreases number of indicated liver transplantations in children with AIH. | Vratislav Smolka Oksana Tkachyk Jiri Ehrmann Eva Karaskova Martin Zapalka Jana Volejnikova | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，1： | 1 |
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