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| 1 | One-year clinical study of NeuroR egen scaffold implantation following scar resection in complete chronic spinal cord injury patients显示文摘The objective of this clinical study was to assess the safety and feasibility of the collagen scaffold, Neuro Regen scaffold, one year after scar tissue resection and implantation. Scar tissue is a physical and chemical barrier that prevents neural regeneration. However, identification of scar tissue is still a major challenge. In this study, the nerve electrophysiology method was used to distinguish scar tissue from normal neural tissue, and then different lengths of scars ranging from 0.5–4.5 cm were surgically resected in five complete chronic spinal cord injury(SCI) patients. The NeuroR egen scaffold along with autologous bone marrow mononuclear cells(BMMCs), which have been proven to promote neural regeneration and SCI recovery in animal models, were transplanted into the gap in the spinal cord following scar tissue resection. No obvious adverse effects related to scar resection or Neuro Regen scaffold transplantation were observed immediately after surgery or at the 12-month follow-up. In addition, patients showed partially autonomic nervous function improvement, and the recovery of somatosensory evoked potentials(SSEP) from the lower limbs was also detected. The results indicate that scar resection and Neuro Regen scaffold transplantation could be a promising clinical approach to treating SCI. | Zhifeng Xiao Fengwu Tang Jiaguang Tang Huilin Yang Yannan Zhao Bing Chen Sufang Han Nuo Wang Xing Li Shixiang Cheng Guang Han Changyu Zhao Xiaoxiong Yang Yumei Chen Qin Shi Shuxun Hou Sai Zhang Jianwu Dai | 2016 | Science China(Life Sciences)2016，59，7： | 18 |
| 2 | Application of next-generation sequencing to screen for pathogenic mutations in 123 unrelated Chinese patients with Marfan syndrome or a related disease显示文摘Marfan syndrome(MFS) is a systemic connective tissue disease principally affecting the ocular, skeletal and cardiovascular systems. This autosomal dominant disorder carries a prevalence of 1:3,000 to 1:5,000. This study aims to define the mutational spectrum of MFS related genes in Chinese patients and to establish genotype-phenotype correlations in MFS. Panel-based targeted next-generation sequencing was used to analyze the FBN1, TGFBR1 and TGFBR2 genes in 123 unrelated Chinese individuals with MFS or a related disease. Genotype-phenotype correlation analyses were performed in mutation-positive patients. The results showed that 97 cases/families(78.9%;97/123) harbor at least one(likely) pathogenic mutation, most of which were in FBN1;four patients had TGFBR1/2 mutations;and one patient harbored a SMAD3 mutation. Three patients had two FBN1 mutations, and all patients showed classical MFS phenotypes. Patients with a dominant negative-FBN1 mutation had a higher prevalence of ectopia lentis(EL). Patients carrying a haploinsufficiency-FBN1 mutation tended to have aortic dissection without EL. This study extends the spectrum of genetic backgrounds of MFS and enriches our knowledge of genotype-phenotype correlations. | Jiacheng Li Chaoxia Lu Wei Wu Yaping Liu Rongrong Wang Nuo Si Xiaolu Meng Shuyang Zhang Xue Zhang | 2019 | Science China(Life Sciences)2019，62，12： | 4 |
| 3 | Simple Predicting Method for Fatigue Crack Growth Rate Based on Tensile Strength of Carbon Steel显示文摘Three types of fatigue tests for an annealed carbon steel containing carbon of 0.42%were carried out on smooth specimens and specimens with a small blind hole in order to investigate the fatigue crack growth law.A simple predicting method for crack growth rates has been proposed involving strengthσband the relation between cyclic stress and strain.The validity of proposed method has been confirmed by experiments on several carbon steels with different loadings. | LI Bo HU Ji-fan QIN Hong-wei MA Nuo AN Kang WANG Xin-lin | 2003 | Journal of Iron and Steel Research(International)2003，10，2： | 4 |
| 4 | Artificial antigen-presenting cells plus IL-15 and IL-21 efficiently induce melanoma-specific cytotoxic CD8^+CD28^+ T lymphocyte responses显示文摘Objective:To develop a novel artificial antigen-presenting system for efficiently inducing melanoma-specific CD8+CD28+ cytotoxic T lymphocyte(CTL) responses.Methods:Cell-sized Dynabeads? M-450 Epoxy beads coated with H-2Kb:Ig-TRP2(181111K and anti-CD28 antibody were used as artificial antigen-presenting cells(aAPCs) lo induce melanoma-specific CD8*CD28’ CTL responses with the help of IL-2I and IL-I5.Dimer staining,proliferation,ELISPOT,and cytotoxicity experiments were conducted to evaluate the frequency and activity of induced CTLs.Results:Dimer staining demonstrated that the new artificial antigen-presenting system efficiently induced melanoma TRP2-specific CD8CD28' CTLs.Proliferation and ELISPOT assays indicated that the induced CTLs rapidly proliferate and produce increased IFN- y under the slimulalion of H-2K:Ig-TRP2-aAPCs,TL-15,and IL-21.In addition,cytoloxicily experiments showed lhat induced CTLs have specific killing activity of target cells.Conclusions:The new artificial antigen-presenting system including aAPCs plus IL-21 and IL-15 can induce a large number of antigen-specific CD8+CD28+ CTLs against the melanoma.Our study provides evidence for a novel adoptive immunotherapy against tumors. | Xia Yu Jian He Sodaly Mongkhoune Yi Peng Yuan Xie Jing Su Su-Fang Zhou Xiao-Xun Xie Guo-Rong Luo Yuan Fang Xi Li Nuo Zhou Yong-Xiang Zhao Xiao-Ling Lu | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，6： | 3 |
| 5 | Fast ambiguous DOA elimination method of DOA measurement for hybrid massive MIMO receiver显示文摘Dear editor,Direction of arrival(DOA)estimation has been widely used in many applications,including wireless communications,radar,navigation,sonar,tracking of various objects,secure and precise wireless transmission(SPWT). | Baihua SHI Xinyi JIANG Nuo CHEN Yin TENG Jinhui LU Feng SHU Jun ZOU Jun LI Jiangzhou WANG | 2022 | Science China(Information Sciences)2022，65，5： | 2 |
| 6 | Besshi-type mineral systems in the Palaeoproterozoic Bryah Rift-Basin, Capricorn Orogen, Western Australia: Implications for tectonic setting and geodynamic evolution显示文摘In this contribution we use VMS mineral systems in the Bryah rift-basin to constrain the tectonic setting of the widespread mafic and ultramafic magmatism that characterises the rift-basin in question.Two distinct,but temporally closely associated,lithostratigraphic sequences,Narracoota and Karalundi Formations,are discussed.The Karalundi Formation is the main host of VMS mineral systems in the region.The Karalundi Formation consists of turbiditic and immature clastic sediments,which are locally intercalated with basaltic hyaloclastites,dolerites and banded jaspilites.We propose that the basaltic hyaloclastites,dolerites and elastics and jaspilites rocks,form a distinct unit of the Karalundi Formation,named Noonyereena Member.The VMS mineral systems occur near the north-east trendingJenkin Fault and comprise the giant and world-class DeCrussa and the Red Bore deposits.The nature of these deposits and their intimate association with terrigenous clastic rocks and dominantly marine mafic volcanic and subvolcanic rocks,as well as the common development of peperitic margins,are considered indicative of a Besshi-type environment,similar to that of present-day Gulf of California.Our Re-Os age data from a primary pyrite yielded a mean model age of 2012 ± 48 Ma,which coincides(within error) with recent published Re-Os data(Hawke et al.,2015) and confirms the timing of the proposed geodynamic evolution.We propose a geodynamic model that attempts to explain the presence of the Narracoota and Karalundi Formations as the result of mantle plume activity,which began with early uplift of continental crust with intraplate volcanism,followed by early stages of rifting with the deposition of the Karalundi Formation(and Noonyereena Member),which led to the formation of Besshi-type VMS deposits.With on-going mantle plume activity and early stages of continental separation,an oceanic plateau was formed and is now represented by mafic-ultramafic rocks of the Narracoota Formation. | Franco Pirajno Yanjing Chen Nuo Li Chao Li Limin Zhou | 2016 | Geoscience Frontiers2016，7，3： | 2 |
| 7 | Optimized Bio-inspired Micro-pillar Dry Adhesive and Its Application for an Unmanned Aerial Vehicle Adhering on and Detaching from a Ceiling显示文摘Various bio-inspired dry adhesive materials have been investigated.In this work,lithography and silicon deep etching method were used to fabricate bio-inspired micro-pillar dry adhesive materials of which the parameters,such as side length,Height to Side length Aspect Ratio(HSAR),and inter-pillar Distance to Side length Aspect Ratio(DSAR)were comprehensively studied to obtain a dry adhesive with high adhesion.An orthogonal array method was designed and a series of fabrication experiments were conducted to identify optimum parameters,which resulted in a high normal adhesion of 2.98 N·cm^-2 and a shear adhesion of 9.59 N·cm^-2.An adhesion and desorption device was further designed on basis of the optimum dry adhesive,which enables an Unmanned Aerial Vehicle(UAV)to successfully adhere on and detach from a ceiling.This would allow an UAV to stay aloft for prolonged time,which could be invaluable to many applications,such as energy conservation and aerial detection. | Qingsong He Xianrui Xu Zhiwei Yu Kai Huo Zhaoyang Wang Nuo Chen Xuean Sun Gui Yin Peile Du Yang Li Zhendong Dai | 2020 | Journal of Bionic Engineering2020，17，1： | 2 |
| 8 | Small-molecule fluorescent probes for the detection of carbon dioxide显示文摘During the last few years, the preparation of novel fluorescent probes for the detection of carbon dioxide has attracted considerable attention since carbon dioxide plays extremely important roles in widespread fields including chemical, environmental, clinical analysis, and agri-food industry. This review focuses on the recent advances in the design principles, recognition mechanisms, and preparation of small-molecule fluorescent probes for the selective detection and monitoring of CO_2. Moreover, their properties and functions will be discussed detailedly as well. | Junlong Zhu Peipei Jia Nuo Li Shaoying Tan Junhai Huang Lin Xu | 2018 | Chinese Chemical Letters2018，29，10： | 2 |
| 9 | Expression of IL-2 and IL-11 and its significance in patients with ankylosing spondylitis显示文摘Objective:To explore the expression of IL-2 and IL-11 and its significance in patients with ankylosing spondylitis(AS).Methods:A total of 48 active AS patients in our hospital and 40 normal control subjects were selected in our study.Bath ankylosing spondylitis disease activity index(BASDAI),Bath ankylosing spondylitis functional index(BASFI),Bath ankylosing spondylitis metrology index(BASMI),ESR and CRP expression levels were compared before treatment,12 h after treatment and 24 h after treatment.IL-2 and IL-11 expression were also compared between these two groups.Results:The BASDAI score,BASH score and BASMI score of the AS patients before treatment significantly decreased compared with those 12 weeks and 24 weeks after treatment(P<0.05).ESB and CRP levels of the AS patients 12 weeks and 24 weeks after treatment significantly decreased compared with those before treatment(P<0.05).Difference was significant in serum IL-2 and IL-11 levels between 12 weeks and 24 weeks after treatment and before treatment(P<0.05).And no statistically significance was observed for serum IL-2 and IL-11 levels between normal control group and those of patients in AS group 24 weeks after treatment(P>0.05). Pearson’s linear-correlation analysis showed that serum IL-2 level had a positive correlation with BASDAI,BASFI,BASMI,ESR and CRP(r=0.661.0.547,0.474,0.362,0.416,P<0.05) and serum IL-11 level had a negative correlation with BASDAI,BASFI,BASMI,ESR and CRP(r=-0.629, -0.412,-0.422,-0.387,-0.408,-0.315,P<0.05).Conclusions:Serum levels of IL-2 in active AS patients significantly increase and will decrease after treatment.However,serum levels of IL- 11 significantly decrease and will increase after treatment,which indicates that serum IL-2 has a positive correlation with the degree of AS and serum IL-11 has a negative correlation with the degree of AS,both of which are correlated closely with the onset of AS. | Feng Liu Fan Wang Cong-Cong Wang Nuo Li Shu-Feng Li | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，1： | 2 |
| 10 | RNA interference?mediated targeting of DKK1 gene expression in Ishikawaendometrial carcinoma cells causes increased tumor cell invasion and migration显示文摘 | Nuo Yi Qin?Ping Liao Zhen?Hua Li Bao?Jiang Xie Yu?Hong Hu Wei Yi Min Liu | 2013 | Oncology Letters2013，，3： | 1 |
| 11 | Fluid evolution of the Yuchiling porphyry Mo deposit, East Qinling, China显示文摘 | Nuo Li Thomas Ulrich Yan-Jing Chen Tonny B. Thomsen Victoria Pease Franco Pirajno | 2012 | Ore Geology Reviews2012，，： | 1 |
| 12 | Isotope systematics and fluid inclusion studies of the Qiyugou breccia pipe-hosted gold deposit, Qinling Orogen, Henan Province, China:implications for ore genesis 显示文摘 | Chen Yanjing Pirajno F Li Nuo | 2009 | Ore Geology Review2009，35，： | 1 |
| 13 | The “bottom-up” synthesis and applications of persistent luminescence nanoparticles显示文摘Persistent luminescence refers to the phenomenon whereby luminescence remains after excitation ceases.In the past few decades,various kinds of persistent luminescent materials have been developed and widely employed in numerous applications,such as security signs,medical diagnostics and photocatalysis.Persistent luminescent materials offer distinctive advantages for biomedical applications,especially for bioimaging,as they can efficiently avoid autofluorescence and tissue-scattered light interference[1]. | Nuo Yu Yang Li Zhanjun Li Gang Han | 2018 | Science China Chemistry2018，61，7： | 1 |
| 14 | A novel biodegradable system based on nanoparticles and poly(actic-co-glycolic acid)microspheres for protein and peptide drug delivery显示文摘 | Wang Nuo Wu XS | 1997 | J Pharm Sic1997，86，： | 1 |
| 15 | Perturbation-based user-input-validation testing of web applications 显示文摘 | Li Nuo Xie Tao Jin Maozhong | 2010 | Journal of Systems and Software2010，83，11： | 1 |
| 16 | Microbes team with nanoscale zero-valent iron: A robust route for degradation of recalcitrant pollutants显示文摘Integrating nanoscale zero-valent iron(nZVI) with biological treatment processes holds the promise of inheriting significant advantages from both environmental nano-and biotechnologies. nZVI and microbes can perform in coalition in direct contact and act simultaneously, or be maintained in separate reactors and operated sequentially. Both modes can generate enhanced performance for wastewater treatment and environmental remediation. nZVI scavenges and eliminates toxic metals, and enhances biodegradability of some recalcitrant contaminants while bioprocesses serve to mineralize organic compounds and further remove impurities from wastewater. This has been demonstrated in a number of recent works that nZVI can substantially augment the performance of conventional biological treatment for wastewaters from textile and nonferrous metal industries. Our recent laboratory and field tests show that COD of the industrial effluents can be reduced to a record-low of 50 ppm. Recent literature on the theory and applications of the nZVI-bio system is highlighted in this mini review. | Nuo Liu Jing Liu Hong Wang Shaolin Li Wei-xian Zhang | 2022 | Journal of Environmental Sciences2022，34，8： | 1 |
| 17 | Multi-sensor multi-target passive locating and tracking显示文摘 | Mei Liu Haihao Li Nuo Xu | 2007 | International Journal of Control Automation and Systems2007，5，2： | 1 |
| 18 | Structural design and modal behaviors analysis of a new swept baffled inflatable wing显示文摘Inflatable wing has significant application value in the design of loitering munitions because of its advantages such as lightweight and foldability.However,due to the flexible characteristics,aeroelastic behaviors of inflatable wings such as flutter are nonnegligible in flight.By designing a certain angle between the inflatable beam and the wing span,the structural dynamic and even the aeroelastic performance of the inflatable wing can be effectively improved.Based on the analysis of the mechanical and geometric characteristics of the inflatable structure,a new inflatable wing with sweep arranged inflatable beams is proposed,and the main design variables and methods are analyzed.For purpose of investigating the aeroelastic performance of the swept baffled inflatable wing,the modal behaviors by considering the wet mode are studied.In consideration of the deficiencies of the traditional wet modal analysis method,by introducing the influence on the additional stiffness of flow field,an added massstiffness method is proposed in this paper,and the advantages are verified by ground vibration experiments.On this basis,the effects of baffles sweep angle,pressure,and boundary conditions on the modal parameters and aeroelastic performance of inflatable wing are analyzed.The results show that the aeroelastic performance of the inflatable wing can be designed by changing the baffles sweep angle,which is enlightened for the aeroelastic tailoring design on inflatable wings. | Nuo Ma Li Liu Fanmin Meng Junhui Meng | 2023 | Defence Technology(防务技术)2023，24，6： | 1 |
| 19 | The benefits of respective and combined use of green tea polyphenols and ERK inhibitor on the survival and neurologic outcomes in cardiac arrest rats induced by ventricular fibrillation显示文摘 | Xiaojun Zhuo Lu Xie Fangying Ruan Shi Nuo Li Xiaoyang Chen Menghua Chen | 2015 | American Journal of Emergency Medicine2015，，： | 1 |
| 20 | Fluid evolution of the Yuchiling porphyry Mo deposit, East Qinling, China显示文摘 | Nuo Li Thomas Ulrich Yan-Jing Chen Tonny B. Thomsen Victoria Pease Franco Pirajno | 2012 | Ore Geology Reviews2012，，： | 1 |
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