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| 1 | One hundred and seventy-eight consecutive pancreatoduodenectomies without mortality:role of the multidisciplinary approach显示文摘BACKGROUND:Pancreatoduodenectomy offers the only chance of cure for patients with periampullary cancers.This,however,is a major undertaking in most patients and is associated with a significant morbidity and mortality.A multidisciplinary approach to the workup and follow-up of patients undergoing pancreatoduodenectomy was initiated at our institution to improve the diagnosis,resection rate,mortality and morbidity.We undertook the study to assess the effect of this approach on diagnosis,resection rates and short-term outcomes such as morbidity and mortality.METHODS:A prospective database of patients presenting with periampullary cancers to a single surgeon between April 2004 and April 2010 was reviewed.All cases were discussed at a multidisciplinary meeting comprising surgeons,gastroenterologists,radiologists,oncologists,radiation oncologists,pathologists and nursing staff.A standardized investigation and management algorithm was followed.Complications were graded according to the Clavien-Dindo classification.RESULTS:A total of 295 patients with a periampullary lesion were discussed and 178 underwent pancreatoduodenectomy (resection rate 60%).Sixty-one patients (34%) required either a vascular or an additional organ resection.Eighty-nine patients experienced complications,of which the commonest was blood transfusion (12%).Thirty-four patients (19%) had major complications,i.e.grade 3 or above.There was no in-hospital,30-day or 60-day mortality.CONCLUSIONS:Pancreatoduodenectomy can safely be performed in high-volume centers with very low mortality.The surgeon's role should be careful patient selection,intensive preoperative investigations,use of a team approach,and an unbiased discussion at a multidisciplinary meeting to optimize the outcome in these patients. | Jaswinder S Samra Raul Alvarado Bachmann Julian Choi Anthony Gill Michael Neale Vikram Puttaswamy Cameron Bell Ian Norton Sarah Cho Steven Blome Ritchie Maher Sivakumar Gananadha Thomas J Hugh | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，4： | 8 |
| 2 | Recent progress in processing and properties of ZnO显示文摘 | Pearton S J Norton D P Ip K | 2005 | Prog Mater Sci2005，50，： | 1 |
| 3 | Optimal Entry Time for a Product Line Extension显示文摘 | Wilson L O Norton J A | 1989 | Marketing Science1989，8，： | 1 |
| 4 | Recombinant humanized anti-HER-2 antibody(herceptin) enhance the activity ofpaclitaxec and doxorubicin against HER2/neu overexpressing human breast cancer xenografts 显示文摘 | BASELGA J NORTON L ALBABELL J | 1998 | Cancer Res1998，58，13： | 1 |
| 5 | Recombinant humanized antiHER2 ntibody (Herceptin) enhances the antihumor activcity of paclitaxel and doxorubicin against HER2/neu overexpressing human breast cancer xenografts 显示文摘 | Baselga J Norton L Albanell J | 1998 | Cancer Res1998，58，13： | 1 |
| 6 | Anti-apoptotic effects of IGF-1 and PDGF on human intervertebral disc cells in vitro 显示文摘 | Gruber H E Norton H J Hanley E N | 2000 | Spine2000，25，17： | 1 |
| 7 | Soil and sediment phosphorus fractions in a forested watershed at Acadia National Park, ME, USA 显示文摘 | Sanclemants M D Fernandez I J Norton S A | 2009 | Forest Ecology and Management2009，258，： | 1 |
| 8 | A diffusion theory model of adoption and substitution for successive generations of high-technology products 显示文摘 | Norton J A Bass F M | 1987 | Management Science1987，33，： | 1 |
| 9 | Soil erosion by surface water flow on a stony,semiarid hillslope显示文摘 | Nearing M A Simanton J R Norton L D | 1999 | Earth Surf Process Landforms1999，24，： | 1 |
| 10 | Evaluation of the genetic diversity of the American chestnut显示文摘 | HUANG H DANE F NORTON J D | 1996 | HortScience1996，31，： | 1 |
| 11 | Perspectives on the ecomorphology of bony fishes显示文摘 | Motta P J Norton S Luczkocich J J | 1995 | Env Biol Fish1995，44，： | 1 |
| 12 | The inhibition of cell division in Saccharomyces cerevisiae (Meyen) by carbon dioxide显示文摘 | Norton J S Krauss R W | 1972 | Plant and Cell Physiology1972，，1： | 1 |
| 13 | Recent progress in processing and properties of ZnO显示文摘 | S J Pearton D P Norton KIp | 2005 | Progress in Materials Science2005，50，3： | 1 |
| 14 | Directed evolution of ionizing radiation resistance in Escherichia coli 显示文摘 | Harris D R Pollock S V Wood E A Goiffon R J Klingele A J Cabot E L Schackwitz W Martin J Eggington J Durfee T J Middle C M Norton J E Popelars M C Li H Klugman S A Hamilton L L Bane L B Pennacchio L A Albert T J Perna N T Cox M M Battista J R | 2009 | Journal of Bacteriology2009，191，16： | 1 |
| 15 | The role of psychological factors in response to treatment in neurocardiogenic (vasovagal) syncope 显示文摘 | Gracie J Newton JL Norton M | 2006 | Europace2006，8，8： | 1 |
| 16 | Epitaxial YBa2 Cu3 07 on Biaxially Textured Nickel (001) : An Approach to Superconducting Tapes with High Critical Current Density显示文摘 | Norton D P Goyal A Budai J D | 1996 | Science1996，274，5288： | 1 |
| 17 | A diffusion theory model of adoption and substitution for generations of high-technology product显示文摘 | Norton J A Bass F M | 1987 | Management Science1987，33，9： | 1 |
| 18 | Recent Contributions to the X-ray Method in the Field of Stress Analysis显示文摘 | Norton J H Rosenthal D | 1987 | Proceedings of the Society for Experimental Stress Analysis1987，5，1： | 1 |
| 19 | Mechanism of adhesion of electroless-deposited silver on poly(ether urethane) 显示文摘 | GRAY J E NORTON P R GRIFFITHS K | 2005 | Thin Solid Films2005，484，12： | 1 |
| 20 | Influence of severity of congenital hypothyroidism and adequacy of treatment on school achievement in young adolescents : a populati0n-based cohort study显示文摘 | Leger J Larroque B Norton J | 2001 | Acta Paediatr2001，90，11： | 1 |
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