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| 1 | Possible key residues that determine left gastric artery blood flow response to PACAP in dogs显示文摘AIM:To determine the effect of pituitary adenylate cy-clase-activating polypeptide (PACAP) on left gastric artery (LGA) flow and to unveil the structural or functional important sites that may be critical for discrimination of different receptor subtypes. METHODS: Peptides, including PACAP-27, PACAP-38, amino acid substituted PACAP-27 and C-terminus truncated analogues PACAP (27-38), were synthesized by a simultaneous multiple solid-phase peptide synthesizer. Flow probes of an ultrasound transit-time blood flowmeter were placed around the LGA of beagle dogs. Whenpeptides were infused intravenously, the blood flow was measured.RESULTS: [Ala4, Val5]-PACAP-27 caused a concentration-dependent vasodepressor action which was similar to that caused by PACAP-27. The LGA blood flow response to [Ala4, Val5]-PACAP-27 was significantly higher than that to PACAP-27, which was similar to that to vasoactive intestinal polypeptide (VIP) at the same dose. [Ala6]-PACAP-27 did not increase the peak LGA ? ow. [Gly8]-PACAP-27 showed a similar activity to VIP. [Asn24, Ser25, Ile26]-PACAP-27 did not change the activity of peptides at all doses. CONCLUSION: NH2 terminus is more important to biological activity of peptides and specifi c receptor recognition than COOH-terminus. | Mu-Xin Wei Ping Hu Ping Wang Satoru Naruse Kiyoshi Nokihara Victor Wray Tsuyoshi Ozaki | 2010 | World Journal of Gastroenterology2010，16，38： | 2 |
| 2 | A new quinoline derivative MS- 209 reverses multidrug resistance and inhibits mulriorgan metastases by p - glycoprotein - expressing human small cell lung cancer cells 显示文摘 | Nokihara H Yano S Nokihara Y | 2001 | Jpn J Cancer Res2001，92，： | 1 |
| 3 | Randomized phase I] study of first-line carboplatin-paclitaxel with or without bevacizumab in Japanese patients with advanced non- squamous non-small-cell lung cancer 显示文摘 | Niho S Kunitoh H Nokihara H | 2012 | Lung Cancer2012，76，3： | 1 |
| 4 | Phase II study of S-1 in non-small cell lung cancer(NSCLC)patients previously treated with aplatinum-based regimen显示文摘 | Nokihara H Nagai S Kato T | 2007 | Thorac Oncol2007，2，： | 1 |
| 5 | Phase I study of LY2181308,an antisense oligonucleotide against survivin,in patients with advanced solid tumors 显示文摘 | Tanioka M Nokihara H Yamamoto N | 2011 | Cancer Chemother Pharmacol2011，68，2： | 1 |
| 6 | A randomized phase Ⅱ study of sequential carboplatin/paclitaxel(CP)and gefitinib(G)in chemotherapy-naive patients with advanced non-small- cell lung cancer (NSCLC): Preliminary results显示文摘 | NOKIHARA H OHE Y KAWAISHI M | 2006 | J Clin Oncol2006，24，18： | 1 |
| 7 | Study on sulfur- containing peptides: tert-butyloxycarbonylsulfenyl and benzyloxycarbonylsulfenyl derivatives as protecting groups for cysteine显示文摘 | Berndt H | 1978 | Journal of Organic Chemistry1978，43，25： | 1 |
| 8 | Angiogenic activity of osteopontin derived peptide SVVYGLR显示文摘 | Hamada Y Nokihara K Okazaki M | 2003 | Biochemical and Biophysical Research Communications2003，310，1： | 1 |
| 9 | Angiogenic activity of osteopontin derived-peptide SVVYGLR 显示文摘 | Hamada Y Nokihara K Okazaki M | 2003 | Biochem Biophys Res Commun2003，310，1： | 1 |
| 10 | A phase I, dose- finding and pharmacokinetic study of olaparib (AZD2281) in Japanese patients with advanced solid tumors 显示文摘 | Yamamoto N Nokihara H Yamada Y | 2012 | Cancer Sei2012，103，3： | 1 |
| 11 | Randomized phase II study of first-line carboplatin-paclitaxel with or without bevacizumab in Japanese patients with advanced non-squamous non-small-cell lung cancer 显示文摘 | NIHO S KUNITOH H NOKIHARA H | 2012 | Lung Cancer2012，76，3： | 1 |
| 12 | A new quinoline derivative MS-209 reverses multidrug resistance and inhibits multiorgan metastases by P-glycoprotein-expressing human small cell lung cancer cells 显示文摘 | Nokihara H Yano S Nishioka Y | 2001 | Jpn J Cancer Res2001，92，7： | 1 |
| 13 | Antioxidant activity of Designed Peptides Based on the Antioxidative Peptide Isolated from Digests of a Soybean Protein 显示文摘 | Chen H M Muramoto K Yamauehi F Nokihara K | 1996 | J Agric Food Chem1996，44，： | 1 |
| 14 | Applications of an automated apparatus for two- dimensional electrophoresis, Model TEP - 1, for microsequence analyses of proteins 显示文摘 | Nokihara K Morita N Kuriki T | 1992 | Electrophoresis1992，13，： | 1 |
| 15 | Figitumumab combined with carboplatin and paclitaxel in treatment-na?ve Japanese patients with advanced non-small cell lung cancer显示文摘 | Yasushi Goto Ikuo Sekine Maki Tanioka Takashi Shibata Chiharu Tanai Hajime Asahina Hiroshi Nokihara Noboru Yamamoto Hideo Kunitoh Yuichiro Ohe Hironori Kikkawa Emiko Ohki Tomohide Tamura | 2012 | Investigational New Drugs2012，，4： | 1 |
| 16 | Multifunctional interleukin-lbeta promotes metastasis human lung cancer cells in SCID mice via enhanced expression of adhesion-, invasion- , and anglogenesis - related molecules 显示文摘 | Yano S Nokihara H Yamamoto A | 2003 | Cancer Sci2003，94，3： | 1 |
| 17 | Risk factors for skeletal-related events in patients with non-small cell lung cancer treatedby chemotherapy显示文摘 | Sekine I Nokihara H Yamamoto N | | 0，，02： | 1 |
| 18 | Docetaxel consolidation therapy following cisplatin,vinorelbine,and concurrent thoracic radiotherapy in patients with unresectable stage Ⅲ non-small cell lung cancer显示文摘 | Sekine I Nokihara H Sumi M | 2006 | J Thorac Oncol2006，1，8： | 1 |
| 19 | Risk factors for skeletal-related events in patients with non-small cell lung cancer treated by chemotherapy 显示文摘 | Sekine I Nokihara H Yamamoto N | 2009 | Lung Cancer2009，65，2： | 1 |
| 20 | Antioxidative Properties of Tripeptide Libraries Prepared by the Combinatorial Chemistry显示文摘 | Saito K Jin D H Ogawa T Muramoto K Hatakeyama E Yasuhara T Nokihara K | 2003 | J Agric Food Chem2003，51，12： | 1 |
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