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您的检索式：作者名="Nobuo Nakajima"
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| 1 | E2FBP1 antagonizes the p16^(INK4A)-Rb tumor suppressor machinery for growth suppression and cellular senescence by regulating promyelocytic leukemia protein stability显示文摘Cellular senescence is an irreversible cell cycle arrest triggered by the activation of oncogenes or mitogenic signaling as well as the enforced expression of tumor suppressors such as p53, p16 INK4A and promyelocytic leukemia protein (PML) in normal cells. E2F-binding protein 1 (E2FBP1), a transcription regulator for E2F, induces PML reduction and suppresses the formation of PML-nuclear bodies, whereas the down-regulation of E2FBP1 provokes the PML-dependent premature senescence in human normal fibroblasts. Here we report that the depletion of E2FBP1 induces the accumulation of PML through the Ras-dependent activation of MAP kinase signaling. The cellular levels of p16 INK4A and p53 are elevated during premature senescence induced by depletion of E2FBP1, and the depletion of p16 INK4A , but not p53 rescued senescent cells from growth arrest. Therefore, the premature senescence induced by E2FBP1 depletion is achieved through the p16 INK4A -Rb pathway. Similar to human normal fibroblasts, the growth inhibition induced by E2FBP1 depletion is also observed in human tumor cells with intact p16 INK4A and Rb. These results suggest that E2FBP1 functions as a critical antagonist to the p16 INK4A -Rb tumor suppressor machinery by regulating PML stability. | Yayoi Fukuyo Akiko Takahashi Eiji Hara Nobuo Horikoshi Tej K. Pandita Takuma Nakajima | 2011 | International Journal of Oral Science2011，3，4： | 11 |
| 2 | Novel Radio on Fiber Access Eliminating External Electric Power Supply at Base Station显示文摘A novel Radio On Fiber(ROF) access is proposed and demonstrated which enables the pico-cell Base Station (BS) for high-speed wireless communications to eliminate external electric power supply facilities. We demonstrated 2.4-GHz band radio signal transmission through the BS without external electric power supply. The electrical power used for BS circuit is feeded by optical power over optical fiber from central station. | Tetsuya Miki Katsuyasu Kawano Nobuo Nakajima Naoto Kishi Masaru Miyamoto Tetsu Aoki | 2003 | 光学学报2003，23，S1： | 3 |
| 3 | Risk Factors for Hypoxemia After Surgery for Acute Type A Aortic Dissection显示文摘 | Takayuki Nakajima Kohei Kawazoe Hiroshi Izumoto Tsuyoshi Kataoka Hiroyuki Niinuma Nobuo Shirahashi | 2006 | Surgery Today2006，，8： | 1 |
| 4 | The Future Generations of Mobile communications Based on Broadband Access Technologies显示文摘 | Yasushi Yamao Nobuo Nakajima | | IEEE Communications Magazine0，2000，： | 1 |
| 5 | Results of the Tokyo Trial of Prevention of Post-ERCP Pancreatitis with Risperidone-2: a multicenter, randomized, placebo-controlled, double-blind clinical trial显示文摘 | Rie Uchino Hiroyuki Isayama Takeshi Tsujino Naoki Sasahira Yukiko Ito Saburo Matsubara Naminatsu Takahara Toshihiko Arizumi Nobuo Toda Dai Mohri Osamu Togawa Hiroshi Yagioka Yoshitsugu Yanagihara Katsuyoshi Nakajima Dai Akiyama Tsuyoshi Hamada Koji Miyaba | 2013 | Gastrointestinal Endoscopy2013，，6： | 1 |
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