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| 1 | Management of duodenal stump fistula after gastrectomy for gastric cancer: Systematic review显示文摘AIM: To identify the most effective treatment of duodenalstump fistula(DSF) after gastrectomy for gastric cancer.METHODS: A systematic review of the literature was performed. Pub Med, EMBASE, Cochrane Library, CILEA Archive, BMJ Clinical Evidence and Up To Date databases were analyzed. Three hundred eighty-eight manuscripts were retrieved and analyzed and thirteen studies published between 1988 and 2014 were finally selected according to the inclusion criteria, for a total of 145 cases of DSF, which represented our group of study. Only patients with DSF after gastrectomy for malignancy were selected. Data about patients' characteristics, type of treatment, short and long-term outcomes were extracted and analyzed. RESULTS: In the 13 studies different types of treatment were proposed: conservative approach, surgical approach, percutaneous approach and endoscopic approach(3 cases). The overall mortality rate was 11.7% for the entire cohort. The more frequent complications were sepsis, abscesses, peritonitis, bleeding, pneumonia and multi-organ failure. Conservative approach was performed in 6 studies for a total of 79 patients, in patients with stable general condition, often associated with percutaneous approach. A complete resolution of the leakage was achieved in 92.3% of these patients, with a healing time ranging from 17 to 71 d. Surgical approach included duodenostomy, duodenojejunostomy, pancreatoduodenectomy and the use of rectus muscle flap. In-hospital stay of patients who underwent relaparotomy ranged from 1 to 1035 d. The percutaneous approach included drainage of abscesses or duodenostomy(32 cases) and percutaneous biliary diversion(13 cases). The median healing time in this group was 43 d. CONCLUSION: Conservative approach is the treatment of choice, eventually associated with percutaneus drainage. Surgical approach should be reserved for severe cases or when conservative approaches fail. | Paolo Aurello Dario Sirimarco Paolo Magistri NiccolòPetrucciani Giammauro Berardi Silvia Amato Marcello Gasparrini Francesco D’Angelo Giuseppe Nigri Giovanni Ramacciato | 2015 | World Journal of Gastroenterology2015，21，24： | 19 |
| 2 | Giant colonic diverticulum,clinical presentation,diagnosis and treatment: Systematic review of 166 cases显示文摘AIM: To investigate the clinical presentation,diagnosis,and treatment of giant colonic diverticulum(GCD,by means of a complete and updated literature review).GCD is a rare manifestation of diverticular disease of the colon.Less than 200 studies on GCD were published in the literature,predominantly case reports or small patient series.METHODS: A systematic review of the literature was performed using the Embase and PubM ed databases toidentify all the GCD studies.The following MESH search headings were used: 'giant colonic diverticulum'; 'giant sigmoid diverticulum'.The 'related articles' function was used to broaden the search,and all of the abstracts,studies,and citations were reviewed by two authors.The following outcomes were of interest: the disease and patient characteristics,study design,indications for surgery,type of operation,and postoperative outcomes.Additionally,a subgroup analysis of cases treated in the last 5 years was performed to show the current trends in the treatment of GCD.A GCD case in an elderly patient treated in our department by a sigmoidectomy with primary anastomosis and a diverting ileostomy is presented as a typical example of the disease.RESULTS: In total,166 GCD cases in 138 studies were identified in the literature.The most common clinical presentation was abdominal pain,which occurred in 69% of the cases.Among the physical signs,an abdominal mass was detected in 48% of the cases,whereas 20% of the patients presented with fever and 14% with abdominal tenderness.Diagnosis is based predominantly on abdominal computed tomography.The most frequent treatment was colic resection with en-bloc resection of the diverticulum,performed in 57.2% of cases,whereas Hartmann's procedure was followed in 11.4% of the cases and a diverticulectomy in 10.2%.An analysis of sixteen cases reported in the last 5 years showed that the majority of patients were treated with sigmoidectomy and en-bloc resection of the diverticulum; the postoperative mortality was null,morbidity was very low(1 patient was hospitalized in the intensive care unit for postoperative hypotension),and the patients were discharged 4-14 d after surgery.CONCLUSION: Giant colonic diverticulum is a rare manifestation of diverticular diseases.Surgical treatment,consisting predominantly of colonic resection with en bloc resection of the diverticulum,is thepreferred option for GCD and guarantees excellent results. | Giuseppe Nigri Niccolò Petrucciani Giulia Giannini Paolo Aurello Paolo Magistri Marcello Gasparrini Giovanni Ramacciato | 2015 | World Journal of Gastroenterology2015，21，1： | 3 |
| 3 | Hepatocellular Carcinomas and Primary Liver Tumors as Predictive Factors for Postoperative Mortality after Liver Resection: A Meta-Analysis of More than 35,000 Hepatic Resections显示文摘 | Ramacciato Giovanni D’Angelo Francesco Baldini Rossella Petrucciani Niccoló Antolino Laura Aurello Paolo Nigri Giuseppe Bellagamba Riccardo Pezzoli Francesca Balesh Albert Cucchetti Alessandro Cescon Matteo Del Gaudio Massimo Ravaioli Matteo | 2012 | EN2012，，4： | 2 |
| 4 | Evidence for oxidative activation of c-myc-dependent nuclear signaling in human coronary smooth muscle cells and in early lesions of watanabe heritable hyperlipidemic rabbits: protective effects of vitamin E显示文摘 | YoussefT Ciafre S | 2000 | Circulation2000，102，17： | 1 |
| 5 | Intracranial arteries of human fetuses are more resistant to hypercholesterolemiainduced fatty streak formation than extracranial arteries显示文摘 | Napoli C Witztum JL de Nigris F | 1999 | Circulation1999，99，： | 1 |
| 6 | Deletion of Yin Yang 1 protein in osteosarcoma cells on cell invasion and CXCR4/angiogenesis and metastasis显示文摘 | De Nigris F Rossiello R Schiano C | | 0，，06： | 1 |
| 7 | The glasgow prognostic score as a predictor of survival in patients with potentially resectable pancreatic adenocarcinoma显示文摘 | La Torre M Nigri G Cavallini M | 2012 | Ann Surg Oncol2012，19，9： | 1 |
| 8 | YY1 overexpression is associated with poor prognosis and metastasis-free survival in patients suffer- ing osteosarcoma显示文摘 | de Nigris F Napoli C | 2011 | BMC Cancer2011，11，： | 1 |
| 9 | Protease-activated receptor-2 activation improves efficiency of experimental ischemic preconditioning显示文摘 | Napoli C De Nigris F Cicala C | 2002 | Am J Physiol Heart Circ Physiol2002，282，6： | 1 |
| 10 | Univariate and mult- ivariate analysis of prognostic factors in the surgical treatment of hi- lar cholangiocarcinoma显示文摘 | Ramacciato G Nigri G Bellagamba P | 2010 | Am Surg2010，76，11： | 1 |
| 11 | Increase in AP-1 activity is a general event in thyroid cell transformation in vitro and in vivo显示文摘 | Battista S De Nigris F Fedele M | | 0，，03： | 1 |
| 12 | Therapeutic effects of concurrent autologous bone marrow cell infusion and metabolic intervention in ischemia-induced angiogenesis in the hypercholesterolemic mouse hindlimb显示文摘 | De Nigris F Williams-Ignarro S Sica V | 2007 | Int J Cardiol2007，117，2： | 1 |
| 13 | Hospital Volume, Margin Status, and Long-Term Survival after Pancreaticoduodenectomy for Pancreatic Adenocarcinoma显示文摘 | La Torre Marco Nigri Giuseppe Ferrari Linda Cosenza Giulia Ravaioli Matteo Ramacciato Giovanni | 2012 | EN2012，，2： | 1 |
| 14 | Meta-Analysis of Trials Comparing Minimally-Invasive and Open Liver Resections for Hepatocellular Carcinoma显示文摘 | Alessandro Fancellu Alan S. Rosman Valeria Sanna Giuseppe R. Nigri Luigi Zorcolo Michele Pisano Marcovalerio Melis | 2011 | Journal of Surgical Research2011，，1： | 1 |
| 15 | Photochemically modulated endothelial cell thrombogenicity via the thrombomodulintissue factor pathway显示文摘 | Fungaloi P Waterman P Nigri G | 2003 | American Society for Photobiology Journal2003，78，5： | 1 |
| 16 | Maintenance treatment of Crohn’s disease显示文摘 | L.Biancone C.Tosti D.Fina M.Fantini F.De Nigris A.Geremia F.Pallone | 2003 | Alimentary Pharmacology & Therapeutics2003，，： | 1 |
| 17 | Glycoxidation of low -density lipoprotein promotes multiple apoptotic pathways and NF - kB activation in human coronary cells 显示文摘 | de Nigris F Gallo L Sica V | 2006 | Basic Res Cardiol2006，101，2： | 1 |
| 18 | Oxidation-sensitive mecha- nisms,vascular apoptosis and atherosclerosis 显示文摘 | De Nigris F Lerman A Ignarro LJ | 2003 | Trends Mo! Med2003，9，8： | 1 |
| 19 | Minimally invasive adrenalectomy for incidentally discovered cavernous hemangioma显示文摘 | Giuseppe Nigri Riccardo Bellagamba Valentina Giaccaglia Francesco Felicioni Paolo Aurello Francesco D’Angelo Massimo Del Gaudio Giovanni Ramacciato | 2008 | Minimally Invasive Therapy & Allied Technologies2008，，4： | 1 |
| 20 | Cloning of the gene for ocular albi- nism type I from the distal short arm of the X chromosome显示文摘 | BASSI MT SCHIAFFINO MV RENIERI A De NIGRIS F GAL LI L BRUTTINI M | 1995 | Nat Genet1995，10，1： | 1 |
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