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| 1 | History of the infantile hepatic hemangioma:From imaging to generating a differential diagnosis显示文摘We aim to provide an up-to-date summary of infantile hepatic hemangioma(IHH) and its misnomers and to dialectically present the differential diagnosis of these rare entities of the liver.Eligible peer-reviewed articles on hepatic infantile hemangiomas,published between 2000 and 2015,were reviewed for this study.IHH is the most common hepatic vascular tumor in children.Once a liver mass is identified in an infant,the differential diagnosis ranges from vascular malformations to benign and malignant tumors including mesenchymal hamartoma,hepatoblastoma,metastatic neuroblastoma,so careful physical examination,imaging studies,and,if indicated,tumor markers and biopsy,are of pivotal importance to ascertain the correct diagnosis.Despite the benign nature of IHHs,some of these lesions may demand medical and/or surgical intervention,especially for multiple and diffuse IHH.Complications can include hepatomegaly,hypothyroidism and cardiac failure.Therefore,a close follow-up is required until complete involution of the lesions.We propose an algorithm to guide the physicians towards the proper management of hepatic lesions. | Maria Gnarra Gerald Behr Alison Kitajewski June K Wu Sudha A Anupindi Carrie J Shawber Nick Zavras Dimitrios Schizas Chris Salakos Konstantinos P Economopoulos | 2016 | World Journal of Clinical Pediatrics2016，5，3： | 27 |
| 2 | Systems biology approaches for studying the pathogenesis of non-alcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD) is a progressive disease of increasing public health concern.In western populations the disease has an estimated prevalence of 20%-40%,rising to 70%-90% in obese and type Ⅱ diabetic individuals.Simplistically,NAFLD is the macroscopic accumulation of lipid in the liver,and is viewed as the hepatic manifestation of the metabolic syndrome.However,the molecular mechanisms mediating both the initial development of steatosis and its progression through non-alcoholic steatohepatitis to debilitating and potentially fatal fibrosis and cirrhosis are only partially understood.Despite increased research in this field,the development of non-invasive clinical diagnostic tools and the discovery of novel therapeutic targets has been frustratingly slow.We note that,to date,NAFLD research has been dominated by in vivo experiments in animal models and human clinical studies.Systems biology tools and novel computational simulation techniques allow the study of large-scale metabolic networks and the impact of their dysregulation on health.Here we review current systems biology tools and discuss the benefits to their application to the study of NAFLD.We propose that a systems approach utilising novel in silico modelling and simulation techniques is key to a more comprehensive,better targeted NAFLD research strategy.Such an approach will accelerate the progress of research and vital translation into clinic. | Ciarán P Fisher Andrzej M Kierzek Nick J Plant J Bernadette Moore | 2014 | World Journal of Gastroenterology2014，20，41： | 2 |
| 3 | Mutifactorial analysis of risk factors for reduced bone mineral density in patients with Crohn’s disease显示文摘AIM: To determine the prevalence of osteoporosis in a cohort of patients with Crohn’s disease (CD) and to identify the relative significance of risk factors for osteoporosis. METHODS: Two hundred and fifty-eight unselected patients (92 M, 166 F) with CD were studied. Bone mineral density (BMD) was measured at the lumbar spine and hip by dual X-ray absorptiometry. Bone formation was assessed by measuring bone specific alkaline phosphatase (BSAP) and bone resorption by measuring urinary excretion of deoxypyridinoline (DPD) and N-telopeptide (NTX). RESULTS: Between 11.6%-13.6% patients were osteoporotic (T score < -2.5) at the lumbar spine and/or hip. NTX levels were significantly higher in the patients with osteoporosis (P < 0.05) but BSAP and DPD levels were not significantly different. Independent risk factors for osteoporosis at either the lumbar spine or hip were a low body mass index (P < 0.001), increasing corticosteroid use (P < 0.005), and male sex (P < 0.01). These factors combined accounted for 23% and 37% of the reduction in BMD at the lumbar spine and hip respectively. CONCLUSION: Our results confirm that osteoporosis is common in patients with CD and suggest that increased bone resorption is the mechanism responsible for thebone loss. However, less than half of the reduction in BMD can be attributed to risk factors such as corticosteroid use and low BMI and therefore remains unexplained. | Sarah A Bartram Robert T Peaston David J Rawlings David Walshaw Roger M Francis Nick P Thompson | 2006 | World Journal of Gastroenterology2006，12，35： | 2 |
| 4 | Activation Of a p38 mitogen-activated protein kinase in human neutrophils by lipopolysaccharide 显示文摘 | Nick JA Avdi N J Gerwins P | 1996 | J Immunol1996，156，12： | 1 |
| 5 | Avian encephalomyelitis virus is a picornavirus and is most closely related to hepatitis A virus显示文摘 | Marvil P Nick J | 1999 | Journal of General Virology1999，80，： | 1 |
| 6 | Activation of NADPH oxidase during progression of cardiac hypertrophy to failure显示文摘 | JIAN M L NICK P G DAVID J G | 2002 | Hypertension2002，40，4： | 1 |
| 7 | Liquid steel analysis by laser-induced emission spectroscopy显示文摘 | Carlhoff C Lorenzen C J Nick K P | 1989 | The International Society for Optical Engineering1989，1012，： | 1 |
| 8 | Bus priority using pre-signals显示文摘 | Wu J P Nick H | 1998 | Transportation Research Part A: Policy and Practice1998，32，8： | 1 |
| 9 | Selective supp ression of neutro2 phil accumulation in ongoing pulmonary inflammation by systemic inhibition of p38 mitogen2activated p rotein kinase 显示文摘 | NICK J A YOUNG S K AMDT P G | 2002 | J Immunol2002，169，9： | 1 |
| 10 | Selective suppression of neutrophil accumulation in ongoing pulmonary inflammation by systemic inhibition of p38 mitogen-activated protein kinase显示文摘 | Nick J A Young S K Arndt P G | 2002 | The Journal of Immunology2002，169，9： | 1 |
| 11 | FAHCT accreditation: common deficiencies during on-site inspections显示文摘 | Warkentin P I Nick L Shpall E J | 2000 | Cytothera- py2000，2，3： | 1 |
| 12 | Role of external signals in regulating the pre-penetration phase of infection by the rice blast fungus, Magnaporthe grisea显示文摘 | Till C J Helen A P Nick D R | 1994 | Planta1994，194，4： | 1 |
| 13 | lnvasive pneumococ- cal disease after routine pneumococc'al conjugate vaccination in chil- dren, England and Wales显示文摘 | Sham- N Ladhani Mary P E Slack Nick J Andrews Pauline A Waight Ray Borrow Elizabeth Miller | 2013 | Emerging infectious diseases2013，19，1： | 1 |
| 14 | Activation of a p38 mitogen-activated protein kinase in human neutrophils by lipopolysaccharide显示文摘 | NICK J A AVDI N J GERWINS P | 1996 | J Immunol1996，156，12： | 1 |
| 15 | Selective suppression of neutrophil accumulation in ongoing pulmonary inflammation by systemic inhibition of p38 mitogen-activated protein kinase显示文摘 | Nick J A Young S K Arndt P G | 2002 | The Journal of Immunology2002，169，9： | 1 |
| 16 | Activation of a p38 mitogen-activated protein kinase in human neutrophils by lipopolysaccharide显示文摘 | Nick J A Avdi N J Gerwins P | 1996 | J Immunol1996，156，： | 1 |
| 17 | Phytomining显示文摘 | BROOKS P R CHAMBERS M F NICKS L J | 1998 | Perspectives1998，3，9： | 1 |
| 18 | Actin is involved in auxin-dependent patterning 显示文摘 | Maiseh J Nick P | 2007 | Plant Physiology2007，143，4： | 1 |
| 19 | The Use of Touch in Counseling:An Ethical Decision-ma-king Model显示文摘 | Calmes S A Nick J P Laux J M | 2013 | Couns Values2013，4，58： | 1 |
| 20 | High temperature superconducting rotating machines for ship applications显示文摘 | Frank M Habelt P Kummeth P Massek P Nick W Rothfischer H Schmidt H Wacker B Neumüller H Nerowski G Frauenhofer J Hartig R Rzadki W | 2006 | IEEE Transactions on Applied Superconductivity2006，16，2： | 1 |
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