|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 亚洲地区肺炎支原体和肺炎衣原体在成人社区获得性肺炎中的流行病学研究显示文摘目的由Malaya大学医学中心牵头进行的非典型病原在亚洲社区获得性肺炎(CAP)患者中的流行病学研究。结果显示,肺炎支原体和肺炎衣原体分别占成人病原的11.4%和5.8%。本研究将对这2种病原所致感染的临床和实验室资料进一步总结分析。方法亚洲7个国家12个研究中心采用统一的检测方法(DNA检测及血清学方法)和判断标准,对16岁以上的CAP患者进行肺炎支原体和肺炎衣原体的检测。结果在急性肺部感染者中,肺炎支原体和肺炎衣原体肺炎的临床表现与其他病原所致者非常相似,并无特征性。肺炎支原体和肺炎衣原体在男性和女性中检出率相仿,但肺炎支原体感染在16至44岁患者中更为多见(22.2%),而肺炎衣原体感染者重症患者相对较多。88例在病程中血清抗体显著增高的肺炎支原体感染者中,48例(54.5%)患者急性期抗体阴性,如果未检测恢复期血清抗体,上述患者则会漏诊;51例肺炎衣原体感染者中急性期血清抗体阴性则较为少见(21.6%)。肺炎支原体和肺炎衣原体既往感染和(或)病原携带率分别为5.7%和7.9%。结论肺炎支原体肺炎和肺炎衣原体肺炎发病率高,诊断困难,因此在亚洲成人CAP抗感染经验治疗时宜选用对这2种病原亦有效的药物。 | 黄海辉 张婴元 汪复 Mediadora SANIEL Marissa ALEJANDRIA Seung-Chul PARK 刘又宁 Po-Ren HSUEH Ahmad M. AZIAH Wing-Hong SETO Cecilia C. L. NGAN Mangunnegoro HADIARTO Subharee SUWANJUTHA Yun-Fong NGEOW Alsagaff HOOD | 2008 | 中国感染与化疗杂志2008，8，2： | 67 |
| 2 | Hereditary diffuse gastric cancer: What the clinician should know显示文摘Hereditary diffuse gastric cancer(HDGC) is an inherited autosomal dominant syndrome with a penetrance of up to 80% affecting diverse geographic populations. While it has been shown to be caused mainly by germline alterations in the E-cadherin gene(CDH1), problematically, the genetic diagnosis remains unknown in up to 60% of patients. Given the important knowledge gaps regarding the syndrome, asymptomatic carriers of CDH1 mutations are advised for a prophylactic total gastrectomy. Intensive annual endoscopic surveillance is the alternative for carriers who decline gastrectomy. As HDGCs have a prolonged indolent phase, this provides a window of opportunity for surveillance and treatment. Recent findings of other gene defects in CTNNA1 and MAP3K6, as well as further characterization of CDH1 mutations and their pathogenicity will change the way HDGC patients are counselled for screening, surveillance and treatment. This review will bring the reader up to date with these changes and discuss future directions for research; namely more accurate risk stratification and surveillance methods to improve clinical care of HDGC patients. | Ryan Ying Cong Tan Joanne Ngeow | 2015 | World Journal of Gastrointestinal Oncology2015，7，9： | 5 |
| 3 | Clinical and molecular characteristics of East Asian patients with von Hippel–Lindau syndrome显示文摘Background: Von Hippel–Lindau(VHL) syndrome is a dominantly inherited multisystem cancer syndrome caused by a heterozygous mutation in the VHL tumor suppressor gene. Previous studies suggested that similar populations of Caucasian and Japanese patients have similar genotype or phenotype characteristics. In this comprehensive study of East Asian patients, we investigated the genetic and clinical characteristics of patients with VHL syndrome.Methods: To create a registry of clinical characteristics and mutations reported in East Asian patients with VHL syndrome, we conducted a comprehensive review of English language and non?English language articles identi?fied through a literature search. Publications in Japanese or Chinese language were read by native speakers of the language, who then performed the data extraction.Results: Of 237 East Asian patients with VHL syndrome, 154 unique kindreds were identified for analysis. Analyzed by kindred, missense mutations were the most common(40.9%, 63/154), followed by large/complete deletions(32.5%, 50/154) and nonsense mutations(11.7%, 18/154). Compared with a previously reported study of both East Asian and non?East Asian patients, we found several key differences. First, missense and frameshift mutations in the VHL gene occurred less commonly in our population of East Asian patients(40.9% vs. 52.0%; P = 0.012 and 8.4% vs. 13.0%; P < 0.001, respectively). Second, large/complete deletions were more common in our population of East Asian patients(32.5% vs. 10.5%; P < 0.001). Third, phenotypically, we observed that, in our population of East Asian patients with VHL syndrome, the incidence of retinal capillary hemangioblastoma was lower, whereas the incidence of renal cell carcinoma was higher.Conclusions: Evidence suggests that the genotypic and phenotypic characteristics of East Asian patients with VHL syndrome differ from other populations. This should be considered when making screening recommendations for VHL syndrome in Asia. | Meihua Wong Ying-Hsia Chu Hwei Ling Tan Hideharu Bessho Joanne Ngeow Tiffany Tang Min-Han Tan | 2016 | Chinese Journal of Cancer2016，35，9： | 3 |
| 4 | An Asian study on the prevalence of atypical respiratory pathogens in community-acquired pneumonia显示文摘 | Ngeow YF Suwanjutha S Chantarojanasriri T | | 0，，03： | 1 |
| 5 | Gaining access through a calcifiedpulp chamber: a clinical challenge 显示文摘 | Ngeow WC Thong YL | 1998 | Int Endod J1998，31，5： | 1 |
| 6 | High SUV uptake on FDG-PET/CT predicts for an aggressive B-cell lymphoma in a prospective study of primary FDG-PET/CT staging in lymphoma显示文摘 | Ngeow JY Quek RH Ng DC | 2009 | Ann Oncol2009，20，： | 1 |
| 7 | An Asian study on the prevalence of atypical respiratory pathogens in community-acquired pneumoniae 显示文摘 | Ngeow YF Suwanjutha S Chantarojanasriri T ct al | 2005 | Int J Infect Dis2005，9，： | 1 |
| 8 | Antimicrobial activities of malaysian plant species 显示文摘 | CHUNG P Y CHUNG L Y NGEOW Y F | 2004 | Pharm Biology2004，42，45： | 1 |
| 9 | Scar less:a review of methods of scar reduction at sites ofperipheral nerve repair显示文摘 | Ngeow WC | 2010 | Oral Surg Oral Med Oral Pathol Oral Ra-diol Endod2010，3，： | 1 |
| 10 | An asianstudyon the prevalence of atririy pical respiratory pathogens ncommunity-ac- quired pneumonia显示文摘 | Ngeow YF Suwan JS Chantar OT | 2005 | Int J Infect Dis2005，9，2： | 1 |
| 11 | An Asian study on the prevalence of a typical respiratory pathogens in community-acquired pneumonia 显示文摘 | Ngeow YF Suwanjutha S Chantarojanasriri T | 2005 | Int J Infect Dis2005，9，： | 1 |
| 12 | Scar less: a review of methods of scar reduction at sites of peripheral nerve repair 显示文摘 | Ngeow W C | 2010 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2010，109，3： | 1 |
| 13 | Second hematologic malignanciesafter ABVD: two case reports and a retrospective study of 183Hodgkin lymphoma patients 显示文摘 | Leong C Ngeow J Tan I | 2010 | Acta Oncoi2010，49，2： | 1 |
| 14 | An asian study on the prevalence of atypical respiratory pathogens in community-acquired pneumonia显示文摘 | Ngeow YF Suwanjutha S Chantarojanasriri T | 2005 | Int J Infect Dis2005，9，3： | 1 |
| 15 | The First NHeterocyclic Carbene-based Nickel Catalyst for C-S Coupling显示文摘 | ZHANG Y NGEOW K N YING J Y | 2007 | Org Lett2007，9，18： | 1 |
| 16 | An asian study on the prevalence of atypical respiratory pathogens in community-acquired pneumonia显示文摘 | Ngeow YF Suwanjutha S Chantarojanasriri T | 2005 | Int J Infect Dis2005，9，3： | 1 |
| 17 | An Asian study onthe prevalence of a typical respiratory pathogens in communityacquired pneumonia显示文摘 | Ngeow YF Suwanjutha S Chantarojanasriri T | 2005 | Int J Infect Dis2005，9，： | 1 |
| 18 | An Asian study on the prevalence of atypical respiratory pathogens in community acquired pneumonia显示文摘 | Ngeow YF Suwanjutha S Chantarojanasriri T | 2005 | Int J Infect Dis2005，9，： | 1 |
| 19 | High SUV uptake on FDG-PET/CT predicts for an aggressive B-cell lymphoma in a prospective study of primary FDG-PET/CT staging in lymphoma 显示文摘 | Ngeow J Y Quek R H Ng D C | 2009 | Ann 0ncol2009，20，9： | 1 |
| 20 | The First N-Heterocyclic Carbene-based Nickel Catalyst for C-S Coupling显示文摘 | ZHANG Y NGEOW K N YING J Y | 2007 | Org Lett2007，9，18： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员