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| 1 | A high methionine,low folate and vitamin B_6/B_(12) containing diet can be associated with memory loss by epigenetic silencing of netrin-1显示文摘Memory-epigenetics which is the loss of memory due to epigenetic modifications can be due to the silencing of genes involved in cognitive functions and this is the basis of the current study.We hypothesize that a diet containing high methionine and low vitamins can lead to memory impairment by increasing global DNA methylation and therefore,silencing the netrin-1 gene,which encodes the glycoprotein involved in neurogenesis,axonal guidance and maintenance of the synaptic plasticity.Wild type(C57 BL/6 J) mice were fed with a diet containing excess methionine(1.2%),low-folate(0.08 mg/kg),vitamin B_6(0.01 mg/kg),and B_(12)(10.4 mg/kg) for 6 weeks.Mice were examined weekly for the long-term memory function,using a passive avoidance test,which determined loss of fear-motivated long-term memory starting from the fourth week of diet.Similarly,an increase in brain %5-methyl cytosine was observed starting from the 4 th week of diet in mice.Mice fed with a high methionine,low folate and vitamins containing diet showed a decrease in netrin-1 protein expression and an increase in netrin-1 gene promotor methylation,as determined by methylation-sensitive restriction enzyme-polymerase chain reaction analysis.The increase in methylation of netrin-1 gene was validated by high-resolution melting and sequencing analysis.Furthermore,the association of netrin-1 with memory was established by administering netrin that considerably restored long-term fear motivated memory.Taken together,these results suggest that a diet rich in methionine and lacking in folate and vitamin B_6/B_(12) can induce defects in learning and memory.Furthermore,the data indicates that decrease in netrin-1 expression due to hyper-methylation of its gene can be associated with memory loss.The animal procedures were approved by the Institutional Animal Care and Use Committee,University of Louisville,USA(No.A3586-01) on February 2,2018. | Anuradha Kalani Pankaj Chaturvedi Komal Kalani Pradip K.Kamat Poonam Chaturvedi Neetu Tyagi | 2019 | Neural Regeneration Research2019，14，7： | 4 |
| 2 | Exosomes in neurological disease, neuroprotection, repair and therapeutics: problems and perspectives显示文摘Exosomes:Exosomes are a sub-population of micro-vesicles ranging from 40–100 nm that were earlier thought as artefacts under electron microscope.They recently came into attention for their storage of biological information,cell-to-cell communication,serving as biomarkers and potential use in | Anuradha Kalani Neetu Tyagi | 2015 | Neural Regeneration Research2015，10，10： | 3 |
| 3 | Homocysteine alters cerebral microvascular integrity and causes remodeling by antagonizing GABA-A receptor显示文摘 | David Lominadze Neetu Tyagi Utpal Sen Alexander Ovechkin Suresh C. Tyagi | 2012 | Molecular and Cellular Biochemistry2012，，1： | 2 |
| 4 | Hydrogen sulfide protects against vascular remodeling from endothelial damage显示文摘 | Thomas P. Vacek William Gillespie Neetu Tyagi Jonathan C. Vacek Suresh C. Tyagi | 2010 | Amino Acids2010，，5： | 1 |
| 5 | Homocysteine to Hydrogen Sulfide or Hypertension显示文摘 | Utpal Sen Paras K. Mishra Neetu Tyagi Suresh C. Tyagi | 2010 | Cell Biochemistry and Biophysics2010，，2： | 1 |
| 6 | GABAA mitigates homocysteine-induced cerebrovascular remodeling in knockout mice 显示文摘 | Munish Kumar Neetu receptor agomst Tyagi Karni S | 2008 | Brain Res2008，1221，： | 1 |
| 7 | KLaF 4 :Er an efficient upconversion phosphor显示文摘 | Neetu Tyagi A. Amarnath Reddy R. Nagarajan | 2010 | Optical Materials2010，，1： | 1 |
| 8 | Homocysteine alters cerebral microvascular integrity and causes remodeling by antagonizing GABA-A receptor显示文摘 | David Lominadze Neetu Tyagi Utpal Sen | 2012 | Mol Cell Biochemt2012，371，12： | 1 |
| 9 | Hydrogen sulfide protects against vascular remodeling from endothelial damage显示文摘 | Thomas P. Vacek William Gillespie Neetu Tyagi Jonathan C. Vacek Suresh C. Tyagi | 2010 | Amino Acids2010，，5： | 1 |
| 10 | Astrocyte mediated MMP-9 activation in the synapse dysfunction: An implication in Alzheimer disease显示文摘 | Pradip K Kamat Supriya Swarnkar Shivika Rai Vijay Kumar Neetu Tyagi | 2014 | Therapeutic Targets for Neurological Diseases2014，，： | 1 |
| 11 | Renal mitochondrial damage and protein modification in type-2 diabetes显示文摘 | Ganesh K. Kartha Karni S. Moshal Utpal Sen Irving G. Joshua Neetu Tyagi Mesia M. Steed Suresh C. Tyagi | 2008 | Acta Diabetologica2008，，2： | 1 |
| 12 | Homocysteine-mediated activation and mitochondrial translocation of calpain regulates MMP-9 in MVEC显示文摘 | Karn: S Moshal Singh Mahavir Sen Utpal Rosenberger Dorothea Susanne E Henderson Brooke Tyagi Neetu Zhang Hong Tyagi Suresh C | 2006 | Amer J Physiology-HeartCirculat Physio12006，291，6： | 1 |
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