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5篇 您的检索式:作者名="Neal Rosen"
    题名 作者 年代 出处 被引量
1Targeted cancer therapies显示文摘With unprecedented understanding of molecular events underlying human cancer in this genomic era, a large number of drugs specifically targeting hypothesized oncogenic drivers to which tumors are potentially addicted to have been developed and continue to be developed. These targeted cancer therapies are being actively tested in clinical trials with mixed successes. This editorial provides an overview on successful targeted cancer drugs on the market and those drugs that are in late clinical development stages. Importantly, the article lays out main challenges in developing molecular targeted therapies and potential path forward to overcome these challenges, as well as opportunities for China in this new era of targeted agents. The editorial serves as an introduction to the Targeted Cancer Therapies series that will review in depth of major pathways and drugs targeting these pathways to be published in the coming issues of the Chinese Journal of Cancer.Li Yan Neal Rosen Carlos Arteaga 2011Chinese Journal of Cancer2011,30,1:3
217AAG:Low target binding affinity and potent cell activity - finding an explanation 显示文摘Gabriela Chiosis Henri Huezo Neal Rosen 2003Mol Cancer Ther2003,2,:1
3AKT Inhibition Relieves Feedback Suppression of Receptor Tyrosine Kinase Expression and Activity显示文摘Sarat Chandarlapaty Ayana Sawai Maurizio Scaltriti Vanessa Rodrik-Outmezguine Olivera Grbovic-Huezo Violeta Serra Pradip K. Majumder Jose Baselga Neal Rosen 2011Cancer Cell2011,,1:1
4Reciprocal Feedback Regulation of PI3K and Androgen Receptor Signaling in PTEN-Deficient Prostate Cancer显示文摘Brett S. Carver Caren Chapinski John Wongvipat Haley Hieronymus Yu Chen Sarat Chandarlapaty Vivek K. Arora Carl Le Jason Koutcher Howard Scher Peter T. Scardino Neal Rosen Charles L. Sawyers 2011Cancer Cell2011,,5:1
5An Acetylation Site in the Middle Domain of Hsp90 Regulates Chaperone Function显示文摘Bradley T. Scroggins Kenneth Robzyk Dongxia Wang Monica G. Marcu Shinji Tsutsumi Kristin Beebe Robert J. Cotter Sara Felts David Toft Larry Karnitz Neal Rosen Len Neckers 2007Molecular Cell2007,,:1
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