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| 1 | Short-and long-term results of endoscopic ultrasoundguided transmural drainage for pancreatic pseudocysts and walled-off necrosis显示文摘AIM To evaluate the short-and long-term results of endoscopic ultrasound-guided transmural drainage(EUS-GTD) for pancreatic fluid collection(PFC) and identify the predictive factors of treatment outcome for walled-off necrosis(WON) managed by EUS-GTD alone.METHODS We investigated 103 consecutive patients with PFC who underwent EUS-GTD between September 1999 and August 2015. Patients were divided into four groups as follows: WON(n = 40), pancreatic pseudocyst(PPC; n = 11), chronic pseudocyst(n = 33), and others(n = 19). We evaluated the short-and long-term outcomes of the treatment. In cases of WON, multiple logistic regression analyses were performed to identify the predictor variables associated with the treatment success. In addition, PFC recurrence was examined in patients followed up for more than 6 mo and internal stent removal after successful EUS-GTD was confirmed.RESULTS In this study, the total technical success rate was 96.1%. The treatment success rate of WON, PPC, chronic pseudocyst, and others was 57.5%, 90.9%, 91.0%, and 89.5%, respectively. Contrast-enhanced computed tomography using the multivariate logistic regression analysis revealed that the treatment success rate of WON was significantly lower in patients with more than 50% pancreatic parenchymal necrosis(OR = 17.0; 95%CI: 1.9-150.7; P = 0.011) and in patients with more than 150 mm of PFC(OR = 27.9; 95%CI: 3.4-227.7; P = 0.002).The recurrence of PFC in the long term was 13.3%(median observation time, 38.8 mo). Mean amylase level in the cavity was significantly higher in the recurrence group than in the no recurrence group(P = 0.02).CONCLUSION The reduction of WON by EUS-GTD alone was associated with the proportion of necrotic tissue and extent of the cavity. The amylase level in the cavity may be a predictive factor for recurrence of PFC. | Yuto Watanabe Rintaro Mikata Shin Yasui Hiroshi Ohyama Harutoshi Sugiyama Yuji Sakai Toshio Tsuyuguchi Naoya Kato | 2017 | World Journal of Gastroenterology2017，23，39： | 7 |
| 2 | Interleukin-1β gene polymorphisms associated with hepatocellular carcinoma in hepatitis C virus infection显示文摘 | Yue Wang Naoya Kato Yujin Hoshida Hideo Yoshida Hiroyoshi Taniguchi Tadashi Goto Masaru Moriyama Motoyuki Otsuka Shuichiro Shiina Yasushi Shiratori Yoichi Ito Masao Omata | 2003 | Hepatology2003，，： | 3 |
| 3 | Current status of diagnosis and therapy for intraductal papillary neoplasm of the bile duct显示文摘Bile duct epithelial tumours showing papillary neoplasm in the bile duct lumen are present in the intrahepatic and extrahepatic bile ducts.Clinicopathological images of these tumours are distinctive and diverse,including histological images with a low to high grade dysplasia,infiltrating and noninfiltrating characteristics,excessive mucus production,and similarity to intraductal papillary mucinous neoplasm(IPMN)of the pancreas.The World Health Organization Classification of Tumours of the Digestive System in 2010 named these features,intraductal papillary neoplasm of the bile duct(IPNB),as precancerous lesion of biliary carcinoma.IPNB is currently classified into type 1 that is similar to IPMN,and type 2 that is not similar to IPMN.Many of IPNB spreads superficially,and diagnosis with cholangioscopy is considered mandatory to identify accurate localization and progression.Prognosis of IPNB is said to be better than normal bile duct cancer. | Yuji Sakai Masayuki Ohtsuka Harutoshi Sugiyama Rintaro Mikata Shin Yasui Izumi Ohno Yotaro Iino Jun Kato Toshio Tsuyuguchi Naoya Kato | 2021 | World Journal of Gastroenterology2021，27，15： | 3 |
| 4 | Hepatic gene expression profiles associated with fibrosis progression and hepatocarcinogenesis in hepatitis C patients显示文摘AIM: To determine fibrosis progression and hepatocellular carcinoma (HCC), using simultaneous gene expression analysis.METHODS: Total RNA samples were extracted from liver biopsies from 19 patients with hepatitis C virus (HCV)infection and 3 patients without HCV infection. Among the 19 HCV-infected patients, 7 and 12 patients had grade F1-2 and F3-4 fibrosis, respectively. Of the 12 patients with F3-4 fibrosis, 8 had HCC. Gene expression in the liver samples was determined using an oligonucleotide microarray. The following comparisons were performed:normal livers vs HCV-infected livers; F1-2 vs F3-4; and F3-4 with HCC vs F3-4 without HCC. Genes that were differentially expressed between these groups were identified based on signal-to-noise ratios.RESULTS: In the HCV-infected livers, genes involved in immune responses were highly expressed. Expression levels of genes for plasma proteins and drug-metabolizing enzymes were decreased and those of genes involved in the cell cycle and oncogenesis were increased in the F3-4 cases as compared to the F1-2 cases. Among the F3-4 cases, genes involved in carbohydrate metabolism tended to be more highly expressed in patients with HCC than in patients without HCC.CONCLUSION: We identified genes that are associated with fibrosis progression and hepatocarcinogenesis. This information may be used to detect increased carcinogenic potential in the livers of patients with HCV infection. | Yujin Hoshida Motoyuki Otsuka Naoya Kato Ryosuke Tateishi Takuma Teratani Shuichiro Shiina Hiroyoshi Taniguchi Masaru Moriyama Takao Kawabe Masao Omata | 2005 | World Journal of Gastroenterology2005，11，13： | 2 |
| 5 | Prospective risk assessment for hepatocellular carcinoma development in patients with chronic hepatitis C by transient elastography显示文摘 | Ryota Masuzaki Ryosuke Tateishi Haruhiko Yoshida Eriko Goto Takahisa Sato Takamasa Ohki Jun Imamura Tadashi Goto Fumihiko Kanai Naoya Kato Hitoshi Ikeda Shuichiro Shiina Takao Kawabe Masao Omata | 2009 | Hepatology2009，，： | 2 |
| 6 | Hepatitis C virus-associated hepatocellular carcinoma after sustained virologic response显示文摘The introduction of a direct-acting antiviral(DAA) for patients with hepatitis C virus(HCV) infection, could lead to higher sustained virologic response(SVR)rates with fewer adverse events, and it could shorten the treatment duration relative to the interferon era. Although most recent clinical studies have demonstrated that the occurrence rates of hepatocellular carcinoma(HCC) are decreased by SVR with both interferon-based and interferon-free-regimens, there are several reports about the unexpected observation of high rates of early tumor occurrence and recurrence in patients with HCV-related HCC undergoing interferon-free therapy despite SVR. Several mechanisms of HCC occurrence and rapid immunological changes, including cytokines and chemokines during and after DAA treatment, have also been reported. We focused on the possibilities that HCC occurs or recurs during and after DAA treatment, based on the reported clinical and basic studies. Further studies and observations will be needed to determine the short-term and long-term effects on hepatocarcinogenesis caused by the eradication of HCV with DAAs. New serum biomarkers and a follow-up system for HCV-patients with SVR should be established. | Reina Sasaki Tatsuo Kanda Naoya Kato Osamu Yokosuka Mitsuhiko Moriyama | 2018 | World Journal of Hepatology2018，10，12： | 2 |
| 7 | Add‐on therapy of pitavastatin and eicosapentaenoic acid improves outcome of peginterferon plus ribavirin treatment for chronic hepatitis C显示文摘 | Motoyuki Kohjima Munechika Enjoji Tsuyoshi Yoshimoto Ryoko Yada Tatsuya Fujino Yoko Aoyagi Nobuyoshi Fukushima Kunitaka Fukuizumi Naohiko Harada Masayoshi Yada Masaki Kato Kazuhiro Kotoh Manabu Nakashima Naoya Sakamoto Yasuhito Tanaka Makoto Nakamuta | 2012 | Virol2012，，2： | 1 |
| 8 | Ultrasound surveillance for early detection of hepatocellular carcinoma among patients with chronic hepatitis C显示文摘 | Takahisa Sato Ryosuke Tateishi Haruhiko Yoshida Takamasa Ohki Ryota Masuzaki Jun Imamura Tadashi Goto Fumihiko Kanai Shuntaro Obi Naoya Kato Shuichiro Shiina Takao Kawabe Masao Omata | 2009 | Hepatology International2009，，4： | 1 |
| 9 | Ultrasound surveillance for early detection of hepatocellular carcinoma among patients with chronic hepatitis C显示文摘 | Takahisa Sato Ryosuke Tateishi Haruhiko Yoshida Takamasa Ohki Ryota Masuzaki Jun Imamura Tadashi Goto Fumihiko Kanai Shuntaro Obi Naoya Kato Shuichiro Shiina Takao Kawabe Masao Omata | 2009 | Hepatology International2009，，4： | 1 |
| 10 | Interleukin-1 beta gene polymorphisms associated with hepatocellular carcinoma in hepatitis C virus infection显示文摘 | YUE WANG NAOYA KATO YUJIN HOSHIDA | 2003 | Hepatology2003，1，： | 1 |
| 11 | Interleukin-1β gene polymorphisms associated with hepatocellular carcinoma in hepatitis C virus infection显示文摘 | Yue Wang Naoya Kato Yujin Hoshida Hideo Yoshida Hiroyoshi Taniguchi Tadashi Goto Masaru Moriyama Motoyuki Otsuka Shuichiro Shiina Yasushi Shiratori Yoichi Ito Masao Omata | 2003 | Hepatology2003，，1： | 1 |
| 12 | Interferon- beta is activated by hepatitis C virus NS5B and inhibited by NS4A, NS4B, and NS5A 显示文摘 | Masaru Moriyama Naoya Kato Motoyuki Otsuka | 2007 | Hepatology International2007，1，2： | 1 |
| 13 | Hepatitis C Virus Core Protein Is a Potent Inhibitor of RNA Silencing-Based Antiviral Response显示文摘 | Yue Wang Naoya Kato Amarsanaa Jazag Narayan Dharel Motoyuki Otsuka Hiroyoshi Taniguchi Takao Kawabe Masao Omata | 2006 | Gastroenterology2006，，3： | 1 |
| 14 | Interleukin-1β gene polymorphisms associated with hepatocellular carcinoma in hepatitis C virus infection显示文摘 | Yue Wang Naoya Kato Yujin Hoshida Hideo Yoshida Hiroyoshi Taniguchi Tadashi Goto Masaru Moriyama Motoyuki Otsuka Shuichiro Shiina Yasushi Shiratori Yoichi Ito Masao Omata | 2003 | Hepatology2003，，1： | 1 |
| 15 | Preliminary study of automatic gastric cancer risk classification from photofluorography显示文摘AIM To perform automatic gastric cancer risk classificationusing photofluorography for realizing effective mass screening as a preliminary study. METHODS We used data for 2100 subjects including X-ray images, pepsinogen Ⅰ and Ⅱ levels, PGⅠ/PGⅡ ratio, Helicobacter pylori (H. pylori) antibody, H. pylori eradication history and interview sheets. We performed two-stage classification with our system. In the first stage, H. pylori infection status classification was performed, and H. pylori-infected subjects were automatically detected. In the second stage, we performed atrophic level classification to validate the effectiveness of our system.RESULTS Sensitivity, specificity and Youden index(YI) of H. pylori infection status classification were 0.884, 0.895 and 0.779, respectively, in the first stage. In the second stage, sensitivity, specificity and YI of atrophic level classification for H. pylori-infected subjects were 0.777, 0.824 and 0.601, respectively. CONCLUSION Although further improvements of the system are needed, experimental results indicated the effectiveness of machine learning techniques for estimation of gastric cancer risk. | Ren Togo Kenta Ishihara Katsuhiro Mabe Harufumi Oizumi Takahiro Ogawa Mototsugu Kato Naoya Sakamoto Shigemi Nakajima Masahiro Asaka Miki Haseyama | 2018 | World Journal of Gastrointestinal Oncology2018，10，2： | 1 |
| 16 | Add‐on therapy of pitavastatin and eicosapentaenoic acid improves outcome of peginterferon plus ribavirin treatment for chronic hepatitis C显示文摘 | Motoyuki Kohjima Munechika Enjoji Tsuyoshi Yoshimoto Ryoko Yada Tatsuya Fujino Yoko Aoyagi Nobuyoshi Fukushima Kunitaka Fukuizumi Naohiko Harada Masayoshi Yada Masaki Kato Kazuhiro Kotoh Manabu Nakashima Naoya Sakamoto Yasuhito Tanaka Makoto Nakamuta | 2012 | J. Med. Virol2012，，2： | 1 |
| 17 | A simple combination of serum type collagenⅣ and prothrombin time to diagnose cirrhosis in patients with chronic active hepatitis C显示文摘 | Yi Qiu Yujin Hoshida Naoya Kato | 2004 | Hepatology Research2004，30，： | 1 |
| 18 | Nucleotide change of codon 38 in the X gene of hepatitis B virus genotype C is associated with an increased risk of hepatocellular carcinoma显示文摘 | Ryosuke Muroyama Naoya Kato Haruhiko Yoshida Motoyuki Otsuka Masaru Moriyama Yue Wang Run-Xuan Shao Narayan Dharel Yasuo Tanaka Miki Ohta Ryosuke Tateishi Shuichiro Shiina Masashi Tatsukawa Kenichi Fukai Fumio Imazeki Osamu Yokosuka Yasushi Shiratori Masa | 2006 | Journal of Hepatology2006，，6： | 1 |
| 19 | Noncompaction of the ventricular myocardium mimicking ischemic cardiomyopathy显示文摘 | Naoya Matsumoto Yuichi Sato Taeko Kunimasa Shinro Matsuo Masahiko Kato Shunichi Yoda Yasuyuki Suzuki Shigemasa Tani Motoichiro Takahashi Satoshi Saito | 2006 | Annals of Nuclear Medicine2006，，9： | 1 |
| 20 | Recent advances in hepatitis C virus research显示文摘 | Masao Omata Naoya Kato | 1994 | Journal of Gastroenterology1994，，3： | 1 |
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