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| 1 | A case of eosinophilic cholangitis:Imaging findings ofcontrast-enhanced ultrasonography, cholangioscopy, andintraductal ultrasonography显示文摘A 38-year-old woman was referred to our institution due to epigastralgia. She presented with obstructive jaundice and eosinophilia. Endoscopic retrograde cholangiopancreatography showed diffuse narrowing from the distal common bile duct to the bifurcation of the hepatic ducts. An endoscopic plastic biliary stent was inserted; the specimen obtained from the common bile duct wall revealed dense infiltration by eosinophils. Treatment was started with prednisolone 60 mg daily. The patient's biliary stenosis and eosinophilia gradually improved. Eosinophilic infiltration in the lungs or stomach is relatively common, but it is rare in the common bile duct. Most of the reported cases of eosinophilic cholangitis presented with eosinophilia; our patient's eosinophil count was over 1000/mm3. Since our patient had allergies to pollen and house dust, a relationship between the allergies and the eosinophilic cholangitis was suspected, but no cause was identified. | Naoki Matsumoto Kiyoshi Yokoyama Kazuhiko Nakai Toshiki Yamamoto Takeshi Otani Masahiro Ogawa Naohide Tanaka Ariyoshi Iwasaki Yasuyuki Arakawa Masahiko Sugitani | 2007 | World Journal of Gastroenterology2007，13，13： | 3 |
| 2 | Histopathology of type C liver disease for determining hepatocellular carcinoma risk factors显示文摘AIM:To evaluate the histopathological findings of type C liver disease to determine risk factors for development of hepatocellular carcinoma(HCC).METHODS:We studied 232 patients,who underwent liver biopsy for type C chronic liver disease between 1992 and 2009,with sustained virological response(SVR)after interferon therapy.The patients were divided into two groups according to the F stage 0+1+2 group(n = 182)and F3+4 group(n = 50).We prospectively observed and compared the incidence of HCC of the patients with SVR in the F0+1+2 and F3+4 groups.Then,the background factors and liver histopathological findings,including the degree of fibrosis,F stage,inflammation,necrosis,bile duct obstruction,fat deposition,and degree of irregular regeneration(IR)of hepatocytes,were correlated with the risk of developing HCC.RESULTS:HCC developed in three of 182(1.6%)patients in the F0+1+2 group,and four of 50(8.0%)in the F3+4 group.The cumulative incidence of HCC in the former group was found to be significantly lower than in the F3+4 group(log rank test P = 0.0224).The presence of atypical hepatocytes among IR of hepatocytes in the F3+4 group resulted in a higher cumulative incidence of HCC,and was significantly correlated with risk of HCC development(RR = 20.748,95%CI:1.335-322.5,P = 0.0303).CONCLUSION:Atypical hepatocytes among the histopathological findings of type C liver disease may be an important risk factor for HCC development along with progression of liver fibrosis. | Hiroshi Matsumura Kazushige Nirei Hitomi Nakamura Teruhisa Higuchi Yasuo Arakawa Masahiro Ogawa Naohide Tanaka Mitsuhiko Moriyama | 2013 | World Journal of Gastroenterology2013，19，30： | 3 |
| 3 | Influence of Occult Hepatitis B Virus Coinfection on the Incidence of Fibrosis and Hepatocellular Carcinoma in Chronic Hepatitis C显示文摘 | Matsuoka Shunichi Nirei Kazushige Tamura Akinori Nakamura Hitomi Matsumura Hiroshi Oshiro Shuu Arakawa Yasuo Yamagami Hiroaki Tanaka Naohide Moriyama Mitsuhiko | 2009 | Intervirology2009，，5： | 1 |
| 4 | Influence of Occult Hepatitis B Virus Coinfection on the Incidence of Fibrosis and Hepatocellular Carcinoma in Chronic Hepatitis C显示文摘 | Matsuoka Shunichi Nirei Kazushige Tamura Akinori Nakamura Hitomi Matsumura Hiroshi Oshiro Shuu Arakawa Yasuo Yamagami Hiroaki Tanaka Naohide Moriyama Mitsuhiko | 2009 | Intervirology2009，，5： | 1 |
| 5 | Detection of serum and intrahepatic hepatocyte growth factor during DEN-induced carcinogenesis in the rat显示文摘 | Hitoshi Okubo Mitsuhiko Moriyama Naohide Tanaka Yasuyuki Arakawa | 2002 | Hepatology Research2002，，4： | 1 |
| 6 | White matter activated glial cells produce BDNF in a stroke model of monkeys显示文摘 | Yuki Sato Yo Chin Tomomasa Kato Yuichi Tanaka Yusuke Tozuka Mitsuhito Mase Naohide Ageyama Fumiko Ono Keiji Terao Yasuhiro Yoshikawa Tatsuhiro Hisatsune | 2009 | Neuroscience Research2009，，1： | 1 |
| 7 | Helicobacter pylori infection influences expression of genes related to angiogenesis and invasion in human gastric carcinoma cells显示文摘 | Yasuhiko Kitadai Atsunori Sasaki Masanori Ito Shinji Tanaka Naohide Oue Wataru Yasui Miki Aihara Kenichi Imagawa Ken Haruma Kazuaki Chayama | 2003 | Biochemical and Biophysical Research Communications2003，，4： | 1 |
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