|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A phase 3,double-blind,randomized placebo-controlled efficacy and safety study of abiraterone acetate in chemotherapynaı¨ve patients with mCRPC in China,Malaysia,Thailand and Russia显示文摘Objective:This double-blind,placebo-controlled phase 3 study was designed to compare efficacy and safety of abiraterone acetate+prednisone(abiraterone)to prednisone alone in chemotherapy-naı¨ve,asymptomatic or mildly symptomatic metastatic castrationresistant prostate cancer(mCRPC)patients from China,Malaysia,Thailand and Russia.Methods:Adult chemotherapy-naı¨ve patients with confirmed prostate adenocarcinoma,Eastern Cooperative Oncology Group(ECOG)performance status(PS)grade 0e1,ongoing androgen deprivation(serum testosterone<50 ng/dL)with prostate specific antigen(PSA)or radiographic progression were randomized to receive abiraterone acetate(1000 mg,QD)t prednisone(5 mg,BID)or placebo t prednisone(5 mg,BID),until disease progression,unacceptable toxicity or consent withdrawal.Primary endpoint was improvements in time to PSA progression(TTPP).Results:Totally,313 patients were randomized(abiraterone:n Z 157;prednisone:n Z 156);and baseline characteristics were balanced.At clinical cut-off(median follow-up time:3.9 months),80% patients received treatment(abiraterone:n Z 138,prednisone:n Z 112).Median time to PSA progression was not reached with abiraterone versus 3.8 months for prednisone,attaining 58%reduction in PSA progression risk(HR=0.418;p<0.0001).Abirateronetreated patients had higher confirmed PSA response rate(50%vs.21%;relative odds=2.4;p<0.0001)and were 5 times more likely to achieve radiographic response than prednisonetreated patients(22.9%vs.4.8%,p=0.0369).Median survival was not reached.Most common(≥10% abiraterone vs.prednisone-treated)adverse events:bone pain(7%vs.14%),pain in extremity(6%vs.12%),arthralgia(10%vs.8%),back pain(7%vs.11%),and hypertension(15%vs.14%).Conclusion:Interim analysis confirmed favorable benefit-to-risk ratio of abiraterone in chemotherapy-naı¨ve men with mCRPC,consistent with global study,thus supporting use of abiraterone in this patient population. | Dingwei Ye Yiran Huang Fangjian Zhou Keji Xie Vsevolod Matveev Changling Li Boris Alexeev Ye Tian Mingxing Qiu Hanzhong Li Tie Zhou Peter De Porre Margaret Yu Vahid Naini Hongchuan Liang Zhuli Wu Yinghao Sun | 2017 | Asian Journal of Urology2017，4，2： | 3 |
| 2 | Firefly-inspired algorithm for discrete optimization problems: An application to manufacturing cell formation显示文摘 | Mohammad Kazem Sayadi Ashkan Hafezalkotob Seyed Gholamreza Jalali Naini | 2012 | Journal of Manufacturing Systems2012，，： | 2 |
| 3 | INTELLIGENT SECURITY SYSTEMS ENGINEERING FOR MODELING FIRE CRITICAL INCIDENTS:TOWARDS SUSTAINABLE SECURITY显示文摘An intelligent security systems engineering approach is used to analyze fire and explosive critical incidents,a growing concern in urban communities.A feed-forward back-propagation neural network models the damages arising from these critical incidents.The overall goal is to promote fire safety and sustainable security.The intelligent security systems engineering prediction model uses a fully connected multilayer neural network and considers a number of factors related to the fire or explosive incident including the type of property affected,the time of day,and the ignition source.The network was trained on a large number of critical incident records reported in Toronto,Canada between 2000 and 2006.Our intelligent security systems engineering approach can help emergency responders by improving critical incident analysis,sustainable security,and fire risk management. | Ali ASGARY Ali SADEGHI NAINI Jason LEVY | 2009 | Journal of Systems Science and Systems Engineering2009，18，4： | 2 |
| 4 | Estimating the mixing matrix in Sparse Component Analysis (SCA) based on partial k-dimensional subspace clustering显示文摘 | NAINI F M MOHINANI G H BABAIE-ZADEH M | 2008 | Neuro computing2008，71，： | 1 |
| 5 | Workstation based Advanced operator training simulator for consolidated Edison显示文摘 | Rajagopal S Rafian Naini M | 1994 | IEEE Trans on Power System1994，9，4： | 1 |
| 6 | Effect of ezetimibe and/ or simvastatin on coenzyme Q10 levels in plasma: a randomised trial 显示文摘 | Berthold HK Naini A Di Mauro S | 2006 | Drug Saf2006，29，8： | 1 |
| 7 | The efficacy of intraverous amiodarone for the conversion of chronic atrial fibrillation 显示文摘 | Faitel K Naini M | 1996 | Arch Intern Med1996，156，： | 1 |
| 8 | Muscle coenzyme Q10 level in statin-related myopathy 显示文摘 | Lamperti C Naini AB Lucchini V | 2005 | Arch Neurol2005，62，11： | 1 |
| 9 | Canine substitution for missing maxillary lateral incisors:the influence of canine morphology, size,and shade on perceptions of smile ttractiveness 显示文摘 | Brough E Donaldson AN Naini FB | 2010 | Am J Orthod Dentofacial Orthop2010，138，6： | 1 |
| 10 | Preoperative and post operative levels of plasma protein and amino acid in esophageal and lung cancer patients显示文摘 | Naini AB Diekeron JW Brown MM | 1988 | Cancer1988，62，2： | 1 |
| 11 | The parkinsonian toxin 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine(MPTP): a technical review of its utility andsafety显示文摘 | PRZEDBORSKI S JACKSON-LEWIS V NAINI A B | 2001 | J Neurochem2001，76，5： | 1 |
| 12 | A mutation in para- hydroxybenzoate-polyprenyl transferase ( COQ2 ) causes primary coenzyme Q10 deficiency显示文摘 | Quinzii C Naini A Salviati L | 2006 | Am J Hum Genet2006，78，： | 1 |
| 13 | The parkinsonian toxin (MPTP): a technical review of its utility and safety 显示文摘 | Przedborskl S Jackson-Lewis V Naini AB | 2001 | J Neurochem2001，76，： | 1 |
| 14 | Isocratie HPLC assay with electrochemical detection of free 7-aminobutyric aeid in eerebrospinal fluid显示文摘 | Naini A B Vontzalidou E Cote L J | 1996 | Clin Chem1996，39，2： | 1 |
| 15 | Joint determination of price and upgrade level for a warranted second-hand product 显示文摘 | Jalali Naini SG Shafiee M | 2011 | International Journal of Advanced Manufacturing Technology2011，54，912： | 1 |
| 16 | The efficacy of intraverous amiodarone for the conversion of chronic atrial fibrillation 显示文摘 | Kerin NZ Faitel K Naini M | 1996 | Archives of Internal Medicine1996，156，4： | 1 |
| 17 | Ischemic injury enhances dendritic cell im- munogenicity via TLR4 and NF kappa B activation显示文摘 | Jurewiez M Takakura A Augello A Naini S M lchimura T Zandi Nejad K | 2010 | J Immu nol2010，184，： | 1 |
| 18 | The influence of corn- bincd surgical treatment on perceptions of attractiveness: a longitudinal study 显示文摘 | Naini FB Donaldson AN McDonald F | 2012 | The European Journal of Or- thodontics2012，23，： | 1 |
| 19 | Hosein Mohimani, Massoud Babaie-Zadeh, Estimating the mixing matrix in Sparse Component Analysis(SCA) based on partial k-dimensional subspace clustering 显示文摘 | Farid Movabedi Naini G | 2008 | Neurocompnting2008，71，： | 1 |
| 20 | Tilted or parallel im- plant placement in the completely edentulous mandible? A three-dimensional finite element analysis 显示文摘 | Naini RB Nokar S Borghei H | 2011 | Int J Oral Maxillofac Implants2011，26，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员