|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 2 | Inflammatory bowel disease in Asia: A systematic review显示文摘 | Lani Prideaux Michael A Kamm Peter P De Cruz Francis K L Chan Siew C Ng | 2012 | Journal of Gastroenterology and Hepatology2012，，8： | 5 |
| 3 | Impaired norepinephrine regulation of monocyte inflammatory cytokine balance in heart failure显示文摘AIM To evaluate the effect of norepinephrine on inflammatory cytokine expression in ex vivo human monocytes and monocytic THP-1 cells. METHODS For human monocyte studies, cells were isolated from 12 chronic heart failure(HF)(66 ± 12 years, New York Heart Association functional class Ⅲ-Ⅳ, left ventricular ejection fraction 22% ± 9%) and 14 healthy subjects(66 ± 12 years). Monocytes(1 × 106/mL) were incubated with lipopolysaccharide(LPS) 100 ng/m L, LPS + norepinephrine(NE) 10-6 mol/L or neither(control) for 4 h. Tumor necrosis factor-alpha(TNFα) and interleukin-10(IL-10) production were determined by ELISA. Relative contribution of α- and β-adrenergic receptor subtypes on immunomodulatory activity of NE was assessed in LPSstimulated THP-1 cells incubated with NE, the α-selective agonist phenylephrine(PE), and the β-selective agonist isoproterenol(IPN). NE-pretreated THP-1 cells were also co-incubated with the β-selective antagonist propranolol(PROP), α2-selective antagonist yohimbine(YOH) or the α1-selective antagonist prazosin(PRAZ). RESULTS Basal TNFα concentrations were higher in HF vs healthy subjects(6.3 ± 3.3 pg/mL vs 2.5 ± 2.6 pg/mL, P = 0.004). Norepinephrine's effect on TNFα production was reduced in HF(-41% ± 17% HF vs -57% ± 9% healthy, P = 0.01), and proportionately with NYHA FC. Increases in IL-10 production by NE was also attenuated in HF(16% ± 18% HF vs 38% ± 23% healthy, P = 0.012). In THP-1 cells, NE and IPN, but not PE, induced a dosedependent suppression of TNFα. Co-incubation with NE and antagonists revealed a dose-dependent inhibition of the NE suppression of TNFα by PROP, but not by YOH or PRAZ. Dose-dependent increases in IL-10 production were seen with NE and IPN, but not with PE. This effect was also antagonized by PROP but not by YOH or PRAZ. Pretreatment of cells with IPN attenuated the effects of NE and IPN, but did not induce a response to PE.CONCLUSION NE regulation of monocyte inflammatory cytokine production may be reduced in moderate-severe HF, and may be mediated through β-adrenergic receptors. | Tien MH Ng Myron L Toews | 2016 | World Journal of Cardiology2016，8，10： | 4 |
| 4 | Comparison of antioxidant activity of clove ( Eugenia caryophylata Thunb) buds and lavender ( Lavandula stoechas L.)显示文摘 | ìlhami Gül?in ?. Güng?r ?at ?ükrü Beydemir Mahfuz Elmasta? ?. ?rfan Küfrevio?lu | 2004 | Food Chemistry2004，，3： | 3 |
| 5 | Plasma and aqueous humor levels of adiponutrin and pannexin 1 in patients with and without diabetic retinopathy显示文摘AIM: To evaluate plasma and aqueous levels of adiponutrin and pannexin 1 in patients with and without diabetic retinopathy.METHODS: The study included three age and gendermatched groups of 20 cataract patients with no diabetes or additional disease(Group C), 20 cataract patients with diabetes and no retinopathy(Group DM+C), and 20 cataract patients with diabetic retinopathy(Group DR+C).All the patients were examined with respect to body mass index(BMI), fasting plasma glucose, hemoglobin A1c(HbA1c), and lipid profile.Phacoemulsification and intraocular lens(Phaco+IOL) implantation were performed to all patients in all the groups, and aqueous samples were taken during the operation.The plasma and aqueous adiponutrin and pannexin 1 levels were analyzed using enzyme-linked immunosorbent assays.RESULTS: A statistically significant difference was determined between the groups with respect to BMI, fasting plasma glucose, and HbA1c levels(P<0.05 for all parameters tested).The plasma adiponutrin levels of Group DR+C were statistically significantly lower than those of Group C and Group DM+C(P<0.001, P=0.004).No statistically significant difference was determined in the aqueous adiponutrin levels in three groups.The plasma pannexin 1 levels of Groups DM+C and DR+C were statistically significantly lower than those of Group C(both P=0.001).The aqueous pannexin 1 levels of Group DR+C were statistically significantly higher than those of Group C and Group DM+C(P=0.001, P<0.001).CONCLUSION: Adiponutrin and pannexin 1, which play an important role in the pathophysiology of diabetes and obesity, and have a regulatory role in hyperglycemia and insulin resistance.The measurement of adiponutrin and pannexin 1 levels may support clinicians in determining the risk of DR development. | Fatih Cem Gül Sabiha Güngör Kobat FatihÇelik Süleyman Aydin Ramazan Fazil Akkoç | 2022 | International Journal of Ophthalmology(English edition)2022，15，3： | 3 |
| 6 | RATIONAL GENERAL SOLUTIONS OF HIGHER ORDER ALGEBRAIC ODES显示文摘This paper generalizes the method of Ngo and Winkler(2010,2011)for finding rational general solutions of a first order non-autonomous algebraic ordinary differential equation(AODE)to the case of a higher order AODE,provided a proper parametrization of its solution hypersurface.The authors reduce the problem of finding the rational general solution of a higher order AODE to finding the rational general solution of an associated system.The rational general solutions of the original AODE and its associated system are in computable 1-1 correspondence.The authors give necessary and sufficient conditions for the associated system to have a rational solution based on proper reparametrization of invariant algebraic space curves.The authors also relate invariant space curves to first integrals and characterize rationally solvable systems by rational first integrals. | HUANG Yanli NG L X Chu WINKLER Franz | 2013 | Journal of Systems Science & Complexity2013，26，2： | 3 |
| 7 | Cytotoxicity and antihepatitis B virus activities of saikosaponins from Bupleurum species 显示文摘 | Chiang L C Ng L T Liu L T | 2003 | Planta Med2003，69，8： | 2 |
| 8 | Premature p34cdc2 activation required for apoptosis显示文摘 | Shi L Nishioka W K Th'ng J | 1994 | Science1994，263，5150： | 1 |
| 9 | Composition and accumulation of secondary carotenoids in Chlorococcum sp显示文摘 | LEE Y K NG M L PHANG S M | 1997 | J Appl Phycol1997，9，： | 1 |
| 10 | N-terminal pro-B-type natriuretic peptide and long-term mortality in acute coronary syndromes显示文摘 | Persson A Ng L | 2002 | Circulation2002，106，23： | 1 |
| 11 | Microcontact printing of catalytic nanoparticles for selective electroless deposition of metals on nonplanar polymeric substrates 显示文摘 | Ng W K Wu L Moran P M | 2002 | Appl Phys Lett2002，81，16： | 1 |
| 12 | A new method for characterizing denitrifying phosphorus removal bacteria by using three different types of electron acceptors显示文摘 | Hu J Y Ong S L Ng W J | 2003 | Water Research2003，37，： | 1 |
| 13 | Caspase-3 is required for alpha-fodrin cleavage but dispensable for cleavage of other death substrates in apoptosis显示文摘 | JANICKE R U NG P SPRENGART M L | 1998 | J Biol Chem1998，273，15： | 1 |
| 14 | Effect of hypo-thyroidism and its treatment on the IGF system in infants andchildren显示文摘 | Purandare A Co Ng L Godil M | 2003 | J Pediatr Endocrinol Metab2003，16，1： | 1 |
| 15 | Structure and attribute index for ap- proximate graph matching in large graphs 显示文摘 | ZHU L NG W K CHENG J | 2011 | Information Systems2011，36，6： | 1 |
| 16 | Adrenocortical carcinoma: diagnosis, evaluation and treatment 显示文摘 | NG L LIBERTINO JM | 2003 | J Urol2003，169，1： | 1 |
| 17 | In situ kinetic studies of microemulsion polymerizations of styrene and methacrylate by raman spectroscopy 显示文摘 | FENG L NG K Y S | 1990 | Macromolecules1990，23，4： | 1 |
| 18 | Six month radiologieal and physiological outcomes in severe acute respiratory syndrome(SARS) survivors 显示文摘 | Ng C K Chan J W Kwan T L | 2004 | Thorax2004，59，： | 1 |
| 19 | N-terminal pro-B-type natriuretic peptide and long-term mortality in acute coronary syndromes显示文摘 | Omland T Persson A Ng L | 2002 | Circulation2002，106，23： | 1 |
| 20 | Implantable cardiover defibrillator therapy:the state of the art and future perspectives显示文摘 | W A NG L X | 2002 | Indian Heart Joumal2002，54，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员