|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Oligomeric Procyanidins Induce Generation of Reactive Oxygen Species and Collapse of Mitochchondrial Membrane Potential in Glioblastoma Cell Lines显示文摘Objective The aim of the present study was to clarify the mechanism underlying glioma cell death upon oligomeric procyanidins (F2) exposure. Methods The cytotoxicity of F2 on U87 (human malignant glioblastoma cell line) and C6 (rat glioma cell line) cancer cells was evaluated, and changes of mitochondrial membrane potential (MMP) and production of reactive oxygen species (ROS) in drug-treated cells were monitored. Moreover, morphological changes associated with F2-induced cells death were examined. Results F2 induced a concentration-dependent increase in ROS production and decrease in MMP. Furthermore, pre-incubation with N-acetylcysteine (NAC) and rotenone (Rt), resulted in partial inhibition of F2-induced ROS generation and marked attenuation of cell death and the cytoplasmic vacuolization induced by F2. In addition, pretreatment with Rt markedly attenuated the MMP loss in F2-treated cells. However, pretreatment with NAC only markedly attenuated the MMP loss in F2-treated C6 cells. Conclusion The increase in ROS level is at least one of mechanisms associated with F2-induced glioma cell death as well as the cytoplasmic vacuolization formation that contribute to the cytotoxicity of F2 in glioma cells. | ZHANG Feng-jiao1, YANG Jing-yu1, MOU Yan-hua1, SUN Bao-shan2, WANG Ji-ming3, WANG Fang1, WU Chun-fu1 1. Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China 2. Estaco Vitivinícola Nacional, Instituto National de Investigaco Agrária, Dois Portos 2565-191, Portugal 3. Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick Maryland 21702, USA | 2009 | Chinese Herbal Medicines2009，1，1： | 3 |
| 2 | Selenocysteine tRNAs as Central Components of Selenoprotein Biosynthesis in Eukaryotes显示文摘Selenocysteine (Sec) tRNAs serve as carrier molecules for the biosynthesis of Sec from serine and to donate Sec to protein in response to specific UGA codons. In this study, we describe the current status of Sec tRNAs in higher animals and further we exarnine: (i) the Sec tRNA population in Drosophila; (ii) transcription of the Sec tRNA in vivo (in Xenopus oocytes) and in vitro (in Xenopus oocyte extracts); (iii) the effect of selenium on the Sec tRNA population in various rat tissues following replenishment of extremely selenium deficient rats with this element; and (iv) the biosynthesis of the modified bases on Sec tRNA in Xenopus | SANG ICK PARK JIN Mo PARK HAROLD S. CHITTUM EUN SUNG YANG BRADLEY A. CARLSON BYEONG JAE LEE AND DOLPH L. HATFIELD(Laboratory of Experimental Chrcinogenesis, National Cancer Insti tute, National Institutes of Health, Bethesda, MD 20892USA Laboratory o | 1997 | Biomedical and Environmental Sciences1997，10，2： | 2 |
| 3 | Vocabulary learning and reading 显示文摘 | SARAGI T NATION O MEISTER G | 1978 | System1978，，6： | 1 |
| 4 | 0 Database 显示文摘 | National Center for O'NET Development Data Dictionary O'NET 14 | 2009 | Employment Security Commission2009，，： | 1 |
| 5 | Update for nurse anesthetistsevidence-based anesthesia: The use of preprocedural ultrasonographyduring labor to facilitate placement of an epidural catheter显示文摘 | Spence D Nations R Rivera O | 2012 | AANAJ2012，80，3： | 1 |
| 6 | The epidemiology of major depressive disorder:results from the National Comorbidity Survey Replication (NCS-R)显示文摘 | Kessler RC Berglund R Demler O Jin R Koretz D Merikangas KR Rush AJ Waiters EE Wang PS National Comorbidity Survey Replication | | 0，，23： | 1 |
| 7 | Oviposition behavior of Biosteres longicaudatus,a parasite of the Caribbean fruit fly,Anastrepha suspensa显示文摘 | Lawrence P O Greany P D Nation J L | | 0，，： | 1 |
| 8 | Almandine megacrysts from Yingfengling Cenozoic basalt in Leizhou Peninsula and their parental magma origin显示文摘The garnet megacrysts from Yingfengling basalts are characterlzed by high FeO (>20%), CaO (7.02% -8.16%) and low MgO (5.88%-10.87%). Significant composition variations are observed in these megacrysts, of which Ni, V, Sc, Co, and HREE are positively correlated with their Mg# and Zr, Hf, Ga, Y, Sr, Nb, Zn and LREE-MREE are negatively correlated with Mg#. Megacryst parent magma is a highly evolved residual melt with strongl depletion in Ti, Sr, Hf, Nb and HREE. This parental magma was generated by more than 60% of crystallization fractionation of clinopyroxene, garnet, plagioclase and ilmenite from quartz tholeiitic magma. It has not erupted to the surface, but stayed at the upper mantle and formed the megacrystic cumulate. Megacrysts and their host basalt are in disequilibrium. | YU Jinhai & S. Y. O’Reilly1. National Key Laboratory of Metallogenic Mechanism of Endogenetic Deposits, Department of Earth Sciences, Nanjing University, Nanjing 210093, China 2. National Key Center of GEMOC, Department of Earth and Planetary Sciences, Macquarie University, North Ryde, NSW 2109, Australia | 2001 | Chinese Science Bulletin2001，46，14： | 1 |
| 9 | Abstract Reflexivity Subspce Lattices and Completely Distributive Collapsibility显示文摘 | LONGSTAFF W E NATION J B PANAIA O | 1998 | Bull Austrl Math Soc1998，58，： | 1 |
| 10 | Water Vapor Variability in the Tropical Western Pacific from 20-year Radiosonde Data显示文摘The 20-year (1976-1995) daily radinsonde data at 17 stations in the tropical western Pacific was ana- lyzed. The analysls shows that the atmosphere is more humid in a warmer climate on seasonal,inter-annual and long-term (20-year) time scales, implying a positive water vapor feedback The vertlcal structure of the long-term trends in relative humidity (RH) is distinct from that on short-term (seasonal and inter-annual) time scales, suggesting that observed water vapor changes on short time scales could not be considered as a surrogate of long-term climate change. The increasing trend of RH (3%-5% / decade) in the upper troposphere is stronger than that in the lower troposphere (1 %-2% / decade). Such verthal structure would amplify positive water vapor feedback in comparison to the common assumption of constant RH changes vertically. The empicical orthogonal function (EOF) analysis of vertical structure of RH varmtions shows distinct features of the vert1cal structure of the first three EOFs. The first three EOFs are optimal for repre- sentation of water vapor profiles and provide some hints on physical mechanisms respons1ble for observed humidity variability. Vaisala radiosondes were used at nine stations, and VIZ radiosondes used at other eight stations The Vaisala data are corrected for temperature-dependence error using the correction siheme developed by NCAR / ATD and Vaisala. The comparison of Vaisala and VIZ data shows that the VIZ-measured RHs after October 1993 have a moist bias of - 10% at RHs < 20%. During 1976-1995, several changes in- cluding both instruments and reporting practice have been made at Vaisala stations and introduce errors to long-term RH variations. | Junhong Wang, Harold L. Cole and David J. Carlson National Center for Atmospheric Research P. O, Box 3000,Boulder, CO 80307 | 2001 | Advances in Atmospheric Sciences2001，18，5： | 0 |
| 11 | Observations of Microwave Ultra-Fast Absorption Phenomena Above Solar Active Region显示文摘While we process observational data of the Flares 22, two rare phenomena of microwave ultra fast absorption (MUFA) are found for the first time. They occurred at 3 67 GHz and 4 00 GHz in the atmospheric layers above both active regions of NOAA/USAF 4808 and 5060 in the interval 05 h50 m17 s~05 h50 m25 s UT on May 19, 1987 and 07 h38 m50 s~07 h38 m58 s UT on June 29, 1988, respectively. These absorption phenomena were observed with Phoenix Ⅱ Micowave Spectrometer at three frequencies (1 42, 2 84 and 3 67 GHz) and (1 42, 2 84 and 4 00 GHz) at Yunnan observatory. Spike emissions appeared at both 2 84 GHz and 1 42 GHz. The notable observational characteristics of both absorption phenomena are given. A possible absorption mechanism of MUFA is discussed. | Chen Xiajuan, Ji Shuchen (Beijing Astronomical Observatory, The Chinese Academy of Sciences,Beinjing 100080, China) (Yunnan Observatory, The Chinese Academy of Sciences, Kunming 650011, China) (National Astronomical Observatories, The Chinese Academy o | 1999 | 天文研究与技术1999，，S1： | 0 |
| 12 | Capillary Electrophoresis in the Presence of Fosfomycin显示文摘WT5”HZ]Fosfomycin, a sodium salt of cis (3 methyioxiranyl) phosphonic acid, was used as electrolyte in binary methanol water media for capillary electrophoresis. The variety of electroosmotic flow with pH *,methanol concentration and ionic strength was investigated. The migration behavior of nine hases was examined under various conditions, and the separation of thymine, cytosine, 5 flurouracil, 4,6 diamino pyrimidine, purine was accomplished. | XIE Min jie, FENG Yu qi , DA Shi lu College of Chemistry and Environmental Science, Wuhan University, Wuhan 430072, China Received date: 1999 09 29 Corresponding author Foundation item: Supported by the National Natural Science Foundation o | 2000 | Wuhan University Journal of Natural Sciences2000，5，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员