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| 1 | Association between low molecular polypeptide 7 single nucleotide polymorphism and response to therapy in hepatitis C virus infection显示文摘AIM: To investigate the relationship between low molecular polypeptide-7 (LMP-7) gene polymorphism and response to interferon (IFN) therapy in chronic hepatitis C virus (HCV) patients. METHODS: LMP-7 polymorphism at codon 49 with nucleotide substitution from A to C was amplified in 104 chronic HCV patients of genotype 4. The amplicons were digested with restriction endonuclease Bsm I and the produced restriction fragment length polymorphism was analyzed. Patients received IFN + regional blood volume therapy for 48 wk and the frequency of thissingle nucleotide polymorphism (SNP) was statistically correlated with treatment response. The exclusion criteria for these patients were stated by the national health program for treating viral hepatitis. Main exclusion criteria included co-infection with hepatitis B virus or schistosomiasis, thyroid dysfunction, uncontrolled diabetes mellitus, history of long term drug or alcohol intake and autoimmune hepatitis. Multivariate analyses were done to correlate LMP-7 SNP plus several factors such as age, gender, weight, serum alpha-fetoprotein (AFP) and alanine aminotransferase levels, liver activity, fibrosis score and viral load with response to therapy. RESULTS: The data presented in this study clearly demonstrated statistically significant differences between sustained virological response (SVR) (defined as the absence of HCV RNA levels in the patient's sera at least 6 mo after discontinuation of treatment) and non-response (NR) (where HCV RNA levels in the patient's sera never become undetectable for 6 mo during or after treatment). Variables were described as odds ratio with 95%CI. The data were considered significant if P values were ≤ 0.05; highly significant if P < 0.01 and very highly significant if P < 0.001. Current data showed that 91.7% of patients carrying LMP-7 C/C allele were associated with SVR, while the other two genotypes C/A and A/A were associated with NR patients, 83.3% and 64.3% respectively, showing that genotype CC was strongly associated with response to interferon (95%CI: 12.0719-134.6572, P = 0.0001). The majority of parameters recorded in SVR and NR patients included higher values of mean age (P = 0.004), alanine aminotransferase (P = 0.001), AFP (P = 0.001), body weight (P = 0.025), viral load (P = 0.025), higher fibrosis and histological activity index indices among NR vs SVR patients. Also, the multivariate statistical analysis of the different factors of fibro-sis score, liver activity grade, genotypes and alleles of LMP-7 gene polymorphism in responders and NRs of HCV patients in this study showed that HCV patients with A allele had a very highly significant association with the NRs, high fibrosis and higher liver activity, while the C allele had a very highly significant association with the responders, low fibrosis and lower liver activity (95%CI: 3.5800-13.2519, P = 0.0001).CONCLUSION: LMP-7 SNP is a candidate gene that should be considered when designing a mathematical model for predicting response to therapy and disease progression in HCV patients. | Moataza H Omran Basma E Fotouh Samar S Youssef Noha E Ibrahim Wael Nabil EL-Sayed M Mahdy Wafaa G Shosha Mostafa K El-Awady | 2013 | World Journal of Hepatology2013，5，3： | 4 |
| 2 | Systematic review of periprosthetic tibia fracture after total knee arthroplasties显示文摘AIM: To investigate the known incidences, treatment options, and related outcomes of periprosthetic tibia fractures after total knee arthroplasty(TKA).METHODS: A literature search was done to identify studies that fit the inclusion criteria. The database search yielded 185 results, which were further reduced by the exclusion criteria to 13 papers, totaling 157 patients that met these criteria. Incidence rates of the different types of periprosthetic tibia fractures were determined and their treatments were subsequently analyzed based on the fracture's subclass, with patient outcomes being overall favorable.RESULTS: Of the 144 documented patients, 54(37.5%) had a subclass C fracture, which are frequently seen in revision arthroplasties or when using cement intraoperatively. The fractures of subclasses A and B occur postoperatively. There were 90 subclass A and B fractures with incidences of 18.75% and 43.75% respectively. When broken down by type, 62(55.36%) were type 1, 24(21.4%) were type 2, 24(21.4%) were type 3, and 2(1.8%) were type 4. Furthermore, from the studies that included origin of injury, the types were further classified as having non-traumatic or traumatic origins. Type 1 had 78%(40/51) non-traumatic origin and 22%(11/51) traumatic origin. Fifteen fractures were type 2, but 5 were falls and 1 through a motor vehicle accident, giving a trauma causation of 40%(6/15). Of the 24 type 3 fractures, 12 were falls and 2 vehicular accidents, leading to a trauma causation of 58%(14/24).CONCLUSION: Type 1 fractures were the most common. Subclass A was treated with locking plates, B required a revision TKA, and C was treated intraoperatively or nonoperatively. | Nabil A Ebraheim Joseph R Ray Meghan E Wandtke Grant S Buchanan Chris G Sanford Jiayong LiuZ | 2015 | World Journal of Orthopedics2015，6，8： | 4 |
| 3 | Stiffness synthesis of a variable geometry six-degrees-of-freedom double planar parallel robot显示文摘 | NABIL S MOSHE S | 2003 | The International Journal of Robotics Research2003，22，9： | 1 |
| 4 | The convergence speed of single and multi-objective immune algorithm based optimization problems显示文摘 | Abo-zahhad M Ahmed S M Nabil S | 2010 | Signal Processing:An International Journal2010，4，5： | 1 |
| 5 | Computational slrategies for nonlinear and fracture mechanics problems: automatic crack propagation tracking显示文摘 | Mark S Shephard Nabil A B Yehia Gary S Burd | 1985 | Computer & Structure1985，20，： | 1 |
| 6 | Effect of lead acetate toxicity on experimental male albino rat显示文摘Objective:To evaluate the effect of different doses of lead acetate(1/20,1/40 and 1/60 of LD_(50))on body weight gain,blood picture,plasma prolein profile and the function of liver,kidney and thyroid gland.Methods:Male albino rats were divided into four groups,the first group represented the health control animals,while the second,third and fourth groups were ingested orally with sub lethal doses of load acetate(1/20,1/40 and 1/60)of the oral LD_(50),respectively.One dose was ingested every two days during the experimental period(14 weeks)including the adaptation time.Blood was collected and used for all analysis.Results:The results showed that,the ingestion of Pb^(2+)induced significant stimulation in glutamic-pyruvic transaminase(ALT)and glutamic-oxalacetic transaminease(AST)activity.Also,total soluble protein and albumin contents of plasma were significantly decreased,while the content of globulin was changed by the Pb^(2+)treatments.The cholinesteiase activity was inhibited,but the activities of alkaline and acid phosphates and lactate dehydrogenase were stimulated,while plasma glucose level was elevated as a result of lead acetate intoxication.In case of blood picture,Pb^(2+)ingestion reduced the contents of hemoglobin and RBCs count of intoxicated rat's blood and the plasma levels of T3,T4 and blood WBCs count were decreased.Conclusions:It can be concluded that lead acetate has harmful effect on experimental male albino rats.Therefore,the present work advises people to prevent exposure to the lead compound to avoid injurious hazard risk. | Nabil M Ibrahim Esam A Eweis Hossam S El-Beltagi Yasmin E Abdel-Mobdy | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，1： | 1 |
| 7 | Contractor pre - qualification model : state - of - the - art 显示文摘 | NABIL E S DAVID E RIFAT R | 2007 | Interna- tional Journal of Project Management2007，25，5： | 1 |
| 8 | Synthesis and characterisation of new Schiff base metal complexes and their use as catalysts for olefin cyclopropanation显示文摘 | Nabil S Youssef Eman E1-Zahany Ahmed M A El-Seidy | 2009 | Inorganica Chimica Acta2009，362，6： | 1 |
| 9 | Reliability Analysis of Discrete Event Dynamic Systems with Petri Nets显示文摘 | Nabil S Hamid D | 2009 | Reliability Engineering and System Safety2009，94，11： | 1 |
| 10 | Scalp Nerve Block in Chil-dren Undergoing a Supratentorial Craniotomy:A Randomized Con-trolled Study显示文摘 | Manal el Gohary MG Girgis K Nabil S | 2009 | Asian Journal of Scientific Research2009，2，： | 1 |
| 11 | Reliability analysis of discrete e- vent dynamic systems with Petri nets 显示文摘 | NABIL S HAMID D | 2009 | Reliability En- gineering and System Safety2009，9，11： | 1 |
| 12 | Incidence and prevention of osteoradionecrosis after dental extraction in irradiated patients: a systematic review 显示文摘 | Nabil S Samman N | 2011 | lnt J Oral Maxillofac Surg2011，40，3： | 1 |
| 13 | Tile quntiataive anatomy of the cervival nerve root groove and the intervertebral foramen显示文摘 | Nabil A Howard S Rongming XU | 1996 | spine1996，21，14： | 1 |
| 14 | The impact of complications on outcomes after resection for esophageal and gastroesophageal junction carcinoma显示文摘 | Nabil P Rizk Peter B Bach Deborah Schrag Manjit S Bains Alan D Turnbull Martin Karpeh Murray F Brennan Valerie W Rusch | 2004 | Journal of the American College of Surgeons2004，，1： | 1 |
| 15 | Ground Water Coagulation Using Soluble Stainless Steel Electrodes显示文摘 | Nabil S Abuzaid | 2002 | Advances in Environmental Research2002，6，： | 1 |
| 16 | Mining frequent itemsets from online data streams: Comparative study 显示文摘 | Nabil H M Eldin A S Belal M A E | 2013 | International Journal of Advanced Computer Science and Applications2013，4，7： | 1 |
| 17 | Decomposition Method for Solving Fractional Riccati Differential Equations 显示文摘 | Shaher M Nabil S | 2006 | Applied Mathematics and Computation2006，182，2： | 1 |
| 18 | Response of a circular cylinderical shell to disturbances in a half-space显示文摘 | NABIL El-akily DATTA S K | 1980 | Earthquake Engineering and Structure Dynamic1980，8，： | 1 |
| 19 | Ground Surface Improvement of the Austenitic Stainless Steel AISI 304 Using Cryogenic Cooling显示文摘 | Nabil B F Habib S Chedly B | 2006 | Surface & Coatings Technology2006，200，： | 1 |
| 20 | Incidence and prevention of osteoradionecrosis after dental extraction in irradiated patients: a systematic review显示文摘 | Nabil S Samman N | 2011 | Int J Oral Maxillofac Surg2011，40，3： | 1 |
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