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| 1 | 西地那非能改善慢性肾功能衰竭大鼠的勃起功能显示文摘勃起功能障碍(ED)和慢性肾衰竭(CRF)之间的关系已在几个研究中被报道。本研究旨在探讨长期使用西地那非是否能增强CRF诱导大鼠的勃起能力。此外,我们评估了该治疗对某些分子的影响,这些分子被认为在勃起生理学及CRF相关的ED中起关键作用。研究分三组:(1)年龄配对的对照组,(2)CRF诱导的大鼠模型组,(3)CRF诱导大鼠给予西地那非慢性给药组((5 mg /kg口服6周[CRF诱导后6周开始治疗])。 3个月时,所有的动物进行海绵体神经刺激(CNS)来评估勃起功能。在所有大鼠组进行,阴茎组织晚期糖化终产物(AGE的) / 5-羟甲基-2-糠醛,丙二醛(MDA),cGMP(ELISA),诱导型一氧化氮合酶(iNOS)和神经元型NOS(nNOS的)(Western印迹)分析。CRF诱导大鼠与对照组相比,勃起功能有显著降低(P 〈0.05)。CRF诱导大鼠西地那非治疗组(第3组),海绵体内压(ICP)和曲线下面积的
增加量,大于CRF诱导大鼠组(第2组)。此外,西地那非治疗下调了AGE,MDA和iNOS的水平,同时保持了CRF诱导阴茎组织的nNOS和cGMP含量。西地那非治疗组AGE,MDA,iNOS的下降和nNOS,cGMP水平的增加,增加了ICP和海绵体神经刺激(CNS)的总ICP,使得CRF诱导大鼠阴茎勃起功能得到改善。本研究的结果表明慢性西地那非给药对CRF诱导大鼠的勃起功能有治疗效果。 | Nilgun Gurbuz Arif Kol Tumay Ipekci Erhan Ates Asli Baykal Mustafa F Usta | 2015 | Asian Journal of Andrology2015，17，5： | 3 |
| 2 | Hypogonadism and erectile dysfunction: an overview显示文摘在人,雄激素衰落表现为包括减少的性兴趣的一幅临床的图画,减少的可勃起的 capasity,推迟或不在的高潮和减少的性快乐。另外,在心情,是的减少的井,疲劳,消沉和易怒变化也与雄激素不足被联系。在阴茎的发展,生长,和 maintanence 的雄激素的关键角色广泛地被接受了。尽管,可勃起的生理学上的雄激素的准确效果仍然保持未经决定,最近的试验性的研究有关于在雄激素和可勃起的功能之间的关系拓宽我们的理解。现出症状之前的潜的研究证明雄激素剥夺在阴茎的神经结构导致阴茎织物萎缩和改变。而且,雄激素剥夺引起了到包含房间的脂肪的累积并且减少内皮和神经元的氮的氧化物 synthases (eNOS 和 nNOS ) 的蛋白质表示,和磷酸二酯酶 type-5 (PDE-5 ) ,哪个戏在正常的关键角色可勃起的生理学。在最近的文学的光上,我们试图也在阴茎织物和可勃起的生理学的结构,开发和 maintanence 上介绍雄激素的直接效果。Furhermore,根据临床的研究,我们在使人变老结束原因论,病理生理学, prevalance,诊断和性腺机能减退的治疗选择。 | Nilgun Gurbuz Elnur Mammadov Mustafa Faruk Usta | 2008 | Asian Journal of Andrology2008，10，1： | 3 |
| 3 | Evaluation of penile hemodynamic status and adjustment of treatment alternatives in Peyronie's disease显示文摘Aim:Erectile dysfunction may be observed in up to 80%of patients with Peyronis's disease.An objective evaluation of the erectile function is attempted to work out in patients with Peyronie's disease.Methods:Penile deformity,sexual function and penile vascular status were analyzed in 123patients with Peyronis's disease,who had not received any pertinent treatment.Results:Penile edformity,palpable plaque and pain on erection were seen in112(91%),97(78.8%)and27(21.9%)of the123patients,respectively.Of the 76patients evaluated by color Doppler ultrasounography,veno-occlusive dysfunction as the vascular component for erectile dysfunction was found in 17(22.3%),arterial insufficiency in10(13.1%)and a mixed picture in 23(30.2%).Conclusion:The documentation of penile erectile function and the determination of the vascular status using color Doppler ultrasonography can guide the appropriate therapeutic choice. | Tibet Erdogru Murat Savas Namik Yilmaz Mustafa Faruk Usta Turker Koksal Mutlu Ates Mehmet Baykara | 2002 | Asian Journal of Andrology2002，4，3： | 2 |
| 4 | The effciency of tannin as a formaldehyde scavenger chemical in me- dium density fiberboard 显示文摘 | Sevda Boran Mustafa Usta Sedat Ond- aral | 2012 | Compos- ites: Part B2012，43，： | 1 |
| 5 | Effect of boron treatment on surface characteritics of medium density (MDF)显示文摘 | Derya Ustaomer Mustafa Usta Salhn Hiziroglu | 2008 | Journal of Materials Processing Technology2008，，199： | 1 |
| 6 | Impact of Postdilation on Intervention Success and Long-Term Major Adverse Cardiovascular Events(MACE)among Patients with Acute Coronary Syndromes显示文摘Postdilation is frequently used during coronary interventions to prevent stent malapposition.Currently there are contradictory fi ndings regarding the benefi ts of postdilation for both intraprocedural and long-term outcomes.We evaluated the impact of postdilation among patients who presented with acute coronary syndromes(ACS)and underwent percutaneous coronary interventions(PCI).A total of 258 consecutive patients who presented with ACS and underwent PCI were included in the study.The patients were followed up for 25±1.7 months for the occurrence of major adverse cardiovascular events(MACE).During follow-up,65 patients(25.2%)had MACE.Among patients without MACE,intracoronary nitrate infusion was less frequently used(P=0.005),myocardial blush grade was higher(P<0.001),and a drug-eluting stent was more frequently used(P=0.005).No signifi cant differences were noted between groups regarding the predilation,recurrent dilation,postdilation,and other angiographic characteristics.In multivariate analysis,female sex(P=0.047),myocardial blush grade(P=0.038),previous coronary artery disease(P=0.030),and peak troponin level(P=0.002)were found to be predictors of MACE.In patients who were treated with PCI for ACS,performing postdilation did not predict fi nal Thrombolysis in Myocardial Infarction(TIMI)fl ow grade,corrected TIMI frame count,myocardial blush grade,or MACE. | Turan Erdogan Hakan Duman Mustafa Cetin Savas Ozer Goksel Cinier Ece Usta Mustafa Usta Tuncay Kiris | 2020 | Cardiovascular Innovations and Applications2020，，1： | 0 |
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