7篇
您的检索式：作者名="Musheng Bao"
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| 1 | Regulation of TLR7/9 signaling in plasmacytoid dendritic cells显示文摘Plasmacytoid dendritic cells(pDCs),also known as type I interferon(IFN)-producing cells,are specialized immune cells characterized by their extraordinary capabilities of mounting rapid and massive type I IFN response to nu-cleic acids derived from virus,bacteria or dead cells.PDCs selectively express endosomal Toll-like receptor(TLR)7 and TLR9,which sense viral RNA and DNA re-spectively.Following type I IFN and cytokine responses,pDCs differentiate into antigen presenting cells and ac-quire the ability to regulate T cell-mediated adaptive immunity.The functions of pDCs have been implicated not only in antiviral innate immunity but also in immune tolerance,inflammation and tumor microenvironments.In this review,we will focus on TLR7/9 signaling and their regulation by pDC-specific receptors. | Musheng Bao Yong-Jun Liu | 2013 | Protein & Cell2013，4，1： | 9 |
| 2 | Phospholipid Scramblase 1 regulates Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells显示文摘像使用费的受体(TLR9 ) 9 在 plasmacytoid 的内涵体察觉到微生物引起的 DNA 树枝状的房间(pDCs ) 和扳机 MyD88 依赖的类型我干扰素(IFN ) 回答。更好在 pDCs 理解 TLR9 生物学,我们建立了酵母为交往 TLR9 蛋白质的鉴定的二混血儿的图书馆。这里,我们报导那 IFN 可诱导的蛋白质, phospholipid scramblase 1 (PLSCR1 ) ,在 pDCs 与 TLR9 交往。由在人的 pDC 的 siRNA 的 PLSCR1 表示击倒房间线导致了 IFN-α 的 60-70% 减小;回答列在后面 CpG-ODN (oligodeoxynucleotide ) 刺激。从生产的 PLSCR1 缺乏的老鼠的主要 pDCs 响应 CpG-ODN 从野类型的老鼠比 pDCs 降低类型 1 IFN 的数量,疱疹单一的病毒和流行性感冒 A 病毒。后面的 CpG -- 刺激,有在和 CpG 的早内涵体的 TLR9 的低得多的数量 -- 在从 PLSCR1 缺乏的老鼠的 pDCs 的 A。我们的学习证明 PLSCR1 是在 pDC 的类型起一个重要作用的交往 TLR9 蛋白质由调整 TLR9 trafficking 到 endosomal 分隔空间的 1 IFN 回答。 | Amjad H Talukder Musheng Bao Tae Whan Kim Valeria Facchinetti Shino Hanabuchi Laura Bover Tomasz Zal Yong-Jun Liu | 2012 | Cell Research2012，22，7： | 2 |
| 3 | DDX1, DDX21, and DHX36 Helicases Form a Complex with the Adaptor Molecule TRIF to Sense dsRNA in Dendritic Cells显示文摘 | Zhiqiang Zhang Taeil Kim Musheng Bao Valeria Facchinetti Sung Yun Jung Amir Ali Ghaffari Jun Qin Genhong Cheng Yong-Jun Liu | 2011 | Immunity2011，，6： | 1 |
| 4 | A human microsatellite DNA-mimieking oligodeoxynucleotide with CCT repeats nega tively regulates TLR7/9-mediated innate immune responses via selected TLR pathways 显示文摘 | Ran Sun Luguo Sun Musheng Bao | 2010 | Clinical immunology2010，134，3： | 1 |
| 5 | Anti-SARS-CoV immunity induced by a novel CpGoligodeoxynucleotide 显示文摘 | Musheng Bao Yi Zhang Min Wan | 2006 | Clin Immunol2006，118，23： | 1 |
| 6 | A human microsatellite DNA-mimic-king oligodeoxynucleotide with CCT repeats negatively regulates TLR7/9-mediated innate immune responses via selected TLR pathways 显示文摘 | Ran Sun Luguo Sun Musheng Bao | 2010 | Clin Immunol2010，134，3： | 1 |
| 7 | A CpG oligodeoxynucleotide acts as a potent adjuvant for inactivated rabies virus vaccine 显示文摘 | Xueju Wang Musheng Bao Min Wan | 2008 | Vaccine2008，，15： | 1 |
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