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| 1 | Risk factors for Barrett’s oesophagus and oesophageal adenocarcinoma:Results from the FINBAR study显示文摘AIM:To investigate risk factors associated with Barrett's oesophagus and oesophageal adenocarcinoma.METHODS:This all-Ireland population-based case-control study recruited 224 Barrett's oesophagus patients,227 oesophageal adenocarcinoma patients and 260 controls.All participants underwent a structured interview with information obtained about potential lifestyle and environmental risk factors.RESULTS:Gastro-oesophageal reflux was associated with Barrett's [OR 12.0(95% CI 7.64-18.7)] and oesophageal adenocarcinoma [OR 3.48(95% CI 2.25-5.41)].Oesophageal adenocarcinoma patients were more likely than controls to be ex-or current smokers [OR 1.72(95% CI 1.06-2.81)and OR 4.84(95% CI 2.72-8.61)respectively] and to have a high body mass index [OR 2.69(95% CI 1.62-4.46)].No significant associations were observed between these risk factors and Barrett's oesophagus.Fruit but not vegetables were negatively associated with oesophageal adenocarcinoma [OR 0.50(95% CI 0.30-0.86)].CONCLUSION:A high body mass index,a diet low in fruit and cigarette smoking may be involved in the progression from Barrett's oesophagus to oesophageal adenocarcinoma. | Lesley A Anderson RG Peter Watson Seamus J Murphy Brian T Johnston Harry Comber Jim Mc Guigan John V Reynolds Liam J Murray | 2007 | World Journal of Gastroenterology2007，13，10： | 5 |
| 2 | Have patients with esophagitis got an increased risk of adenocarcinoma? Results from a population-based study显示文摘AIM: To examine an increased risk of esophageal adenocarcinoma is restricted to patients who develop Barrett's esophagus or whether esophagitis per se is a risk factor for adenocarcinoma.METHODS: A population-based cohort of patients with histological evidence of esophagitis without Barrett's esophagus was constructed using electronic pathology reports relating to all esophageal biopsies in Northern Ireland between 1993 and 1996. Person-years of followup and incident cases of esophageal cancer were calculated by linking the cohort to death files and the Northern Ireland Cancer Registry records. Standardized incidence ratios (SIR) were calculated for esophageal cancers (adenocarcinoma, squamous cell carcinoma (SCC), and histologically unspecified cancers).RESULTS: A total of 2 013 patients in the cohort provided 13 559 patient-years of follow-up (mean follow-up 6.7 years). None of the patients developed adenocarcinoma. Three patients developed SCC, and six developed histologically unspecified cancers. The SIR for all esophageal cancers and for SCC were 2.73 (95%CI 1.25-5.19) and 2.93 (95%CI 0.61-8.59), respectively. In a sensitivity analysis in which all unspecified esophageal cancers were treated as adenocarcinomas, the SIR for adenocarcinoma was 2.64 (0.97-5.75).CONCLUSION: The risk of adenocarcinoma is not elevated in patients with histological evidence of esophagitis without Barrett's esophagus; however, these patients may have a moderately increased risk of SCC.Further studies are required to confirm these findings,which suggest that Barrett's esophagus, not esophagitis,is the key precursor lesion in the development of adenocarcinoma. | Seamus J Murphy Lesley A Anderson Brian T Johnston Deirdre A Fitzpatrick Peter RG Watson Pauline Monaghan Liam J Murray | 2005 | World Journal of Gastroenterology2005，11，46： | 4 |
| 3 | CD133 expression is not restricted to stem cells, and both CD133^sup +^ and CD133^sup -^ metastatic colon cancer cells initiate tumors显示文摘 | Shmelkov Sergey V Butler Jason M Hooper Andrea T Hormigo Adilia Kushner Jared Milde Till Clair Ryan St Baljevic Muhamed White Ian Jin David K Chadburn Amy Murphy Andrew J Valenzuela David M Gale Nicholas W Thurston Gavin Yancopoulos George | 2008 | Journal of Clinical Investigation2008，，： | 2 |
| 4 | Impact of preexisting statin use on adhesion molecule expression in patients presenting with acute coronary syndromes显示文摘 | MURPHY R T FOLEY J B MULVIHILL N | 2001 | Am J Cardiol2001，87，： | 1 |
| 5 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 6 | Controlling nitrification in a water distribution system using sodium chlorite 显示文摘 | O' CONMOR T MURPHY B O' CONMOR J T | 2001 | Water Engineering & Management2001，148，9： | 1 |
| 7 | Iron-stimulated growth and microcystin production of Microcystis novacekii UAM 250 显示文摘 | Li H Murphy T Guo J | 2009 | Limnologica - Ecology and Management of Inland Waters2009，39，3： | 1 |
| 8 | Prop- erties of Electrical Contacts on Bulk and Epitaxialn-type ZnO 显示文摘 | Murphy T E Blaszczak J O MoazzamiI K | 2005 | Journal of Electronic Materials2005，34，4： | 1 |
| 9 | Natural history and familial characteristics of isolated left ventricular noncompaction显示文摘 | Murphy R T Thaman R Blanes J G | 2005 | Eur Heart J2005，26，2： | 1 |
| 10 | Two sesquiterpene furans with new carbocyclic ringsystems and related thiol acetates from a species of thesponge genus Dysidea显示文摘 | KAZLAUSKAS R MURPHY P T WELLS R J | 1978 | Tetrahedron Lett1978，49，： | 1 |
| 11 | 2002, Evolutionary re-organization of a large operon in adzuki bean chloroplast DNA caused by inverted repeat movement显示文摘 | Perry A S Brennan S Murphy D J Kavanagh T A Wolfe K H | 2002 | DNA Research2002，9，5： | 1 |
| 12 | The development of fear of falling among community-living older women:predisposing factors and subsequent fall events显示文摘 | Murphy S Dubin J Gill T | 2003 | A Biol Sci Med Sci2003，58，10： | 1 |
| 13 | Charac- terization of poly (3,3-bisethoxymethyl oxetane) and poly(3,3-bisazido methyl oxetane) and their block co- polymers显示文摘 | Murphy E A Ntozakhe T Murphy C J | 1989 | J ApplPolymSci1989，37，： | 1 |
| 14 | Anew sesquiterpene from the sponge Dysidea herbacea显示文摘 | KAZLAUSKAS R MURPHY P T WELLS R J | 1978 | Tetrahedron Lett1978，49，： | 1 |
| 15 | Development of a geometrycompensated neutron time-of-flight detector for ICF applications with approximately 200 ps time response显示文摘 | MURPHY T J LERCHE R A | | 0，，10： | 1 |
| 16 | Recombinant phycobiliproteins-Recombinant C-phycocyanins equipped with affinity tags, oligomerization, and biospecific recongnition domains显示文摘 | Cai Y A Murphy J T Wedemayer G J | 2001 | Anal Biochem2001，290，： | 1 |
| 17 | Enhancement of the cementitious properties of steel making slag 显示文摘 | J N Murphy T R Meadowcroft P V Barr | | Canadian Metallurgical Quarterly0，36，5： | 1 |
| 18 | Ethnical and Attitudes toward Patient Autonomy显示文摘 | Blackhall J L Murphy S T Flank G | 1995 | JAMA1995，274，10： | 1 |
| 19 | Enhancement of the cementitious properties of steehnaking slag 显示文摘 | Murphy N J Meadowcroft T R | 1997 | Canadian Metallurgical Quarterly1997，36，5： | 1 |
| 20 | Absolute Isotopic Abundance Ratio and the Atomic Weight of Chlorine 显示文摘 | Shields W R Murphy T J Garner E L | 1962 | Journal of the A- merican Chemical Society1962，84，： | 1 |
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