|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The influence on liver parenchymal function and complications of radiofrequency ablation or the combination with transcatheter arterial embolization for hepatocellular carcinoma显示文摘 | Masahiko Koda Masaru Ueki Yoshiko Maeda Ken-Ichi Mimura Kinya Okamoto Yoshiko Matsunaga Manri Kawakami Keiko Hosho Yoshikazu Murawaki | 2004 | Hepatology Research2004，，1： | 2 |
| 2 | 帮助, P53,和 Mlh1 蛋白质在的表示内视镜地 resected 区分类型的早胃的癌症显示文摘 AIM: To analyze the expression of the tumor-related proteins in differentiated-type early gastric carcinoma (DEGC) samples. METHODS: Tumor specimens were obtained from 102 patients (75 males and 27 females) who had received an endoscopic tumor resection at Tottori University Hospital between 2007 and 2009. Ninety-one cancer samples corresponded to noninvasive or intramucosal carcinoma according to the Vienna classification system, and 11 samples were submucosal invasive carcinomas. All of the EGCs were histologically differenti- ated carcinomas. All patients were classified as having Helicobacter pylori (H. pylori ) infections by endoscopic atrophic changes or by testing seropositive for H. pylori IgG. All of the samples were histopathologically classified as either tubular or papillary adenocarcinoma according to their structure. The immunohistochemi- cal staining was performed in a blinded manner with respect to the clinical information. Two independent observers evaluated protein expression. All data were statistically analyzed then. RESULTS: The rates of aberrant activation-induced cytidine deaminase (AID) expression and P53 overexpression were both 34.3% in DEGCs. The expression of Mlh1 was lost in 18.6% of DEGCs. Aberrant AID expression was not significantly associated with P53 overexpression in DEGCs. However, AID expression was associated with the severity of mononuclear cell activity in the non-cancerous mucosa adjacent to the tumor (P = 0.064). The rate of P53 expression was significantly greater in flat or depressed tumors than in elevated tumors. The frequency of Mlh1 loss was significantly increased in distal tumors, elevated gross-type tumors, papillary histological-type tumors, and tumors with a severe degree of endoscopic atrophic gastritis (P < 0.05). CONCLUSION: Aberrant AID expression, P53 overexpression, and the loss of Mlh1 were all associated with clinicopathological features and gastric mucosal alterations in DEGCs. The aberrant expression of AID protein may partly contribute to the induction of nuclear P53 expression. | Yohei Takeda Kazuo Yashima Akihiro Hayashi Shuji Sasaki Koichiro Kawaguchi Kenichi Harada Yoshikazu Murawaki Hisao Ito | 2012 | World Journal of Gastrointestinal Oncology2012，4，6： | 2 |
| 3 | Tissue inhibitor of metalloproteinase-1 in the liver of patients with chronic liver disease显示文摘 | Murawaki Y Ikuta Y Idobe Y | 1997 | J Heptol1997，26，6： | 1 |
| 4 | Combination therapy with transcatheter arterial chemobolization and percutaneous ethanol injection compared with percutaneous injection alone for patients with small pepatocellular carcinoma:a randomized control study显示文摘 | Koda M Murawaki Y Mitsuda A | 2001 | Cancer2001，92，12： | 1 |
| 5 | Renovascular resistance assessed by color Doppler ultrasonography in patients with chronic liver diseases显示文摘 | Koda M Murawaki Y Kawasaki H | 2000 | Journal of Gestroenterology and hepatology2000，15，12： | 1 |
| 6 | Clinical usefulness of serum matrix metalloproteinase-2 concentration in patients with chronic viral liver disease显示文摘 | Yamada S Ikuta Y | 1999 | J Hepatol1999，30，6： | 1 |
| 7 | Clinical significance of serum hyaluronan in patients with chronic viral liver disease显示文摘 | Murawaki Y Ikuta Y Kodo M | 1996 | J Gastroenterol Hepatol1996，11，： | 1 |
| 8 | Expression of transforming growth factor-beta 1 in hepatocellular carcinoma in comparison with the non-tumor tissue 显示文摘 | ldobe Y Murawaki Y Kitamura Y | 2003 | Hepatogastro-enterology2003，50，49： | 1 |
| 9 | Renovascular resistance assessed by color Doppler ultrasonography in patients with chronic liver diseases显示文摘 | Koda M Murawaki Y Kawasaki H | 2000 | J Gastroenterol Hepatol2000，15，： | 1 |
| 10 | Clinical usefulness of serum matrix metalloproteinase - 2 concentration in patients with chronic virul liver disease显示文摘 | Murawaki Y Yamada S Ikuta Y | 1999 | J Hepatol1999，30，6： | 1 |
| 11 | Expression of transforming growth factor-beta 1 in hepatocellular carcinoma in comparison with the non-tumor tissue显示文摘 | Idobe Y Murawaki Y Kitamura Y | 2003 | Hepatogastroenterology2003，50，49： | 1 |
| 12 | Serum matrix metalloproteinase-1 in patients with chronic viral hepatitis显示文摘 | Murawaki Y Ikuta Y Idobe Y | 1999 | J Gastroenterol Hepatol1999，14，2： | 1 |
| 13 | Tissue inhibitor of metalloproteinase - 1 in the liver of patients with chronic liver disease显示文摘 | Ikuta Y Idobe Y | 1997 | J Hepatol1997，26，6： | 1 |
| 14 | Tissue inhibitor of metalloproteinase-1 in liver of patients with chronic liver disease显示文摘 | Ikuta Y Idobe Y | 1997 | J Hepatol1997，26，： | 1 |
| 15 | Serum markers for fibrosis and plasma transforming growth factor beta-1 in patients with hepatoeellular carcinoma in comparison with patients with liver cirrhosis显示文摘 | Murawaki Y Ikuta Y Nishimura Y | 1996 | J Gastroenterol Hepatol1996，11，： | 1 |
| 16 | Diagnostic value of serum markers of connective turnover for predicting histological staging and grading in patients with chronic hepatitis C显示文摘 | Murawaki Y Ikuta Y Okamoto K | 2001 | J Gastroenterol2001，36，6： | 1 |
| 17 | Preventive and therapeutic effects of angiotensin II type 1 receptor blocker on hepatic fibrosis induced by bile duct ligation in rats显示文摘 | Masaru Ueki Masahiko Koda Satoru Yamamoto Yoshiko Matsunaga Yoshikazu Murawaki | 2006 | Journal of Gastroenterology2006，，10： | 1 |
| 18 | Free and small peptidebound hydroxyproline synthes is in rat liver in vitro in CCl4-induced hepatic fibrosis显示文摘 | Koda M Murawaki Y Hirayama C | 1988 | Biochem Biophs Res Commun1988，151，： | 1 |
| 19 | Serum type Ⅲ procollagen peptide,type Ⅳ collagen 7S domain,central triple-helix of type Ⅳ collagen and tissue inhibitor of mwtallopteinases in patients with chronic viral liver disease:relationship to liver histolog显示文摘 | Murawaki Y lkuta Y Koda M | | H0，，： | 1 |
| 20 | miR-29b, miR-205 and miR-221 Enhance Chemosensitivity to Gemcitabine in HUH28 Hu- man Cholangiocarcinoma Cells显示文摘 | Okamoto K Miyoshi K Murawaki Y | 2013 | PloS one2013，，77： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员