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| 1 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics显示文摘交往受体的蛋白质 kinase-3 (RIP3 或 RIPK3 ) 是执行 “ 的细胞的机械的必要部分; programmed”或 “ regulated”坏死。这里,我们证明那规划坏死响应许多化学疗法的代理人被激活并且贡献导致化疗的房间死亡。然而,我们证明那 RIP3 表情经常在化学疗法的死亡期间由于它的 transcriptional 开始地点, MLKL 的这样 RIP3 依赖的激活和下游地规划的坏死附近的 genomic methylation 是在癌症房间的 silenced 大部分被镇压。不过,有 hypomethylating 代理人的治疗恢复 RIP3 表示,并且从而以一种 RIP3 依赖的方式把敏感提升到 chemotherapeutics。RIP3 表示在 85% 乳癌病人与正常织物相比在肿瘤被减少,建议那 RIP3 缺乏断然在肿瘤生长 / 发展期间被选择。因为 hypomethylating 代理人在病人是相当容忍得好的,我们建议病人们可以从收到 hypomethylating 代理人与常规 chemotherapeutics 在治疗以前导致 RIP3 表示有益于的那 RIP3 缺乏的癌症。 | Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim | 2015 | Cell Research2015，25，6： | 20 |
| 2 | TNFα and reactive oxygen species in necrotic cell death显示文摘 | Michael J Morgan You-Sun Kim Zheng-gang Liu | 2008 | Cell Research2008，18，3： | 13 |
| 3 | 腰椎骨盆固定和三角固定术在不稳定型骶骨骨折治疗中的应用显示文摘骶骨是构成骨盆后环的蕈要结构和脊柱重力线分佑到两侧髋臼的枢纽部位,垂直不稳定型骶骨骨折多由高能量损伤引起,常合并神经损伤和多发性创伤而引起骨盆环不稳定,特殊类型的骶骨骨折可引起脊柱一骨盆的不稳定。近年来,随着研究的深入,多种内固定方法用于垂直不稳定型骶骨骨折的治疗,包括横向固定装置,如骶髂螺钉、骶骨棒、 | 易成腊 Steven Morgan David J Hak | 2011 | 中华创伤骨科杂志2011，13，4： | 8 |
| 4 | Epidemiology of Cryptosporidium : transmission, detection and identification显示文摘 | Ronald Fayer Una Morgan Steve J Upton | 2000 | International Journal for Parasitology2000，，12： | 3 |
| 5 | Hematopoietic AMPK [Beta]1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity显示文摘 | Galic Sandra Fullerton Morgan D Schertzer Jonathan D Sikkema Sarah Marcinko Katarina Walkley Carl R Izon David Honeyman Jane Chen Zhi-Ping van Denderen Bryce J Kemp Bruce E Steinberg Gregory R | 2011 | Journal of Clinical Investigation2011，，12： | 2 |
| 6 | Causes of encephalitis and differences in their clinical presentations in England: a multicentre, population-based prospective study显示文摘 | Julia Granerod Helen E Ambrose Nicholas WS Davies Jonathan P Clewley Amanda L Walsh Dilys Morgan Richard Cunningham Mark Zuckerman Ken J Mutton Tom Solomon Katherine N Ward Michael PT Lunn Sarosh R Irani Angela Vincent David WG Brown Natasha S Crowcroft | 2010 | The Lancet Infectious Diseases2010，，12： | 2 |
| 7 | 葡糖胺和半乳糖胺的测定显示文摘定量测定葡糖胺和半乳糖胺的分析操作已由Elson和Morgan(1933)报道[1]。这一方法基于Pauly和Ludwig(1922)的发现,即在100℃的碱性溶液中氨基糖与乙酰丙酮反应形成一生色物质,这一物质经对二甲氨基苯甲醛酸性乙醇溶液处理产生一个或多个发色团。光电分光光度计的开发和应用很大程度上提高了技术灵敏度和准确度,虽然已报道了很多此方法的改良设计操作。 | Rondle C J M Morgan W T J 陈祥娥 | 2010 | 食品与药品2010，12，11： | 2 |
| 8 | 比色法测定N-乙酰葡糖胺和N-乙酰半乳糖胺显示文摘乙酰葡糖胺与对二甲氨基苯甲醛的反应最初由Müller发现,即当戊-乙酰葡糖胺溶液与稀氢氧化钾共热后,加入盐酸酸化的对二甲氨基苯甲醛溶液(Ehrlich试剂)可产生强紫红色。 | Morgan W T J Elson L A 陈祥娥 | 2010 | 食品与药品2010，12，9： | 2 |
| 9 | Population Incidence of Guillain-Barre Syndrome: A Systematic Review and Meta-Analysis显示文摘 | Sejvar James J Baughman Andrew L Wise Matthew Morgan Oliver W | 2011 | EN2011，，2： | 2 |
| 10 | Genetic influences on beef longissimus palatability in Charolais-and Limousin-sired steers and heifers显示文摘 | Wulf D M Tatum J D Green R D Morgan J B Golden B L and Smith G C | 1996 | J Anim Sci1996，74，： | 2 |
| 11 | Osmoregulation and Water Stress in Higher Plants显示文摘 | J M Morgan | 1984 | Annual Review of Plant Physiology1984，，： | 2 |
| 12 | Epidemiology of Cryptosporidium : transmission, detection and identification显示文摘 | Ronald Fayer Una Morgan Steve J Upton | 2000 | International Journal for Parasitology2000，，12： | 2 |
| 13 | Transepithelial leak in Barrett's esophagus patients: The role of proton pump inhibitors显示文摘AIM: To determine if the observed paracellular sucrose leak in Barrett's esophagus patients is due to their proton pump inhibitor (PPI) use. METHODS: The in vivo sucrose permeability test was administered to healthy controls, to Barrett's patients and to non-Barrett's patients on continuous PPI therapy. Degree of leak was tested for correlation with presence of Barrett's, use of PPIs, and length of Barrett's segment and duration of PPI use. RESULTS: Barrett's patients manifested a near 3-fold greater, upper gastrointestinal sucrose leak than healthy controls. A decrease of sucrose leak was observed in Barrett's patients who ceased PPI use for 7 d.Although initial introduction of PPI use (in a PPI-na ve population) results in dramatic increase in sucrose leak, long-term, continuous PPI use manifested a slow spontaneous decline in leak. The sucrose leak observed in Barrett's patients showed no correlation to the amount of Barrett's tissue present in the esophagus. CONCLUSION: Although future research is needed to determine the degree of paracellular leak in actual Barrett's mucosa, the relatively high degree of leak observed with in vivo sucrose permeability measurement of Barrett's patients reflects their PPI use and not their Barrett's tissue per se . | Christopher Farrell Melissa Morgan Owen Tully Kevin Wolov Keith Kearney Benjamin Ngo Giancarlo Mercogliano James J Thornton Mary Carmen Valenzano James M Mullin | 2012 | World Journal of Gastroenterology2012，18，22： | 2 |
| 14 | Chromosomal location of a wheat osmoregulation gene using RFLP analysis显示文摘 | MORGAN J M TAN M K | 1996 | Aust J Plant Physiol1996，23，： | 1 |
| 15 | Wnt signaling maintains the hair-inducing activity of the dermal papilla显示文摘 | Burgeson RE Morgan BA | 2000 | Genes Dev2000，14，： | 1 |
| 16 | Salinity effects on oxygen consumption,gill Na+,K+-ATPase and ion regulation in juvenile coho salmon显示文摘 | | 1998 | Joural of Fish Biology1998，53，5： | 1 |
| 17 | Asset and Liability Management Systemfor Towers Perrin-Tillinghast显示文摘 | Gould G Morgan C | 2000 | Interfaces2000，30，1： | 1 |
| 18 | Beneficial effect of micro- injected trehalose on the cryosurvival of human oocytes 显示文摘 | Erdag G Eroglu A Morgan J R | 2002 | Fer- til Steril2002，44，： | 1 |
| 19 | Analysis of intraoperative rupture in the surgical treatment of 1694 saccular anemysms 显示文摘 | Leipzig TJ Morgan J Homer TG | 2005 | Neurosurgery2005，56，3： | 1 |
| 20 | Biological costs and benefits to plant-microbe interactions in the rhizosphere 显示文摘 | Morgan J A W Bending G D White P J | 2005 | Journal of Experimental Botany2005，56，417： | 1 |
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