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| 1 | Laparoscopic common bile duct exploration 显示文摘 | Shuchleib S Chousleb A Mondragon A | 1999 | World J Surg1999，23，7： | 4 |
| 2 | AIF-regulated oxidative phosphorylation supports lung cancer development显示文摘Cancer is a major and still increasing cause of death in humans. Most cancer cells have a fundamentally different metabolic profile from that of normal tissue. This shift away from mitochondrial ATP synthesis via oxidative phosphorylation towards a high rate of glycolysis, termed Warburg effect, has long been recognized as a paradigmatic hallmark of cancer, supporting the increased biosynthetic demands of tumor cells. Here we show that deletion of apoptosis-inducing factor (AIF) in a Kras^G12D-driven mouse lung cancer model resulted in a marked survival advantage, with delayed tumor onset and decreased malignant progression. Mechanistically, Aif deletion leads to oxidative phosphorylation (OXPHOS) deficiency and a switch in cellular metabolism towards glycolysis in non-transformed pneumocytes and at early stages of tumor development. Paradoxically, although Aif-deficient cells exhibited a metabolic Warburg profile, this bioenergetic change resulted in a growth disadvantage of Kras^G12D-driven as well as Kras wild-type lung cancer cells. Cell-autonomous re-expression of both wild-type and mutant AIF (displaying an intact mitochondrial, but abrogated apoptotic function) in Aif-knockout Kras^G12D mice restored OXPHOS and reduced animal survival to the same level as AIF wild-type mice. In patients with non-small cell lung cancer, high AIF expression was associated with poor prognosis. These data show that AIF-regulated mitochondrial respiration and OXPHOS drive the progression of lung cancer. | Shuan Rao Laura Mondragon Blanka Pranjic Toshikatsu Hanada Gautier Stoll Thomas Kocher Peng Zhang Alexander Jais Alexander Lercher Andreas Bergthaler Daniel Schramek Katharina Haigh Valentina Sica Marion Leduc Nazanine Modjtahedi Tsung-Pin Pai Masahiro Onji Iris Uribesalgo Reiko Hanada Ivona Kozieradzki Rubina Koglgruber Shane J. Cronin Zhigang She Franz Quehenberger Helmut Popper Lukas Kenner Jody J. Haigh Oliver Kepp Malgorzata Rak Kaican Cai Guido Kroemer Josef M. Penninger | 2019 | Cell Research2019，29，7： | 2 |
| 3 | Single droplet drying of detergents:Experimentation and modelling显示文摘This study evaluates the single droplet drying(SDD)of detergents.Experimental data are used to validate a theoretical multistage model.The experiments are carried out in an acoustic levitator analysing six different detergent formulations at 393 K.The work is completed by developing a model based on conservation equations.The model is composed of the three stages observed in the drying curve.In the first stage,an external surface drying stage occurs until the surface is saturated and the crust is formed.In the next stage,the drying rate is governed by diffusion through the pores.At the same time,the particle heats up until boiling conditions are achieved in the core of the particle.At this point,the third stage begins.In the final stage,the droplet core is in boiling conditions which are governed by the pressure drop through the crust and the concentration of salts.This model has been evaluated for the different formulations being flexible to predict the drying of different mixtures with good accuracy. | Borja Hernandez Rosa Mondragon Mark A.Pintoa Leonor Hernandez J.Enrique Julia Juan Carlos Jarque Sergio Chiva Mariano Martin | 2021 | Particuology2021，19，5： | 2 |
| 4 | Mechanical properties of short flax fibre bundle/polypropylene composites: Influence of matrix/fibre modification, fibre content, water uptake and recycling显示文摘 | A. Arbelaiz B. Fernández J.A. Ramos A. Retegi R. Llano-Ponte I. Mondragon | 2005 | Composites Science and Technology2005，，10： | 2 |
| 5 | Accurately modeling the Intemet topology显示文摘 | Zhou S Mondragon R J | 2004 | Phys Rev E2004，70，： | 1 |
| 6 | Transanal endo - rectal pull - through for Hischpmng ~s disease 显示文摘 | DE LA TORRE - MONDRAGON L ORTEGA - SALGADO JA | 1998 | J Pediatr Surg1998，33，8： | 1 |
| 7 | Reactivity of coal gasification with steam and CO2 显示文摘 | Alejandro Molina arJd Fanor Mondragon | 1998 | Fuel1998，77，15： | 1 |
| 8 | A model of packet traffic using a random wall model显示文摘 | | 1999 | Int J of Bif and Chaos1999，9，7： | 1 |
| 9 | The rich-club phenomenon in the Internet显示文摘 | Zhou S Mondragon R J | 2004 | IEEE Communications Letters2004，8，3： | 1 |
| 10 | Accurately modeling the Intemet topology 显示文摘 | Zhou S Mondragon RJ | 2004 | Physical Review E (S1539-1755)2004，70，6： | 1 |
| 11 | The rich club phenomenon in the Intemet topology显示文摘 | Zhou S Mondragon R J | 2004 | IEEE Communication Letters2004，8，3： | 1 |
| 12 | New perspectives for coal ash utilization: syntheisis of zeolitc materials 显示文摘 | Fanor Mondragon Fabio Rincon Ligia Sierra | 1990 | Fuel1990，69，2： | 1 |
| 13 | Current state of conservative management of ectopic pregnancy 显示文摘 | Marin Cantu VA Mondragon Alcocer H Cherem Cherem B | 1996 | Ginecol Obstet Mex1996，64，： | 1 |
| 14 | Physico-chemical characterization of lignins from different sources for use in phenol-formaldehyde resin synthesis显示文摘 | Tejado A Pena C Labidi J Echeverria J Mondragon I | | 0，，08： | 1 |
| 15 | The use of differential scanning calorimetry to identify coals susceptible to spontaneous combustion显示文摘 | Pilar Garcia Peter J. Hall Fanor Mondragon | 1999 | Thermochimica Acta1999，，1： | 1 |
| 16 | New perspectives for coal ash utilization:synthesis of zeolitic materials显示文摘 | Mondragon R F | 1990 | Fuel1990，69，2： | 1 |
| 17 | Transanal endorectal pull - through for Hischsprung' s disease 显示文摘 | De la Torte - Mondragon L Ortega - Salgado JA | 1998 | J Pediatr Surg1998，33，8： | 1 |
| 18 | The Rich-Club Phenomenon in the Internet Topology 显示文摘 | Shi Zhou Mondragon R J | 2004 | IEEE Communications Letters2004，8，3： | 1 |
| 19 | Accurately modeling the Internet topology显示文摘 | ZHOU Shi MONDRAGON R J | 2004 | Physical Review E2004，70，06： | 1 |
| 20 | Accurately modeling the Intemet topology显示文摘 | Zhou S Mondragon R J | 2004 | Physical Review E2004，70，6： | 1 |
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