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| 1 | Role of anti-stromal polypharmacy in increasing survival after pancreaticoduodenectomy for pancreatic ductal adenocarcinoma显示文摘AIM: To investigate the survival impact of common pharmaceuticals, which target stromal interactions, following a pancreaticoduodenectomy for pancreatic ductal adenocarcinoma. METHODS: Data was collected retrospectively for 164 patients who underwent a pancreaticoduodenectomy for pancreatic ductal adenocarcinoma(PDAC). Survival analysis was performed on patients receiving the following medications: angiotensin-converting enzyme inhibitors(ACEI)/angiotensin Ⅱ receptor blockers(ARB), calcium channel blockers(CCB), aspirin, and statins. Statistical analysis included Kaplan-meier survival estimates and cox multivariate regression; the latter of which allowed for any differences in a range of prognostic indicators between groups. Medications showing a significant survival benefit were investigated in combination with other medications to evaluate synergistic effects.RESULTS: No survival benefit was observed with respect to ACEI/ARB(n = 41), aspirin or statins on individual drug analysis(n = 39). However, the entire CCB group(n = 26) showed a significant survival benefit on multivariate cox regression; hazard ratio(HR) of 0.475(CI = 0.250-0.902, P = 0.023). Further analysis revealed that this was influenced by a group of patients who were taking aspirin in combination with CCB; median survival was significantly higher in the CCB + aspirin group(n = 15) compared with the group taking neither drug(n = 98); 1414 d vs 601 d(P = 0.029, logrank test). Multivariate cox regression revealed neither aspirin nor CCB had a statistically significant impact on survival when given alone, however in combination the survival benefit was significant; HR = 0.332(CI = 0.126-0.870, P = 0.025). None of the other medications showed a survival benefit in any combination.CONCLUSION: Aspirin + CCB in combination appears to increase survival in patients with PDAC, highlighting the potential clinical use of combination therapy to target stromal interactions in pancreatic cancer. | Samuel J Tingle John A Moir Steven A White | 2015 | World Journal of Gastrointestinal Pathophysiology2015，6，4： | 2 |
| 2 | Degrees of reaction of the slag in some blends with Portland cements显示文摘 | Lumley J S Gollop R S Moir G K | 1996 | Cement and Concrete Research1996，26，1： | 2 |
| 3 | Heterologous protein secre- tion from yeast显示文摘 | Smith R A Duncan M J Moir D T | 1985 | Science1985，20，： | 1 |
| 4 | Changes in activity of the Cu-Zn superoxide dismutase enzyme in tissues of the rat with changes in dietary copper显示文摘 | Paynter DI Moir R J Underwood EJ | 1979 | J Nutr1979，109，： | 1 |
| 5 | Conjugated linoleic acids (CLAs) regulate the expression of key apoptotic genes in human breast caner ceUs显示文摘 | MAJUMDER B WAHLE K W J MOIR S | 2002 | FASEB2002，16，： | 1 |
| 6 | The purification of ammonia monooxygenase from Paracoccus denitrificans显示文摘 | Moir J W Crossman L C Spiro S | 1996 | FEBS Lett1996，387，： | 1 |
| 7 | Degrees of reaction of the slag in some blends with Portland cements 显示文摘 | LUMLEY J S GALLOP R S MOIR G K | 1996 | Cem Concr Res1996，26，1： | 1 |
| 8 | Hydraulic and sedimentary characteristics of habitat utilized by Atlantic salmon for spawning in the Girnock Burn,Scotland显示文摘 | MOIR H J SOULSBY C YOUNGSON A | 1998 | Fisheries Management and Ecology1998，5，3： | 1 |
| 9 | Changes with time in the form and availability of residual fertilizer phosphorus on Chernozemic soils 显示文摘 | WAGER B I STEWART J W B MOIR J O | 1986 | Can J Soil Sci1986，66，： | 1 |
| 10 | Anti-microbial action of melanocortin peptides and identification of a novel X-Pro-D/L-Val sequence in Gram-positive and Gram-negative bacteria显示文摘 | CHARNLEY M MOIR A J DOUGLAS C W | 2008 | Peptides2008，29，6： | 1 |
| 11 | The biochemical characterization of novel non-heam-iron hydroxylamine oxidase from Paracoccus denitrificans GB17 显示文摘 | Moir J W B Wehrfritz J M | 1996 | Biochem J1996，319，： | 1 |
| 12 | Degrees of reaction of the slag in some blends with portland and cements显示文摘 | Lumley J S Gollop R S Moir G K | 1996 | Cement and Concrete Research1996，26，： | 1 |
| 13 | Heterotroph- ic nitrification in Paracoccus denitrificans显示文摘 | CROSSMAN L C MOIR J W SPIRO S | 1998 | Biochemical So- ciety Transactions1998，26，3： | 1 |
| 14 | Mode of action, purification and amino acid sequence of plantaricin C19,an anti-Listera bacteriocin produced by Lactobacillus plantarum C 19 显示文摘 | Atrih A Rekhif N Moir A J G | 2001 | Int J Food Microbiol2001，68，6： | 1 |
| 15 | Endourological management of urolithiasis in donor kidneys prior to renal transplant显示文摘 | Vasdev N Moir J Dosani MT | 2011 | ISRN Urol2011，，24： | 1 |
| 16 | Detection and characterization of a bacteriocin produced by Lactobacillus plantarum C 19显示文摘 | Atrih A Rekhif N Moir A J G | 1993 | Canadan Journal of Microbiology1993，39，： | 1 |
| 17 | Mode of action,purification and amino acid sequence of plantaricin C19,an anti-Listera bacteriocin produced by Lactobacillus plantarum C19显示文摘 | Atrih A Rekhif N Moir A J G | 2001 | International Journal of Food Microbiology2001，68，： | 1 |
| 18 | Acute promyelocytic transformation in a case of acute myelomonocytic leukemia显示文摘 | MOIR D J PEARSON J BUCKLE V J | 1984 | Cancer Genet Cytogenet1984，12，： | 1 |
| 19 | Degree of reaction of the slag in some blends with Portland cements显示文摘 | Lumley J S Gollop R S Moir G K | 1996 | Cement and concrete research1996，26，1： | 1 |
| 20 | The Purification of a cdl type nitrite reductase from the aerobic denitrifier Thiophaera pantotropha 显示文摘 | Moir J W Baratta D Richardson D J | 2003 | Eur J Bichem2003，212，： | 1 |
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