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| 1 | Mesenchymal VEGFA induces aberrant differentiation in heterotopic ossification显示文摘Heterotopic ossification(HO)is a debilitating condition characterized by the pathologic formation of ectopic bone.HO occurs commonly following orthopedic surgeries,burns,and neurologic injuries.While surgical excision may provide palliation,the procedure is often burdened with significant intra-operative blood loss due to a more robust contribution of blood supply to the pathologic bone than to native bone.Based on these clinical observations,we set out to examine the role of vascular signaling in HO.Vascular endothelial growth factor A(VEGFA)has previously been shown to be a crucial pro-angiogenic and pro-osteogenic cue during normal bone development and homeostasis.Our findings,using a validated mouse model of HO,demonstrate that HO lesions are highly vascular,and that VEGFA is critical to ectopic bone formation,despite lacking a contribution of endothelial cells within the developing anlagen. | Charles Hwang Simone Marini Amanda KHuber David MStepien Michael Sorkin Shawn Loder Chase APagani John Li Noelle DVisser Kaetlin Vasquez Mohamed AGarada Shuli Li Jiajia Xu Ching-Yun Hsu Paul BYu Aaron WJames Yuji Mishina Shailesh Agarwal Jun Li Benjamin Levi | 2019 | Bone Research2019，7，4： | 4 |
| 2 | Relapse of both small cell lung cancer and Lambert-Eaton myasthenic syndrome after a 13-year disease-free survival period显示文摘Lambert-Eaton myasthenic syndrome(LEMS) is a paraneoplastic syndrome and only 3%of small cell lung carcinoma(SCLC) patients have LEMS.Moreover,the recurrence of SCLC after a disease-free survival(DFS) of more than 10 years is rare.We report a patient who had a recurrence of both SCLC and LEMS after a 13-year DFS period.A 69-year-old man was diagnosed with LEMS and SCLC(cT0N2M0,stage ⅢA) 13 years ago.Chemoradiotherapy was performed and a complete response was achieved.With anticancer treatment,the LEMS symptoms was alleviated.At the age of 82 years,gait disturbance appeared followed by left supraclavicular lymphadenopathy and further examination revealed the recurrence of SCLC.Careful screening for the recurrence of SCLC might be needed when the patient has recurrent or secondary paraneoplastic neurological syndrome even after a long DFS period. | Fumio Asano Keisuke Watanabe Masaharu Shinkai Yoshitaka Tei Kei Mishina Mikiko Tanabe Hiroshi Ishii Masahiro Shinoda Tadasuke Shimokawaji Makoto Kudo Takeshi Kaneko | 2016 | Chinese Journal of Cancer2016，35，11： | 3 |
| 3 | Nonsteroidal Anti-Inflammatory Drug-Activated Gene-1 Over Expression in Transgenic Mice Suppresses Intestinal Neoplasia显示文摘 | Seung Joon Baek Ryuji Okazaki Seong-Ho Lee Jeanelle Martinez Jong-Sik Kim Kiyoshi Yamaguchi Yuji Mishina David W. Martin Ahmed Shoieb Michael F. Mcentee Thomas E. Eling | 2006 | Gastroenterology2006，，5： | 2 |
| 4 | Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling 显示文摘 | I-luang SM Mishina YM Liu S | 2009 | Nature2009，461，7264： | 1 |
| 5 | Crossed cerebellar diaschisis in patients with cortical infarction: logistic regression analysis to control for confounding effects显示文摘 | Komaba Y Mishina M Utsumi K | 2004 | Stroke2004，35，2： | 1 |
| 6 | Aerodynamic Performance of a Centrifugal Compressor With Vaned Diffusers显示文摘 | Yoshinaga Y Gyobu I Mishina H Koseki F | 1980 | ASME Journal of Fuids Engineering1980，102，12： | 1 |
| 7 | Population pharmacokinetics of sirolimus in kidney transplant patients 显示文摘 | Ferron GM Mishina EV Zimmerman JJ | 1997 | Clin Pharmacol Ther1997，61，4： | 1 |
| 8 | BMP signaling and early embryonic patterning 显示文摘 | KISHIGAMI S MISHINA Y | 2005 | Cytokine Growth Factor Rev2005，16，： | 1 |
| 9 | A Risk-stratifi- cation model of non-small cell hmg cancers using eyclin E, Ki-67, and ras p21 显示文摘 | Dosaka-Akita H Hommura F Mishina T | 2001 | Cancer Res2001，61，6： | 1 |
| 10 | Design, synthesis, and structure-activity relationships of 2-substituted-2-amino-1,3-propanediols: Discovery of a novel immunosuppressant, FTY720显示文摘 | Kunitomo Adachi Toshiyuki Kohara Noriyoshi Nakao Masafumi Arita Kenji Chiba Tadashi Mishina Shigeo Sasaki Tetsuro Fujita | 1995 | Bioorganic & Medicinal Chemistry Letters1995，，8： | 1 |
| 11 | Spatial variabil- ity of organic matter dynamics in the semi-arid croplands of Northern Kazakhstan 显示文摘 | Yanai J Mishina A Furakawa S | 2005 | Soil Science Plant Nutri- ent2005，51，2： | 1 |
| 12 | Tankyrase inhibi tion stabilizes axin and antagonizes Wnt signalling 显示文摘 | Huang SM Mishina YM Liu S | 2009 | Nature2009，461，7264： | 1 |
| 13 | Heterozygosity with respect to Zfp148 causes complete loss of fetal germ cells during mouse embryogenesis显示文摘 | TAKEUCHI A MISHINA Y MIYAISHI O | 2003 | Nat Genet2003，33，2： | 1 |
| 14 | BMP receptor I- A is required in mammalian neural crest cells for development of the cardiac outflow tract and ventricular myocardium 显示文摘 | Stottmann RW Choi M Mishina Y | 2004 | Development2004，131，9： | 1 |
| 15 | Atmospheric characteristics in friction and and wear of metals显示文摘 | Mishina H | 1992 | Wear1992，152，1： | 1 |
| 16 | Bone morphogenetic protein type IA receptor signaling regulates postnatal osteoblast function and bone remodeling显示文摘 | Mishina Y Starbuck MW Gentile MA | 2004 | J Biol Chem2004，279，27： | 1 |
| 17 | Are More Resources Always Better for Growth? Resource Stickiness in Market and Product Ex- pansion 显示文摘 | Mishina Y Pollock T G Porac J F | 2004 | Strategic Management Journal2004，25，12： | 1 |
| 18 | Is video-assisted thoracoscopic surgery a feasible approach for clinical NO and postoperatively pathological N2 non-small cell lung cancer显示文摘 | Watanabe A Mishina T Ohori S | 2008 | European Journal of Cardio-Thoracic Surgery2008，，5： | 1 |
| 19 | Struvite recovery from wastewater having low phosphate concentration 显示文摘 | Mitani Y Sakai Y Mishina F | 2003 | Journal of Water and Environment Technology2003，1，1： | 1 |
| 20 | Is video-assisted thoracoscopic surgery a feasible approach for clinical NO and postopera-tively pathological N2 non-small cell lung cancer显示文摘 | Watanabe A Mishina T Ohori S | 2008 | Eur J Car-diothorac Surg2008，33，5： | 1 |
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